CHOWDHURY TASNEEM HASIN
CHIEF DIETICIAN & HEAD OF THE DEPT
DIETETICS AND NUTRITION
UNITED HOSPITAL LTD
   The Dietitian will look at your…
     Medical History,
     Weight History,
     Blood Levels,
     Recent Dietary Intake with a Diet History.
   Excretion of metabolic waste through urine
   Water and Electrolyte Homeostasis
   Acid/base balance
   Maintenance of bone health
     Activation of vitamin D
     Calcium/phosphorus homeostasis
   Blood Pressure Regulation
     Renin-Angiotensin-Aldosterone
   Stimulate red blood cell production
     Erythropoietin
 Decreased excretion of nutrients/waste
 Abnormal calcium/phosphorus metabolism
  leading to bone disease
 Weight loss and malnutrition
 Fluid and electrolyte imbalances
 Cardiovascular disease and mortality
   GFR = (140-age) X body weight (kg) X 0.85 if female
           [72 X serum creatinine (mg/dL)]
   GFR of 100 approximates 100% kidney fxn
   Normal GFR = 120 to 130 mL/min
 Best index of kidney function
 Used to establish stage of CKD
 GFR is the amount of filtrate formed per minute
  based on total surface area available for filtration
  (number of functioning glomeruli)
 Can be determined using injected isotope (inulin)
  measurement in urine
 Can be calculated from serum creatinine using
  standard equations
Stage 1   CVD risk reduction      GFR > 90 ml/min
          Treat co-morbidities
Stage 2   Monitor progression     GFR = 60-89 ml/min
Stage 3   Evaluate                GFR = 30-59 ml/min
          Test complications
Stage 4   Preparation for renal   GFR = 15-29 ml/min
          replacement therapy
Stage 5   Renal replacement       GFR < 15ml/min
          therapy (RRT)            or on dialysis
   Diabetic Nephropathy damage to the nephrons in the
    kidneys from unused sugar in the blood, usually due to
    Diabetes.
   High Blood Pressure can damage the small blood
    vessels in the kidneys. The damaged vessels cannot
    filter poison from the blood as they are supposed to.
   Polycystic Kidney Disease (PKD) is a hereditary
    kidney disease in which many cysts grow in the
    kidneys. These cysts may lead to kidney failure.
   Acute Renal Failure - Sudden kidney failure caused
    by blood loss, drugs or poisons. If the kidneys are
    not seriously damaged, acute renal failure may be
    reversed.
   Chronic Renal Failure - Gradual loss of kidney
    function is called Chronic Renal Failure or Chronic
    Renal Disease.
   End-Stage Renal Disease - The condition of total or
    nearly total and permanent kidney failure.
       Glomerular diseases
         Nephrotic syndrome
         Nephritic syndrome—tubular or interstitial
       Tubular defects
         Acute renal failure (ARF)
       Other
         End-stage renal disease (ESRD)
         Kidney stones
1.   BP >140/90
2.   Edema
3.   Weight changes
4.   Urine output
5.   Urine analysis:
     —Albumin
     —Protein
6.   Kidney function
     Creatinine clearance
     Glomerular filtration rate (GFR)
7.   Blood values
     BUN 10 to 20 mg/dl (<100 mg/dl)
     Creatinine 0.7 to 1.5 mg/dl (10-15
        mg/dl)
     Potassium 3.5 to 5.5 mEq/L
     Phosphorus 3.0 to 4.5 mg/dl
     Albumin 3.5-5.5 g/dl
     Calcium 9-11 mg/dl
   % usual body weight (%UBW)
   % standard body weight (%SBW)
   Height
   Skeletal frame size
   BMI
   Skinfold thickness
   Mid-arm muscle area, circumference, or
    diameter
   Use dry weight or edema-free body weight
     In HD: post-dialysis weight
     In PD: weight after drainage of dialysate with
      peritoneum empty
   In obese or very underweight people, use
    adjusted edema-free body weight
                  Adjusted EFBW=
            BWef + [SBW*-BWef x .25]
*Use NHANES II data for standard body weight (SBW)
      National Kidney Foundation. K/DOQI clinical practice guidelines for nutrition in chronic
      renal failure. Am J Kidney Dis 2000;35(suppl);S27-S86.
   Eat small meals regularly.
   Make every mouthful count…
     Choose nutritious foods that are energy
      dense.
     Make sure your drinks are nutritious.
   Your kidneys work harder if you are
    overweight.
   Losing weight can help your kidneys work as
    well as they can for as long as they can.
   Measure of the nitrogenous waste products
    of protein
   High BUN in CKD may reflect high protein
    intake, GI bleeding or inadequate dialysis,
    increased catabolism due to infection,
    surgery, poor nutrition
   Decreased BUN may mean protein
    anabolism, overhydration, protein loss, low
    dietary protein
     Source: Byham-Gray, Wiesen, eds. A Clinical Guide to Nutrition Care in Kidney Disease.
     ADA, 2004
 Nitrogenous waste product of muscle metabolism
 Produced proportionate to muscle mass
 Unrelated to dietary protein intake (DPI)
 Sensitive marker of renal function: the higher the
  serum creatinine, the greater the loss of renal
  function; may reflect inadequate dialysis or muscle
  catabolism
 A decrease in creatinine over time may reflect loss
  of lean body mass
    Source: Byham-Gray, Wiesen, eds. A Clinical Guide to Nutrition Care in Kidney
    Disease. ADA, 2004
   Protein 0.8 to 1 g/kg IBW 80% HBV
   Sodium based on fluid status
   Potassium and other minerals (calcium,
    phosphorus) monitored and
    individualized
   Fluid unrestricted
   Diet therapy probably not effective for
    hyperlipidemia; may require medication
    Byham-Gray L, Wiesen K. A clinical guide to nutrition care in kidney
    disease.ADA, 2004
   Protein,
   Sodium (Salt),
   Fluid,
   Potassium,
   Phosphate.
   Diet to treat underlying disease
   Restrict diet if necessary to control
    symptoms
   Protein restricted in uremia
   Sodium restriction in hypertension
   Potassium restriction in hyperkalemia
   Energy: BEE X 1.2-1.3 or 25-35 kcal/kg
   Protein: .8-1.2 g/kg noncatabolic, without dialysis;
    1.2-1.5 g/kg catabolic and/or initiation of dialysis
   Fluid: 24 hour urine output + 500 ml (750-1500 ml)
   Sodium: 2.0-3.0 grams
   Potassium: 2.0-3.0 grams
   Phosphorus: 8-15 mg/kg; may need binders; needs
    may increase with dialysis, return of kidney
    function, anabolism
      Source: Byham-Gray, Wiesen, eds. A Clinical Guide to Nutrition Care in Kidney Disease.
      ADA, 2004
                      CKD               Hemodialysis CAPD or CCPD
Protein               0.6-1.0                1.1-1.4            1.2-1.5
g/kg/day
Energy                30-35                  30-35              30-35
(kcal/kg IBW)
Phosphorus             8-12 indiv            <17 indiv          <17 indiv
(mg/kg IBW)
Sodium                1000-3000              2000-3000          2000-4000
(mg/d)
Potassium             Individualized         ~ 40               Individualized
(mg/kg IBW)
Fluid                 Unrestricted           500-750 +          Individualized
(ml/d)                                       urine output
                                             (1000 if anuric)
Calcium               Individualized         Individualized     Individualized
(mg/d)                based on serum level   ~1000 mg/day       ~1000 mg/day
Use adjusted IBW if obese
     National Renal Diet Professional Guide 2nd edition, ADA 2002
Calories       30-35 kcals/kg IBW
Protein         0.6-0.8 gm/kg IBW
Sodium            1000-4000mg
Fluids       Evaluate need to restrict
Potassium    Evaluate need to restrict
Calcium             <2000mg
Phosphorus         800-1000 mg
Vitamins          Individualized
 Recommended energy intake = 30 to 35 day kcals/kg
    ▪ Spares body protein
    ▪ Maintains neutral nitrogen balance
    ▪ Promotes higher serum albumin levels
 Challenges
    ▪ Decreased appetite from uremia
    ▪ Various CKD dietary restrictions
    ▪ Finding food sources for added calories
   Hard candy 4 pieces
   Jam or jelly 2 T
   Honey 2 T
   Sugar brown or white 2 T
   Fruit snacks and candies 1 oz
 Protein is found in red and white meats, fish,
  eggs, dairy products and legumes.
 It’s important to have the right amount of
  protein you need for growth, healing and
  fighting infection.
                                 too much protein can lead
                                 to a build up of a waste
                                 product called Urea.
       Too little protein
       could lead to
       under nutrition.
                RENAL EXCHANGES FOR MEAL PLANNING
Food Groups     Kcal   CHO g.   PRO g. FAT g.   Na mg.   K+ mg.   PO4 mg.
Milk ( ½ c.)    85     6        4      5        80       185      110
Meat            65     0        7      4        25       100      65
Starch          80     15       2      1        80       35       35
Vegetable       25     5        1      0        15       150      20
Fruit           60     15       0.5    0        5        150      15
Fat (1TB.)      100    0        0      11       150      0        5
Calorie         60     15       0      0        15       20       5
Boosters
Beverages:      0      0        0      0        0        100      0
Coffee (1c.)
tea (1 bag)
wine (4 oz.)
beer (12 oz.)
   Reduces nitrogenous waste
   Reduces inorganic ions
   Reduces metabolic/ clinical disturbance
    (uremia)
   Slows rate of decline in GFR
   0.75 grams per kg/day for CKD stages 1 thru 3
   0.6 grams per kg/day for CKD stages 4, 5
   50% of the dietary protein should be HBV
     HBV protein produces less nitrogenous waste
   45 to 60 grams protein per day
   No Protein Restriction for Dialysis Patients
      ▪ 1.2 g per kg/day hemodialysis
        ▪ 10-12 grams lost per HD treatment
      ▪ 1.3 g per kg/day peritoneal dialysis
        ▪ 5-15 grams lost per PD treatment
             Carbohydrate Protein        Fat
  Food         4 kcals/g   4 kcals/g   9 kcals/g
1 cup milk        12          8         0 –10
1 oz meat          0          7         1 – 12
1 oz bread        15          3            0
1 cup veg          5          2            0
1 fruit           15          0            0
1 teaspoon         0          0            5
fat/ oil
                  1 tsp
3 oz
          1 cup
           &
          ½ cup
  ¼ cup
                  1 oz
   1 oz meat, poultry, fish = 7 g
     ¼ cup tuna
     ½ cup beans, peas, or lentils
     2 Tablespoons peanut butter
     2 egg whites = 7 g
   1 cup milk = 8 g
     1 oz cheese
     1/3 cup cottage cheese
   1 cup veg = 2 g
   1 slice bread = 3 g
     ½ cup rice or pasta
     ½ cup cereal
   Fruit, fats, sugars = 0
   Milk
   Cheese
   Beans
   Peanut butter
   Potassium is a mineral needed by the body to
    make your muscles and cells work.
   High or Low blood levels can be dangerous for
    your heart.
   Not everyone needs a low potassium diet.
     You will only need to start a low potassium diet
      if your blood levels are high.
 >6 mEq/L – abnormal,              Metabolic acidosis
  potentially dangerous             Drug interactions
 Renal failure (kidney is          Catabolism of malnutrition
  primary filter)                    or cell damage caused by
 Excessive nutritional
  intake                             injury or surgery
 Chronic constipation              Decreased urinary output
 Infection                         Chewing tobacco
 GI bleeding
 Insulin deficiency (high BG)
   Vomiting, diarrhea
   Diuresis
   Potassium binder
   K+ too low in dialysate
   Urine output >1000 mL/day or serum NL, do
    not need to restrict K+
   Potassium Restriction Indications
     Urine output < 1 liter per day
     GFR < 10 mL/min
     ACE inhibitors, beta blockers, lasix
     Hyperglycemia
     Serum potassium > 5.0 mEq/L
   Dietary Potassium Restriction = 2 grams/day
   Serum Potassium Goal: 3.5- 5.0 mEq/L
 Apple                 Peach
 Apple juice ½ c       Pear
 Applesauce ½ c        Pineapple
 Apricot nectar ½ c    Plums (1)
 Blackberries ½ c      Watermelon
 Fruit cocktail ½ c
 Grapes ½ c
 Lemon
 Lime
   Apricots          Prunes (5)
   Bananas           Raisins
   Dates
   Kiwifruit
   Orange
   Orange Juice
   Prune juice
   Potato
   Phosphate is a mineral that is important for
    strong bones and teeth.
   High levels can weaken your bones and damage
    your blood vessels.
 As renal function decreases, phos accumulates in
  the blood
  phos triggers release of PTH that releases calcium
  from bone
 Phos binders prevent phosphorus from being
  absorbed in the gut; form insoluble compound so
  phos is excreted in stool
 ↓ phos may mean excess phos binder or poor p.o.
   High serum phosphorus
     Bone decalcification
     Soft tissue calcifications
     Hyperparathyroidism
   Phosphorus restriction for GFR < 25mL/min
     Normal dietary phosphorus = 1000 to 1800 mg/day
     Dietary restriction = 560 to 850 mg/day
   Phosphate binders:
     Bind phosphorus in the GI tract
       Must take with meals
     Phoslo (calcium containing)
     Renvela (Sevelamer) (calcium free)
     Fosrenol (chewable)
DAIRY
Cheese              1 oz            150 mg
Milk                ½ cup           120 mg
PROTEIN
Egg                 1 large         100 mg
Liver               1 oz            150 mg
Peanut butter       2 Tbsp          120 mg
Sea Fish            1 oz             75 mg
Nuts                1 oz            100 mg
VEGETABLES
Baked beans         ½ cup           130 mg
Soybeans            ½ cup           160 mg
BREADS
Bran                ½ cup           350 mg
Cornbread           2 inch square   200 mg
Whole-grain bread   1 slice          60 mg
BEVERAGES
Cola                12 oz can       50 mg
 Most abundant mineral in human body
 Nearly half of calcium is bound to albumin; if serum
  calcium is low, evaluate albumin level; can correct for
  low albumin
 Calcium-Phosphorus Product: multiply serum calcium
  x serum phos: if >55-75, calcification can occur
 <2000 mg/day elemental calcium from diet + binders
  stage 3-4
 High ca+: calcification, nausea, vomiting, muscle
  twitching may mean too much Ca+ from meds or diet
   Kidney Failure leads to…
      ▪ Decreased production of active Vit D
      ▪ Low serum calcium
      ▪ Phosphorus retention
      ▪ Elevated PTH
      ▪ Secondary Hyperparathyroidism
          Mineral and Bone Disorder
   Not a reliable indicator of sodium intake in
    CKD
   Fluid retention due to decreased urine
    production can dilute an elevated level
   Serum levels must be evaluated in
    conjunction with fluid status
   Dietary sodium restriction prevents:
     Excessive thirst
     Edema
     Hypertension
     CHF
   Sodium restriction = 2000 mg/day
     Range from 1000mg to 4000mg
     Varies depending on co-morbidities
     More liberal sodium with frequent dialysis
   Sodium excretion falls at GFR < 20mL/min
1 tsp salt = 2,300 mg sodium
 Fresh foods
 Limit
   Cured/pickled foods
   Processed
   Can/bottled/packaged
   Instant cereals, mixes
 Avoid salt substitutes (potassium chloride)
 Flavor foods with spices, vinegar, lemon juice,
  pepper
   Fluid: “any food that is liquid at room temp”
      Soup, gelatin, ice cream, popsicles
   Excess fluid can cause:
     High blood pressure,
     Swelling in the ankles, hands and face,
     Shortness of breath.
   Check with your Renal Team regularly about how
    much fluid you should drink.
   Fluid is not just water.
     .
 Approx 48oz/day
 Pre-measure mealtime liquids
 Drink very hot or very cold
  beverages
 Drinking from smaller cups
 Use spray bottle to mist mouth
 Freeze juice in ice cube tray and
  eat like popsicles
   Vitamin C 90 mg/day
   Over 75% of kidney disease patients have increased
    homocysteine levels.
     Folic acid 1 mg/day
     B6 5 mg/day
   No Vitamin A due to its accumulation in CKD
   Vitamin D in its active form
    1,25 dihydroxycholecalciferol
         [1,25 (0H2)D3]
   iron supplementation
   Prevent deficiencies
   Control edema and serum electrolytes
   Prevent renal osteodystrophy
   Provide an attractive and palatable diet
   Removes concentrated molecules and excess
    fluid from pts blood through diffusion and
    ultrafiltration
   Three parts of the system are the dialyzer
    (artificial kidney), the dialysis machine, and
    the dialysate
   Requires vascular access, usually through an
    AV (arteriovenous) fistula
   Typical diet order
     2000 calorie, 80 g protein, 2 g Na+, 3 g K+, low
     phosphorus, 1500 cc fluid restriction
    10-12 g free amino acids lost per treatment
     during dialysis
    Greater amino acid losses with glucose-
     free dialysate and high flux dialyzers
    1.2 g protein/kg standard body weight
     (SBW) with 50% high biological value
     (meat, poultry, fish, eggs, soy, dairy)
    Most HD patients take in less than 1 g/day
NKF K/DOQI practice guidelines. Am J Kid Dis 2000;35(suppl):S40-S41, Cited in Byham-
Gray, p. 45-46
   Adults <60 years: 35 kcal/kg SBW
   Adults > 60 or obese: 30-35 kcals/kg body
    weight
   Actual intakes of HD patients in studies are
    lower than that (mean 23 kcals/kg in HEMO
    study)
      NKF K/DOQI practice guidelines. Am J Kid Dis 2000;35(suppl):S40-S41, Cited in
      Byham-Gray, p. 46
   HD patients at risk for lipid disorders
   Recommended fat intake<30% of calories
    and saturated fat<10%; cholesterol <300
    mg/day
   Optimum fiber intake 20-25 g/day
   These restrictions are difficult to achieve
    along with other restrictions of HD diet
 ≥ 1 L fluid output: 2-4 g
  Na and 2 L fluid
 ≤ 1 L fluid output: 2 g Na
  and 1-1.5 L fluid
 Anuria: 2 g Na and 1 L
  fluid
 Restrict Na+ if ↑
  interdialytic wt gain, CHF,
  edema, HTN, low serum
  sodium
   Potassium needs related to urinary output
   Most patients on HD can tolerate 2.5 g of K+
   Stricter diet may be indicated for pts w/
    insulin deficiency, metabolic acidosis, treated
    with beta blockers or aldosterone
    antagonists, hypercatabolic
   Individuals: 40 mg/kg edema-free IBW or
    SBW
   Maintain s. phos 3.5-5.5 mg/dL
   Usually ok until GFR ↓ to 20-30 mL/min
   Dialysis removes 500-1000 mg/treatment
   Use phosphorus binders with meals: absorb
    50% of dietary phosphorus
   Dietary intake: 800 to 1000 mg/day or <17
    mg/kg IBW.
   Identify high protein, low phos food sources
   High from excess Ca++ type binders, vitamin
    D analogs, Ca++ fortification
   Goal 8.4-9.5 mg/dl
   CaXPhos product: goal <55
   H2O soluble vitamins
   Dialyzable – take after H.D.
   B vitamins and vitamin C in renal vitamin
    ↑ Vit. C → ↑ oxalate → calcification of soft tissues
      and stones
   Individualize need for:
     Fe++ (IV most common), Vitamin D, Ca++, Zinc.
   Vitamin D is activated in the kidney to
    calcitriol, or vitamin D3
   As D3 levels fall, calcium absorption ↓ and
    phos excretion ↓
   Vitamin D3 therapy helps prevent renal bone
    disease but may cause hypercalcemia
   Renal pts should use calcitriol supplements
    under the supervision of a physician
   Energy: 35 kcals/kg/day SBW or adjusted
    body weight for pts<60 years; 30 kcals/kg for
    those >60
   Calories provided in the dialysate should be
    included in total intake (may absorb as much
    as 1/3 of daily energy needs)
   PD patients lose 5-15 grams of protein a day,
    primarily as albumin
   Goal 1.2-1.3 g/kg SBW
   PD clears sodium very well, so sodium can be
    fairly liberal
   However, high salt diets increase thirst and
    may make adherence to fluid limits more
    difficult
   General recommendation is 2-4 grams
    sodium
   Potassium: is easily cleared by PD; some
    patients may need K+ supplementation
   Calcium: limit to 2000 mg elemental calcium
     Generally pts get ~1500 mg from calcium-based
      phosphate binders
     Serum calcium should be maintained in low
      normal range (8.4-9.5 mg/dl)
   Phosphorus: limited to 800-1000 mg/day
    which is difficult with high protein diet
     Use phosphate binders
   Fluid: can be adjusted by varying the dextrose
    concentrations of the dialysate
     May need to be restricted if pts cannot achieve
     fluid balance without frequent hypertonic
     exchanges
   Increase exercise as allowed
   Limit sodium and fluid to minimize
    hypertonic exchanges
   Modify energy intake to facilitate wt loss
   Modify intake of sugars and fats, especially
    saturated fats
   Patient education regarding protein goals
    and ways to meet them
   Suggest pt eat protein foods first and limit
    fluids at mealtime
   Frequent smaller portions of protein and easy
    to eat proteins such as egg white, cottage
    cheese, etc
1. Types: related donor
2. Posttransplant management:
         Corticosteroids
         Cyclosporine
3. Diet while on high-dose steroids:
         1.3 to 2 g/kg BW protein
         30 to 35 kcal/kg BW energy
         80 to 100 mEq Na
4. Diet after steroids:
         1 g/kg BW protein
         Kcal to achieve IBW
         Individualize Na level
Well Mr. Osborne, it may not be kidney stones after all.
1. Particulate matter crystallizes
   Ca salts (Ca oxalate or Ca phosphate)
   Uric acid
   Cystine
   Struvite (NH4, magnesium and phosphate)
2. Ca salts in stones—Rx: high fluid; evaluate
   calcium from diet; may need more!
3. Treat metabolic problem; low-oxalate diet
   may be needed; acid-ash diet is sometimes
   useful but not proven totally effective
4. Uric acid stones
   Alter pH of urine to more alkaline
   Use high-alkaline-ash diet
   Food list in Krause text
5. Cystine stones (rare)
6. Struvite (infection stones) antibiotics and/or
surgery
   Increases acidity of urine (contains chloride,
    phosphorus, and sulfur)
   Meats, cheese, grains emphasized
   Fruits and vegetables limited (exceptions are
    corn, lentils, cranberries, plums, prunes)
   Increases alkalinity of urine (contains sodium,
    potassium, calcium, and magnesium)
   Fruits and vegetables emphasized
    (exceptions are corn, lentils, cranberries,
    plums, prunes)
   Meats and grains limited
   Your kidney team will tell you if you need to
    start a special diet.
   There is no need to avoid potassium or
    phosphate foods unless your blood levels are
    high.
   There is no one special diet for people
    with renal disease.
   It all depends on…
     Your level of renal function.
     What your blood tests show.
     What kind of dialysis you choose.
   NKF K/DOQI practice guidelines. Am J Kid Dis
    2000;35(suppl):S40-S41, Cited in Byham-Gray, p.
    46
   Byham-Gray L, Wiesen K. A clinical guide to
    nutrition care in kidney disease.ADA, 2004
   Byham-Gray L, Wiesen K. A clinical guide to
    nutrition care in kidney disease.ADA, 2004
   National Kidney Foundation. K/DOQI clinical
    practice guidelines for nutrition in chronic renal
    failure. Am J Kidney Dis 2000;35(suppl);S27-S86.
   National Kidney Foundation. K/DOQI clinical
    practice guidelines for nutrition in chronic renal
    failure. Am J Kidney Dis 2000;35(suppl);S27-S86.