JANUARY 2008

1) N.R is a patient with gout has recently increase in blood pressure, what antihypertensive not to be
taken

a- b-blocker b-thiazides c-ACE inhibitors

Tips : all diuretics increase uric acid HYPER GLUC

2-One is suffering from allergic rhinitis, all are symptoms except

a-rhinorrea b-itchy eye c-hives d-sneezing e-watery eye

Tips: Nasal symptoms- Obstruction, Rhinoorhea, Mucosal itching, Mucosal swelling

Ocular Symptoms- Conjunctival itching, conjunctival watering, Redness, Burning, Clear and watery
discharge

3-The sedimentation of particles follow which equation

a-Stock’s law

b-Fick’s law (diffusion)

c-Noyes whitney(dissolution)

d-Raoult’s law

e-Michael’s mentens(rate of elimination)

4-phenothiazines side effects (k type)

a-extra pyramidal

b-increase prolactin

c-postural hypotension

d all of above

Tips : orthostatic hypotension is most common in elderly with low potency (FGA) first generation
antipsychotics ( chlorpromazine, methotrimeprazine)

Phenothiazines examples are Chlorpromazine, Fluphenazine, Trifluperazine, Thioridazine

Thioridazine contain piperidine ring in side chain , therefore low EPS

Hyperprolactinemia is common with FGA especially high potency agent such as haloperidol (CTC -7)

5-photosenstivity shows

a-increase sun burns b-purities

6-lung cancer

a-influenced by environment

b-mortality in prostate cancer is higher than lung cancer

c-Japan is the least country with lung cancer

d- men are at high risk than female

7-xenical(orlistat) is all except

a-oily stools

b-taken 1 tablet after every fatty meal

c-should keep high fat diet

d-should exercise

8-hepatitis b vaccine which is not true

a-given to an infected person

b-taken as a mixture hepatitis A&B together

c-3 doses frequent in 3 months

Tips : combined hepatitis A and B (Twinrix)

Dose Adults : > 19 y – 1ml im * 3 at 0 , 1, 6 months OR Day (0, 7, 21, 365 days)

Children 1 to 18 y --- 0.5ml im * 3 at 0, 1 and 6 months

Children 1 to 15 y (alternative 2 dose schedule) --- 1 ml im * 2 at 0 and 6-12 months

9-a manager is feeling his staff doesn’t give enough care for patients in her multicultural (divert)
community. Should do all except

a-give courses
b-hire multi ethnic staff

c-give alternative safe medication

10-all used in gene transfer except

a-retrovirus

b-adenovirus

c-mycobacterium

11-all contain DNA except

a-fungus b-virus c-bacteria d-helminth e-prions

Tips : Prions are infectious protein material.

12-isotonicity are all except

a-it is colligative property

b-used to measure tonicity

c-if solution is hypertonic we should add NaCl to make it isotonic

Tips: Isotonic :- The solute concentration is the same on both sides of the membrane.(misbhah 34-6)

13-suspention eye drops (k type)

a-more bioavailable than ophthalmic solutions

b-contain suspending agent

c-partially insoluble in aqueous medium

d all are correct

14-all are used in skeletal muscle relaxant except

a-baclofen

b-dantrolene

c-suxamethonium
d-pancronium

e-tinidazole (for infections of amoebae, and trichomonas, like metronidazole)

15-a nurse calls about a patient having fentanyl patch that falls during bathing and destroyed, the refill
stay 2 days after.

She wants to get another patch.what should the pharmacist do

a-call the prescriber to have a written confirmation to dispense it today

b-give the nurse instruction how to use the patch again

c-give the patient instruction how to use the patch again

d-advance 2 days refill and make documentation

16-which is true for simple syrup

a-support microbial growth

b-contain alcohol 10%v/v

c-contain sucrose 85%w/v

d-form turbid solution

17-elder patient switched to oral liquid solution instead of oral pills, the cause is

a-dysphagia

b-cognitive disorder

c-parkinson disorder

d-allergy

18-the difference between pain & touch nerves, which is wrong

a-touch has thinner nerve fiber

b-the velocity of transmission is higher in pain nerve

c-morphine blocks touch nerve

19-CSF, all are true except

a-covers brain and spinal cord

b-passes through vertebrae

c-turbid fluid

d-synthesized by choroid plexus

20-a,b,c,d,e are patients having different drugs. order them from the most important to the least to be
reported to the dose

patient drug renal excretion kidney function

a 1 70% 10%

b 2 90% 5%

c 3 50% 10%

d 4 70% 25%

e 5 10% 90%

A- b-a-d-c-e

B- b-a-c-d-e

C- a-c-b-e-d

21-flowability of powder measured by angle of repose

22-isotonic solution

a-0.09% w/v NaCl

b-0.9% w/v NaCl

23-drug renally excreted means it is (k type)

a-filtered b-secreted c-reabsorbed

24-Ca carbonate regimen

a-500 mg twice on empty stomach

b-500 mg twice with food

c-1000mg once on empty stomach

d-1000 mg twice

25-valproic acid conjugated with

a-glucoronide b-glutamate c-acetylation d-methylation

26-non adherence to antidepressant causes

a-insomnia b-sedation c-anxiety

27-serum creatinine is less in elder men compared to young because

a-protein binding is more in elder

b-decreased body protein in muscles

c-renal clearance is more in elder (low muscle mass)

28-what is the meaning of latin cam corpum “cc”

a-according to body weight

b-outside the body

c-with meals or food

29-woman in her 24 week of pregnancy suffer from polipteal pain(pain in the back knee)which is the
sign of deep vein thrombosis, she should take

a-ASA

b-clopidogrel

c-heparin iv followed by warfarin

d-warfarin

e-dalteparin

Tips : The drug of choice of DVT in pregnancy is LMWH or heparin .

Heparin is prophylaxis only

Warfarin is safe in the postpartum period only.( misbah)

30-45 years old man has to check his blood for insurance purpose, he found fasting blood level
8mmole/l .his brother 40 yrs was diagnosed with diabetes mellitus 2 yrs ago. what would be the
convenient therapy

a-insulin

b-metformin

c-metformin+glypiride

d-weight control and exercise

31- assay of warfarin

a-appt

b-thromboplastin time

c-international normalized ratio

32-which is wrong about dalteparin

a-longer half life than heparin

b-higher availability than heparin

c-lower incidence of thrombosis

d-given subcutaneously

e-has no antidote in overdose

33-which information is not found in patient self care

a-candida

b-smoking cessation

c-xerostamia

d-diaper rash

e-vaccination schedules

34-treatment of acne are all except

a-doxycycline

b-minocycline

c-erythromycin

d-ciprofloxacin

e-tetracycline

Tips : patient with acne and resistant to oral antibiotics , use isotretinoin

35-skin does not contain which receptor

a-pressure b-pain c-touch d-temperature e-olfactory

36-which is least to induce liver cancer

a-hepatitis A b-hepatitis B c-hepatitis C d-hepatitis D e-EBV

37-pharmacist will protect the confidentiality of the patient, which is wrong

a-refuse to give the information of the patient to the doctor

b-release information to a concerned party if the aim is to prevent him from committing suicide

c-give the patient a copy of the prescription

38-a lady uses sun block with SPF 15, that’s means

a-conc of active ingredient is 15%

b-15 sun protection factors are present

c-she should apply it every 15 min

d-sun burn will occur 15 times less if sun block was not applied

e-without sun block sun burn will be 15 more times

39-what is the most complicated form if one wants to establish a pharmacy

a-partnership
b-corporation

c-co operative

d-franchise

e-sole ownership

40-problems confronting sole proprietary

a-double taxation for profit

b-take all responsibility and decision

c-bank doesn’t give loan easily

41-ointement compounded by 10gm of 0.25%zinc ointment

mixed with 8gm of 0.2%zinc ointment and 14gm ointment base, what is the final conc of zinc

A. 0.128 % B. 0.235% C. 0.149 %

0.025 gm in 10gm and 0.016 gm in 8 gm . Now ointment base is 14 gm so total base is 32 gm and med is
0.041gm, find out for 100gm, and you will get the %

42-how long it will take for a drug with k=0.0005day -1 to reach 10%

(4606 days)

43- SF36 survey in health control cares about

a-health quality of life b-clinical c-economy

44-patient taking acetaminophen, which increases risk of liver cirrhosis

a-hypertension b-diabetic c-alcoholic

45-patient with C.H.F should take best

a-propranolol b-bisoprolol c-nadolol d-pindolol

46-diuretic used in treatment of oedema in a patient of renal failure

a-loop diuretic (furosemide) b-spironolactone c-thiazide

47-which has no crystal lattice (amorphous)

48-which affects liver microsomal enzymes (K TYPE)

a-ketoconazole b-itraconazole c-nystatin (ANY AZOLE)

49-which must be given with caution with erythromycin

a-theophylline b-warfarin c-pheyntoin d-all

50-complications of diabetes

A-retinopathy b-neuropathy c-coronary artery disease d-all

51-for antihyperlipidemic which is true

A-give 2 statins may increase efficacy

b-if statins inactive shift to other group

c-cholestyramine not preferred in pregnancy

52-for emulsions all are true except

a-o/w is hydrophilic

b-w/o conducts electricity (o/w)

c-w/o is hydrophopic

53-which decreases phenytoin conc (folic acid)

54-all are symptoms of rhabdomyolysis except

a-muscle pain&cramps

b-muscle weakness
c-colored urine ("tea-colored", due to the presence of myoglobin)
d-odor in urine

55-When a pharmaceutical company starts a research for a new medication, it has to protect her rights
by making registration for : 2007

a) Logo

b) Copy Right

c) Trade Name

d) Patency

e) Brand Name

56- A patient has dark urine, and muscle pains (rhabdomyolysis) . Which of the following drug may be
patient on?

A-Metronidazole

B-Atorvastatin

C- Rifampin

D-Bismuth

E-Lithium

57-patient on diet we should advise him with all except

a-drink a lot of water b-take a lot of fibers

c-adapt to his shape d-parents encourage

58-all are sexual transmitted diseases except

a-herpes simplex

b-herpes zoster

c-treponema

d-nisseria

e-HIV

Tips: viral disease; painful skin rash with blisters

59- vitamin K is secreted from:

a- Lung

b- Kidney

c- Colon It is the highest PH

d- Spleen

e- Liver

Tips: vitamin K1 or Phylloquinone primarily found in green leafy vegetables

Vitamin K2 or Menaquinone synthesized by intestinal bacteria

60-pharmacist tell the pharmacy assistant to council a patient about antibiotic, this is against

a-justice b-autonomy c-paternalism d-beneficience

61-doctor advise patient to decrease GIT pain (k type)

a-avoid tight clothes b-stop smoking c-lay down after eating

62-to proper measure a liquid solution

a-shake before measuring

b-put in larger container

c-measure at the level of sight

63-all are used in UTI except

a-cotrimoxazole b-nitrofurantoin c-norfloxacin d-oxacillin

64-What is NOT a function of the skeletal system?2006

a) Blood vessel innervations and soft tissue

b) Transport food and oxygen through the body (innervation)

c) Shape and support

d) Protection of vital organs

e) Bone marrow production and blood formation

65-the most carcinogenic causes vomiting

a. cisplatin b.cyclophosphamide

c. bleomycin d. 5 fluoro uracil

66-can be used as a filler

a-Mg stearate b-lactose c-dicalcium phosphate

67-treatment of scabies

a-all family members are treated

b-from neck to foot

c-leave 8-12hrs

d)all of the above

68-which prevent uric acid production (allopurinol)

69-causes increase in Na,Cl and causes urine acidosis (thiazides)

70-all secreted from anterior pituitary gland except (vasopressin)

71-large parentral infusion, we should check for

a-preservative b-particle free c-pyrogen free d-a&b e-a&b&c f-b&c

72-for HPLC

a-stationary phase is hydrophobic (reverse)

b-mobile phase is polar (reverse)

c-polar is separated first

73-GLC separation depends on

a-molecular wt b-polarity c-hydrophilicity

74-which is photosensitive

a-cephalexin b-ciprofloxacin c-erythromycin

75-epitetracycline-----------tetracycline (epimerization)

76-compound with 3 asymmetric carbon has—isomers

a-12 b-8 c-16 d-4

77-which is used in treatment of glaucoma (dorzolamide)

78-drug which is extensively metabolized and there is renal failure, which is affected

a-systemic clearance

b-1st pass clearance

 c-non renal clearance

d-protein binding

79-in renal failure, all are true except (increase in albumin level in blood)

80-which is responsible for bone reshape

a-osteoclast b-osteoblast c-chondrocytes

81-warfarin is (increased by deficiency of vit k)

82-phenytoin is to be taken once daily

a-30mg tab b-100mg tab c-50mg chewable d-a&b&c e-b&c

83-turn over = (cost of products sold / inventory)

84-which passes B.B.B the least (choose the least partition coefficient)

85-which is expressed as hemolytic anemia (thalasemia)

anemia due to genetic defect

86-which is not found in nucleotide

a-ribose b-deoxyribose c-pyridine d-proline

Sugar - Either ribose or deoxyribose (in RNA or DNA)

Nitrogenous base - Adenine, guanine, cytosine, thymine (only in DNA), uracil (only in RNA)

Phosphates - One to three, two of which are usually hydrolyzed to provide the energy to attach the
nucleotide and form the phosphodiester bond

87- which is not true for cones

a-activated by light
 b-found in large no. than rods

c-responsible for sharp vision

Tips :The rods are more numerous, some 120 million, and are more sensitive than the cones.

However, they are not sensitive to color. The cones 6 to 7 million .

88-which acts on cell membrane (insulin)

89- serotonin is responsible for all except

a. mood b. motor activity

c. appetite d. sleep

90-for blood clotting,which is wrong

a-dalteparin has no antidote

b-bleeding in warfarin,use vit k

c-major bleeding in heparine use protamine sulphate

d-safe INR 2-3

e-if INR exceeds 4.5 major bleeding

91-growth hormone is secreted from (anterior pituitary gland)

92- what is azotemia

Excessive retention of nitrogen waste products (BUN & createnin)

in blood

93- metabolic acidosis is estimated by

a.↓ HCO3 b. ↓ CO2 c. ↑ HCO3 d. ↑ CO2

94-patient needs non sedative antihistaminic you will give him

(loratidine)

95-herpes is mainly transmitted by (contact of lesions)

96-when essential amino acid is not taken

a-no protein synthesis

b-proteins synthesis occurs without this amino acid

c-no health problem due to presence of other nutrients

d-body will form this amino acid

Tips: essential amino acids are the components of proteins that make them essential in the diet.

97-mineral oil in ointment is used for

(levigation)

98-cotrimoxazole

a-PABA structure

b-THFR inhibitor

c-synergetic with sulphamethoxazole

99-which is not amino glycoside

(vancomycin)

100-secreted from adrenal medulla

(epinephrine)

101-for choosing appropriate dose of antibiotic we should put in consideration all except

a-weight b-age c-affected organ d-kind of disease

102-bed sores due to

(pressure atrophy)

103-nicotine replacement therapy which is n't true ?

a-minimum duration for gum treatment is 3 months

b-minimum duration for patches treatment is 6 months

c-patients has allergy from patches can take gum

104-i.v infusion

a-intermittent or continuous

b-steady state

c-0.9 NaCl or 5% dextrose

d-all the above

105-which triggers asthma

a-non adherence to drug

b-cats in environment

c-hypertention

Tips : Risk factors are

Allergens ( Pollens , mold , dust mite )

Respiratory infections (cold, flu)

Air pollutants\ irritants (smoke)

Drugs: beta blockers, NSAIDS\ASA\COX2 inhibitors, tartrazine, sulfites, radio contrast media

106-all are communicating disease except

a-gonorhea

b-hepatitis

c-herpes

d-botulism
Tips: It is fatal disease caused by a toxin produced by the bacterium Clostridium botulinum.

107-iron deffeciency anemia ,all except

a-microcytic

b-oral and parentral for more than 6 months

c-does not affect iron stores

d-serum ferritin is used for testing

e-most common type of anemia

108-nicotine treatment ,all except

a-headach indicates high nicotine

b-has allergy from patches, should avoid gum also

c-need 3 months for patches, 4-8 weeks for gum

Tips: Better dosing flexibility and outcomes with gum/patch combination therapy {CTC-7 page 184}

109-treatment of epilepsy by

a-inhibiting GABA neurotransmitter

b-stimulating NMDA neurotransmitter

c-decrease firing threshold of impulse

Tips: In epilepsy treatment potentiation of GABA activity required (Tiagabine, Topiramate) and also
reduces NMDA receptor activation.

110-thiazolidinediones st. used for

a-osteoporosis

b-diabetes

c-hypertension

Tips: Agonist PPAR- gamma ( Rosiglitazone, Pioglitazone)

111-council on ACE inhibitors, all except

a-dry cough

b-swollen face, refer to physician

c-take high protein diet

d-increase prolactin

Tips : proteinurea is side effect of ACEi

112-food increase absorbtion of

a-amoxicillin

b-etidronate

c-cefuxetine acetate

d-norfloxacin

113-soluble diluent, directly compressible (k type)

a-sprayed direct lactose

b-dicalcium phosphate

c-magnesium stearate

114-a female has a prescription for corticosteroids cause she suffer from inflammatory bowel disease,

the concern of the pharmacist to ask her if she suffers from all except

a-diabetes mellitus

b-hypertension

c-breast cancer

d-infection

e-osteoporosis

115-infliximab is used in

a-ashma

b-glomuronephritis

c-chronic inflammatory bowel disease

d-hepatitis

Tips: infliximab is effective in inducing and maintaining remmision in patients with moderate to severe
Crohn’s disease (best with combination therapy with azathioprine) CTC-7 reference

116-which is wrong about emulsion

a-if we add water to o/w emulsion, it will be miscible with it

b-w/o emulsion conducts electricity

c-dispersed phase can be more than 50%

d-decrease creaming by decrease droplet size

e-o/w emulsion is hydrophilic

117- which is used in chronic hepatitis

a. interferon

b. amantadin

c. acyclovir

d. infliximab

e.etaneracept

Tips: Peg Interferon alfa-2a used in chronic hepatitis B {180 microgram once weekly for 48 weeks}

118- in BPH treatment which drug make hot flushes

a. flutamide

b. finasteride

c. other drugs

Tips : No longer being manufactured for sale In Canada.

119- long term use of coticosteriod make all except

a. hypokalemia

b. decrease gluconeogenesis

c.peptic ulcer
d. inhibit pit. Function

Tips: it causes hyperglycemia

120- what is syncope? Temporary loss of consciousness

Tips – Fall in blood pressure

121- what is mechanism of action of antipsychotic?

Dopamine receptor antagonist

122- which in included in glycine conjugation

a. SAM b. cytochrom P450

c. PAPS d. UDP

e.acetyl co-enzyme A

123-lactone ring[given structure] this ring is characteristic to

a. penicillin

b.warfarin

c. benzodiazepin

d. glycosides (digoxin)

124-all of these drugs increase weight except;

a.glyburid b. valproic acid

c. lithium d. topiramate

125- anemia due to loss of blood is

a. aplastic anemia b. hemolytic anemia

c.microcytic anemia d. megaloblastic anemia

126- cholestyramine which is true ?

a. bind bile acid

b. decrease cholesterol synthesis

c. absorbed from GIT

127.vegetarian human must take which vitamin

a. thiamin b. folic acid

c. B12 )animal source) d. riboflavin

128. separation of bar bodies into equal halfes termed

a. sagital b. mid sagital c. frontal

129. Which age group shows the highest clearance for theophylline?

a) 1-2 weeks

b) 4-6 weeks

c) 2-6 years

d) 18-25 years

e) 40-65 years

130. Specificity means :

a) To have negative results with people who don't have the disease

b) To have positive results with people who have the disease

Sensitivity (also called the true positive rate, or the recall in some fields)

measures the proportion of positives that are correctly identified as such

(e.g., the percentage of sick people who are correctly identified as having the condition).

Tips :Specificity (also called the true negative rate) measures the proportion of negatives that are

correctly identified as such (e.g., the percentage of healthy people who are correctly identified as not
having the condition).
131. vit. D toxicity (Hypervitaminosis D) ?

An excess of vitamin D causes abnormally high levels of calcium in the blood (hypercalcemia).

This can severely damage the kidneys, soft tissues, and bones over time. Constipation, Decreased
appetite (anorexia),

Dehydration,Fatigue, Frequent urination, Irritability, Muscle weakness,Vomiting, Excessive thirst

(polydipsia), High blood pressure,

Passing large amounts of urine (polyuria)

132- which of the following is a function of lymph system

a. transfer fat in body

b. responsible for fat absorption from digestive system

133- Wilcoxon rank test for

a. parametric b. non parametric

Tips: The Wilcoxon signed-rank test is a non-parametric statistical hypothesis test used

when comparing two related samples, matched samples, or repeated measurements on a single sample

to assess whether their population mean ranks differ (i.e. it is a paired difference test)

134- circular DNA ?

Circular DNA is DNA that forms a closed loop and therefore has no free ends. Examples include:

Plasmids – mobile genetic elements

cccDNA – formed by some viruses inside cell nuclei

Circular bacterial chromosomes

Mitochondrial DNA (mtDNA)

Chloroplast DNA (cpDNA) and that of other plastids

135- contraindicated with celecoxib

1- sulfa allergy

2- renal impairement

136- Css

a. when rate of absorption = rate of elimination

b. equal to infusion rate divided by clearance

Tips: Steady State concentration is eventually achieved when a drug is administered at a constant rate.

At steady state, rate in = rate out. Steady state is achieved after 4 t1/2

(94% of steady state concentration (Css)) to 5 t1/2 (97 % of Css). Loading dose is usually given to get
plasma concentration to steady state quickly

The Steady-State Concentration is a factor of half life

137- chronic bronchitis use corticosteroids or not? Yes

Tips : Two major classes of medications are used to treat chronic bronchitis, bronchodilators and
steroids. .Bronchodilators (for example, albuterol
[Ventolin, Proventil, AccuNeb, Vospire, ProAir], metaproterenol [Alupent], formoterol
[Foradil],salmeterol [Serevent]) work by relaxing the smooth muscles that encircle the bronchi, which
allows the inner airways to expand. Anticholinergic drugs also can act as bronchodilators, including
tiotropium (Spiriva) andipratropium (Atrovent).

.Steroids (for example,prednisone, methylprednisolone [Medrol, Depo-Medrol]) reduce the

inflammatory reaction and

thus decrease the bronchial swelling and secretions that in turn allows better airflow because of
reduced airway obstruction.

Often inhaled steroids are administered since they have fewer side effects than systemic (oral) steroids.

Examples include budesonide (Pulmicort), fluticasone (Flovent), beclomethasone (Qvar), and

mometasone (Asmanex).

Combination therapy with both steroids and bronchodilators is often utilized.

These include fluticasone/salmeterol (Advair), budesonide/formoterol (Symbicort), and

mometasone/formoterol (Dulera).

138- Salt form is made from acid or base in order to

a. ↑ bioavailability

b. change the pharmacological action

c. change the physicochemical properties

139- patient with jaundice , lower limb. Oedema , abdomin distension . which describes ascitis?

a. jaundice

b. lower limb oedema

c. abdominal distension

Tips: sign and symptoms include

Abdominal distension

Weight gain

Dyspnea (shortness of breath)

140- hormones act on cell surface ?

a.

b. estrogen

c. progesterone

141- which predispose to cancer

a. Hiatus hernia b. H.pylori

142- at ovulation , which hormone increases

a. FSH & LH b. Estrogen

c. FSH d. progesterone

143- SC …………….. subcutaneous

144- PO …………….. orally

145- cornea most lipophylic part ?

The epithelial surface of the cornea

the “hydrophilic” (water-attracting) mucoid or mucin layer of the tear film is laid down

onto the surface of the cornea by “goblet cells"

146- mechanism of action of Zafirlukast ?

is a selective and competitive receptor antagonist of leukotriene D4 and E4 (LTD4 and LTE4)

147- NH2-----CooH ?

Example of oxidative deamination

Oxidative deamination is a form of deamination that generates oxoacids in the liver

148- drug is highly excreted , so it is;

a.Actively secreted

b. filtered only

c. partially reabsorbed

d. a & b

149- thixotropy is ;

a. shear thickening

b. shear thinning
Tips: Pseudoplastic flow ( Gel ------------to convert---------- solution)

Decrease viscosity , Increases flow

150- what is nystagmus ?

a. exophthalmos of the eye

b. rapid eye movement

151- what is the form with low solubility ?

a. crystal form

b. amorphous form

151- phenytoin metabolite ( given structure ) due to conjugation with ? with glucuronic acid

152- Oxygen toxicity can cause seizures in the brain which is linked directly to the inhibition of:

a) monoamine oxidase

b) catechol-orthomethyl transferase

c) lactate dehydrogenase

d) glutathione reductase

e) glutamate oxidase treated by

Tips: glutamate reductase is an integral component of the antioxidant defense mechanism.

Inhibition of this enzyme results in an alteration in sensitivity of the organism to the toxic effect of
Oxygen.

153- solid state resolution is best described as :

a. size exclusion b.ion ext. resin

c. adsorption chr. d.partition chr.

154- inhaled florinated anesthetic agents are metabolized by………?

Metabolic degradation

155- manager of pharmacy who when there’s a problem , he doesn’t council his assistants . this type is
called :

a. autocratic b. burocratic c. co operative

156- this structure is for antibiotic . Given against gram –ve that can be used also in :

a.M.S.

b.endocarditis

c.hyperthyroidism

d.polycyctic kidney disesase

157. time is plotted against conc.Of camphor in H2O At X

a. one phase b. two phase

158- IV bolus with 0.236e + 0.567e + 0.7839e . Number of compartments ?

a. 1 b. 2 c. 3 d. 4

159- mechanism of action of monoclonal antibodies in cancer treatment ?

1. Make the cancer cell more visible to the immune system.

2. Block growth signals

3. Stop new blood vessels from forming

4. Deliver radiation to cancer cells

5. Deliver chemotherapy to cancer cells

160- hereditary anemia causes increase in reticular cells is

a. thalassemia

b. spherocytosis

c. G6PD. Dif.

d. sickle cell anemia

161- for drug A route AUC

IV 130

Oral 38

I.P 38

So this drug is

a. highly metabolized by systemic circulation

b. ………………… by gut

c. ……………………by 1st pass metabolism

162- which of Ca channel blockers causes bradycardia

a.nefidipine b. verapamil

c.diltiazem d. b & c

163- what decreases sedimentation rate in suspension ?

a. Small particle size

b. Increase vehicle denisity

c. Increase vehicle viscosity

d. All the above

Tips : The sedimentation rate in a suspension can be determined by the Stoke's equation.
164- which drug depends in its action on the presence of thrombin factor Ш

a.heparin

b.warfarin

c.aspirin

165- antiplatelet aggregation

a. aspirin b. ticlopidine c.clopidogrel

d. b & c e. a & b & c

166- presence of B amyloid is characteristic to

a. Alzheimer b. parkinsonism

167- which is not included in Canada program vaccine

a. meningococcal

b. pneumococcal

c. dephteria

d.pertusis

168- treatment regimen of AIDS patient , which is most correct :

a. take 2 medications that give synergetic action

b. it’s not true to take 2 medications with each others

c. give 2 medications with additive effect of different groups

d. treatment with each drug group alone

169- which is the most powerful form of vitamin E

a. α tocopherol

b. β tocopherol

c. γ tocopherol
 d. δ tocopherol

170- question about melanoma & nevi

MELANOMA, one of the deadliest forms of skin cancer, most often appears as an asymmetrical,

irregularly bordered, multicolored or tan/brown spot or growth that continues to increase in

size over time. It may begin as aflat spot and become more elevated. In rare instances, it

may not be pigmented.

DYSPLASTIC NEVI (atypical moles) are unusual benign moles that may resemble melanoma.

People who have them are at increased risk of developing single or multiple melanomas.

The higher the number of these moles someone has, the higher the risk; those who have 10 or more
have 12 times

the risk of developing melanoma compared to the general population. Dysplastic nevi are found
significantly more

often in melanoma patients than in the general population.