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Treatment Research
Harnessing T-cell “stemness” could enhance cancer immunotherapy
Posted: March 28, 2019
A new study provides insight into how cancer immunotherapy works and suggests ways to
enhance the treatment’s effectiveness. The NCI-led study, published in Science, examined
the effect of high potassium levels on T cells.
Managing Cancer Pain: Are Better Approaches on the Horizon?
Posted: January 23, 2019
Pain is a common and much-feared symptom among people with cancer and long-term
survivors. As more people survive cancer for longer periods, there is a renewed interest in
developing new, nonaddictive approaches for managing their chronic pain.
Study finds elevated risk of certain rare blood cancers after chemotherapy for
most solid tumors
Posted: December 20, 2018
In a new study, NIH investigators found that patients treated with chemotherapy for most
solid tumors had an increased risk of tMDS/AML, a rare but often fatal blood cancer. The
study, which used population-based data, was published in JAMA Oncology.
Tailored Radiation to Treat Brain Metastases Reduces Impact on Cognitive
Function
Posted: November 26, 2018
Results from a clinical trial suggest that, in patients with brain metastases, an advanced
radiotherapy technique limits harm to patients’ cognitive function without affecting the
treatment’s effect on tumors.
NCI-MATCH Update: More Labs, New Arms, and Initial Findings
Posted: November 15, 2018
NCI’s Dr. Lyndsay Harris provides an update on the NCI-MATCH trial, including the opening
of new trial treatment arms and the addition of new laboratories to perform testing on
tumor samples of prospective trial participants.
Heart Problems: Investigating the Cardiac Side Effects of Cancer Treatments
Posted: September 21, 2018
Certain cancer treatments can damage the heart and the cardiovascular system, a problem
known as cardiotoxicity. Cardiologists and oncologists met recently to discuss strategies
and future research directions for addressing these side effects.
Integrating Geriatric Assessment into Cancer Care: A Conversation with Dr.
Supriya Mohile
Posted: September 11, 2018
Dr. Supriya Mohile discusses the unique issues experienced by older adults with cancer and
efforts to incorporate geriatric assessment into patient care, including the publication of
recent ASCO clinical guidelines on geriatric cancer care.
High-Fat Diet or Diabetes Drug May Enhance Response to Targeted Cancer
Drug
Posted: August 8, 2018
A study in mice may have identified a way to help overcome resistance to targeted cancer
drugs known as PI3K inhibitors. The approach appears to work by reducing insulin levels
in patients receiving these drugs.
Mouse Study Links Immune Cells to Diarrhea Caused by Chemotherapy
Posted: July 20, 2018
A study in mice sheds light onto how some chemotherapies cause diarrhea. The findings
could be the basis for developing new treatments for patients with cancer who develop
gastrointestinal side effects from chemotherapy.
The Opioid Epidemic and Cancer Pain Management: A Conversation with Dr.
Judith Paice
Posted: July 16, 2018
Dr. Judith Paice, of the Cancer Pain Program at Northwestern University’s Feinberg School
of Medicine, discusses the impacts of the opioid epidemic on cancer patients and how
providers can address concerns about opioid misuse when managing cancer pain.
Can Age Affect Response to Immune Checkpoint Inhibitors?
Posted: July 6, 2018
A new study has linked age with how well patients with melanoma responded to treatment
with immune checkpoint inhibitors. Experiments in mice suggested that the response
pattern may be due to an age-related shift in the kinds of immune cells in tumors.
NExT: Advancing Promising Cancer Therapies from the Lab to Clinical Trials
Posted: June 29, 2018
The NCI Experimental Therapeutics (NExT) program works with researchers and top
scientific experts to advance promising or novel cancer therapies from the earliest stages of
research to human clinical trials.
Biosimilars for Cancer Emerge as Patents on Widely Used Biological Drugs
Expire
Posted: June 18, 2018
As the patents on some widely used drugs to treat cancer expire in the coming years,
biosimilar drugs are being developed for the treatment of patients with cancer. Are
biosimilars effective and will they expand treatment options for patients?
