Scribd
Upload
897 views2 pages

Parecoxib

Parecoxib is a prodrug of valdecoxib that is a selective COX-2 inhibitor used for short-term treatment of postoperative pain in adults. It works by inhibiting prostaglandin synthesis via COX-2 inhibition. The recommended dosage for postoperative pain in adults is 40 mg via IV/IM injection initially, followed by 20-40 mg injections every 6-12 hours as needed, with a maximum daily dose of 80 mg. Common side effects include changes in blood pressure, dizziness, back pain, stomach upset, and constipation. Serious adverse effects include nausea, hypotension, and an increased risk of heart attack or stroke.

Uploaded by

Peetah Pan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
897 views2 pages

Parecoxib

Parecoxib is a prodrug of valdecoxib that is a selective COX-2 inhibitor used for short-term treatment of postoperative pain in adults. It works by inhibiting prostaglandin synthesis via COX-2 inhibition. The recommended dosage for postoperative pain in adults is 40 mg via IV/IM injection initially, followed by 20-40 mg injections every 6-12 hours as needed, with a maximum daily dose of 80 mg. Common side effects include changes in blood pressure, dizziness, back pain, stomach upset, and constipation. Serious adverse effects include nausea, hypotension, and an increased risk of heart attack or stroke.

Uploaded by

Peetah Pan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 2

Generic Name: Parecoxib

Brand Name: Dynastat

Drug Class: Analgesic, antipyretic and anti-inflammatory agent

Pregnancy Category: C

Mechanism of Action: Parecoxib is the prodrug of valdecoxib. It is a selective cyclo-oxygenase-2 (COX-2)


inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to
inhibition of prostaglandin synthesis via inhibition of COX-2.

Dosage:

Adult: IV/IM 40 mg, then 20 or 40 mg 6-12 hrly. Max: 80 mg/day.

Postoperative pain

Adult: 40 mg via slow IM or IV inj, then 20 or 40 mg 6-12 hrly as required. Max dose: 80 mg/day.

Elderly: <50 kg: Half the usual dose. Max: 40 mg/day.

Indications: For the short-term treatment of postoperative pain in adults.

Contraindications: Hypersensitivity; history of allergy to sulfonamides; history bronchospasm, acute


rhinitis, nasal polyps, angioneurotic oedema, urticaria or allergic-type reactions after taking aspirin,
NSAIDs including COX-2 inhibitors. Patient w/ inflammatory bowel disease, CHF (NYHA class II-IV),
ischaemic heart disease, peripheral arterial disease, or cerebrovascular disease; treatment of post-op
pain following CABG; active peptic ulceration or GI bleeding. Severe hepatic impairment (Child-Pugh
score ≥10). Pregnancy (3rd trimester) and lactation.

Common Side Effects: Changes in blood pressure;

Dizziness or light-headedness due to low blood pressure;

Back pain;

Earache;

Feeling numb (your skin may lose sensitivity to pain and touch);

Stomach upset including nausea (feeling sick), vomiting, heartburn, indigestion, cramps;

Constipation, diarrhoea, pain in the stomach, wind, bloating;

Dizziness;

Sore throat;

Swollen and sore gums;

Increased sweating;

Passing less urine than normal;


Inflammation and pain after a tooth extraction.

Adverse Effects: Nausea, pharyngitis, alveolar osteitis (dry socket), anaemia post-op, hypokalaemia,
agitation, insomnia, hypoaesthesia, dizziness, HTN, hypotension, resp insufficiency, abdominal pain,
vomiting, constipation, dyspepsia, flatulence, pruritus, hyperhidrosis, back pain, oliguria, peripheral
oedema, MI, deep-vein thrombosis, pulmonary embolism, stroke, deep surgical infections, sternal
wound complications, renal impairment, increased blood creatinine.

Potentially Fatal: Anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Drug Interactions: May reduce the effect of diuretics and antihypertensives. May increase the
nephrotoxic effect of tacrolimus and ciclosporin. May increase risk of bleeding complications w/
warfarin or other anticoagulants. May increase lithium level leading to toxicity.

Nursing Responsibilities:

1. Tell your doctor if you have any allergies like medication, foods, preservatives or dyes.

2. Monitor Vital Signs

3. Tell patient that dizziness or light headedness is the most common side effect.

4. Instruct the patient to report if she notice any of the following *skin rash, including hives, raised red,
and itchy spots.

5. Raise side rails

You might also like