Alex Balder – Another DEA agent and Max's best friend.
He grew up with Max, and while
    Max joined the NYPD, Alex joined the DEA and became one of their top agents. He was
    betrayed and killed by B.B Hensley himself.
        Candy Dawn – A prostitute who works for the Punchinello family by obtaining blackmail
    evidence against her wealthy clients. Payne comes across her with Rico Muerte and both are
    killed by him in the subsequent gunfight. She was revealed that she was employed by Horne to
    blackmail Woden into silence since she was videotaping her and Woden in the act.
        Boris Dime – A former member of Lem's mob who defected to the Punchinello family. He is
    killed by Payne on the ship.
        Joey Finito – One of the Finito brothers who is a subordinate of Gognitti within the
    Punchinello mob. He is killed, along with his brother, during a confrontation with Payne.
        Virgilio Finito – One of the Finito brothers who is a subordinate of Gognitti within the
    Punchinello mob. He is killed, along with his brother, during a confrontation with Payne.
        B.B. Hensley – A corrupt DEA agent and a former friend of Max and Alex. Receiving
    payouts from Horne, he sends Max to meet agent Alex Balder at the train station and then
    shoots Balder dead, framing Max for his murder. He eventually meets Max, who has determined
    his treachery, and is killed in the subsequent confrontation.
        Nicole Horne – A business tycoon and the key figure behind Project Valhala, initiated
    around the time of Operation Desert Storm to develop drugs to enhance morale and stamina,
    when the project failed to yield the desired results, she refused to shut it down, and years later
    began distributing it as a designer drug named Valkyr. She is killed by Payne when he knocks
    her building's satellite tower onto her helicopter.
        Jack Lupino – Punchinello's underboss, and the target of an extensive investigation by the
    NYPD and the DEA in the first game, believed to be a source of Valkyr. However, he is just a
    minor player, and only resells the drug. He is also a constant user of the drug, which has driven
    him insane, and a cult leader, signing a deal with the Devil. He operates from his shady
    nightclub, the Ragna Rok, which is bought by Vladimir Lem soon after. He is killed by Payne in
    the club's inner sanctum.
        Rico Muerte – A hitman in the Punchinello mob and a former Chicago assassin. He was
    hired by Horne to assassinate the mayor, using a sniper rifle from a storage container from Boris
    the Dime, who defected from Lem, but he was killed by Payne in his club.
        Vince Mugnaio – The leading member of "The Trio", a sadistic enforcement team who serve
    as hitmen for the Punchinello family. He is killed along with the rest of The Trio by Payne in
    Punchinello's mansion; he is the last member of The Trio to die.
        Pilate Providence (a.k.a. Big Brother) – A member of "The Trio", he is killed along with the
    rest of The Trio by Payne in Punchinello's mansion; he is the first member of The Trio to die.
        Joe "Deadpan" Salem – A member of "The Trio", he is killed along with the rest of The Trio
    by Payne in Punchinello's mansion; he is the second member of The Trio to die.
        Frankie "The Bat" Niagara – A hitman in the Punchinello mob, who is tasked with disposing
    of Payne after Payne was found drugged not far from where he killed Jack Lupino. He leaves
    Payne to get a drink from the bar (where Candy Dawn and Rico Muerte were previously killed by
    Payne), leaving Payne to escape, follow him, and confront him; ultimately killing him. He got his
    nickname because he likes to beat up his victims with a bat.
        Angelo Punchinello – The godfather of the Punchinello crime family. A sadistic wife-beater,
    it is discovered that he is actually a pawn for Nicole Horne, and she was blackmailing him. He is
    killed by Horne's forces in his mansion.
        Lisa Punchinello – Angelo Punchinello's wife and Mona Sax's sister, she is found dead by
    Payne in Punchinello's mansion after presumably being beaten to death by her husband.