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Amino Acid Metabolism Overview

The document discusses several key metabolic pathways involved in amino acid metabolism. It outlines the gamma-glutamyl cycle, the central role of the liver, and pathways such as the urea cycle, phenylalanine/tyrosine metabolism, and the catabolic fates of amino acid carbon chains. Specific enzymes are highlighted for each pathway. The document also briefly discusses the glucose-alanine cycle and synthesis of non-essential amino acids.

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Ravi Singh Rathore
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123 views6 pages

Amino Acid Metabolism Overview

The document discusses several key metabolic pathways involved in amino acid metabolism. It outlines the gamma-glutamyl cycle, the central role of the liver, and pathways such as the urea cycle, phenylalanine/tyrosine metabolism, and the catabolic fates of amino acid carbon chains. Specific enzymes are highlighted for each pathway. The document also briefly discusses the glucose-alanine cycle and synthesis of non-essential amino acids.

Uploaded by

Ravi Singh Rathore
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Overall Sources & Utilization of Amino Acids

Gamma-glutamyl Cyacle – Meister’s Cycle

 3 Requirements:
1) membrane-bound enzyme
(Gamma glutamyl transpeptidase)
2) a mol of GSH
3) 3 moles of ATP
Central Role of the Liver in Amino Acid Metabolism

Urea Cycle

Enzymes:
1. Carbamoyl PO4 synthetase
2. Ornithine transcarbamoylase
3. Argininosuccinate synthetase
4. Argininosuccinase
5. Arginase
Metabolic Pathway of Phe/Tyr

 Enzymes:
1. Phenylalanine
monooxygenase or
phenylalanine oxidase
or phenylalanine
hydroxylase
2. Homogentisate 1,2- dioxygenase
3. Tyrosinase

Catabolic Disposition (Fates) of Carbon Chains of Amino Acids


Methionine

Inborn Errors
1. Homocystinuria
- Deficiency of cystathionine
synthetase
2 Cystathioninuria
- Deficiency of cystathionase
Glucose – Alanine Cycle

Synthesis of Non-essential amino acids


1. Glycine Serine
2. Proline Glutamic acid
3. Arginine Glutamic acid
4. Histidine Glutamic acid
5. Tryptophan Alanine
6. Phenylalanine Tyrosine
7. Threonine Glycine
8. Methionine Cysteine
9. Aspartic acid Asparagine
10. Glutamic acid Glutamine
11. Pyruvate Alanine
12. Oxaloacetate Aspartic acid
13. -ketoglutarate Glutamic acid
14. 3-phosphoglycerate Serine

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