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Gyncomastia

This document summarizes information about gynecomastia, which is an increased amount of breast tissue in males. It describes the clinical presentation of gynecomastia in young boys, old men, and other cases. It also discusses the histology of gynecomastia tissue, which shows abundant collagenous dense stroma with small ductular tissue and loss of lobular units. Causes of gynecomastia include idiopathic cases, cirrhosis, drugs, Klinefelter syndrome, and prolactinomas.

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69 views3 pages

Gyncomastia

This document summarizes information about gynecomastia, which is an increased amount of breast tissue in males. It describes the clinical presentation of gynecomastia in young boys, old men, and other cases. It also discusses the histology of gynecomastia tissue, which shows abundant collagenous dense stroma with small ductular tissue and loss of lobular units. Causes of gynecomastia include idiopathic cases, cirrhosis, drugs, Klinefelter syndrome, and prolactinomas.

Uploaded by

fado
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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 I    Pathology

Tiffany M. Graham, M.D.

INFOR
     A FOCAL SOURCE OF PATHOLOGY INFLAMMATION
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Gynecomastia
Updated: Aug 16, 2018

General

Gynecomastia simply refers to an


increased amount of breast tissue in
a male
Uncommon condition.
A minority of cases are associated
with BRCA2 mutation.

Clinical picture
1. Young boy with enlarged breasts (can be
unilateral).

May be idiopathic & resolve


spontaneously. Some require surgery

2. Old man with enlarged breasts

Due to high estrogen levels:

1. Cirrhosis (decreased hepatic clearance


of estrogen)
2. Some drugs
3. Klinefelter syndrome (XXY)
4. Leydig cell tumor of testis

3. Other

Can be seen in hyperthyroidism, prolactinomas, or AIDS patients on HAART therapy

Histology
Abundant collagenous dense stroma with only small ductular tissue with loss of lobular
units

End ducts without lobules

Can have well or poorly de ned borders


Can see ductal epithelial hyperplasia or prominent periductular edema

looks similar to desmoplastic stromal reaction or pseudoangiomatous stromal


hyperplasia

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Breast, [Right/Left], mammoplasty:
- Benign breast tissue, (weight) g.

AP Topics • Surg Path • Breast

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