Wnhs Og Sgaiugr
Wnhs Og Sgaiugr
Contents
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                                                                                                                   SGA & IUGR
                                              Diagnose
                          Arrange ultrasounds
                          · AFI/Dopplers/fetal biometry/BPP
                          · Anatomy (if not already performed)
                                                Manage
                          ·   Serial ultrasounds
     Routine Care         ·   Schedule ultrasounds and antenatal visits on the
                              same day
                          ·   If SGA is confirmed but not IUGR and there is no
                              fetal compromise, document an individualised
                              care plan
                                                                                           Daily
                                                                                           UA Doppler
    Fortnightly                                                                            DV Doppler
                                Twice weekly
·    UA Doppler                                                                            CTG > 32/40
                                 UA Doppler
·    MCA Doppler
                                CTG > 32/40
·    AC & EFW
                                                               Birth
                                                               · Recommended by 32 weeks, after
Birth                                                              steroids.
· Offer by 37 weeks-timing d/w consultant                      · Consider 30-32 weeks
· Recommended by > 34 weeks if                                 ·    Recommended < 32 weeks after
    Static growth over 34 weeks                                    steroids if abnormal DV Doppler &/or
    MCA Doppler PI <5th centile                                    CTG
· Consider steroids if CS birth & appropriate                       > 24 weeks & EFW >500g
NO YES
                                                             Review by Registrar/Consultant
            Urgent review by the Registrar                   Arrange:
            or Consultant                                    • Ultrasound weekly for AFI, BPP,
                                                               and Doppler studies
                                                             • Ultrasound fortnightly for biometry
YES NO
    Assessment
    1.       Confirm the gestational age by the woman’s dating ultrasound or last
             menstrual period dates. Ensure a copy of the ultrasound report is available in
             the medical records.
    2.       Review the result of the First Trimester and Second Trimester Screen if
             available. Ensure a copy of the result is in the woman’s medical records.
    3.       Document the medical and obstetric history. Note any risk factors that may
             contribute to a SGA fetus.
    4.       Palpate the abdomen as appropriate to determine:
             ·   Symphysis fundal height
             ·   Lie
             ·   Presentation
    5.       Arrange an ultrasound scan for fetal biometry, amniotic fluid index (AFI),
             umbilical artery (UA) Doppler velocities.
    6.       On confirmation of SGA diagnosis:
             ·   If more than 32 weeks gestation, commence cardiotocography (CTG)
                 monitoring.
             ·   If less than 32 weeks gestation discuss with Registrar or Consultant if CTG
                 monitoring is required.
    See the section on Intrauterine growth restriction for antenatal management of the
    SGA fetus confirmed as intrauterine growth restricted.
Ultrasound Assessment
    CTG monitoring
    The frequency of CTG monitoring will depend on the fetal gestation and clinical
    picture.
    Management
    ·   Inform the obstetric team of all results before the woman is discharged home. A
        management plan is formulated prior to discharge.
    ·   Document test results and management plan for future follow-up management in
        MFAU and the antenatal clinic.
    ·   Attempt where possible to arrange appointments in MFAU to coincide with the
        antenatal clinic appointments. This allows review of the results by her team during
        clinic appointments.
    ·   The frequency of antenatal clinic appointments will depend on the clinical picture
        and medical consultation
    ·   Consider administering Betamethasone if pre term birth is anticipated.
    Background Information
    50-70% of the Small-for-Gestation Age (SGA) fetuses are constitutionally small but
    healthy1. Approximately 10-15% of SGA fetuses are classified to be ‘true’ IUGR
    cases, and another 5-10% are associated with chromosomal/structural anomalies,
    or chronic intrauterine infection.2
    A fetus is considered to have intrauterine growth restriction when the ultrasound fetal
    measurements, particularly the abdominal circumference or serial weight
    measurements, are below what is considered normal for that age and gestation. 3
    This is usually below the 5th or 10th centile when compared to the normal growth and
    gestational age by ultrasound measurements.4 The IUGR infant has not reached
    their genetic growth potential due to a pathological reason or event in utero causing
    placental dysfunction.5 The IUGR fetus is associated with an increased risk of
    perinatal mortality and morbidity and long term health consequences for survivors. 2, 6,
    7
      Current evidence suggests long term consequences for IUGR infants are that they
    are prone to heart disease, type 2 diabetes, strokes, hypertension and even
    osteoporosis later in life.4
    The Growth Restriction Intervention Trial (GRIT) concluded that generally if the fetus
    is less than 31 weeks gestation it is best to delay delivery if there is uncertainty about
    need for intervention, rather than immediate delivery. Evidence to date indicates that
    by delivering the fetus early to pre-empt severe hypoxia and acidosis does not
    reduce adverse outcomes.2, 8
    Umbilical artery (UA) Doppler measurement is a tool used to identify if the SGA fetus
    is affected by placental dysfunction which occurs with the IUGR fetus.9 With
    worsening severity of placental insufficiency there is higher placental resistance
    which can lead to absent or reversed end-diastolic flow velocities. This is associated
    with poorer perinatal outcomes and mortality.1, 7 Fetal circulatory redistribution due
    to placental insufficiency leads to abnormal Doppler indices in the cerebral and
    umbilical arteries10 providing valuable information to assist decision making regarding
    timing of birth. Doppler abnormalities have been shown to deteriorate before
    biophysical profile scores (BPS) in the preterm fetus with IUGR prior to 32 weeks
    gestation.10
    In 2013, identification of babies with IUGR birthed >40wks formed Indicator 8 for
    clinical audit. See: Indicator 8: IUGR, in RANZCOG/ACHS Obstetric Clinical
    Indicators 2011.
    Key Points
    1.      An accurate expected delivery date (EDD) is a critical component to allow
            monitoring, assessment and optimal timing of delivery.
    2.      Management of the IUGR fetus must include a balance of the risks of intra-
            uterine chronic hypoxia with preterm delivery and its associated risks.
    3.      Fetal Doppler studies provide the most accurate non-invasive assessment for
            placental function. Absent or reversed UA Doppler’s are associated with poor
            perinatal outcome and high perinatal mortality.12
    Abdominal Palpation
    ·    The ability to detect fetal weight by palpation is limited.9 If there is suspicion of
         SGA, or IUGR, management should be discussed with the obstetric team. A
         follow up ultrasound examination may be required.9, 13
    ·    Document a management plan on the MR 004 ‘Obstetric Special Instruction
         Sheet’ after consultation with the Obstetric team if a SGA or IUGR fetus is
         suspected from palpation.
    Ultrasound examination
    If there is suspicion of SGA or IUGR ultrasound examination should be performed to
    assess:
    ·    Biometry – assessment of growth requires at least 2 measurements two weeks
         apart.1 Three weeks apart reduces false positive rate.9
    ·    Doppler studies – Doppler studies are a valuable tool to differentiate the SGA
         fetus that is healthy, and the true IUGR fetus.1, 9
    ·    Amniotic Fluid Volume (AFV)
    ·    Fetal well-being – Biophysical profile (BPP)
    ·    Anatomy examination - if an anatomy scan has not been done or is unavailable,
         this scan is required to exclude fetal anomalies, and fetal aneuploidy.9, 15
    Management
    1.      Frequency of fetal surveillance is assessed at each visit, and management plan
            adjusted by Obstetric team according to fetal and maternal clinical condition.
    2.      Antenatal surveillance may be conducted with antenatal clinic visits and by
            outpatient review in the Maternal Fetal Assessment Unit (MFAU). If the
            maternal or fetal clinical condition requires more intensive surveillance in-patient
            hospitalisation should be considered in consultation with the team Obstetrician.
    3.      All ultrasound examinations, CTGs, and BPP must be reviewed and
            documented by the Registrar or Consultant prior to discharge of a woman.
    4.      Document the assessment and test results at each visit to MFAU on the
            Maternal Fetal Assessment Outpatient form MR 226.
    Ultrasound Surveillance
    1. Amniotic fluid volume (AFV) and Doppler studies
           ·   If normal at the initial visit: continue fortnightly assessment of AFV and
               UA/ MCA Doppler studies.9
           ·   If abnormal at the initial visit:
                 If end diastolic velocities (EDV) present/ pulsatility index (PI) or
                  resistance index (RI) >2SD: Arrange twice-weekly assessment of
                  AFV and Doppler studies, or more frequent surveillance if the clinical
                  condition requires closer monitoring.9
                 If absent / reversed end diastolic velocities (AREDV): Repeat UA and
                  DV Doppler daily.9 Discuss with Obstetric Consultant/ refer for fetal
                  medicine specialist opinion.9
    2. Fetal Biometry- Abdominal circumference (AC) and estimated fetal weight
       (EFW):
           ·   If normal Doppler, arrange fetal biometry fortnightly.9, 15
           ·   If abnormal Doppler, arrange weekly.9
    CTG MONITORING
    If the gestation is more than 32 weeks:
    ·   Arrange a weekly CTG in MFAU on the woman’s Obstetric Team day on duty in
        the antenatal clinic.
    ·   If abnormal AFI or Doppler’s arrange bi-weekly CTG monitoring in MFAU.
    ·   If abnormal Doppler with AREDV attend daily CTG.9
    If the gestation is less than 32 weeks gestation discuss with the Registrar and
    Consultant if CTG monitoring is required.
    Timing of Delivery
    Delivery is indicated when risk of fetal death or morbidity is greater than the risk of
    prematurity.
    Intrapartum management
        ·   Early admission in spontaneous labour.9
        ·   Apply continuous CTG monitoring from onset of uterine contractions.9
        ·   Caesarean birth is recommended in the IUGR fetus with UA AREDV.9
        ·   Induction of labour can be offered where normal UA Doppler or abnormal UA
             PI with EDV present.9
    Background Information
    The term ‘small for gestational age ‘(SGA) refers to the fetus that has failed to reach a
    specific biometry or estimated weight threshold by a specific gestational age. 1, 2 It is
    estimated that 50-70% of fetuses born weighing less than the 10th centile for
    gestational age are constitutionally small, with the growth appropriate for the parental
    size and ethnicity. The outcome is usually associated with normal placental function
    and normal outcomes. SGA fetuses with a birth weight less than the 50 th centile for
    gestational age have a greater likelihood of intrauterine growth restriction (IUGR).1
    SGA fetuses are at greater risk for stillbirth, birth hypoxia, neonatal complications,
    impaired neurodevelopment, and possibly Type 2 diabetes and hypertension in adult
    life, although the high incidence of adverse perinatal outcomes maybe contributed to
    the IUGR foetuses in this group. The majority of term SGA infants have no
    appreciable morbidity or mortality.2
    Biometric tests used to assess fetal size assist diagnosis of SGA, while biophysical
    tests are used to detect fetal wellbeing and are more indicative of IUGR.2 The use of
    the customised fundal height chart has been demonstrated to improve the accuracy to
    predict a SGA fetus, but ultrasound measurements of the abdominal circumference
    and estimated fetal weight provide the most accurate way to predict SGA. 2 Symphysis
    fundal height (SFH) measurements may improve sensitivity and specificity for
    predicting SGA, whilst abdominal palpation alone has limited accuracy for identification
    of a SGA fetus2. The impact on perinatal outcomes of SFH measurement, compared
    to abdominal palpation, is uncertain with a Cochrane systematic review finding only
    one controlled trial that showed SFH measurements did not significantly change
    perinatal outcomes.3 Continuation of SFH measurement at each antenatal
    appointment has been recommended.2, 3
    Assessment of fetal growth, abdominal circumference (AC) and estimated fetal weight
    (EFW), requires two ultrasound measurements at least three weeks apart, which will
    differentiate normally growing fetuses from those with IUGR.2 More frequent scanning
    may be required by the Obstetric team where awareness of EFW would assist in
    obstetric management, for reasons other than SGA diagnosis. 2 Routine biometry is
    not justified in third trimester as it does not reduce the risk of SGA and does not
    improve perinatal outcomes2. Measurements only provide limited information to assist
    decision making for management for timing of delivery. Associated antenatal
    surveillance techniques assist in clinical judgement for timing of delivery. These
    techniques differentiate between a SGA fetus with a predicted normal outcome, and
    the fetus which is growth restricted resulting in adverse perinatal morbidity and
    mortality.1, 2 Umbilical artery (UA) Doppler measurements can identify if a confirmed
    SGA fetus is affected by placental dysfunction, with end-diastolic flow velocity results
    providing valuable information on risk for perinatal mortality and morbidity. 1, 2, 4
    Key Points
    1.       SGA describes the fetus that has failed to reach the normal biometric weight
             by a specific gestational age. This does not always indicate a fetus is growth
             restricted.
    2.       The use of ultrasound biometry and biophysical tests can assist differentiation
             between the SGA with no expected perinatal morbidity or mortality risk, and
             the IUGR fetus with predicted poor perinatal outcomes.
    3.       To evaluate fetal growth over time at least two subsequent measurements two
             weeks apart should be performed.5 A three week interval further reduces
             false positive results.2
    4.       Management is individualised according to gestation, fetal wellbeing and any
             compounding maternal or fetal health factors.2
    Diagnosis
    Most methods to detect SGA require an accurate estimation of gestation as a
    prerequisite.
    Management
    At booking identify those needing increased monitoring:
        · Where SFH is less accurate (large uterine fibroids, >BMI) = serial growth
           ultrasounds2.
        · One major or three minor risk factors present (see below).2
    Consider preventative interventions in high risk groups (smoking cessation advice,
    antiplatelet agents in women at high risk of pre-eclampsia).2
       ·   Previous stillbirth2
       ·   Pre- eclampsia2 (previous pregnancy or this pregnancy)
       ·   Maternal or paternal SGA2
       ·   Pregnancy interval (<6months or >60months) 2
       ·   Heavy bleeding2 (threatened miscarriage), unexplained APH2, or Placental
           abruption2
       ·   Echogenic fetal bowel2
       ·   Caffeine >300mg/day in third trimester2
       ·   PAPP- A < 0.4 MoM2
       ·   Smoking
       ·   Multiple pregnancy
Fetal Surveillance
    Ultrasound scans
    1.    If severe SGA identified on anatomy scan (from external results), arrange
          detailed anatomical ultrasound and uterine artery Doppler2 with fetal medicine
          sonographer.
    CONFIRMED SGA
     1. Abnormalities of ultrasound examination or CTG monitoring should have
        urgent review by the Consultant or the Senior Registrar.
         CONFIRMED IUGR
          1. If IUGR is diagnosed refer to Section Intrauterine Growth Restriction
           2.    Consider administration of corticosteroids if pre-term delivery is anticipated.2
References
1.       Alberry M, Soothill P. Management of growth restriction. Archives Disease and Childhood, Fetal
         and Neonatal Edition. 2007;72(1):F62-F7.
2.       Sheridan C. Intrauterine growth restriction. Australian Family Physician. 2005;34(9):717-23.
3.       Maulik D. Fetal Growth Compromise: Definitions, Standards, and Classification. Clinical Obstetrics
         and Gynecology. 2006;49(2):214-8.
4.       Sifianou P. Small and growth-restricted babies: Drawing the distinction. Acta Paediatrica.
         2006;95:1620-4.
5.       Bamburg C, Kalache KD. Prenatal diagnosis of fetal growth restriction. Seminars in Fetal &
         Neonatal Medicine. 2004;9(5):387-94.
6.       Illanes S, Soothill P. Management of fetal growth restriction. Seminars in Fetal & Neonatal
         Medicine. 2004;9(5):395-401.
7.       Marsal K. Obstetric management of intrauterine growth restriction. Best Practice & Research
         Clinical Obstetrics and Gynaecology. 2009;23:857-70.
8.       The GRIT study group. Infant wellbeing at 2 years of age in the Growth Restriction Intervention Trial
         (GRIT): multicentred randomised controlled trial. The Lancet. 2004;364:513-20.
9.       Royal College of Obstetricians and Gynaecologists. Green-top guideline No. 31: The investigation
         and management of the small for gestational age fetus. 2nd ed. UK: RCOG; 2013.
10.      Miller J, Turan S, Baschat AA. Fetal Growth Restriction. Seminars in Perinatology. 2008;32:274-80.
11.      Pairman S, Tracy S, Thorogood C, Pincombe J. Midwifery: Preparation for practice. 2nd ed.
         Chatswood, NSW: Elsevier Australia; 2010.
12.      Chauhan SP, Gupta LM, Hendrix NW, et al. Intrauterine growth restriction: comparison of American
         College of Obstetricians and Gynecologists practice bulletin with other national guidelines. American
         Journal of Obstetrics and Gynecology. 2009;409:e1-e6.
13.      Haram K, Softeland E, Bukowski R. Intrauterine growth restriction. International Journal of
         Gynecology and Obstetrics. 2006;93:5-12.
14.      Australian Health Ministers' Advisory Council. Clinical practice guidelines: Antenatal care- Module
         1. Canberra: Australian Government Department of Health and Ageing; 2012. Available from:
         http://www.health.gov.au/antenatal.
15.      Kinzler WL, Vinzileos AM. Fetal growth restriction: a modern approach. Current Opinion in
         Obstetrics and Gynecology. 2008;20:125-31.
16.      Royal College of Obstetricians and Gynaecologists. Green-top guideline No. 7: Antenatal
         corticosteroids to reduce neonatal morbidity and mortality. 4th ed. UK: RCOG; 2010.
Keywords:               SGA, IUGR,CTG, corticosteroids, ultrasound, AFI, fundal height, fetal compromise,
                        Doppler, small for gestation, intrauterine growth restriction
Document owner:         OGCCU
Author / Reviewer:      Evidence Based Clinical Guidelines Co-ordinator
Date first issued:      April 2008
Last reviewed:          Oct 2016                                       Next review date:   Oct 2019
Endorsed by:            Maternity Services Management Committee        Date:               18.10.16
Standards Applicable:   NSQHS Standards: 1       Clinical Care is Guided by Current Best Practice
                      9 Clinical Deterioration,
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