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Introduction of Clinical Biochemistry

The document provides an introduction to clinical biochemistry. It discusses the functions of clinical laboratories which include supporting disease diagnosis, monitoring disease progression and treatment effectiveness, screening for diseases and risk factors, checkups, and epidemiological studies. The main sections of clinical laboratories are chemistry, hematology, urine analysis, microbiology, and immunoserology. Samples that can be examined include blood, urine, feces, cerebrospinal fluid, and transudate. The purpose of clinical biochemistry education is to understand biochemical changes related to diseases and identify biochemical markers that can be examined in clinical tests.

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631 views32 pages

Introduction of Clinical Biochemistry

The document provides an introduction to clinical biochemistry. It discusses the functions of clinical laboratories which include supporting disease diagnosis, monitoring disease progression and treatment effectiveness, screening for diseases and risk factors, checkups, and epidemiological studies. The main sections of clinical laboratories are chemistry, hematology, urine analysis, microbiology, and immunoserology. Samples that can be examined include blood, urine, feces, cerebrospinal fluid, and transudate. The purpose of clinical biochemistry education is to understand biochemical changes related to diseases and identify biochemical markers that can be examined in clinical tests.

Uploaded by

Karen Low
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Introduction of Clinical Biochemistry

by : Eli Halimah

The Function of Clinical Laboratory


1. Supporting the diagnosis of disease 2. Monitoring the course of the disease (prognosis) 3. Monitoring therapy (effectiveness of treatment) 4. Screening of the diseases or risk factors 5. Check up (prevention) 6. Epidemiological studies 7. Supporting health research

The Clinical Laboratory


1. Chemistry 2. Hematology 3. Urine analysis 4. Microbiology 5. Imunoserology

6. Therapeutic drug monitoring

Samples
1. Blood / serum/ plasma 2. Urine 3. Faeces 4. Cerebrospinal fluid 5. Transudate / exudate

Examination in the Clinical Laboratory


1. 2. 3. 4. 5. 6.

7. 8. 9. 10. 11. 12. 13.

Metabolyte Enzym Electrolyte Proteine Hormone AntigenBacteri/virus Antibody Allergen Koagulation factors ABO/Rhesus HLA Drugs Trace elemen

The purpose of education


Examination of routine clinical chemistry : basic principles, methodology, instrumentation
ability to understand the biochemical consequences of a desease, the value of referral, pathophysiology, indications and interpretation of test results

Pathological Conditions
(patient)

Biochemical Changes

Biochemical Markers
(markers that could be examined in clinical laboratories)

Immuno-chemistry Methodes
Generation 1

: RIA

(1980 early)) Generation 2 (1980 medio

Generation 3 (1990)

: ELISA EMIT FPIA Nephelometry : IRMA ELISA Streptavidin-biotin MEIA CEDIA ICMA

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