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Anaphylaxis - Different Causes: Ige-Independent Idiopathic

This document summarizes different causes of anaphylaxis, which can be IgE-dependent or nonimmunologic. IgE-dependent causes include food allergies, insect stings and bites, medications, biologic materials, natural rubber latex, food additives, inhalants, and occupational allergens. Nonimmunologic triggers include physical factors, medications like opioids and NSAIDs, and radiocontrast agents. Some causes of anaphylaxis are idiopathic or IgG-dependent.

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26 views1 page

Anaphylaxis - Different Causes: Ige-Independent Idiopathic

This document summarizes different causes of anaphylaxis, which can be IgE-dependent or nonimmunologic. IgE-dependent causes include food allergies, insect stings and bites, medications, biologic materials, natural rubber latex, food additives, inhalants, and occupational allergens. Nonimmunologic triggers include physical factors, medications like opioids and NSAIDs, and radiocontrast agents. Some causes of anaphylaxis are idiopathic or IgG-dependent.

Uploaded by

dregleav
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Anaphylaxis - Different Causes

IgE-dependent
Nonimmunologic triggers → direct
activation of mast cells and basophils
1. Food allergy. Rare: storage
mite-contaminated flour. Meat: alpha-gal
1. Physical factors → exercise, cold, heat
sIgE, WDEIA - omega-5 gliadin sIgE
2. Medications - opioids, NSAIDs
2. Insect stings/bites - kissing bugs,
3. Radiocontrast agents
mosquitoes, pigeon ticks, green ants,
4. Alcohol (ethanol), may augment, rarely
pharaoh ants, venoms from jellyfish,
induces
scorpions, snakes
3. Medications - antibiotics, NSAIDs
4. Biologic materials - allergen
immunotherapy, monoclonal antibodies,
chemotherapy, vaccines (gelatin)
5. Natural rubber latex
6. Food additives - spices, insect-derived IgE-independent
Idiopathic
colorants (carmine), vegetable gums
- IgG-dependent (rare) -
7. Inhalants (rare) - horse dander, cat - hidden or previously high-molecular weight
dander, grass pollen unrecognized trigger? dextran, infliximab
8. Human seminal fluid (rare trigger of
anaphylaxis in women) - systemic mastocytosis - Coagulation system
9. Occupational allergens - stinging insects, vs. mast cell activation activation - heparin
natural rubber latex syndrome contaminated with
oversulfated chondroitin
sulfate)

AllergyGoAway.com, updated: 2019

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