The Well-Built, Patient-Oriented Clinical Question
Question Components                                                     Your Question
P – Patient or Population
Describe the most important characteristics of the                     30year old male with patellofemoral pain
patient.
(e.g., age, disease/condition, gender)
I – Intervention; Prognostic Factor; Exposure
                                                                          Quadriceps strengthening with
Describe the main intervention.                                           blood flow restriction
(e.g., drug or other treatment, diagnostic/screening test)
C – Comparison (if appropriate)
                                                                        Quadriceps strengthening without
Describe the main alternative being considered.                         blood flow restriction
(e.g., placebo, standard therapy, no treatment, the gold standard)
O – Outcome
Describe what you’re trying to accomplish, measure,                       Decrease patellofemoral pain
improve, affect.
(e.g., reduced mortality or morbidity, improved memory, accurate and
timely diagnosis)
The well-built clinical question:
“For 30-year old male with patellofemoral pain, is quadriceps strengthening with blood flow
restriction more effective than quadriceps strengthening alone in reducing patellofemoral pain?”
Type of Question                 Ideal Type of Study
 Therapy                        RCT
Prevention                       RCT > Cohort Study > Case Control
Diagnosis                        Prospective, blind controlled trial comparison to gold standard
Prognosis                        Cohort Study > Case Control > Case Series/Case Report
Etiology/Harm                    RCT > Cohort Study > Case Control
Cost analysis                    economic analysis
Note: Meta-analyses and systematic reviews, when available, often provide the best answers
      to clinical questions.
                                       Search Strategy Development
            Primary search term                                Synonym 1                 Synonym 2
P            Male                                               Man                       Boy
             Patellofemoral pain                                Runner’s Knee             Anterior knee pain
I           Quads strengthening with Blood flow restriction    Occlusion training        Hypoxic training
C            Quads strengthening without blood flow restriction
O          Decrease patellofemoral pain                         Relieve pain            Alleviate pain
Dartmouth Biomedical Libraries                                                                        10/12/2006