1784987371
A dynamic data model for mobile GIS
Computers & Geosciences, 2009
A fast response time is a major objective for Mobile Geographic Information System (GIS) applications. This study provides a solution for improving the performance of response time by a dynamic data model. A conceptual dynamic data model is proposed, which covers (a) “position” information of selected geographic objects relevant to the GIS user's interest within his current location, (b) the selected attribute information in which the mobile GIS user is interested. In this approach, first, the attribute information is selected through a validating process making use of the temporal and attribute filters. Second, a specially designed dynamic database is employed to enable the implementation of the conceptual dynamic data model. This dynamic database is co...
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New Insights Into Interactions of Presynaptic Calcium Channel Subtypes and SNARE Proteins in Neurotransmitter Release
Front. Mol. Neurosci., 2018
Action potential (AP) induces presynaptic membrane depolarization and subsequent opening of Ca2+ channels, and then triggers neurotransmitter release at the active zone of presynaptic terminal. Presynaptic Ca2+ channels and SNARE proteins (SNAREs) interactions form a large signal transfer complex, which are core components for exocytosis. Ca2+ channels serve to regulate the activity of Ca2+ channels through direct binding and indirect activation of active zone proteins and SNAREs. The activation of Ca2+ channels promotes synaptic vesicle recruitment, docking, priming, fusion and neurotransmission release. Intracellular calcium increase is a key step for the initiation of vesicle fusion. Various voltage-gated calcium channel (VGCC) subtypes exert different ph...
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Microflora associated with the internal surfaces of rubber and stainless steel milk transfer pipeline
Journal of Applied Bacteriology, 1987
Journal Article Microflora associated with the internal surfaces of rubber and stainless steel milk transfer pipeline Get access Stephanie J. Lewis, Stephanie J. Lewis The Queen's University of Belfast, Agriculture and Food Science Centre, Newforge Lane, Belfast BT9 5PX, Northern Ireland Search for other works by this author on: Oxford Academic Google Scholar A. Gilmour A. Gilmour Department of Agriculture for Northern Ireland, Agriculture and Food Science Centre, Newforge Lane, Belfast BT9 5PX, Northern IrelandThe Queen's University of Belfast, Agriculture and Food Science Centre, Newforge Lane, Belfast BT9 5PX, Northern Ireland Address for correspondence: Dr A. Gilmour, Agriculture & Food Science Centre, Newforge Lane, Belfast BT9 5PX, Northern Ireland. Se...
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Predictors of Outcomes and Complications After Microsurgical and Endovascular Treatment of 1300 Intracranial Aneurysms
World Neurosurgery, 2019
We performed a rigorous statistical analysis of the complications and outcomes of patients with ruptured or unruptured intracranial aneurysms. Our emphasis was on the potential predictive factors when both surgical and endovascular management are offered by a team with balanced microsurgical and endovascular expertise.From January 2005 to December 2011, 1297 consecutive patients presenting with ruptured (n=829) or unruptured (n=468) aneurysms were prospectively enrolled in our vascular database. The treatment modality was determined by consensus of the endovascular and microsurgical teams. The patients' medical and neurological conditions and aneurysm characteristics were compared against the postintervention complication rates and outcomes using multivariat...
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Luteotropic Effects of Prostaglandin E2on the Human Corpus Luteum of the Menstrual Cycle and Early Pregnancy*
The Journal of Clinical Endocrinology & Metabolism, 1988
Human corpora lutea (CL) of the menstrual cycle and early pregnancy were excised at operation, cut into pieces, and incubated or superfused in the presence of hCG or prostaglandin (PG) E2. After incubation, the tissue levels of cAMP and the medium concentrations of progesterone (P) were determined, while the concentration of P was analyzed after superfusion. PGE2 stimulated cAMP formation in CL from all phases of the menstrual cycle as well as from early pregnancy and caused an increase in P formation in CL from the early and midluteal phases of the menstrual cycle as well as from early pregnancy. A difference was found in the latency, the lag phase until maximal response, and the duration of response between the effects of PGE2 and hCG on both cAMP and P fo...
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Sequence Bundles: a novel method for visualising, discovering and exploring sequence motifs
BMC Proc, 2014
We introduce Sequence Bundles--a novel data visualisation method for representing multiple sequence alignments (MSAs). We identify and address key limitations of the existing bioinformatics data visualisation methods (i.e. the Sequence Logo) by enabling Sequence Bundles to give salient visual expression to sequence motifs and other data features, which would otherwise remain hidden. For the development of Sequence Bundles we employed research-led information design methodologies. Sequences are encoded as uninterrupted, semi-opaque lines plotted on a 2-dimensional reconfigurable grid. Each line represents a single sequence. The thickness and opacity of the stack at each residue in each position indicates the level of conservation and the lines' curved paths e...
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Comparison of iso-effective and cost-effective high-dose-rate brachytherapy treatment schedules in cervical cancer – regional cancer center experience
jcb, 2019
The study is to evaluate the difference between outcomes of two high-dose-rate fractionation schedules in the treatment of intracavitary brachytherapy (ICBT) of cervical cancer.A retrospective analysis of 163 cervical cancer patients was completed. All patients received external beam radiotherapy (EBRT) to whole pelvis with concurrent weekly chemotherapy, followed by ICBT with either 7 Gy per fraction in three fractions (arm A) or 9 Gy per fraction in two fractions (arm B). Median follow-up was 19 months. The outcomes were compared in terms of 2-year actuarial local control, disease-free survival, overall survival, and late toxicity in the two treatment arms.The 2-year actuarial local control rates in arm A and arm B were 88.5% and 91.5%, respectively. The a...
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Market Foods, Own Production, and the Social Economy: How Food Acquisition Sources Influence Nutrient Intake among Ecuadorian Farmers and the Role of Agroecology in Supporting Healthy Diets
Sustainability, 2021
Rural Ecuadorians are experiencing a double burden of malnutrition, characterized by simultaneous nutrient inadequacies and excesses, alongside the social and environmental consequences of unsustainable agriculture. Agriculture can support farmer nutrition by providing income for market purchases and through the consumption of foods from own production. However, the nutritional contributions of these food acquisition strategies vary by context. We surveyed smallholder women farmers (n = 90) in Imbabura province to assess the dietary contributions of foods obtained through market purchase, own production, and social economy among farmers participating in agroecology—a sustainable farming movement—and neighboring reference farmers. We found that foods from...
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Functional MRI lateralization of memory in temporal lobe epilepsy
Neurology, 1998
To determine the feasibility of using functional magnetic resonance imaging (fMRI) to detect asymmetries in the lateralization of memory activation in patients with temporal lobe epilepsy (TLE).Assessment of mesial temporal lobe function is a critical aspect of the preoperative evaluation for epilepsy surgery, both for predicting postoperative memory deficits and for seizure lateralization. fMRI offers several potential advantages over the current gold standard, intracarotid amobarbital testing (IAT). fMRI has already been successfully applied to language lateralization in TLE.fMRI was carried out in eight normal subjects and 10 consecutively recruited patients with TLE undergoing preoperative evaluation for epilepsy surgery. A complex visual scene encoding ...
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Current treatment strategies and emerging therapies for cutaneous lymphoma
The Journal of Dermatology, 2021
AbstractCutaneous lymphoma is generally treated with skin‐directed therapies (SDT) during the early and localized stages. For the refractory or advanced stages, systemic therapies are used. Previously, retinoids and interferons were used for SDT‐resistant cases. Only a few chemotherapy options were available for more advanced disease. In recent years, many novel agents have been introduced and the strategy for systemic therapy has changed, especially for cutaneous T‐cell lymphoma (CTCL). For SDT, helical tomotherapy, a new radiation modality, has been drawing attention as an option for radiotherapy. Targeted therapies such as histone deacetylase inhibitors, mogamulizumab, brentuximab vedotin, and denileukin diftitox are...
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Witnessed resuscitation: A concept analysis
Intensive and Critical Care Nursing, 2021
The advance in the practice of resuscitation is globally recognised and fully sanctioned in scientific world. However, practicing family presence during resuscitation, also known as witnessed resuscitation, is yet to be endorsed by healthcare professionals. Many professional nursing and physician organisations have endorsed the practice of witnessed resuscitation by issuing guidelines. These organisations support family presence during resuscitation due to the research proving its benefit for patients and families. The purpose of this paper is to analyse the concept of witnessed resuscitation. A concept analysis was undertaken using Rodger’s (2000) evolutionary method. The concept analysis suggests that witnessed resuscitation refers to the presence of a f...
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Reassessing the role of precious metals as safe havens–What colour is your haven and why?
Journal of Commodity Markets, 2017
Abstract The role of gold as a safe haven asset has been extensively studied in recent years. This article extends previous literature and examines time varying safe haven properties versus equities and bonds of four precious metals (gold, silver, platinum and palladium) across eleven countries. Results suggest that the metals each play safe haven roles; there are times when one metal is not while another may be a safe haven against an asset. The second part of this article attempts to identify robust economic and political determinants of precious metals safe haven properties applying zero-inflated Poisson regression (ZIP) and extreme bound analysis (EBA). Economic Policy Uncertainty is found to be a positive and robust determinant of a precious metal being...
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Oxidation resistance of Al2O3-nanostructured/CSZ composite compared to conventional CSZ and YSZ thermal barrier coatings
Mater. Res. Express, 2016
Thermal barrier coatings are widely used in combustion sections of turbine engines, however, their main disadvantage is the spallation from the bond coat, occurring due to oxidation and formation of thermally grown oxide (TGO). In this paper, the oxidation resistance of yttria stabilized zirconia (YSZ), ceria stabilized zirconia (CSZ), and Al2O3-nanostructured/CSZ composite coatings have been studied and compared with each other. Samples were heated in air at 1100 °C using an electrical furnace. Three types of the top coats were applied by thermal spray technique on IN738LC base metal. Scanning electron microscopy was used to study the microstructure of the coatings before and after the oxidation. The experimental results showed that Al2O3-nanostructured/CS...
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Electron disequilibrium in high-energy x-ray beams
Med. Phys., 1996
The ratio between scatter dose and scatter kerma for points on the central axis of 15-MV x-ray beams has been examined by Monte Carlo calculations. This ratio, beta'S, behaves differently from that between the primary dose and kerma, beta'p. Both the primary and scatter components of beta' undergo an initial rapid buildup, however, beta'S begins from a much higher surface value. In addition, the depth required for longitudinal electron equilibrium is larger for beta'S than for beta'P. The variation of beta'S with field size and depth is attributed to the spatial variation of scatter kerma in the photon beam. The approximation beta'S = 1 is accurate enough for clinical dose-calculation purposes, leading to less than 0.5% error in total dose, while the assumpt...
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Acute ischemic complications after therapeutic parent artery occlusion with revascularization for complex internal carotid artery aneurysms
Surgical Neurology, 2009
Parent artery occlusion (PAO) is an alternative surgical strategy for complex internal carotid artery (ICA) aneurysms, which are unclippable because of their anatomical structures, including a broad neck, fragile dome, critical branch, and cavernous sinus location. Despite revascularization, ischemic complications occur after the PAO because of several factors, such as hypoperfusion, embolism, and perforator impairment. Acute ischemic complications and their mechanisms were analyzed in a consecutive series of 32 patients presenting with complex ICA aneurysms treated by PAO. Fourteen ruptured and 18 unruptured aneurysms were located in the cavernous sinus (n = 16) and paraclinoid portion (n = 16). Preoperative balloon test occlusion was performed to investiga...
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A reappraisal of various methods for measuring motor nerve refractory period in humans
Clinical Neurophysiology, 2005
To compare various techniques of stimulation and methods of analysis to estimate absolute (ARP) and relative (RRP) refractory periods in motor nerve trunks of humans. Double collision (DC) technique and two types of paired pulse (PP) technique, with test stimulation of supramaximal (PPsupra) or submaximal (PPsub) intensity, were applied to 32 healthy subjects. The ulnar nerve was stimulated either at a single site (wrist) for the PP techniques or at two sites (wrist and elbow) for the DC technique, with various distal interstimuli intervals (ISIs). The elicited compound muscle action potentials (CMAPs) were recorded from the abductor digitorum minimi muscle. The DC technique provided estimates of minimal and maximal ARPs, whereas maximal RRP values were obta...
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Phenotypic and proteomic characterization of treponemes associated with bovine digital dermatitis
Veterinary Microbiology, 2019
Bovine digital dermatitis (BDD) is a multifactorial polymicrobial infectious disease associated with multiple species and phylotypes of treponemes. However, despite the abundance of molecular signatures for treponemes that are identified in bovine lesions, relatively few isolates are cultured, and even fewer have been characterized at the level of protein expression. Here we report the successful isolation and characterization of novel strains of T. brennaborense and T. phagedenis from cases of BDD in Iowa dairy cows, and compare them to a well characterized strain of T. phagedenis, and the type strain of the more recently recognized T. pedis. Propagation of T. brennaborense was only possible at room temperature in Cooked Meat Medium, and not in oral trepone...
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Multiple Cerebral Aneurysms Associated With Neurofibromatosis Type 1
Journal of Stroke and Cerebrovascular Diseases, 2019
Neurofibromatosis type 1 (NF1) is a rare disease with an incidence of approximately one in every 3000 births. NF1 is mainly recognized as a tumor suppressor. Vasculopathy in NF1 is well described in the literature, but the association between NF1 and cerebral aneurysm has not been determined. We report a case of a 67-year-old female with NF1 accompanied by 8 cerebral aneurysms. Two of the patient's unruptured aneurysms, the large distal anterior cerebral artery (ACA) aneurysm and anterior communicating artery aneurysm, were initially treated with microsurgical clipping. The peripheral ACA aneurysm gradually increased in size and ruptured after 5 years. Coil embolization was performed for the ruptured aneurysm. Four of the 5 remaining unruptured aneurysms wer...
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Robust Stereo Image Matching for Spaceborne Imagery
IEEE Trans. Geosci. Remote Sensing, 2007
This paper presents a computationally efficient method for stereo image matching of remote sensing images. Traditional correlation methods often fail to give correct matching when the slope of the terrain is very high. A novel technique called aspect-based estimation is proposed here to find the best match points and to estimate the slope of the terrain. Stereo image matching is implemented in a hierarchical manner using wavelets to reduce the computational cost. A robust technique for identifying outliers based on local statistics is also presented here. Experimental results with CARTOSAT-1 images indicate that the aspect-based correlation and blunder detection works very efficiently and effectively in stereo image matching of remote sensing images. It is o...
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Review of the T -history method to determine thermophysical properties of phase change materials (PCM)
Renewable and Sustainable Energy Reviews, 2013
Phase change materials (PCM) are able to store thermal energy when becoming liquid and to release it when solidifying. Latent heat storage has gained importance due the applications towards increasing energy efficiency in several systems. Thus, a correct and accurate thermal characterization of these materials should be achieved. Among all possible thermal analysis methods to determine PCM thermophysical properties, the T-history method presents certain advantages. The T-history method is known to be suitable to obtain fusion enthalpy, specific heat and thermal conductivity for large phase change materials samples. On the other hand, no experimental T-history equipment is commercially available yet. Therefore, the goal of this paper is moving towards a conse...
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Levels of macrophage migration inhibitory factor and glucocorticoids in chronic wound patients and their potential interactions with impaired wound endothelial progenitor cell migration
Wound Repair Regeneration, 2012
Macrophage migration inhibitory factor (MIF), a structurally and functionally unique pleiotropic mediator in inflammation and immune processes, was identified decades ago. There is now strong evidence that MIF promotes revascularization and is involved in wound healing processes. However, its exact role in wound healing is still a matter of debate. A cohort of 33 patients was recruited, including 14 patients with acute and 19 patients with chronic wounds. Both serum and wound fluid samples were collected from each patient, and MIF and cortisol concentrations were determined. To functionally underscore MIF's potential role in wound revascularization, a chemotaxis assay was adapted to test whether and to what extent serum samples and wound fluids of each group...
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The Group Analytic Model
International Journal of Group Psychotherapy, 2017
Drawing upon psychoanalysis, sociology, and group dynamics, the basic clinical model of group analysis was first described by Foulkes (1948, 1964) and Foulkes and Anthony (1964): Four men and four women, plus the conductor, sit around a small table and engage in free-floating conversation for a 90-minute session once a week. Groups might meet more often and be supplemented by combined or conjoint therapy (Maratos, 2000). All group members actively engage in treatment processes, but the conductor is responsible for monitoring and maintaining the boundaries of the group and facilitating the processes of clarification, translation, and interpretation. The conductor should resist being tempted to give personal information to patients and should not violate the b...
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Pleasure, meaning or spirituality: Cross-cultural differences in orientations to happiness across 12 countries
Journal of Business Research, 2021
Firms and institutions are increasingly embracing well-being initiatives as a critical way to retain and engage with their employees, customers and citizens all over the world. However, cross-cultural research on the paths to happiness remains scarce and fragmented, typically conceptualizing happiness as an individualistic pleasure-based construct without considering its collectivistic meaning-based dimension. This research investigates simultaneously how hedonic (pleasure) and eudaimonic (meaning and spirituality) orientations to happiness (life satisfaction) vary across 12 countries and among 2615 individuals representing different regions of the world (six continents) and different cultural contexts (individualism or collectivism). Findings reveal no sign...
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Association of HIV Infection, Hepatitis C Virus Infection, and Metabolic Factors With Liver Stiffness Measured by Transient Elastography
Journal of Infectious Diseases, 2013
Background. Few studies have examined the relationship of human immunodeficiency virus (HIV) monoinfection and its associated perturbations with liver fibrosis. Methods. Using multivariable linear regression, we examined the demographic, behavioral, metabolic and viral factors associated with transient elastography–measured liver stiffness in 314 participants (165 HIV positive/hepatitis C virus [HCV] negative, 78 HIV positive/HCV positive, 14 HIV negative/HCV positive, 57 HIV negative/HCV negative) in the Women's Interagency HIV Study. Results. Compared with HIV negative/HCV negative women, HIV positive/HCV positive women had higher median liver stiffness values (7.1 vs 4.4 kPa; P < .001); HIV positive/HCV negative and HIV negative/HCV negative women had s...
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A novel curcumin gallium complex as photosensitizer in photodynamic therapy: Synthesis, structural and physicochemical characterization, photophysical properties and in vitro studies against breast cancer cells
Journal of Molecular Structure, 2021
The synthesis, detailed structural and physicochemical characterization of a novel Ga(III)-curcumin complex with the ancillary aromatic chelator 1,10-phenanthroline is presented herein. The complex constitutes the only crystallographically characterized structure with Ga(III) as the metal core and a curcuminoid as the ligand. The photophysical properties of the complex revealed a significant red-shift in absorption, increased photostability and comparable free radical generation compared to plain curcumin. They all are highly desirable properties for a photosensitizer. Photodynamic therapy is a non-invasive method for the treatment of various cancers which requires a photosensitizing molecule able to generate reactive oxygen species upon light irradiation. C...
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4. On Entomostraca collected in Natal by Mr. James Gibson
Proceedings of the Zoological Society of London, 1904
Proceedings of the Zoological Society of LondonVolume 74, Issue 3 p. 121-134 4. On Entomostraca collected in Natal by Mr. James Gibson G. Stewardson Brady M.D. LL.D. D.Sc F.R.S. C.M.Z.S., G. Stewardson Brady M.D. LL.D. D.Sc F.R.S. C.M.Z.S.Search for more papers by this author G. Stewardson Brady M.D. LL.D. D.Sc F.R.S. C.M.Z.S., G. Stewardson Brady M.D. LL.D. D.Sc F.R.S. C.M.Z.S.Search for more papers by this author First published: October 1904 https://doi.org/10.1111/j.1469-7998.1904.tb08317.xCitations: 5Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of...
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Experimental studies in plastic wave propagation
Journal of the Mechanics and Physics of Solids, 1962
The dynamic stress-strain curves of annealed specimens of pure copper, pure aluminium and an aluminium alloy have been measured by experiments in which short bars of these materials were fired from a compressed air gun at a steel pressure bar. It was found that for copper and aluminium the dynamic curves lay appreciably above the static ones, whereas for the aluminium alloy there appeared to be no appreciable rate-of-strain effect. These dynamic results have been used to test the prediction of the strain-rate independent theory of plastic wave propagation and it was found that the theory gave a reliable relation between the permanent strain produced at the end of a bar and its velocity of impact. The theoretical predictions of strain distribution were less s...
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Cold-Induced Ascites in Broiler Chickens and Its Improvement by Temperature-Controlled Rearing
Avian Diseases, 2002
Pulmonary hypertension syndrome (PHS), also known as ascites, in broiler chickens prevailed in the local area of Ibaraki prefecture, Japan, and was investigated epidemiologically, serologically, and pathologically. PHS developed in chickens older than 35 days of age when rapid increase of body weight started. Approximately 90% of affected birds were males, in which weight increase was greater than in females. Serologic test revealed that PHS broilers had an increase of hematocrit value. Pathologic studies indicated that the heart of affected birds had an obese-induced pressure and cold exposure triggered congestion in the right ventricle/cava and an increase in peritoneal fluid. These changes were consistent with the previous reports of PHS, so we designed t...
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Comparative Analysis and Identification of miRNAs and Their Target Genes Responsive to Salt Stress in Diploid and Tetraploid Paulownia fortunei Seedlings
PLoS ONE, 2016
Salt stress is a global environmental problem that affects plant growth and development. Paulownia fortunei is an adaptable and fast-growing deciduous tree native to China that is environmentally and economically important. MicroRNAs (miRNAs) play important regulatory roles in growth, development, and stress responses in plants. MiRNAs that respond to biotic stresses have been identified; however, how miRNAs in P. fortunei respond to salt stress has not yet been reported. To identify salt-stress-responsive miRNAs and predict their target genes, four small RNA and four degradome libraries were constructed from NaCl-treated and NaCl-free leaves of P. fortunei seedlings. The results indicated that salt stress had different physiological effects on diploid and t...
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Glucose shields RINm5F beta cells against arsenic-induced apoptosis
Sci Rep, 2025
Type 2 Diabetes (T2D) is characterized by hyperglycemia due to pancreatic beta cell failure and the development of insulin resistance. Although high carbohydrate intake and arsenic exposure increase the risk of developing T2D, their interactions and mechanisms associated with changes in insulin signaling pathways that lead to beta-cell apoptosis remain unknown. We determined the effects of in vitro exposure for 48 and 72 h to arsenic (As, 2 µM), glucose (Gluc, 22 mM), and their interaction (As + Gluc) on the apoptosis in RINm5F insulinoma beta-cells and explored the possible mechanisms dependent on alterations in insulin signaling pathways. We found that arsenic induced early apoptosis, while glucose co-treatment reduced arsenic-induced apoptosis. Mechanist...
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Film boiling from a downward-facing curved surface in saturated and subcooled water
International Journal of Heat and Mass Transfer, 1996
Film boiling from a downward-facing curved surface in saturated and 5 K, 10 K, and 14 K subcooled water was investigated experimentally. Local and surface average Nusselt number correlations developed for both saturation and subcooled conditions were within ± 10% of data. Surface rewetting in saturation boiling was hydrodynamically driven, but thermally driven in subcooled boiling. Consequently, surface rewetting in the former occurred earlier at higher qmin; the critical film thickness prior to rewetting, however, was higher than that at 10 K and 14 K subcooling, but lower than at 5 K subcooling. Surface rewetting occurred first at lowermost position, θ = 0°, then sequentially at higher inclinations. For saturation boiling, the critical film thickness wa...
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Defining the states of consciousness
Neuroscience & Biobehavioral Reviews, 2001
Consciousness remains an elusive concept due to the difficulty to define what has been regarded for many years as a subjective experience, therefore irrelevant for scientific study. Recent development in this field of research has allowed to provide some new insight to a possible way to define consciousness. Going through the extensive literature in this domain, several perspectives are proposed to define this concept. (1) Consciousness and Attention may not reflect the same process. (2) Consciousness during wake and sleep may not involve the same mechanisms. (3) Besides physiological states of consciousness, human beings can experience modified states of consciousness either by self-training (transcendental meditation, hypnosis, etc.) or by drug intake (hal...
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Enterobacteriaceae, coliforms, faecal coliforms and salmonellas in raw ewes'milk
Journal of Applied Bacteriology, 1987
Thirty-nine samples of freshly drawn ewes' milk collected at 13 farms, and 120 samples of raw ewes' milk collected on arrival at a dairy were examined. Farm samples had geometric mean counts of 4.4 X 10(2) Enterobacteriaceae/ml, 3.9 X 10(2) coliforms/ml and 2.0 X 10(2) faecal coliforms/ml, whereas the respective mean counts were 6.2 X 10(3)/ml, 5.4 X 10(3)/ml and 1.3 X 10(3)/ml for dairy samples. Salmonellas were not detected by enrichment procedures in any of the 159 samples examined. Escherichia coli (47.5% strains), Enterobacter cloacae (17.7%), Ent. agglomerans (11.3%), Hafnia alvei (6.5%) and Klebsiella oxytoca (6.0%) were the predominant species in 434 Enterobacteriaceae strains isolated from farm samples. Levels and species of Enterobacteriaceae found...
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Prognostic Value of Post-exercise Oxygen Uptake Kinetics in Heart Failure with Reduced Ejection Fraction
Journal of Cardiac Failure, 2018
Objectives Recent data indicate high predictive value of oxygen uptake (VO 2 ) kinetics following exercise test in patients with heart failure (HF). The aim of this study was to confirm prognostic significance of VO 2 recovery delay (VO 2 RD) in HF with reduced ejection fraction (HFrEF). Methods We retrospectively analyzed the subgroup of 70 patients with HFrEF, NYHA classes II-III (55 male, mean age 58.8±12,6 years, mean EF=29,7±8,4%) previously included in the prospective observational study. All patients were on optimal medical treatment. At baseline the patients underwent comprehensive investigation including standard clinical examination, echocardiography and cardiopulmonary exercise testing. VO 2 RD defined as time from the end of loaded exercise unt...
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Electrophysiological features of patients with POEMS syndrome
Clinical Neurophysiology, 2005
Polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome is a rare cause of polyneuropathy. Although the polyneuropathy component is essential for the diagnosis of the disease, the pattern of associated electrodiagnostic abnormalities has not been characterized in detail. The purpose of this study was to elucidate the features of nerve conduction abnormalities in POEMS syndrome.We reviewed the medical records and nerve conduction studies (NCS) of 12 consecutive patients with POEMS.A total of 68 motor and 46 sensory nerves were examined. Compound muscle action potentials (CMAPs) and sensory nerve action potentials (SNAPs) were not elicited in lower limbs more frequently compared with in upper limbs (P
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Survey of retinal haemorrhages in neonatal thoroughbred foals
Veterinary Record, 2000
Twenty-seven of 167 neonatal thoroughbred foals (16 per cent) were found to have retinal haemorrhages after a careful examination of the entire fundus. Experience in differentiating haemorrhages from other lesions, and the selection of foals from normal populations, were considered to have an important effect on their apparent incidence. Bilateral haemorrhages were more common and there was a significantly higher incidence in female foals. The numbers of haemorrhages ranged between one and 20; 36 per cent of eyes with retinal haemorrhages had the small punctate type and 56 per cent had the splash-like form. There was no change from one type of haemorrhage to another, and the patterns of resolution were similar. The haemorrhages were in the tapetal fundus, ex...
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Identification and characterization of novel Kirrel isoform during myogenesis
Physiol Rep, 2013
Somatic cell fusion is an essential component of skeletal muscle development and growth and repair from injury. Additional cell types such as trophoblasts and osteoclasts also require somatic cell fusion events to perform their physiological functions. Currently we have rudimentary knowledge on molecular mechanisms regulating somatic cell fusion events in mammals. We therefore investigated during in vitro murine myogenesis a mammalian homolog, Kirrel, of the Drosophila Melanogaster genes Roughest (Rst) and Kin of Irre (Kirre) which regulate somatic muscle cell fusion during embryonic development. Our results demonstrate the presence of a novel murine Kirrel isoform containing a truncated cytoplasmic domain which we term Kirrel B. Protein expression levels of...
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Electrochemical detection of uric acid via uricase-immobilized graphene oxide
Analytical Biochemistry, 2016
Measurement of the uric acid level in the body can be improved by biosensing with respect to the accuracy, sensitivity and time consumption. This study has reported the immobilization of uricase onto graphene oxide (GO) and its function for electrochemical detection of uric acid. Through chemical modification of GO using 1-ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysulfosuccinimide (NHS) as cross-linking reagents, the enzyme activity of the immobilized uricase was much comparable to the free enzyme with 88% of the activity retained. The modified GO-uricase (GOU) was then subjected to electrocatalytic detection of uric acid (UA) via cyclic voltammetry (CV). For that reason, a glassy carbon electrode (GCE) was modified by adhering the GO alo...
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Tetradecyl 2,3-dihydroxybenzoate alleviates oligodendrocyte damage following chronic cerebral hypoperfusion through IGF-1 receptor
Neurochemistry International, 2020
Currently, there is no effective therapy for chronic cerebral hypoperfusion-induced subcortical ischemic vascular dementia (SIVD), which displays cognitive deficits and progressive white matter damage. Tetradecyl 2,3-dihydroxybenzoate (ABG-001) is a lead compound derived from gentisides with neuritogenic activity. In this report, we intended to investigate the effect of ABG-001 on the SIVD experimental model through right unilateral common carotid arteries occlusion (rUCCAO) in mice. We found that ABG-001 remarkably alleviated white matter damage and cognitive deficits after cerebral hypoperfusion induced by rUCCAO. The protection of ABG-001 on the white matter was related to an amelioration of the oligodendrocyte apoptosis and demyelination rather than prom...
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Venetoclax: Management and Care for Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
CJON, 2017
Venetoclax (Venclexta™) is a potent, selective, orally available, small-molecule B-cell lymphoma 2 inhibitor that achieves response rates of about 80% and has an acceptable safety profile for patients with relapsed or refractory chronic lymphocytic leukemia (CLL). .The aim was to describe treatment management considerations when caring for patients using venetoclax. .A review was done of safety and management considerations based on current clinical practice and 240 patients with CLL who received venetoclax monotherapy on clinical trials from 2011-2016. .Common adverse events were neutropenia, diarrhea, nausea, anemia, upper respiratory tract infection, thrombocytopenia, and fatigue. Because of rapid tumor reduction with venetoclax, nurses should be aware ...
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Conjugated linoleic acid in diets for juvenile Atlantic salmon (Salmo salar); effects on fish performance, proximate composition, fatty acid and mineral content
Aquaculture, 2004
We have examined the effects of different levels of dietary conjugated linoleic acid (CLA) on the growth and body composition of 0.7 g Atlantic salmon fry. Groups of fish were fed diets containing 0%, 0.5%, 1.0% or 2.0% CLA for a period of 12 weeks. The fish were weighed in bulk at start and after each 4-week interval, and samples were collected for analysis of the proximate composition, fatty acid composition and mineral composition. Growth rates were calculated, as were the fatty acid content in body burden increase (BBI) of lipid and the deposition ratio (RD) of fatty acids. CLA did not have a significant effect on the growth rate or on the proximate composition of salmon fry, even though there was a trend (P=0.08) towards higher final weight in the fish ...
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Polyelectrolyte nanocapsule probe for the determination of imidacloprid in agricultural food samples
Food and Agricultural Immunology, 2019
Layer-by-layer (LBL) technique is a well-established method for the formation of nanocapsules, which could encapsulate nanoparticles by polyelectrolyte and has received great interest in some areas of research. In this study, colloidal gold nanoparticles (AuNPs) were used as a vehicle for loading horseradish peroxidase (HRP), and AuNPs-HRP was encapsulated by using LBL technique to form a signal amplification nanocapsule probe. Based on the probe, an immunoassay was developed for the detection of imidacloprid in agricultural food samples (rice, pear and cabbage). The IC50 value of the assay was 0.11 ng mL−1 which was 8-9954 times lower than those of traditional ELISAs and well below the maximum residue limits (MRLs) permitted by the European Union (EU). Th...
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Lactobacillus plantarum C29 alleviates NF-κB activation and Th17/Treg imbalance in mice with TNBS-induced colitis
Food and Agricultural Immunology, 2018
In this study, we examined whether Lactobacillus plantarum C29 could restore 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced T helper 17 (Th17)/regulatory T cells (Tregs) imbalance in mice. Treatment with C29 inhibited the differentiation of splenic T cells into Th17 cells and the expression of retinoic acid receptor-related orphan receptor gamma t (RORγt) and IL-17 in vitro, whereas promoting the differentiation into Tregs. Oral administration of Lactobacillus plantarum C29 in mice attenuated TNBS-induced colon shortening, myeloperoxidase (MPO) activity, inducible Nitric oxide (NO) synthase, and cyclooxygenase-2 expression, and activation of NF-κB in the colon of mice. C29 treatment downregulated TNF-α, IL-17, and IL-1β expression, while increasing IL...
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Water based homogenous carbon ink modified electrode as an efficient sensor system for simultaneous detection of ascorbic acid, dopamine and uric acid
Electrochimica Acta, 2017
Development of new sensor material suitable for simple, cost effective and quick practical application is a demanding research interest in electroanalytical chemistry. Carbon based inks prepared using different type carbon materials and binders as a gel or suspension have been often used as active sensor materials. Unfortunately, those systems are involved with complicated preparation route and usage of hazardous chemicals. Herein, we report a water based carbon ink composed of low cost carbon black powder, chitosan and acetic acid (prepared within 15 ± 2 min) for electrochemical sensor applications. A new carbon ink modified electrode was fabricated in this work by drop-casting of micro-litre quantity of the CB-Chit ink on a cleaned glassy carbon electrode...
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Speckle reduction of ultrasound images based on Rayleigh-trimmed anisotropic diffusion filter
Pattern Recognition Letters, 2011
A novel method is proposed to reduce speckle in ultrasound images. Based on the assumption of Rayleigh distribution of speckle, a Rayleigh-trimmed filter is first proposed to estimate the relative standard deviations of local signals and the results are used to determine the parameter that controls an alpha-trimmed mean filter for suppressing the primary noise. Then the anisotropic diffusion is subsequently applied to further reduce noise while enhancing features and structures in the original image. We also extend the proposed method to three-dimensional space by introducing time as one additional dimension. The proposed method effectively utilizes the statistical characteristics of speckle and the two-step despeckling algorithm reduces speckle significantl...
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Effects of High-Pressure Processing on the Safety, Quality, and Shelf Life of Ready-to-Eat Meats
Journal of Food Protection, 2004
Ready-to-eat (RTE) meats (low-fat pastrami, Strassburg beef, export sausage, and Cajun beef) were pressure treated at 600 MPa, 20 degrees C, for 180 s to evaluate the feasibility of using high-pressure processing (HPP) for the safe shelf-life extension of these products. After processing, samples were stored at 4 degrees C for 98 days during which time microbiological enumeration and enrichments were performed. Additionally, sensory analyses were undertaken to determine consumer acceptability and purchase intent over the duration of storage. Counts of aerobic and anaerobic mesophiles, lactic acid bacteria, Listeria spp., staphylococci, Brochothrix thermosphacta, coliforms, and yeasts and molds revealed that there were undetectable or low levels for all types...
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Pre-school hyperactivity/attention problems and educational outcomes in adolescence: prospective longitudinal study
Br J Psychiatry, 2013
High levels of attentional and hyperactivity problems in school-aged children, even if subthreshold for attention-deficit hyperactivity disorder (ADHD), are associated with academic under-achievement. Few large-scale, community-based studies have investigated the relationship between pre-school and adolescence.To investigate whether pre-school hyperactivity/inattention and conduct problems are independently associated with academic outcomes at age 16.Data from the prospective, population-based Avon Longitudinal Study of Parents and Children (ALSPAC) were used. After adjusting for a broad range of confounder variables, the associations between parent-rated hyperactivity/inattention and conduct problems measured at age 3 and academic outcomes at age 16 (nation...
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Throughput Maximization in Wireless Powered Communication Networks
IEEE Trans. Wireless Commun., 2014
This paper studies the newly emerging wireless powered communication network in which one hybrid access point (H-AP) with constant power supply coordinates the wireless energy/information transmissions to/from a set of distributed users that do not have other energy sources. A "harvest-then-transmit" protocol is proposed where all users first harvest the wireless energy broadcast by the H-AP in the downlink (DL) and then send their independent information to the H-AP in the uplink (UL) by time-division-multiple-access (TDMA). First, we study the sum-throughput maximization of all users by jointly optimizing the time allocation for the DL wireless power transfer versus the users' UL information transmissions given a total time constraint based on the users' D...
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Phenotypic and proteomic characterization of treponemes associated with bovine digital dermatitis
Veterinary Microbiology, 2019
Bovine digital dermatitis (BDD) is a multifactorial polymicrobial infectious disease associated with multiple species and phylotypes of treponemes. However, despite the abundance of molecular signatures for treponemes that are identified in bovine lesions, relatively few isolates are cultured, and even fewer have been characterized at the level of protein expression. Here we report the successful isolation and characterization of novel strains of T. brennaborense and T. phagedenis from cases of BDD in Iowa dairy cows, and compare them to a well characterized strain of T. phagedenis, and the type strain of the more recently recognized T. pedis. Propagation of T. brennaborense was only possible at room temperature in Cooked Meat Medium, and not in oral trepone...
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Discriminating varieties of tea plant based on Vis/NIR spectral characteristics and using artificial neural networks
Biosystems Engineering, 2008
A method for discriminating varieties of tea plant based on their visible/near infrared reflectance (Vis/NIR) spectral characteristics was developed. Field experiments were conducted in three different tea gardens, and 293 samples of the three tea varieties were selected for Vis/NIR spectroscopy measurement. The spectral data were pretreated to eliminate system noise and external disturbances; several pretreatments were evaluated for their discrimination accuracies. Diagnostic information was extracted mathematically to build the discrimination model. The methods were the integrated wavelet transform (WT), principal component analysis and artificial neural networks (ANN). The diagnostic information from WT was re-expressed and visualised in principal compone...
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Acinetobacter baumannii rOmpA vaccine dose alters immune polarization and immunodominant epitopes
Vaccine, 2013
The rOmpA vaccine has been shown to protect mice from lethal infection caused by extreme-drug-resistant (XDR) Acinetobacter baumannii. The role of dose in immunology of the rOmpA vaccine was explored.Mice were vaccinated with various doses of rOmpA plus aluminum hydroxide (Al(OH)(3)) adjuvant. The impact of dose on antibody titers, cytokine production, and immunodominant epitopes was defined.Anti-rOmpA IgG and IgG subtype titers were higher at larger vaccine doses (30 and 100 μg vs. 3 μg). The 3 μg dose induced a balanced IFN-γ-IL-4 immune response while the 100 μg dose induced a polarized IL-4/Type 2 response. Epitope mapping revealed distinct T cell epitopes that activated IFN-γ-, IL-4-, and IL-17-producing splenocytes. Vaccination with the 100 μg d...
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Electrochemical Synthesis of Photoactive MoS2
J. Electrochem. Soc., 1983
The growth of polycrystalline films and single crystals of molybdenum disulfide by electrolytic reduction of a sodium tetraborate‐sodium fluoride melt containing molybdenum trioxide and sodium sulfate has been examined and physical properties of those deposits studied. Polycrystalline n‐type is readily obtained from a melt at 800°C while larger single‐crystals are obtained if the melt temperature is raised to 900°C. is a semiconductor with bandgap well matched to the solar‐spectrum and with unusual resistance to photoelectrochemical corrosion. Electrochemically‐grown single crystals and polycrystalline films were employed as photoanodes in aqueous iodide‐triiodide electrolytes under ∼40 mW/cm2tungsten‐halogen illumination. Open‐circuit ph...
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Conserving agrobiodiversity for sustainable food systems in the Hindu Kush Himalaya
International Journal of Agricultural Sustainability, 2022
The Hindu Kush Himalaya (HKH) is a rich region in agrobiodiversity. As elsewhere in the world, agrobiodiversity is declining in this region, and this is impacting the functioning of ecosystems and has profound implications for agricultural sustainability and food security. Today, the challenge faced by the global community is how to slow or reverse the present trend of loss of agrobiodiversity to safeguard future food supplies. Taking examples from the HKH, this paper explores the link between agrobiodiversity and food security, identifies the key issues and challenges to maintaining agrobiodiversity, and explores potentials and opportunities for improving agrobiodiversity that are conducive to maintaining and increasing food security, ecosystem services, an...
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The SIIR index—a non-linear combination of waveform size and irregularity parameters for classification of motor unit potentials
Clinical Neurophysiology, 2005
In clinical electromyography, motor unit potential (MUP) size is used to indicate the myo- or neurogenic origin of the pathological process, whereas the irregularity of MUP shape is considered not useful in this respect. The aim of the present study was to find a method to improve classification of MUPs using a combined analysis of the size and irregularity of the potential. The records with at least 20% of irregular potentials from 14 healthy subjects and 34 patients were analysed. Principal Component Analysis (PCA) was applied in the analysis of data to find a linear function combining the size and the irregularity of a MUP. The linear combination of size and irregularity measures, i.e. size index (SI) and irregularity coefficient (IR) obtained using Princ...
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Reactions of staff members and lay people to family presence during resuscitation: the effect of visible bleeding, resuscitation outcome and gender
Journal of Advanced Nursing, 2011
itzhaki m., bar-tal y. & barnoy s. (2012) Reactions of staff members and lay people to family presence during resuscitation: the effect of visible bleeding, resuscitation outcome and gender. Journal of Advanced Nursing68(9), 1967–1977. Abstract Aim. This article is a report on a study conducted to examine the views of healthcare professionals and lay people regarding the effect of family presence during resuscitation on both the staff performing the resuscitation and the relatives who witness it. Background. Family presence during resuscitation is controversial. Although many professional groups in different countries have recently issued position statements about the practice and have recommended new policy moves, the Israel Ministry of Health has not iss...
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Two different T-cell systems in humans, one of which is probably equivalent to Qa or Tla in mice
Human Immunology, 1985
Two different alloantigenic systems, expressed mainly on TG and TM lymphocytes and called TCA and TCB, respectively, are described. Alloantisera from parous women are absorbed with Epstein-Barr virus-transformed B cell lines from the husband of the serum producer to remove all anti HLA-A,B,C and DR antibodies. The absorbed sera are tested against a random panel and against lymphocytes from families. Family studies indicate that the TCA system might be encoded by a gene linked to HLA and located on the telomeric side of HLA-A. The total lod scores for the material of 15 informative families is +3.301 at a recombination fraction of 15%. Furthermore we can show that the TCA molecule is associated with beta 2-microglobulin by blocking with turkey anti-beta 2 mic...
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Small-cell osteosarcoma: Correlation of in vitro and clinical radiation response
International Journal of Radiation Oncology*Biology*Physics, 1988
Small-cell osteosarcoma is an entity which shares some clinical and pathological features with both classic osteosarcoma and Ewing's sarcoma of bone. While noted to be "not radiosensitive" when first described, a retrospective review the National Cancer Institute experience of five patients with small-cell osteosarcoma treated with radiation therapy following biopsy (three pts) or limited excision (two pts) showed local control in all five patients with two long-term disease-free survivors (12, 18 years). This compares to three patients treated with surgery alone where one patient failed locally and one patient is a long-term disease-free survivor (7 years). We have studied the in vitro radiation response of a recently established small-cell osteosarcoma cel...
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Peptostreptococcal pericarditis complicating anti-tumour necrosis factor α treatment in rheumatoid arthritis
Annals of the Rheumatic Diseases, 2002
Rheumatoid arthritis (RA) is a common cause of disability and deformity for which treatment is often of limited value in controlling the disease process and outcome.1
Infliximab (chimeric antibody to tumour necrosis factor α (TNFα)) is clearly efficacious in up to 70% of patients, but treatment may be complicated by the development of infections that are occasionally serious and life threatening. Pooled analysis reported a 21% incidence of infection among 453 patients treated with infliximab compared with an 11% incidence in 109 placebo recipients.2 Infections considered serious occurred in 3.4% and 1.8% of patients, respectively. As of August 2001, 84 of 170 000 patients treated with infliximab world wide had developed active tuberculosis, including 14 de...
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Hybrid particle swarm optimization‐grey wolf optimization basedsmall‐signalmodeling applied toGaNdevices
Int J RF Mic Comp-Aid Eng, 2022
In this research, four different equivalent circuit models that characterize the substrate/buffer loading effect for GaN high electron mobility transistor (HEMT) on Si substrate have been investigated. Y-parameter measurements of an open de-embedded structure have been used to characterize this effect in GaN HEMT on Si. An optimization technique based on hybridization between two meta-heuristic techniques, which are particle swarm optimization (PSO) and grey wolf optimization (GWO) has been developed to extract physical relevant model elements. The proposed optimization technique is applied on GaN HEMTs of different sizes and validated by means of S-parameters fitting. In addition, the extracted elements are evaluated in terms of their reliability and scalab...
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A Promising Electrochemical Platform for Dopamine and Uric Acid Detection Based on a Polyaniline/Iron Oxide-Tin Oxide/Reduced Graphene Oxide Ternary Composite
Molecules, 2020
A ternary polyaniline/Fe2O3-SnO2/reduced graphene oxide (PFSG) nanocomposite was prepared using a simple two-step hydrothermal treatment. The composite was applied as a glassy carbon electrode modifier (GCE) to enhance dopamine (DA) and uric acid (UA) detection. The ternary PFSG composite was compared with its binary precursor Fe2O3-SnO2/reduced graphene oxide (FSG). The influence of the modified GCE electrodes on their performance as a sensing platform was determined. GCE/PFSG showed better sensing parameters than GCE/FSG due to the introduction of polyaniline (PANI), increasing the electrocatalytic properties of the electrode towards the detected analytes. GCE/PFSG enabled the detection of low concentrations of DA (0.076 µM) and UA (1.6 µM). The peak pot...
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Ampicillin‐dextrin agar medium for the enumeration of
Aeromonas
species in water by membrane filtration
Journal of Applied Bacteriology, 1987
Published selective media were evaluated for the isolation of Aeromonas spp. from environmental samples by membrane filtration. Satisfactory recoveries were obtained only with mA agar (Rippey & Cabelli) and dextrin‐fuchsin‐sulphite agar (Schubert), but neither was sufficiently selective. The positive aspects of these two media were combined in a new medium, ampicillin‐dextrin agar. Recovery from pure cultures and environmental samples was optimal at an ampicillin concentration of 10 mg/l and incubation for 24 h at 30°C under aerobic conditions, and specificity was high (i.e. confirmation rate usually <90%, no false negative colonies encountered). The medium can also be used for isolation of Aeromonas spp. from sea water provided that the vibrio...
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Electron paramagnetic resonance (EPR) dosimetry using lithium formate in radiotherapy: comparison with thermoluminescence (TL) dosimetry using lithium fluoride rods
Phys. Med. Biol., 2004
Solid-state radiation dosimetry by electron paramagnetic resonance (EPR) spectroscopy and thermoluminescence (TL) was utilized for the determination of absorbed doses in the range of 0.5-2.5 Gy. The dosimeter materials used were lithium formate and lithium fluoride (TLD-100 rods) for EPR dosimetry and TL dosimetry, respectively. 60Co gamma-rays and 4, 6, 10 and 15 MV x-rays were employed. The main objectives were to compare the variation in dosimeter reading of the respective dosimetry systems and to determine the photon energy dependence of the two dosimeter materials. The EPR dosimeter sensitivity was constant over the dose range in question, while the TL sensitivity increased by more than 5% from 0.5 to 2.5 Gy, thus displaying a supralinear dose response....
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Helping Those with Hoarding Behaviors
The Consultant Pharmacist, 2011
Hoarding--the excessive acquisition of and failure to discard possessions, which preclude the appropriate use of living spaces--undermines safety and health by increasing risk for fire, falls, and infections. Hoarding does not result from deprivation early in life, nor are elders with hoarding behaviors merely "thrifty or frugal." Up to 64% of elders with hoarding behaviors have self-care deficits. Comorbid depression, anxiety, alcohol dependence, physical trauma, and damage to the prefrontal and orbitofrontal cortex are common. Hoarding was historically viewed as a variant of obsessive-compulsive disorder (OCD), but compulsive hoarding is a symptom in just 24% of all OCDs. Approximately half of elders with hoarding behaviors suffer from psychiatric conditio...
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Protein Translocation Across Biological Membranes
Science, 2005
Subcellular compartments have unique protein compositions, yet protein synthesis only occurs in the cytosol and in mitochondria and chloroplasts. How do proteins get where they need to go? The first steps are targeting to an organelle and efficient translocation across its limiting membrane. Given that most transport systems are exquisitely substrate specific, how are diverse protein sequences recognized for translocation? Are they translocated as linear polypeptide chains or after folding? During translocation, how are diverse amino acyl side chains accommodated? What are the proteins and the lipid environment that catalyze transport and couple it to energy? How is translocation coordinated with protein synthesis and folding, and how are partially transloca...
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Deformation infrared calorimetry for materials characterization applied to study cyclic superelasticity in NiTi wires
Materials & Design, 2021
Abstract In this article, we introduce the Deformation Infrared Calorimetry (DIRC) technique for resolving spatial distributions of heat and work in samples subjected to uniaxial loading under isothermal conditions. Heat and work distributions are computed from synchronized temperature and strain fields obtained by infrared thermography (IRT) and digital image correlation (DIC). The DIRC data acquisition and processing are described in the first part of the article. Then, we show the relevance and usage of DIRC by employing it to characterize the cyclic evolution of the thermomechanical response of a superelastic NiTi wire termed functional fatigue. Particularly, we evaluated the evolution of the heat, work, and internal energy changes upon the repeated prop...
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Family Presence During Resuscitation and Invasive Procedures: The Nurse Experience
Qual Health Res, 2009
The purpose of this study was to understand the experiences of nurses who participate with families during resuscitation and invasive procedures in the hospital. Seventeen nurses in a large metropolitan area in the northeastern United States were interviewed about their thoughts and feelings about participating with families during these procedures. Conversations were audiotaped and transcribed verbatim for analysis. Transcripts were analyzed using van Manen's technique of isolating thematic statements. Four main themes were identified from the data: forging a connection, engaging the family, transition to acceptance, and a cautious approach.The experience of participating in family presence during resuscitation or invasive procedures can be a positive exper...
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Response of natural fine-grained soils for seismic design practice: A collection of research findings from British Columbia, Canada
Soil Dynamics and Earthquake Engineering, 2019
Abstract This paper summarizes the results from a comprehensive laboratory experimental research program conducted at the University of British Columbia, Canada to study the mechanical behavior of natural fine-grained soils. Constant-volume direct simple shear tests were performed on natural silt samples collected from various locations in British Columbia to investigate the monotonic and cyclic shear loading response of these materials. Influencing factors such as effective confining stress, over-consolidation ratio, initial static shear bias, soil plasticity, and soil fabric/micro-structure on the mechanical behavior of silts were systematically investigated using a series of controlled laboratory tests. The key observations arising from these examinations...
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Sarcopenia: Current treatments and new regenerative therapeutic approaches
Journal of Orthopaedic Translation, 2020
Sarcopenia is characterized by loss of muscle and reduction in muscle strength that contributes to higher mortality rate and increased incidence of fall and hospitalization in the elderly. Mitochondria dysfunction and age-associated inflammation in muscle are two of the main attributors to sarcopenia progression. Recent clinical trials on sarcopenia therapies such as physical exercise, nutraceutical, and pharmaceutical interventions have revealed that exercise is the only effective strategy shown to alleviate sarcopenia. Unlike nutraceutical and pharmaceutical interventions that showed controversial results in sarcopenia alleviation, exercise was found to restore mitochondria homeostasis and dampen inflammatory responses via a complex exchange of myokines an...
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Effect of Al2O3 Particle Concentration on the Characteristics of Microarc Oxidation Coatings Formed on Pure Titanium
International Journal of Electrochemical Science, 2018
Microarc oxidation coatings were successfully fabricated on pure titanium substrates by microarc oxidation (MAO) in electrolytes with Al2O3 particles of varying concentrations, which ranged from 0 to 4 g·L-1 (0, 1, 2, 3, 4 g·L-1). The voltage versus time curves, surface and cross-sectional morphologies, thicknesses, microhardnesses, phase compositions, coating adhesive strengths, thermal shock resistances and polarization curves of MAO coatings were investigated. The results revealed that the voltage, the microhardness and the thickness of the coatings increased with the addition of Al2O3 particles. Both the number and size of sintered discs on the coating surface increased gradually with the ascending concentration of Al2O3 particles. The XRD results indi...
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Surface Mechanical Attrition Treatment and Corrosion Resistance Behavior of TA2 Anodic Oxide Film
International Journal of Electrochemical Science, 2018
A new method of surface mechanical attrition treatment (SMAT) for controlling the microstructure of a film was proposed, and the microstructure as well as the corrosion resistance of the film were investigated. The thickness and elemental distribution of the film were determined via scanning electron microscopy and energy dispersive spectroscopy. The crystallinity and valence state composition of the film were investigated by means of X-ray diffraction, Raman spectroscopy, and X-ray photoelectron spectroscopy. In addition, the corrosion resistance behavior of the film was assessed with an electrochemical workstation. The results revealed that SMAT can increase the growth rate, thickness, compactness, adhesion strength, and stability of the film. Furthermore,...
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An Internet-of-Things solution for food safety and quality control: A pilot project in China
Journal of Industrial Information Integration, 2016
Abstract Serval shaking-world food safety incidents happened in China recently shows that Chinese are facing with a serious problem of food safety, happened in China recently. Because food supplies are decentralized in many regions and agencies, it is very hard for the Chinese government to supervise these supplies’ businesses. Fortunately, with the help of the technologies of the Internet of Things, the food supplies can become more transparent and safer than before. Hence, on the basis of the Internet of Things, this paper introduces a pilot project in China: the Internet of Agricultural Things (AIoT for short), which integrates state-of-the-art technologies to provide a method to easily track and trace the supply processes of foods. So that, AIoT can co...
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Management of Caesarean Scar Ectopic Pregnancy: A Report of Three Cases
Journal of Minimally Invasive Gynecology, 2012
Caesarean Scar Ectopic Pregnancy (CSP) is a relatively new clinical entity, and is possibly the rarest type of ectopic pregnancy. Natural history, risk factors, optimal management are not known. Literature shows various treatment options like – expectant, ultrasound guided suction evacuation, systemic & local methotrexate, hysteroscopic and laparoscopic management etc. I present three cases of caesarean scar pregnancy (CSP) that were managed with a combination methotrexate and hysteroscopic and/or laparoscopic evacuation. Case reports. Private practice. All three cases presented as post abortal bleeding following voluntary medical or surgical termination in the first trimester. Diagnosis was confirmed by High resolution transvaginal sonography and diagnost...
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Evaluation of the complexity of motor unit potentials in anal sphincter electromyography
Clinical Neurophysiology, 2005
Motor unit potential (MUP) morphology can be quantified using parameters describing electrophysiological size and shape (complexity). Traditionally, MUP complexity has been estimated using parameters number of phases and turns. Recently, ‘irregularity coefficient’ (IR), measuring the length of the MUP curve normalized with its amplitude, has been introduced. The aim of this study was to evaluate IR in the external anal sphincter muscle. Sensitivity was examined in 61 patients with chronic cauda equina lesions, and specificity in 75 controls using a standard concentric EMG needle and EMG system with multi-MUP analysis. When evaluated separately the sensitivity of IR was 16% lower, and specificity 5% higher compared to number of turns, with both difference...
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Spectroscopic analysis of electromigration at gold nanojunctions
Physica E: Low-dimensional Systems and Nanostructures, 2010
We have investigated the electromigration process at gold nanojunctions by introducing a novel spectroscopic approach. When the junction voltage exceeded certain critical values, conductance showed successive drops by one quantum conductance, corresponding to one-by-one removal of gold atoms. The observed critical voltages agree with the activation energies for surface diffusion of gold atoms. This fact clearly indicates that the elementary process of electromigration is the self-diffusion of metal atoms driven by microscopic kinetic energy transfer from a single conduction electron to a single metal atom. This new finding can be applied to reproducible formation of atomic-spacing gaps for single molecular junctions and also to the failure-tolerant interconn...
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Intestinal commensal bacteria promote T cell hyporesponsiveness and down-regulate the serum antibody responses induced by dietary antigen
Immunology Letters, 2010
Colonization of the gut by commensal bacteria modulates the induction of oral tolerance and allergy. However, how these intestinal bacteria modulate antigen-specific T cell responses induced by oral antigens remains unclear. In order to investigate this, we used germ-free (GF) ovalbumin (OVA)-specific T cell receptor transgenic (OVA23-3) mice. Conventional (CV) or GF mice were administered an OVA-containing diet. Cytokine production by CD4(+) cells from spleen (SP), mesenteric lymph nodes (MLN) and Peyer's patches (PP) was evaluated by ELISA, as was the peripheral antibody titer. T cell phenotype was assessed by flow cytometry. CD4(+) cells from the SP and MLN of CV and GF mice fed an OVA diet for 3 weeks produced significantly less IL-2 than the correspondi...
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Antibiotics in Yersinia enterocolitica infections
J Antimicrob Chemother, 1987
A prospective study was undertaken to evaluate the incidence, course, effects of treatment and outcome of patients with Yersinia enterocolitica infections. A total of 189 patients were followed: 62.5% had enteric forms of illness, 20.6% extramesenteric forms, 23.2% arthritis and erythema nodosum. Lymphadenopathy with high fever and weight loss, a septic syndrome and hepatitis were predominant manifestations of the extramesenteric form. Ten per cent of the isolates (135) were susceptible to amoxycillin (4 mg/l), 38% to cephradine (8 mg/l), 82% to doxycycline (4 mg/l), 83% to chloramphenicol (4 mg/l), 85% to trimethoprim (1 mg/l), 87% to cefuroxime (8 mg/l), 92% to piperacillin (16 mg/l), 99% to gentamicin (1 mg/l) and 100% to cefotaxime (4 mg/l), pefloxacin (...
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Mo1327 Evaluating the ASGE Guidelines on the Role of Endoscopy in Suspected Choledocholithiasis
Gastrointestinal Endoscopy, 2012
In 2010 the ASGE released guidelines to stratify the risk of choledocholithiasis in patients with symptomatic cholelithiasis. The guidelines divide patients into three groups based on their probability of having common bile duct (CBD) stones. Low probability patients (50%) can proceed directly to ERCP. Predictors for the presence of CBD stones are very strong, (CBD stone on trans-abdominal US, clinical ascending cholangitis, and bilirubin > 4), strong (Dilated CBD on US > 6mm and bilirubin level of 1.8-4), and moderate predictors (other abnormal liver tests, age >55, and gallston...
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Effect of soybean meal fermented with Bacillus subtilis BS12 on growth performance and small intestinal immune status of piglets
Food and Agricultural Immunology, 2017
ABSTRACTThis study was aimed to screen a high-efficient strain for degrading antigenic protein in soybean meal (SBM) and evaluate the effect of fermented soybean meal (FSBM) on growth performance of piglets. A Bacillus subtilis strain BS12 was selected through plate and fermentation experiment, which reduced 92.36% less glycinin and 88.44% less β-conglycinin in SBM. A total of 192 piglets were assigned to receive either a diet of SBM with antibiotics (the control group) or a diet containing 10% FSBM without antibiotics. The average daily gain and feed intake of pigs fed FSBM were superior (p
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Sonic hedgehog signaling regulates the expression of insulin‐like growth factor binding protein‐6 during fetal prostate development
Developmental Dynamics, 2005
At the onset of ductal morphogenesis in the developing prostate, Shh expression condenses at evaginations of urogenital sinus epithelium and activates Gli transcription factors in the adjacent mesenchyme. Abrogation of Hedgehog signaling disrupts proper prostatic budding, ductal growth, and branching. We now show that Hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 (Igfbp-6) in the developing mouse prostate. Igfbp-6 is a secreted factor that specifically binds insulin-like growth factor-II (IGF-II), prevents its binding to the IGF-I receptor, and is thought to regulate the activity of IGF-II in growth and differentiation. Igfbp-6 is expressed in both the developing and adult prostate. In the urogenital sinus, Igfbp...
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Hybrid Combination of GIS,GPS,WSN and GPRS Technology in Modern Digital Agriculture Application
AMR, 2010
In order to improve the information management of the modern digital agriculture, combined several modern digital agriculture technologies, namely wireless sensor network (WSN), global positioning system (GPS), geographic information system (GIS) and general packet radio service (GPRS), and applied them to the information collection and intelligent control process of the modern digital agriculture. Combining the advantage of the local multi-channel information collection and the low-power wireless transmission of WSN, the stable and low cost long-distance communication and data transmission ability of GPRS, the high-precision positioning technology of the DGPS positioning and the large-scale field information layer-management technology of GIS, such a hybrid...
1784987365
Voices of the academy: academics’ responses to the corporatizing of academia
Critical Perspectives on Accounting, 2002
Abstract This study explores the ways in which continuing and casual academics make sense of their roles in a post-Dawkins Australian university. The traditional affiliations of discipline and campus are being competitively eroded in favour of more entrepreneurial liaisons. These shifting liaisons result in organizational silences, which some academics strive to fill. Their selective interpretations of the changing tertiary environment enable them to create a disparate range of academic identities. The narratives of academics who were interviewed in this study suggest that the espoused stories and strengths of the unique profession of academia have less relevance in the unfamiliar corporate academy, which is resistant to the metaphor, myth and traditional ty...
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Numerical modeling of normal fault-pipeline interaction and comparison with centrifuge tests
Soil Dynamics and Earthquake Engineering, 2018
Abstract Pipelines extend thousands of kilometers across wide geographic areas to provide products for modern life. It is inevitable therefore that pipelines must pass through active faulting zones. The safety of pipe networks should be maintained by employing an appropriate design method. Beam-on-spring analysis is the normal design approach, but it is difficult to choose the spring stiffness for pipelines crossing a dip-slip (normal/reverse) fault, since the native soils beneath the pipe trench may provide extra restraints on relative pipe-soil movement. Alternatively, three-dimensional finite element analysis has the potential to provide useful design calculations which account for (a) axial and flexural stiffness of the pipe, (b) geometry and kinematics ...
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Biosorption and biodegradation of pyrene by Brevibacillus brevis and cellular responses to pyrene treatment
Ecotoxicology and Environmental Safety, 2015
Biodegradation has been proposed as an effective approach to remove pyrene, however, the information regarding cellular responses to pyrene treatment is limited thus far. In this study, the biodegradation and biosorption of pyrene by Brevibacillus brevis, along with cellular responses caused by pollutant were investigated by means of flow cytometry assay and scanning electron microscopy. The experimental results showed that pyrene was initially adsorbed by B. brevis and subsequently transported and intracellularly degraded. During this process, pyrene removal was primarily dependent on biodegradation. Cell invagination and cell surface corrugation occurred due to pyrene exposure. Nevertheless, cell regrowth after 96 h treatment was observed, and the proporti...
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The ecosystem of a ‘wealth-tech’ culture: the birth of networked financial subjects in South Korea
Media, Culture & Society, 2019
Starting with an online financial community in South Korea, this article explores the simultaneous production of a new form of subjectivity and a networked ecosystem of financial cultures. Using a multi-sited ethnography to track the movements of users as they moved across different spaces, this article finds that users gifted financial information to each other, blended laity and expertise, and reappropriated financial communities into a third place defined as an informal, public place hosting sociable conversations. Through the grafting of prosocial activities (e.g. sharing, gifting, and social networking) onto financial self-management, users were shaped as networked financial subjects and exhibited a distinctive mode of selfhood informed by both financia...
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Sensitivity enhancement effects in the thermoluminescence of LiF TLD-100 at radiation doses below 10 Gy
Phys. Med. Biol., 1987
LiF TLD-100 ribbons are frequently used for a wide range of radiobiological dosimetry applications using various sources in the dose range 0.1-10 Gy. It is suggested that an accuracy of 5-6% and a precision of 2-3% is required for the determination of absorbed dose in biological applications. To minimise the random errors, the dosemeters are calibrated individually. The authors examine the systematic errors that may be introduced by this procedure. They have observed, for instance, that the calibration procedure itself enhances the sensitivity of the dosemeters by 1-2% and that this enhancement is dependent upon their thermal history. They describe the procedures that have been established at the Gray Laboratory for routine precision thermoluminescence dosim...
1784987364
Anticancer effect of Limonin against benzo(a)pyrene‐induced lung carcinogenesis in Swiss albino mice and the inhibition of A549 cell proliferation through apoptotic pathway
J Biochem & Molecular Tox, 2019
The main purpose of the current study is to reveal the anticancer action of limonin against benzo(a)pyrene [B(a)P]-treated lung carcinogenesis in Swiss albino mice and A549 lung cancer cells. B(a)P was orally supplemented (50 mg/kg body weight) twice a week for four weeks induction of lung cancer in mice. The lung weight, body weight, incidence of tumor, lipid peroxidation, carcinoembryonic antigen (CEA), enzymatic and nonenzymatic antioxidants (superoxide dismutase, GPx, glutathione, glutathione reductase, catalase, and glutathione S-transferase), serum marker enzymes (aryl hydroxylase, lactate dehydrogenase, 5'-nucleotidases, and γ-glutamyl transpeptidase), and inflammatory mediators (interleukin-1β, interleukin-6, and tumor necrosis factor-α) were esti...
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Detection of EEG background abnormalities in epilepsy by a new spectral index
Clinical Neurophysiology, 2005
In epileptic disorders, EEG background activity is disorganized in or near the epileptogenic focus and spectral EEG analysis (SEA) can provide useful information about the focus. We tried to develop a new spectral index from basic spectral parameters to detect the epileptic abnormalities at EEG background activity.A new spectral EEG index, epileptic abnormality index (EAI), was constructed from frequency band power and power asymmetry parameters. Within the index, parameters were weighted due to both conventional EEG knowledge and their power in discrimination healthy subjects from patients. EEG background activity from 99 epileptic patients and 146 healthy subjects was examined both by EAI and by a conventional SEA method, by using z-scoring statistic. Each...
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EYE-LASH IN THE LACRIMAL PUNCTUM
British Journal of Ophthalmology, 1949
Stimulus and location specificity are long considered hallmarks of visual perceptual learning.This renders visual perceptual learning distinct from other forms of learning, where generalization can be more easily attained, and unsuitable for practical applications, where generalization is key.Based on hypotheses derived from the structure of the visual system, we test here whether stimulus variability can unlock generalization in perceptual learning.We train subjects in orientation discrimination, while we vary the amount of variability in a task-irrelevant feature, spatial frequency.We find that independently of task difficulty, this manipulation enables generalization of learning to new stimuli and locations, while not negatively affecting the overall amou...