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DNA Translation Questions

The document contains 8 questions about topics related to translation including: the biochemical basis of erythromycin's antibacterial action; the role of tRNA in accurate reading of nucleotides; the steps involved in protein synthesis in the rough ER; the effects of a defective mRNA with an intron segment; the effects of a gene with a deleted nucleotide; the role of vitamin C in post-translational modifications; the role of aminoacyl tRNA synthetases in protein synthesis; and the significance of signal sequences in secretory protein synthesis.

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290 views2 pages

DNA Translation Questions

The document contains 8 questions about topics related to translation including: the biochemical basis of erythromycin's antibacterial action; the role of tRNA in accurate reading of nucleotides; the steps involved in protein synthesis in the rough ER; the effects of a defective mRNA with an intron segment; the effects of a gene with a deleted nucleotide; the role of vitamin C in post-translational modifications; the role of aminoacyl tRNA synthetases in protein synthesis; and the significance of signal sequences in secretory protein synthesis.

Uploaded by

cataztropher
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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TRANSLATION

1. Explain the biochemical basis for the action of erythromycin as an antibacterial agent.
(50)
(AL1998 CAT2)
2. Explain the role of tRNA in the accurate reading of the nucleotide.(40)
(AL1999 CAT2)
3. List the steps involving in the synthesis of proteins in the rough ER.(60)
(AL2000 CAT2)
4. Defective splicing of a pre-mRNA resulted in a small portion of an intron being
present in the final mRNA (see figure below).Predict the effects of translation of this
mRNA giving reasons.(50)
Exon 1

Exon 2

Exon 3

GPPP
AAAA
Part of intron 2
(AL2001 CAT2)
5. Shown below is a nucleotide sequence and corresponding amino acids of a protein
coding gene.
1 2 3 4 5 6 7 8 9 10 11 12 13
G C G G A T C G T A G C C

Alanine

Aspartate Arginine Serine

The sixth nucleotide was deleted in this gene.


(GAC-aspartate GCG-alanine GTA- valine)
Briefly explain the possible effects of this deletion.(50)

(AL2002 CAT2)

6. Explain the role of vitaminC in post translational modifications.(50)


(AL2002 CAT2)
7. Explain the role of aminoacyl tRNA synthetases in protein synthesis.(50)
(AL2003main)
8. Explain the significance of signal sequence in the synthesis of secretory proteins.(50)
(AL2003 CAT2)

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