Mindanao State University – Iligan Institute of Technology Student: Section: 263

PHARMACOLOGY

DRUG STUDY

Brand Name: Trandate Generic Name: labetalol Drug Classification: Alpha-, beta-adrenergic blocker, Antihypertensive

Dosage, Route & Frequency Drug-Drug & Drug-Food Side Effects Adverse Reactions
Drug Action Indications Contraindications
Recommended Prescribed Interactions (By System) (By System)
PO: Blocks alpha1 -, DRUG: May decrease Management of Hypersensitivity to Drowsiness, dizziness, May precipitate,
ADULTS, beta1 -, beta2 - effects of beta2 -adrenergic hypertension. IV labetalol. Bronchial excessive fatigue, aggravate HF due to
ELDERLY: Initially, (large doses) agonists, theophylline. Beta for severe asthma, history of dyspnea, peripheral decreased myocardial
100 mg twice daily. adrenergic receptor blockers , calcium channel hypertension. obstructive airway edema, depression, stimulation. Abrupt
Adjust in increments of sites. Therapeutic blockers, digoxin may Management of disease, cardiogenic anxiety, constipation, withdrawal may
100 mg twice daily q2– Effect: Slows sinus increase risk of bradycardia. preeclampsia, shock, uncompensated diarrhea, nasal precipitate myocardial
3days. Usual dose: heart rate; decreases HERBAL: Ephedra, severe HF, second- or third- congestion, weakness, ischemia, producing
100–300 mg twice peripheral vascular ginseng, yohimbe may hypertension in degree heart block diminished sexual chest pain, diaphoresis,
daily. May require up resistance, B/P. worsen hypertension. Garlic pregnancy, (except in pts with function, transient scalp palpitations, headache,
to 2,400 mg/day. may increase hypertension functioning pacemaker), tingling, insomnia, tremor.
CHILDREN: 1–3 antihypertensive effect. during acute severe bradycardia, nausea, vomiting,
mg/kg/day in 2 divided Licorice may cause water ischemic stroke, conditions associated abdominal discomfort
doses. Maximum: 10– retention, increased serum pediatric with severe, prolonged
12 mg/kg/day up to sodium, decreased serum hypertension. hypotension.
1,200 mg/day. potassium.
FOOD: None known.

Responsibilities in the Nursing Process (ADPIE) Responsibilities in the Nursing Process (ADPIE)
ASSESSMENT  To manage and reduce complication of preeclampsia
 Assess baseline renal function, LFT. IMPLEMENTATION
 Assess B/P, apical pulse immediately before drug administration (if pulse is 60/min or  Monitor B/P for hypotension.
less or systolic B/P is lower than 90 mm Hg, withhold medication, contact physician).  Assess pulse for quality, irregular rate, bradycardia.
 Question history of bradycardia, HF, second- or third-degree heart block, myasthenia  Monitor EKG for cardiac arrhythmias.
gravis.  Assist with ambulation if dizziness occurs.
DIAGNOSIS  Assess for evidence of HF
EVALUATION
PLANNING  Patient’s BP is within normal range
 The patient’s BP will be within normal range