Study Questions for Chapter 16
1. Melanocytes are found in which epidermal (C) Psoriasis
layer? (D) Ichthyosis
(A) Stratum basale (E) Piebaldism
(B) Stratum corneum
(C) Stratum granulosum 4. A young infant shows skin blisters over
(D) Stratum lucidum the entire body with generalized skin ero-
(E) Stratum spinosum sion. Pathology indicates a cleft between the
epidermis and dermis. What is the most likely
2. A young black girl shows isolated patches of diagnosis?
skin and hair that lack melanin pigment. In ad- (A) Psoriasis
dition, other skin lesions are observed that look (B) Junctional epidermolysis bullosa
suspiciously like a malignant melanoma. What (C) Ichthyosis
is the most likely diagnosis? (D) Ehlers-Danlos syndrome
(A) Type I oculocutaneous albinism (E) Type II oculocutaneous albinism
(B) Type II oculocutaneous albinism
(C) Piebaldism 5. The administration of which of the following
(D) Ichthyosis agents may result in discoloration of both de-
(E) Psoriasis ciduous and permanent teeth?
(A) Cephalosporin
3. A young infant shows extremely stretch- (B) Chloramphenicol
able and fragile skin, hypermobile joints, and (C) Erythromycin
cigarette-paper scars over the knees. What is (D) Penicillin
the most likely diagnosis? (E) Tetracycline
(A) Ehlers-Danlos syndrome
(B) Junctional epidermolysis bullosa
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Answers and Explanations
1. A. Melanocytes are found in the stratum basale, the deepest layer of the epidermis, at the
dermoepidermal junction.
2. C. Piebaldism is an autosomal dominant disorder and is basically a localized albinism.
3. A. Ehlers-Danlos syndrome is an autosomal dominant disorder involving the gene for peptidyl
lysine hydroxylase.
4. B. Junctional epidermolysis bullosa refers to a group of autosomal recessive disorders caused
by a mutation in the gene for laminin 5.
5. E. Tetracyclines are bound to calcium in newly formed teeth both in utero and in young
children. They may cause discoloration and enamel dysplasia.
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