The future of biology is being written in code. We’re excited to co-host an ML × Bio Mixer at NeurIPS 2025 with Blank Bio (YC S25) to connect researchers, founders, and engineers who are turning ML breakthroughs into biotech reality. 🧬🤖 If you’re exploring the intersection of machine learning and biology, from RNA foundation models to drug discovery platforms, join us on Dec 4 at 6 PM for an evening of food, drinks, and great conversation with fellow builders. Hosted by Sahir Raoof, Philip Fradkin, Ruian Shi, and Jonathan Hsu. RSVP → https://luma.com/1ycvcndz
SignalFire
Venture Capital and Private Equity Principals
San Francisco, California 19,242 followers
Built like startups we fund
About us
SignalFire is the first venture capital firm built like a technology company to better solve for the needs of founders. The core of its value-add is Beacon, the AI engine SignalFire has been refining since the firm's launch in 2013. Beacon tracks more than 600 million employees and 80 million companies to guide the fund’s investing and assist portfolio companies with scaling their teams and revenue. SignalFire also helps early-stage founders navigate the toughest parts of building a company at every stage, with expert advisors, 100 skill-building workshops a year, and an in-house team of recruiters, data scientists, PR experts, and go-to-market leaders. With over $2.1 billion in assets under management, SignalFire focuses on investing from seed to scale. The firm’s key sectors include AI/ML, developer tools, B2B SaaS, healthcare, cybersecurity, and consumer. https://www.signalfire.com/disclosures
- Website
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http://www.signalfire.com
External link for SignalFire
- Industry
- Venture Capital and Private Equity Principals
- Company size
- 11-50 employees
- Headquarters
- San Francisco, California
- Type
- Privately Held
- Founded
- 2012
Locations
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Primary
Get directions
501 2nd St
100
San Francisco, California 94107, US
Employees at SignalFire
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Tom Ryan
Hypergrowth entrepreneur & CEO — from 0 to 1 and 1 to ~$9B 🚀 Launched and scaled Pluto TV and Paramount+. Originated FAST
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Jim Stoneham
Partner, SignalFire
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Chris Scoggins
Former builder of companies now helping current builders of companies at Signalfire.
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Rogier Verhulst
Co-Founder, KwantumLabs.ai | Advisor | ex‑LinkedIn, ex‑Microsoft | AI‑First Brand Measurement & Market Fit
Updates
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What a night! 🔥🔥🔥 Still buzzing from our TechCrunch Disrupt after-party at The Phoenix Hotel SF where 700+ founders, developers, VCs, and builders clocked out for an evening with pool floats, LED dance floors, dancing robots, and silent disco headphones. Eight awesome DJs and performers kept the beats rolling while robot battles turned into robot dance-offs, and the silent disco became anything but silent. Between the splash-zone moves, cocktails and tacos, and energetic conversations, it was pure controlled chaos, and we loved every second of it! 🎧🫶 If you were there, you felt it, the mix of energy, optimism, and weird brilliance that makes this ecosystem what it is. To everyone who showed up, danced, debated, or accidentally joined a robot battle… thanks for bringing your best vibes. This community reminds us why we love being part of the future of tech. See you next year: same city, same chaos, but with a new venue and even bigger energy.💥💃 Huge thanks to our sponsors Inworld AI and JetBrains for helping make this an epic night. #TechCrunchDisrupt #Startups #SFEvents
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SignalFire reposted this
Venture Partner for consumer at SignalFire, sharing pitch strategies based on 8 years at TechCrunch
11 years ago, I met my future wife at a TechCrunch Disrupt after-party. That slightly geeky but earnest gathering changed my life, so I feel a duty to keep hosting them. Last night at our SignalFire Disrupt after-party, I bet someone found their co-founder, new job, lead investor, or maybe their forever person. Founders should stay locked. BUT if they only clock out for a few hours, we want to give them a place to commune and be reinspired by the world they’re building for. Plus, you might hit the jackpot too
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The next leap in enterprise AI starts with cleaner, smarter data. Say hello to AIDA, your new data copilot. Congratulations to our portfolio company Anomalo on launching AIDA, an 'Intelligent Data Analyst,' built in collaboration with Google Cloud, Databricks, and Snowflake. AIDA lets teams ask questions, visualize insights, and create data quality checks, all in natural language. Every interaction makes your data smarter, healthier, and more reliable—a huge step toward truly agentic AI for enterprise data.
Introducing AIDA - Anomalo’s Intelligent Data Analyst AIDA is a first-of-its-kind AI Data Analyst built in conjunction with the world’s leading data and AI innovators like Google Cloud, Databricks and Snowflake. AIDA combines our enterprise data quality platform with cutting edge AI letting you ask questions of your data, visualize insights instantly, and create data quality checks, all in natural language. With every interaction, AIDA improves your data’s quality and health. Read about our announcement here - https://lnkd.in/dFdNmK2j #AIDA, #dataquality, #aiquality, #datagovernance, #agenticAI
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From the main stage to the startup battlefield to the dance floor, here’s where to find us at TechCrunch Disrupt this week 👇 🎤 Startup Battlefield – Session 3 📅 Oct 28 | 10:00–11:05 AM | Disrupt Stage SignalFire Founding Partner & CTO Ilya Kirnos joins judges from New Enterprise Associates (NEA), Khosla Ventures, IVP, and Lockstep to hear pitches from the world’s top early-stage founders vying for the iconic Startup Battlefield Cup and $100K equity-free prize. 💡 Fundraising Process Workshop 📅 Oct 27 | 1:30–2:20 PM | Breakout Stage SignalFire Venture Partner Josh Constine breaks down how to build a fundraising CRM, get investor FOMO, and close your round faster. Straight talk from someone who’s seen both sides of the pitch. 🌍 Do Startups Still Need Silicon Valley? 📅 Oct 28 | 1:20–2:00 PM | Builders Stage SignalFire Operating Partner Tawni L. Nazario-Cranz joins founders and investors from Lago and Revolution’s Rise of the Rest to debate whether the Valley is still the ultimate launchpad—or if the next wave of unicorns is being built everywhere else. 💦 TechCrunch Disrupt After-Party 📅 Oct 28 | 8PM-late | RSVP → We’re taking over one of SF’s most iconic hotels with 8 DJs (incl. a DJ set by Poolside 🎧), silent disco, and yes, robot fights. 🤖 🎟️ RSVP now before it caps → https://lnkd.in/gQ2qQbt2 [RSVP doesn’t guarantee entry.] Huge thanks to our sponsors JetBrains and Inworld AI for also powering the night. #TechCrunchDisrupt #TechCrunchDisrupt2025
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The best investors have always trusted their instincts, but today the smartest ones are refining them with data. This Nikkei Financial article highlights our CEO Chris Farmer’s thoughts on why the next generation of VC will be defined by a blend of data-driven foresight and human judgment. - Beacon AI, our proprietary data platform, tracks 650M people and 80M companies to spot breakout founders before anyone else sees them. - AI-native company building is redefining scale. Lean, high-output teams are now reaching what used to take hundreds of employees. - The VC model itself must evolve: secondary markets, faster M&A, and new liquidity cycles to keep innovation moving. At SignalFire, we started building for this new era over a decade ago, making venture smarter, faster, and truly founder-centric. https://lnkd.in/gYXVF4Wi
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#TBT Our epic TechCrunch Disrupt after-party from last year with 3,000+ RSVPs and a line that wrapped around the block. This year, we’re going bigger, louder, and poolside. 💦 Join us on Tue, Oct 28 as SignalFire takes over one of SF’s most iconic hotels (The Phoenix Hotel SF) for an unforgettable evening featuring"'''': 🪩 8 DJs and performers, including Poolside (DJ Set) 🤖 Robot fights (yes, with actual robots) 🎧 Silent disco + 🎷 live music Huge thanks to our sponsors JetBrains and Inworld AI. 🎟️ RSVP now to snag a spot → https://lnkd.in/gQ2qQbt2 #TechCrunchDisrupt2025 #Disrupt2025 #SFEvents
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🚕 VC Taxi is pulling up at TechCrunch Disrupt 2025! One ride, one pitch, seven minutes of straight talk with SignalFire General Partner Wayne Hu. Get candid, actionable feedback on your pitch from a VC who’s helped scale some of the most successful startups in tech. Apply to ride → https://lnkd.in/gpkGuHrh
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Real impact where it matters most. This case study from our portfolio company, Roger Healthcare, is a great example of how innovation can truly ease clinician burnout, and improve the quality of care.
What's killing home healthcare? It's not the patients. It's not the pay. It's paperwork. Mike and Anthony are clinical directors at Central Coast Home Health, Inc. They were watching their team burn out - spending 2-3 hours every night documenting care for elderly patients after long days in the field. The home healthcare industry is at a breaking point. As America ages and more seniors choose to stay in their homes, the burden on clinicians has never been higher. More patients. More complexity. More documentation. Something had to change. They brought in AI documentation for their team. The results: → Cutting doc time by at least half (many by even 80-90%) → More eye contact and engagement during patient visits → Better work-life balance → Nurses even sleeping better without the late-night screen time But here's what really mattered to Mike and Anthony... "My clinicians say I can be so much more engaged with the patient instead of having to try and capture that information while I'm trying to pretend to be engaged." More eye contact with patients. Better care. Happier clinicians. This is what good technology should do - get out of the way so clinicians can actually care for patients. Full case study with Mike and Anthony in the comments 👇
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Real innovation doesn’t just patch broken systems, it rebuilds the entire operating system beneath it. We’re proud to see two SignalFire portfolio companies Mandolin and Qualified Health named to the CB Insights Digital Health 50, recognizing the world’s highest-potential private digital health startups of 2025! 🏥💊 - Mandolin is redefining access to life-saving specialty therapies. Their AI agents automate the manual workflows behind drug infusions,from insurance verification to billing, helping 700+ infusion centers treat more patients, in days not weeks. - Qualified Health is building the safety layer for healthcare AI. Their governance and monitoring infrastructure gives health systems the guardrails and transparency to deploy GenAI responsibly across clinical and operational workflows. Both teams are re-wiring healthcare’s most entrenched systems one model, one patient, and one workflow at a time. Congratulations to founders Will Yin, Rohit Rustagi, Justin Norden, MD, MBA, MPhil, Shantanu Phatakwala, Beau Norgeot, PhD, Nirav R. Shah, and Dr. Kedar Mate! View the full list here: https://lnkd.in/e_tTgu8Z #DigitalHealth #AI #HealthcareAI #HLTH2025
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