Health Promotion & Education                                                       cases with irregular wounds or signs of infection,9 and in cases that may involve
litigation, such as a wound inflicted by an unleashed dog.7
      Dog Bite Prevention Tips
                                                                                         TABLE 1
                                                                                         Medical Conditions Associated with a High Risk of Infection After a Dog Bite
Annually more than four million Americans, approximately half of them children,
suffer dog bite injuries. Injury rates are highest among children between the
ages of five and nine, with boys being bitten more often than girls in the same          Chronic disease
age group. The number of dog bite injuries increases between the months of               Chronic edema of the extremity
April and September, with the peak occurring in July.                                    Diabetes mellitus
                                                                                         Immunosuppression
                                                                                         Liver dysfunction
According to the CDC, as many as 800,000 people require medical attention for            Previous mastectomy
dog bites annually. Of those, 368,000 are treated in hospital emergency                  Prosthetic valve or joint
departments and about a dozen die each year from dog bite injuries.                      Splenectomy
                                                                                         Systemic lupus erythematosus
Responsible dog ownership along with teaching children how to act around
dogs, are proven ways to prevent dog bites. Remember direct adult supervision
of children remains the hallmark of Injury Prevention.
                                                                                         Adapted with permission from Lewis KT, Stiles M. Management of cat and dog
                                                                                         bites. Am Fam Physician 1995;52:482.
Safety Tips for Adults and Children
                                                                                         Timely and copious irrigation with normal saline or Ringer's lactate solution may
          Never approach an unfamiliar dog.                                             reduce the rate of infection markedly. Injection of the tissue with irrigant
          Never run from or scream around a dog.                                        solution should be avoided, because this can spread the infection.5,7 Necrotic or
          If you believe a dog is about to attack you, try to place something           devitalized tissues should be removed, but care must be taken not to debride so
           between yourself and the dog, such as a backpack or a bicycle.                much tissue as to cause problems with wound closure and appearance.9
          If a dog knocks you over, roll into a ball, cover your face and stay still.   Baseline radiographs may be obtained, especially with puncture wounds near a
          Children should never play with dogs unless supervised by an adult.           joint or bone.5
          Children should tell an adult if they see a stray dog or a dog acting
           strangely.
                                                                                         The role of wound closure remains controversial. Puncture wounds, wounds that
          Don't look a dog directly in its eye.
                                                                                         appear clinically infected and wounds more than 24 hours old may have a better
          Don't disturb a dog that is sleeping, eating or caring for puppies.
                                                                                         outcome with delayed primary closure or healing by secondary intention.5,6
          Don't play with a dog without allowing him to see and sniff you first.
                                                                                         Some physicians close wounds that are less than eight hours old and wounds
           Children should never approach a dog unless supervised by an adult.
                                                                                         located on the face.5 The success of closing facial wounds can probably be
          Adults should never leave an infant or young child alone with any
                                                                                         attributed to the enhanced blood supply to the face and the lack of dependent
           dog, not even the family pet.
                                                                                         edema.5 Plastic surgery, general surgery or maxillofacial surgery may be
                                                                                         necessary for deep wounds or those requiring significant debridement and
                                                                                         closure. Cultures are usually not helpful unless the wound appears infected or is
If bitten by a dog:                                                                      unresponsive to appropriate antibiotic therapy. When a culture is necessary,
                                                                                         aerobic and anaerobic cultures should be obtained and observed for a minimum
                                                                                         of seven to 10 days to allow for slow-growing pathogens.7 Orthopedic
          Seek medical attention immediately.
                                                                                         consultation should be considered for wounds that directly involve joints or
          Control bleeding and wash the area of the bite with soap and water.
                                                                                         other bony structures.
          Report the bite to your local county health department, animal
           control agency or police.
          Provide authorities with an accurate description of the dog, the              ANTIBIOTIC TREATMENT
           circumstances surrounding the bite, and the dog owner's identity, if
           known.                                                                        Only 15 to 20 percent of dog bite wounds become infected. Crush injuries,
                                                                                         puncture wounds and hand wounds are more likely to become infected than
                                                                                         scratches or tears.9 Most infected dog bite wounds yield polymicrobial
                                                                                         organisms.8 Pasteurella multocida and Staphylococcus aureus are the most
                                                                                         common aerobic organisms, occurring in 20 to 30 percent of infected dog bite
                                                                                         wounds.4,5 Other possible aerobic pathogens include Streptococcus species,
                                                                                         Corynebacterium species, Eikenella corrodens and Capnocytophaga canimorsus
Management of Dog Bites                                                                  (formerly known as DF-2).5,7,8 Anaerobic organisms, including Bacteroides
                                                                                         fragilis, Fuso-bacterium species and Veillonella parvula, have also been
INITIAL WOUND MANAGEMENT                                                                 implicated in infected dog bites. One review article8 identified 28 species of
                                                                                         aerobic organisms and 12 species of anaerobic organisms isolated from dog bite
                                                                                         wounds.
After confirming that the victim is medically stable, physicians should begin a
primary assessment by taking a history. Several medical conditions place a
patient at high risk of wound and rabies virus infection from a dog bite (Table          Treatment with prophylactic antibiotics for three to seven days is appropriate
1).7 Information that can help determine the patient's risk of infection includes        for dog bite wounds, unless the risk of infection is low or the wound is
the time of the injury, whether the animal was provoked, and the general                 superficial.4,5,7 If frank cellulitis is evident, a 10- to 14-day course of treatment
health, immunization status and current location of the animal.7 In some                 is more appropriate.9 Amoxicillin-clavulanate potassium (Augmentin) is the
locations, notification of animal control or local law enforcement may be                antibiotic of choice for a dog bite. For patients who are allergic to penicillin,
necessary. Also, the patient's tetanus immunization status, current medications          doxycycline (Vibramycin) is an acceptable alternative, except for children
and allergies must be noted in the record.7 During the physical examination, the         younger than eight years and pregnant women. Erythromycin can also be used,
measurement and classification of the wound (laceration, puncture, crushing or           but the risk of treatment failure is greater because of antimicrobial
avulsion), and the range of motion of the affected and adjacent areas should be          resistance.7,10 Other acceptable combinations include clindamycin (Cleocin)
documented. Nerve, vascular and motor function, including pertinent negative             and a fluoroquinolone in adults or clindamycin and trimethoprim-
findings, should be recorded. Diagrams and photographs are useful, especially in         sulfamethoxazole (Bactrim, Septra) in children.11 When compliance is a
concern, daily intramuscular injections of ceftriaxone (Rocephin) are                From Diphtheria, tetanus, and pertussis: recommendations for vaccine use and
appropriate.7                                                                        other preventive measures. Recommendations of the Advisory Committee on
                                                                                     Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 1991;40:21.
Occasionally, outpatient treatment of infection fails and the patient needs to be
hospitalized and treated intravenously with antibiotics. Reasons for                 Rabies immunization should begin within 48 hours after the bite, but it can be
hospitalization include systemic signs of infection; fever or chills; severe or      subsequently discontinued if the animal is shown to be free of rabies virus.
rapidly spreading cellulitis or advancement of cellulitis past one joint; and        Rabies immunization consists of an active immune response with a vaccine and a
involvement of a bone, joint, tendon or nerve.5                                      passive immune response with rabies immune globulin (RIG). Guidelines for
                                                                                     rabies immunization are given in Table 3.14
Consultation with a maxillofacial or plastic surgeon may be required if the
patient has a facial or other highly visible wound. For patients hospitalized with   Three types of rabies vaccine are currently available in the United States: human
cellulitis or abscess formation in an extremity, surgical consultation should be     diploid cell vaccine (HDCV), rabies vaccine adsorbed (RVA) and purified chick
considered immediately because of the risk of worsening infection and tissue         embryo cell vaccine (PCEC). All are formulated for intramuscular use, but HDCV
damage. Depending on community practices and the location of the injury,             is also available for intradermal use.14 All forms seem to have equivalent safety
general orthopedic surgery, hand surgery or general surgery consultation may         and efficacy.14,15 Once the vaccine series has begun, it is usually completed
be appropriate. Tetanus immunization and tetanus immune globulin should be           with the same vaccine type. Vaccine is administered on days 0, 3, 7, 14 and 28.
administered, if appropriate. Recommendations for tetanus prophylaxis are
given in Table 2.12
                                                                                     RIG is administered once and provides rapid immunity with a half-life of 21
                                                                                     days.14 RIG is not administered to patients who have been previously
ASSESSING THE RISK OF RABIES                                                         vaccinated.14
The patient's risk of infection with rabies virus must be addressed immediately.     TABLE 3
Because of the serious risk to the public of a rabid animal on the loose, it is      Guidelines for Rabies Immunization
important to document the conditions surrounding the attack. As a result of
widespread vaccination of dogs against rabies in the United States, the most         Vaccination
common source of the rabies virus is now wild animals, specifically raccoons,        status      TreatmentRegimen*
skunks and bats.7 Nonetheless, there are still reported cases of rabies virus        Not         RIG      Administer 20 IU per kg body weight. If anatomically
associated with a dog bite.13 Patients with a bite from a nonprovoked dog            previously           feasible, the fulldose should be infiltrated around the
should be considered at higher risk for rabies infection than patients with a bite   vaccinated           wound(s) and any remaining volume should be
from a provoked dog. If the dog owner is reliable and can confirm that the                                administered IM at an anatomic site distant from
animal's vaccination against rabies virus is current, the dog may be observed at                          vaccine administration. Also, RIG should not be
the owner's home. Observation by a veterinarian is appropriate when the                                   administered in the same syringe as vaccine. Because
vaccination status of the animal is unknown. If the animal cannot be                                      RIG may partially suppress active production of
quarantined for 10 days, the dog bite victim should receive rabies immunization.                          antibody, no more than the recommended dose should
                                                                                                          be given.
TABLE 2                                                                                          Vaccine HDCV, RVA, or PCEC 1 mL, IM (deltoid area†), once daily
Summary of ACIP Recommendations for Tetanus Prophylaxis in Routine Wound                                  on days 0‡, 3, 7, 14 and 28
Management                                                                           Previously RIG       RIG should not be administered.
                                                                                     vaccinated§
                                                                                                 Vaccine HDCV, RVA, or PCEC 1.0 mL, IM (deltoid area†), once
                                           Clean, minor         All other
                                                                                                          daily on days 0‡ and 3
                                           wounds               wounds*
History of adsorbed tetanus toxoid
(doses)                                    Td†         TIG      Td†         TIG
Unknown or less than three                 Yes         No       Yes         Yes      RIG = rabies immune globulin; IU = immunizing unit; IM = intramuscularly; HDCV
Three or more‡                             No§         No       No∥         No       = human diploid cell vaccine; RVA = rabies vaccine adsorbed; PCEC = purified
                                                                                     chick embryo cell vaccine.
ACIP = Advisory Committee on Immunization Practices; DTP = diphtheria tetanus        *—These regimens apply to all age groups, including children.
and pertussis; Td = tetanus and diphtheria toxoids adsorbed (adult); TIG =
tetanus immune globulin (Hyper-Tet).
                                                                                     †—The deltoid area is the only acceptable site of vaccination for adults and
                                                                                     older children. For younger children, the outer aspect of the thigh may be used.
*—Including, but not limited to, wounds contaminated with dirt, feces, soil or       Vaccine should never be administered in the gluteal area.
saliva; puncture wounds; avulsions; and wounds resulting from missiles,
crushing, burns and frostbite.
                                                                                     ‡—Day 0 is the day the first dose of vaccine is administered.
†—For children younger than seven years, DTP (dT, if pertussis vaccine is
                                                                                     §—Any person with a history of preexposure vaccination with HDCV, RVA or
contraindicated) is preferred to tetanus toxoid alone. For persons seven years or
                                                                                     PCEC, prior postexposure prophylaxis with HDCV, RVA or PCEC, or previous
older, Td is preferred to tetanus toxoid alone. Diphtheria and tetanus toxoids
                                                                                     vaccination with any other type of rabies vaccine and a documented history of
and acellular pertussis vaccine (DTaP) may be used instead of DTP for the fourth
                                                                                     antibody response to the prior vaccination.
and fifth doses.
                                                                                     Reprinted from Human rabies prevention—United States, 1999.
‡—If only three doses of fluid toxoid have been received, then a fourth dose of
                                                                                     Recommendations of the Advisory Committee on Immunization Practices (ACIP).
toxoid, preferably an adsorbed toxoid, should be given to complete the series.
                                                                                     MMWR Morb Mortal Wkly Rep 1999;48(RR-1):1–21 [Published erratum appears
                                                                                     in MMWR Morb Mortal Wkly Rep 1999;48:16].
§—Yes, if it has been more than 10 years since the last dose.
                                                                                     FOLLOW-UP
∥—Yes, if it has been more than five years since the last dose. (More frequent
boosters are not needed and can accentuate side effects.)
Patients who have been bitten by a dog should be instructed to elevate and           Immediately report stray dogs or dogs with unusual behavior.
immobilize the involved area. Most bite wounds should be reexamined in 24 to         Avoid direct eye contact with a dog.
48 hours, especially bites to the hands.9                                            Do not disturb a dog that is eating, sleeping or caring for puppies.
                                                                                     Do not pet a dog without letting it first sniff you.
                                                                                     Tell children to report a dog bite to an adult immediately.
TABLE 4
Breed-Specific Information About Aggressiveness*
Aggressive dogs (higher attack rate)                                                 Information from Sacks JJ, Lockwood R, Hornreich J, Sattin RW. Fatal dog attacks,
Bull Terrier        German Shepherd dog                                              1989–1994. Pediatrics 1996;97:891–5.
Cocker Spaniel      Great Dane
Chow Chow           Pit bull
                                                                                     Educate children and adults to remain calm when threatened by a dog. Direct
Collie              Rottweiler
                                                                                     eye contact should be avoided because the dog may interpret that as
Doberman PinscherSiberian Husky
                                                                                     aggression. Standing still (“like a tree”) with feet together, fists folded under the
Less aggressive dogs (“family dogs”)
                                                                                     neck, and arms placed against the chest is recommended. If knocked to the
Boxer               Golden Retriever
                                                                                     ground by a dog, recommendations include lying face down and becoming still
Dalmatian           Irish Setter
                                                                                     “like a log,” with legs together and fists behind the neck with forearms covering
English Setter      Labrador Retriever
                                                                                     the ears. If a dog perceives no movement, it will lose interest and go away.
English Springer    Spaniel
*—In alphabetical order.
                                                                                     Bee Sting Treatment
Information from Iazzetti L. Anticipatory guidance: having a dog in the family. J
Pediatr Health Care 1998;12:73–9, and Bradshaw JW, Goodwin D, Lea AM,
Whitehead SL. A survey of the behavioural characteristics of pure-bred dogs in       Medical Author: Melissa Conrad Stoppler, MD
the United Kingdom. Vet Rec 1996;138:465–8.                                          Medical Editor: William C. Shiel, Jr, MD, FACP, FACR
Prevention of Dog Bites                                                              When bees or wasps sting a person, they inject venom through their stinger into
                                                                                     the skin of the victim. Wasps, yellow jackets, and hornets have stingers without
                                                                                     barbs that are usually retracted upon stinging, and these insects can sting
WHEN FAMILIES ARE CONSIDERING GETTING A DOG
                                                                                     people multiple times. The honey bee has a barbed stinger that remains in the
                                                                                     victim's skin with its venom sack attached. About 3% of people stung by bees
Dogs can play an important role in family life. As the canine population grows, so   and wasps have an allergic reaction to the sting, and up to 0.8% of bee sting
does the need for guidance to prevent dog bites. Prevention can begin with           victims experience the severe and life-threatening allergic reaction known as
information from primary care professionals and veterinarians. Because a large       anaphylaxis.
percentage of dog bite victims are younger than 14 years, it is appropriate to
begin prevention education with children and parents. Families acquiring a pet
                                                                                     Most people will have only a localized reaction to a bee sting. In the normal
should consider their home environment and be told that a dog younger than
                                                                                     reaction to a bee sting, the skin is reddened and painful. Swelling and/or itching
four months is preferred. An older dog should not be introduced into a
                                                                                     may also occur, but the pain usually disappears over a few hours. In the so-
household with children because the dog's behavior cannot be predicted.
                                                                                     called large local reaction to an insect sting, the swelling, redness, and pain may
Prospective dog owners should obtain breed-specific information before getting
                                                                                     persist for up to a week. Areas adjacent to the site of the skin may also be
a new dog.
                                                                                     involved in the large local reaction.
Some breeds of dogs are more likely to attack despite training. Other breeds
                                                                                     In a systemic allergic reaction, the entire body is affected. The victim may
seem to be accepted more as “family dogs” (Table 4).4,16 Families should be
                                                                                     develop hives, redness, or swelling at sites on the body distant from the site of
educated to avoid “humanizing” their dog (e.g., allowing it to sleep on the
                                                                                     the sting. Symptoms can also include:
furniture and to beg for food at the dinner table) and treating the dog as a child
or a substitute for a mate.4 This type of behavior makes it more difficult for the
animal to distinguish between animal and master and may increase the risk of                   vomiting,
the dog biting.                                                                                nausea ,
                                                                                               diarrhea, and
BEHAVIOR TO PREVENT A BITE                                                                     dizziness.
Measures for preventing dog bites are given in Table 5.2 Dogs have a tendency        In anaphylactic reactions, victims experience wheezing, difficulty breathing, and
to chase a moving object. Therefore, children need to learn to avoid running and     a drop in blood pressure that leads to shock if not treated promptly. Around 50
screaming in the presence of a dog. Dogs should not be greeted by presenting         people are killed each year in the U.S. due to severe anaphylactic reactions to
an outstretched hand. Do not pet a dog without letting it sniff you first. Hugging   bee stings. These type of reactions usually occur within minutes of the bee sting.
and “kissing” a dog express a sense of submission to the animal, which is            Since most people who have allergies to bee stings will have a worsened
confusing because the animal is used to viewing humans as being in charge.4          reaction to every subsequent sting, those individuals with bee sting allergies
This confusion may lead to more aggressive behavior by the animal.                   should talk to their doctor about taking special precautions, including carrying
                                                                                     an injectable form of the drug epinephrine (used to treat anaphylactic reactions)
                                                                                     at all times.
TABLE 5
Measures for Preventing Dog Bites
                                                                                     If you are stung by a bee:
Never approach an unfamiliar dog.
Never run from a dog or scream in the presence of a dog.                                  1.    Call emergency medical services if you have a history of severe
Be still, “like a tree,” when approached by a dog.                                              reactions to insect stings or if you experience any severe symptoms
If knocked down, become “like a log.”                                                           as described above.
Children should never play with a dog without an adult present.
     2.    Determine if the stinger is still present (look for a small black dot at
           the sting site) and remove it immediately if is visible in the wound.
           Many doctors recommend using a hard object like a credit card or
           blunt knife to swipe over the area and remove the stinger. The honey
           bee venom sack, which remains in the skin of the victim, can take 2-3
           minutes to release all of its venom, so prompt removal of the stinger
           can reduce the severity of the sting.
     3.    Apply ice or cold packs to the area to reduce the body's
           inflammatory response.
     4.    Clean the area with soap and water, then apply hydrocortisone
           cream to the site to decrease the severity of the reaction. Alternative
           treatments include a paste made of unseasoned meat tenderizer and
           water (the enzyme in meat tenderizer can break down bee venom) or
           a paste of baking soda and water.
     5.    Taking an antihistamine such as Benadryl (diphenhydramine) in
           tablet form and/or nonprescription pain relievers such as ibuprofen
           or acetaminophen can also provide relief of symptoms.
Stings in the mouth or nose, even in persons not known to be allergic to bee
stings, also require emergency medical attention, since they can lead to swelling
that can interfere with breathing