Think Coag

Think Tcoag

Catalogue
Your Coagulation Company
 CONTENTS

Reagents

TriniCLOTTM Routine Reagents Tcoag Control offering 13

PT 4
aPTT 5 TriniLIZETM ELISA based Assays
Fibrinogen 6
TriniLIZETM tPA Activity 14
Thrombin Time 6
TriniLIZETM PAI-1 Antigen 14
Factor Deficient Plasmas 7
TriniLIZETM PAI-1 Activity 14
Solutions 7
TriniLIZETM Stabilyte tubes 15
TriniLIZETM tPA/PAI Depleted Plasma RUO 15
TriniLIATM D-Dimer
TriniLIZETM PAI Activity Control RUO 15
TriniLIATM D-Dimer 8 Fibrinolysis Reference Plasma RUO 15
NEW TriniLIATM D-Dimer II 8
Platelet Aggregation Reagents
TriniCLOTTM Speciality Reagents
Ristocetin Cofactor Assay 16
NEW TriniCLOTTM PC II 9 Platelet Agonists 16
NEW TriniCLOTTM PS II 9
TriniCLOTTM Lupus Screen and Confirm 9

TriniCHROMTM Speciality Reagents

Instruments and Consumables
TriniCHROMTM Antithrombin IIa 10
TriniCHROMTM Antithrombin Xa 10
NEW DT 100 by TcoagTM 20
TM
Destiny MaxTM 22
TriniCAL Reference Plasmas Destiny PlusTM 24
TriniCALTM INR & Quick 11 KC4 DeltaTM and KC1 DeltaTM 26
TriniCALTM Reference Plasma 11
TriniCALTM Fibrinogen 11
TriniCALTM PC/PS 11

TriniCHECKTM Controls
NEW TriniCHECKTM Controls 12

1
2
Reagents

TriniCLOTTM Routine Reagents

TriniLIATM D-Dimer

TriniCLOTTM Speciality Reagents

TriniCHROMTM Speciality Reagents

TriniCHECKTM Controls

TriniCALTM Reference Plasmas

TriniLIZETM ELISA based Assays

Platelet Agregation Reagents

3
 TriniCLOTTM Routine Reagents
PT
The PT test is commonly used to monitor oral anticoagulants, factor deficiencies TriniCLOTTM PT HTF (HTF = Human Tissue Factor) TriniCLOTTM PT Excel S and TriniCLOTTM PT Excel
and for general preoperative screening. An abnormal or extended PT test usually • Human thromboplastin origin: “mimics” a true in vivo response. • Secure: all ISIs are assigned against the appropriate International Reference
indicates a deficiency in one or more of the factors in the extrinsic or common • Secure: all ISIs* are assigned against the appropriate International Reference Preparation (IRP) in accordance with WHO guidelines(1).
pathway of blood coagulation. Preparation (IRP) in accordance with WHO guidelines(1). • Accommodates local practices: low ISI (TriniCLOTTM PT Excel S: ISI 1.0-1.3)
TriniCLOTTM PT Reagents are lyophilised thromboplastins from either rabbit • Addresses the latest guidelines: low ISI (1.0-1.3)(2). and higher ISI (TriniCLOTTM PT Excel: ISI 1.8-2.0).
or human sources which guarantee consistently accurate results. Convenient • Flexible packaging sizes: 6 mL and 20 mL to suit all types of throughput. • Flexible packaging sizes: 6 mL and 20 mL.
and reliable, TriniCLOTTM PT Reagents are the quality PT reagents of choice for • Used with TriniCHECKTM plasmas. • Ease of use and security: buffer for reconstitution included in each package.
your haemostasis laboratory. • Used with TriniCHECKTM plasmas.

PART NUMBER PRODUCT NAME PACKAGING ISI SOURCE STABILITY

T1101 TriniCLOTTM PT HTF 20 mL 10 x 20 mL 1.0-1.3 Human 10 days at 2-8°C
T1102 TriniCLOTTM PT HTF 6 mL 10 x 6 mL 1.0-1.3 Human 10 days at 2-8°C
T1103 TriniCLOTTM PT Excel S 20 mL 5 x 20 mL 1.0-1.2 Rabbit 4 days at 2-8°C
T1104 TriniCLOTTM PT Excel S 6 mL 10 x 6 mL 1.0-1.2 Rabbit 4 days at 2-8°C
T1106 TriniCLOTTM PT Excel 6 mL 10 x 6 mL 1.8-2.0 Rabbit 4 days at 2-8°C
* International Sensitivity Index.
(1) WHO Technical Report Series No.889, 1999, Annex 3, Guidelines for thromboplastins and plasma used to control oral anticoagulant therapy
(2) Clinical and Laboratory Standards Institute document (CLSI), One-Stage Prothrombin Time (PT) Test and Activated Partial Thromboplastin Time (APTT) Test; Approved Guideline - Second
Edition. CLSI document H47-A2. Vol. 28 No. 20, 200.

4
 aPTT
The Activated Partial Thromboplastin Time (APTT) assay is a universally accepted TriniCLOTTM Automated aPTT is a lyophilised aPTT reagent and is considered to • Flexible packaging sizes: suitable for all throughput environments
screening procedure used to detect abnormalities in the intrinsic coagulation be the reagent of choice in the market due to its moderate factor and heparin (3 mL, 6 mL and 10 mL).
system. sensitivity. • Extended shelf lives (24-30 months) to minimize lot change frequency.
In addition, it can be used to detect lupus anticoagulants and when monitoring It contains a Platelet Factor 3 reagent (rabbit brain phospholipids) plus a • Used with TriniCHECKTM plasmas.
heparin therapy. particulate activator (micronized silica) in a suitable buffer.  Universal reagent: TriniCLOTTM aPTT S and TriniCLOTTM Automated
APTT are appropriately sensitive to deficiencies of all intrinsic factors
• Ease of use and security: TriniCLOTTM aPTT S and TriniCLOTTM aPTT HS
TriniCLOTTM aPTT S and TriniCLOTTM aPTT HS are liquid, ready to use, aPTT including Fletcher factor (prekallikrein) and moderately sensitive to
comes in an easy to use, liquid format. For TriniCLOTTM aPTT S the calcium
reagents intended for screening for deficiencies of the intrinsic coagulation lupus anticoagulant. The sensitivity of these reagents also allows for the
chloride solution is provided in the kit for your convenience and added
pathway. These reagents contain purified phospholipids and a particulate monitoring of unfractionated Heparin.
security.
activator (micronized silica), which are stabilized in an appropriate buffer.  Second line reagent: TriniCLOTTM aPTT HS has a higher sensitivity to
lupus and is therefore adapted for use as a second line reagent. It is also
PART NUMBER PRODUCT NAME PACKAGING FORMAT ACTIVATOR STABILITY appropriately sensitive to deficiencies of all intrinsic factors and can be used
T1201 TriniCLOTTM aPTT S 10 mL 5 x 10 mL Liquid Silica 30 days at 2-8°C for the monitoring of unfractionated Heparin.
TM
T1202 TriniCLOT aPTT S 3 mL 5 x 3 mL Liquid Silica 30 days at 2-8°C
T1203 TriniCLOTTM aPTT HS 10 mL 10 x 10 mL Liquid Silica 30 days at 2-8°C
T1204 TriniCLOTTM aPTT HS 3 mL 10 x 3 mL Liquid Silica 30 days at 2-8°C
T1205 TriniCLOTTM Automated aPTT 6 mL 10 x 6 mL Lyophilised Silica 7 days at 2-8°C
T1206 TriniCLOTTM Automated aPTT 3 mL 10 x 3 mL Lyophilised Silica 7 days at 2-8°C
TM
T1902 TriniCLOT Calcium Chloride 0.025 M 10 x 10 mL Liquid Until expiry date

5
 TriniCLOTTM Routine Reagents
Fibrinogen
TriniCLOTTM Fibrinogen is intended for quantitative determination of fibrinogen PART NUMBER PRODUCT NAME PACKAGING
in plasma. TriniCLOTTM Fibrinogen utilizes the Clauss method for fibrinogen
TriniCALTM Fibrinogen: 2 x 1 mL
determination. An excess of thrombin is used to convert fibrinogen to fibrin in
T1301 TriniCLOTTM Fibrinogen Kit TriniCLOTTM Fibrinogen reagent (75NIH): 3 x 6 mL
diluted plasma such that the rate of reaction is a function of fibrinogen concentration.
TriniCLOTTM Imidazole Buffer: 2 x 20 mL
• Convenient format: TriniCLOTTM Fibrinogen is provided in a kit format and
as individual components.
• Wide working range to address different clinical contexts PART NUMBER PRODUCT NAME PACKAGING STABILITY
(e.g. 0.45g/L – 14 g/L in Optical mode using re-dilution) T1302 TriniCLOTTM Fibrinogen 6 mL (75NIH) 10 x 6 mL 12 days at 2-8°C
• Extended on board and 2-8°C stability to suit all types of activities.
T1901 TriniCLOTTM Imidazole Buffer 6 x 20 mL 7 days
T5104 TriniCALTM Fibrinogen 10 x 1 mL 8 hours

Thrombin Time PART NUMBER PRODUCT NAME PACKAGING STABILITY

T1411 TriniCLOTTM Thrombin Time 1 mL (10NIH) 10 x 1 mL 30 days at -20°C
TriniCLOTTM Thrombin Time is intended for the determination of functional
fibrinogen in human plasma. The enzyme, thrombin, is the penultimate protein T1414 TriniCLOTTM Thrombin Time 4 mL (10NIH) 10 x 4 mL 30 days at -20°C

in the clotting sequence, acting upon soluble fibrinogen and converting it to

insoluble fibrin. A prolonged thrombin clotting time will result at fibrinogen
levels of approximately 200 mg/dL and below. Nonfunctional fibrinogen
molecules will also result in a prolonged thrombin time. TriniCLOTTM Thrombin
Time is sensitive to the presence of heparin.

• Used with TriniCHECKTM Control 1 (T4101) and TriniCHECKTM Abnormal

Control (T4104).

6
Factor Deficient plasmas
A full suite of immuno-depleted TriniCLOTTM Factor Deficient Plasmas for all PART NUMBER PRODUCT NAME PACKAGING STABILITY
the extrinsic and intrinsic factors is provided.
T1502 TriniCLOTTM Factor II 10 x 1 mL 8 hours at 2-8°C
TriniCLOTTM Factor II, V, VII or X Deficient Human Plasma are intended for the T1505 TriniCLOTTM Factor V 10 x 1 mL 8 hours at 2-8°C
quantitative determination of extrinsic factors in human plasma by clotting assay.
T1507 TriniCLOTTM Factor VII 10 x 1 mL 8 hours at 2-8°C
TriniCLOTTM Factor VIII, IX, XI or XII Deficient Human Plasma are intended for the
TM
T1508 TriniCLOT Factor VIII 10 x 1 mL 8 hours at 2-8°C
quantitative determination of intrinsic factors in human plasma by clotting assay.
T1509 TriniCLOTTM Factor IX 10 x 1 mL 8 hours at 2-8°C
• TriniCLOTTM Factor VIII may also be used as a negative control in Von
T1510 TriniCLOTTM Factor X 10 x 1 mL 8 hours at 2-8°C
Willebrand Factor assays.
T1511 TriniCLOTTM Factor XI 10 x 1 mL 8 hours at 2-8°C
• Used with TriniCHECKTM Control 1 (T4101), TriniCHECKTM Abnormal Control
(T4104) and TriniCALTM Reference Plasma (T5102). T1512 TriniCLOTTM Factor XII 10 x 1 mL 8 hours at 2-8°C
Factor IXa Reagent: 3 x 1 mL 8 hours at 2-8°C
T2608 TriniCHROMTM Factor VIII:C Factor X Reagent: 3 x 2 mL 7 days at 2-8°C
TriniCHROM FVIII:C Factor Xa Substrate: 3 x 2 mL 60 days at 2-8°C

TriniCHROM FVIII:C* is designed for the quantitative determination of Factor Dilution Buffer (10X): 3 x 5 mL 30 days at 2-8°C
VIII:C in human plasma and Factor VIII concentrate by chromogenic assay.

Haemophilia A is a bleeding disorder caused by the deficiency of Factor VIII Solutions

procoagulant activity (VIII:C). The quantitative determination of Factor VIII:C is
PART NUMBER PRODUCT NAME PACKAGING STABILITY
useful in the diagnosis of Haemophilia A and in the determination of the severity
of the disorder. T1901 TriniCLOTTM Imidazole Buffer 6 x 20 mL Until expiration date

Factor VIII:C is a blood plasma protein which exists as a complex with Von T1902 TriniCLOTTM Calcium Chloride 0.025 M 10 x 10 mL Until expiration date
Willebrand factor. After activation by thrombin, Factor VIII:C acts as a cofactor in T1903 TriniCLOTTM Owren’s Buffer 24 x 15 mL Until expiry date
the conversion of Factor X to Factor Xa when calcium and phospholipid are present.
The quantity of Factor Xa generated is determined using a specific chromogenic
substrate and is directly proportional to the amount of Factor VIII:C in the sample.

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*Coming soon
 D-Dimer
Elevated levels of D-Dimer are associated with thrombotic disorders, such as PART NUMBER PRODUCT NAMEE MODE PACKAGING
PACKAGIN STABILITY
Deep Venous Thrombosis (DVT), Pulmonary Embolism (PE) and Disseminated
D-Dimer Reagent: 4 x 2 mL Reagent: 14 days at 2-8°C
Intravascular Coagulation (DIC) as well as other conditions, such as cancer.
D-Dimer Reaction Buffer: 4 x 4 mL Reaction Buffer: 14 days at 2-8°C
The presence of elevated D-Dimer levels is not sufficient for the diagnosis of a T3101 ATM D-Dimer
TriniLIA Automated
D-Dimer Diluent: 1 x 4 mL Diluent: 14 days at 2-8°C
thrombotic disorder, but the absence of elevated D-Dimer levels when used with TriniCAL D-Dimer: 1 x 1 mL TriniCAL D-Dimer: 3 days at 2-8°C
the appropriate algorithm may be used to rule out the presence of DVT and PE.
T4303
3 KTM D-Dimer 1
TriniCHECK Control plasma 4 x 1 mL 2 days at 2-8°C

TriniLIATM D-Dimer T4304 KTM D-Dimer 2

TriniCHECK Control plasma 4 x 1 mL 3 days at 2-8°C
TM
TriniLIA D-Dimer is a polystyrene micro-particle agglutination assay for the T4305 KTM D-Dimer 3
TriniCHECK Control plasma 4 x 1 mL 3 days
day at 2-8°C
quantitative determination of fibrin degradation products containing D-Dimer in
m.
citrated human plasma on the Destiny Max and Destiny Plus analysers at 405 nm.

• Controls sold separately.

NEW TriniLIATM D-Dimer II PART NUMBER PRODUCT NAME MODE PACKAGING STABILITY
TM
TriniLIA D-Dimer II kit is intended for the quantitative determination
ination of
Automated,
sed to aid
D-Dimer in plasma by the immuno-turbidimetric method. It can be used T3104 ATM D-Dimer II
TriniLIA Latex: 6 x 6ml, Buffer: 6 x 5ml 15 days on board stability
pre-calibrated
in the diagnosis of deep venous thrombosis and pulmonary embolism disease.

utination
In this assay, an antigen-antibody reaction takes place, leading to an agglutination
of the latex microparticles which induces an increase in turbidity of the reaction TriniCHECKTM LIA Control N, 12 x 1 ml
T4306 KTM LIA Control Set
TriniCHECK Control plasma 8 hours on board
boa stability
TriniCHECKTM LIA Control ABN, 12 x 1 ml
medium. This increase in turbidity is reflected by an increase in absorbance, ce, the
ncctio
latter being measured photometrically. The increase in absorbance is a function tion
n
of the D-Dimer level present in the test sample.

• Used with TriniCHECKTM LIA Control Set (T4306)

• To be used on DT 100TM and Destiny MaxTM

• Precalibrated

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 TriniCLOTTM Speciality Reagents
NEW TriniCLOTTM PC II PART NUMBER PRODUCT NAME STABILITY

TM
The TriniCLOT PC II kit is intended for the quantitative measurement of the TriniCLOTTM PC II

functional protein C level based on the prolongation of the activated partial T1607 Reagent 1 (TriniCLOTTM PC Def Plasma): 3 x 1mL 8 hours on board stability
thromboplastin time (APTT). Reagent 2 (TriniCLOTTM PC Activator): 3 x 1mL 8 hours on board stability

In this assay, Protein C is activated in the presence of the specific activator

extracted from Agkistrodon c. contortrix venom. The resulting activated protein
C inhibits the factors V and VIII, and thus prolongs the APTT of a system in which
all the factors are present, constant and in excess (provided by the Reagent 1),
except the protein C which is derived from the sample being tested.

• Used with TriniCHECKTM Control 1 (T4101), TriniCHECKTM Abnormal

Control (T4104) and TriniCALTM PC/PS (T5105).

NEW TriniCLOTTM PS II PART NUMBER PRODUCT NAME STABILITY

The TriniCLOTTM PS II kit is intended for the quantitative measurement of the TriniCLOTTM PS II
functional protein S level based on the principle of factor Va inhibition. Reagent 1 (TriniCLOTTM PS Def Plasma): 2 x 1mL 4 hours on board stability
The principle of the assay is based upon the cofactor activity of protein S which T1608
TM
Reagent 2 (TriniCLOT PS Pca): 2 x 1mL 4 hours on board stability
enhances the anticoagulant action of activated protein C.
TM
This enhancement is reflected by the prolongation of the clotting time of a system Reagent 3 (TriniCLOT PS Factor Va): 2 x 1mL 4 hours on board stability

enriched with factor Va which is a physiological substrate for activated proteinC.

• Used with TriniCHECKTM Control 1 (T4101), TriniCHECKTM Abnormal

Control (T4104) and TriniCALTM PC/PS (T5105).

TriniCLOTTM Lupus Screen and Confirm PART NUMBER PRODUCT NAME PACKAGING STABILITY

TriniCLOTTM Lupus Screen and TriniCLOTTM Lupus Confirm are simplified dilute T1604 TriniCLOT TM
Lupus Screen 10 x 2 mL 48 hours at 2-8ºC
Russell’s Viper Venom Time (dRVVT) reagents, intended to specifically detect TM
T1605 TriniCLOT Lupus Confirm 10 x 1 mL 48 hours at 2-8ºC
Lupus Anticoagulants (LAs), a type of anti-phospholipid antibody. The reagents
are simple one step clotting tests that can be performed either manually or T4203 TM
TriniCHECK Lupus Positive Control 6 x 1 mL 8 hours at 2-8ºC
on automated coagulation instruments.

• TriniCHECKTM Lupus Positive Control also available (T4203).

• Mixing tests may be used to exclude Factor II, V and X deficiencies that may
prolong TriniCLOTTM Lupus Screen and TriniCLOTTM Lupus Confirm results.

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 TriniCHROMTM Speciality Reagents
TriniCHROMTM Antithrombin IIa and PART NUMBER PRODUCT NAME PACKAGING STABILITY
TriniCHROMTM Antithrombin Xa AT Heparin/Thrombin Reagent: 4 x 10 mL AT Heparin/Thrombin Reagent: 2 week at 2-8°C
T2602 TriniCHROMTM Antithrombin IIa AT Thrombin Substrate: 4 x 2 mL AT Thrombin Substrate: 2 weeks at 2-8°C
TriniCHROMTM Antithrombin IIa and TriniCHROMTM Antithrombin Xa are
AT IIa Dilution Buffer (10X): 2 x 5 mL AT IIa Dilution Buffer: 2 weeks at 2-8°C
intended for the quantitative determination of AT activity in human plasma by
chromogenic assay. AT Factor Xa Reagent: 4 x 3 mL All reagents are stable for 1 month at 2-8°C
T2603 TriniCHROMTM Antithrombin Xa AT Factor Xa Substrate: 4 x 3 mL
AT is the major inhibitor of plasma thrombin and Factor Xa. It is also an important
AT Xa Dilution Buffer (10X): 4 x 5 mL
inhibitor of activated Factors IXa, XIa, and XIIa. The inhibitory activity of AT
towards thrombin is greatly increased (2–3 orders of magnitude) in the presence
of heparin. TriniCHROMTM Antithrombin IIa and TriniCHROMTM Antithrombin Xa
utilize a thrombin based reagent which is added to a plasma dilution containing
AT in the presence of heparin. After incubation, residual thrombin is determined
with a thrombin-specific chromogenic substrate. The residual thrombin activity
is inversely proportional to the antithrombin concentration.

• TriniCHROMTM Antithrombin IIa assay has been developed to decrease the

interference from HCII to a level where discrimination between normal and
abnormal levels is similar to that achieved by Factor Xa based Antithrombin
assays.
• TriniCHROMTM Antithrombin IIa assay is sensitive to Heparin Cofactor.
TriniCHROMTM Antithrombin Xa assay is insensitive to Heparin Cofactor.
• Based on the characteristics of TriniCHROMTM Antithrombin IIa, it is the
most commonly used AT reagent.
• TriniCHROMTM Antithrombin Xa is more dedicated to specialised used.
• Used with TriniCHECKTM Control 1 (T4101), TriniCHECKTM Abnormal
Control (T4104) and TriniCALTM Reference Plasma (T5102).

10
 TriniCALTM Reference Plasmas
TriniCALTM Reference control plasmas are citrated freeze-dried human plasmas PART NUMBER PRODUCT
CT NAME PACKAGING STABILITY
which guarantee consistently accurate results.
T5101 TriniCALTM INR & Quick 4 x 1 mL (1 x 4 levels) 4 hours at 18-25°C

TriniCALTM INR & Quick

Monitoring of coumadin or coumadin-like Oral Anticoagulant Therapy (OAT) is
generally performed with the Prothrombin Time (PT) test. When used for
monitoring OAT, the World Health Organization recommends normalizing and
reporting the results of the PT test as an INR rather than seconds. The PT may
also be reported in a normalized format as a Percent Activity.

TriniCALTM INR & Quick Calibrator Set may be used to:

1. Determine the patient’s INR directly by establishing an INR calibration curve.
2. Determine the patient’s Percent Activity directly by establishing a Percent
Activity curve.
3. Determine a local ISI value of the measurement reagent/instrument
system used in the PT test.
• Four point curve for better discrimination across therapeutic range
compared with other commercially available kits.
• Level 1 corresponds to a normal PT.
• Levels 2 through 4 correspond to increasing levels of coumadin anticoagulation.
• Instrument specific assignments provided for all PT Reagents for INR and % Activity.
• Each level’s INR is assigned using International Reference Preparation
thromboplastin(s).

TriniCALTM Reference Plasmas PART NUMBER PRODUCT NAME PACKAGING STABILITY

TM
TM
TriniCAL Reference Plasma is an assayed human plasma that has been T5102 TriniCAL Reference Plasma 10 x 1 mL 2 hours at 2-8°C
lyophilised to maintain the integrity of the constituents. It is intended for use
as a reference plasma for the quantitation of coagulation proteins and control
in routine coagulation assays.

TriniCALTM Fibrinogen PART NUMBER PRODUCT NAME PACKAGING STABILITY

TriniCALTM Fibrinogen is a citrated lyophilised normal human plasma assigned T5104 TriniCALTM Fibrinogen 10 x 1 mL 1 day at 2-8°C
and is specifically designed for use with the TriniCLOTTM Fibrinogen.

NEW TriniCALTM PC/PS PART NUMBER PRODUCT NAME PACKAGING STABILITY

TM
TriniCALTM PC/PS is plasma intended for use as calibration plasma for the T5105 TriniCAL PC/PS 6 x 1 mL 4 hours on board the Destiny Max
functionnal assays of protein C and protrein S by the clotting method.

11
 TriniCHECKTM Controls
QC TriniCHECKTM control plasmas PART NUMBER PRODUCT NAME PACKAGING STABILITY 2 - 8°C

Un-Assayed
TriniCHECKTM control plasmas are pooled citrated freeze-dried human plasmas
which guarantee consistently accurate results. Convenient and reliable, T4111 TriniCHECKTM Level 1 10 x 1 mL 24 hours

TriniCHECKTM plasmas are the Quality controls of choice for your haemostasis T4112 TriniCHECKTM Level 2 10 x 1 mL 24 hours
laboratory. T4113 TriniCHECKTM Level 3 10 x 1 mL 24 hours

• Freeze-dried human plasmas guarantee reliable and accurate results. Assayed

• Both Assayed and Unassayed presentation. T4101 TriniCHECKTM Control 1 10 x 1 mL 24 hours
• Convenient pack sizes. T4102 TriniCHECKTM Control 2 10 x 1 mL 24 hours
• Consistent value assignments from lot to lot. TM
T4103 TriniCHECK Control 3 10 x 1 mL 24 hours
T4104 TriniCHECKTM Abnormal Control 10 x 1 mL 4 hours

Speciality
T4203 TriniCHECKTM Lupus Positive Control 6 x 1 mL 8 hours

D-Dimer
T4303 TriniCHECKTM D-Dimer 1 4 x 1 mL 2 days
T4304 TriniCHECKTM D-Dimer 2 4 x 1 mL 3 days
T4305 TriniCHECKTM D-Dimer 3 4 x 1 mL 3 days
TM
NEW TriniCHECK LIA Control Set
T4306 TriniCHECKTM LIA Control N 12 x 1 mL 8 hours on board stability
TM
T4306 TriniCHECK LIA Control ABN 12 x 1 mL 8 hours on board stability

12
Tcoag Control offering
TRINICHECKTM CONTROL 1 TRINICHECKTM CONTROL 2 TRINICHECKTM CONTROL 3 TRINICHECKTM ABNORMAL CONTROL TRINICHECKTM D-DIMER 2 & 3 TRINICHECKTM LIA CONTROLS
PARAMETER
(T4101) (T4102) (T4103) (T4104) (T4304 & T4305) (T4306)

PT   
APTT   
FIB  
TT  
AT  
Factor II, V, VII & X  
Factor VIII, IX, XI & XII  
D-Dimer 
D-Dimer II 
Protein C  
Protein S  

13
 TriniLIZETM ELISA based Assays
TriniLIZETM tPA Activity PART NUMBER PRODUCT NAME PACKAGING STABILITY
TM
TriniLIZE tPA Activity kit is a bio-functional immunosorbent assay (BIA) Microtest strips: 12 strips Microtest Strips: 4 weeks at 2-8°C
intended for the quantitative determination of human tissue plasminogen PET Buffer: 1 vial PET Buffer: 4 weeks at 2-8°C
tPA Activity Standard: 1 x 0.5 mL tPA Activity Standard: 8 hours on ice
activator activity in plasma. The clinical utility of the assay is to detect disorders T6002 TriniLIZETM tPA Activity
Substrate Reagent: 1 x 6 mL Substrate Reagent: 4 weeks at -20°C
of the fibrinolytic system.
Plasminogen Reagent: 1 x 6 mL Plasminogen Reagent: 4 weeks at -20°C
Citrate Buffer: 1 x 8 mL

TriniLIZETM PAI-1 Antigen PART NUMBER PRODUCT NAME PACKAGING STABILITY

TM
TriniLIZE PAI-1 Antigen is an enzyme immunoassay (ELISA) for the Microtest strips: 6 strips All components are stable for 1 month at 2-8°C
quantitative determination of human plasminogen activator inhibitor, type 1 PET Buffer: 1 vial
(PAI-1) antigen in human plasma. PAI-1 Depleted Plasma: 1 vial, 0.5 mL
PAI-1 Standard Plasma: 1 vial, 0.5 mL
T6003 TriniLIZETM PAI-1 Antigen
Conjugate: 1 vial, 7 mL
Substrate: 1 vial, 2 mL
Hydrogen Peroxide: 1 vial, 2 mL
Reagent Reservoirs: 6 each

TriniLIZETM PAI-1 Activity PART NUMBER PRODUCT NAME PACKAGING STABILITY

TM
TriniLIZE PAI-1 Activity assay is a bio immunoassay (BIA) for the Microtest strips: 12 strips Microtest Strip: 1 month at 2-8°C
quantitative determination of active human plasminogen activator inhibitor, PET Buffer: 1 vial PET Buffer: 1 month at 2-8°C
PAI-1 Standard Plasma: 0 IU/mL, 4 x 0.25 mL PAI-1 Standards: 4 hours 2-8°C
type 1 (PAI-1) in human plasma.
PAI-1 Standard Plasma: 50 IU/mL, 4 x 0.25 mL Conjugate: 1 month at -20°C
T6004 TriniLIZETM PAI-1 Activity
Conjugate: 1 x 5 mL HRP Substrate Solvent: 1 month at 2-8°C
HRP Substrate Solvent: 1 x 20 mL HRP Substrate: 1 month at 2-8°C
HRP Substrate: 4 tablets x 5 mg
Reagent Reservoirs: 6 each

14
TriniLIZETM Stabilyte tubes PART NUMBER PRODUCT NAME PACKAGING STABILITY
TM
TriniLIZE Stabilyte tubes are intended for collection of blood samples for the T6006 TriniLIZETM Stabilyte tubes 30 tubes Until expiry date
determination of tissue plasminogen activator (tPA), plasminogen activator
inhibitor (PAI-1) and fibrinogen.

TriniLIZETM tPA/PAI Depleted Plasma RUO PART NUMBER PRODUCT NAME PACKAGING STABILITY

TriniLIZETM tPA/PAI Depleted Plasma: tPA antigen and PAI-1 antigen were T6007 TriniLIZETM tPA/PAI Depleted Plasma 5 vials 2 weeks at -20°C
removed by absorption with immobilized anti-tPA immunoglobulins and anti-
PAI-1 immunoglobulins. For Research Use Only.

TriniLIZETM PAI Activity Control RUO PART NUMBER PRODUCT NAME PACKAGING STABILITY
TM
To control the accuracy of PAI-1 activity determinations using the TriniLIZE TM T6008 TriniLIZE PAI Activity Control 0.5 mL x 4 levels Store reconstituted vials frozen at -20°C or colder
PAI-1 Activity (T6004) kit. A range of activity controls are provided in the kit,
from approximately 4 IU/mL to 40 IU/mL. For Research Use Only.

Fibrinolysis Reference Plasma RUO PART NUMBER PRODUCT NAME PACKAGING STABILITY
T6010 Fibrinolysis Reference Plasma 5 vials x 0.5 mL Use within 30 minutes
For Research Use Only. The Fibrinolysis Reference Plasma is intended to be
used to verify the performance and accuracy of the following products:

• TriniLIZETM tPA Activity (T6002).

• TriniLIZETM PAI Activity (T6004).
• TriniLIZETM PAI-1 Antigen (T6003).

15
 Platelet Aggregation Reagents
Ristocetin Cofactor Assay PART NUMBER PRODUCT NAME PACKAGING STABILITY

The Ristocetin Cofactor Assay is used for the quantitative determination of 50750 Ristocetin Cofactor Assay Ristocetin 7.5 mg/vial Ristocetin: 7 days at 2-8°C
Factor VIII Ristocetin Cofactor activity in plasma. lyophilised Human Platelets 6 mL Von Lyophilised Human Platelets: 8 days at 2-8°C Von Willebrand
Willebrand Reference Plasma: Normal 1 mL Von Reference Plasma,
Von Willebrand disease is associated with a decrease in Von Willebrand factor or Willebrand Reference Plasma: Deficient 0.5 mL Normal: 4 hours at 2-8°C Von Willebrand Reference Plasma,
Ristocetin Cofactor activity and it is generally accepted that the Ristocetin Cofactor Tris Buffered Saline (TBS) 12 mL Deficient: 4 hours at 2-8°C
activity is the most useful in vitro assay for the diagnosis of Von Willebrand disease. Tris Buffered Saline (TBS): until expiration date
Levels of Ristocetin Cofactor activity are determined by the ability of the test
50705 Ristocetin 7.5 mg/vial 10 x 0.5 mL 7 days at 2-8°C
plasma and Ristocetin to induce aggregation in a standardised platelet suspension.
50710 Platelets 3 x 6 mL 8 days at 2-8°C
Ristocetin is a lyophilised reagent derived from Norcardia lurida which induces
platelet aggregation in normal Platelet Rich Plasma (PRP). In Von Willebrands
disease, Ristocetin-induced platelet aggregation is impaired.
Lyophilised platelets are a preparation of fixed human platelets which have been
lyophilised for long-term stability. Each vial of lyophilised platelets is reconstituted
with the appropriate volume of Tris Buffered Saline to yield a platelet count of
approximately 275,000 per μL.
• Provided as a kit and as separate components.

Platelet Agonists PART NUMBER PRODUCT NAME PACKAGING STABILITY

Both quantitative and qualitative platelet defects can result in altered 50704 ADP 3 x 0.5 mL 30 days at 2-8°C
Haemostasis. We provide the common agonists, namely: ADP and Collagen
to assess normal platelet function and aid in the diagnosis of platelet function
defects by way of Platelet Aggregometry.

16
 Instruments

NEW DT 100 by TcoagTM

Destiny MaxTM

Destiny PlusTM

KC4 DeltaTM

KC1 DeltaTM

17
18
Instruments & Consumables

The Tcoag Family of Instrumentation

By offering unparalleled flexibility in our analyzer selection, the choice is truly yours…

ACTIVITY DETECTION MODE

TCOAG INSTRUMENTATION HIGH VOLUME HIGH TO MID VOLUME LOW VOLUME MECHANICAL CLOT DETECTION OPTICAL CLOT DETECTION

DT 100 by Tcoag TM NEW   

Destiny Max™   

Destiny Plus™   

KC4 Delta™  

KC1 Delta™  

19
 N EW

DT 100 by Tcoag™
So Small, So Smart, So Fast
Fully-automated coagulation analyser with multiple measuring mode for clot-based, chromogenic and immunoturbidimetric tests

Smart Sample Handling

• Rack continuous loading to ensure maximum productivity

• Optimised pipetting for precious samples

• True STAT management

Optimized Reagent Management Unique Patented Cuvette Plate Software with coagulation expertise

• Continuous loading and unloading • Optimised 4x4 cuvette processing • Smart result management with reflex testing and auto-validation

• Tilted vial for low dead volume • 1 cuvette = 1 test • Fully automated factor parallelism testing and graphical display

• Unique VIN (Vial Identifier Number) • All-in-one reaction plate • Comprehensive QC monitoring, Westgard rules and Levey-Jennings
20
What Dual Technology Why Dual Technology

Optical Coagulation Detection • Optical: Clot Waveform Analysis

• State-of-the-art photometric module method • Mechanical: No need for HIL sorting and result provided even with turbid
sample
• 4-simultaneous wavelength reading

• Blue dye to guarantee reagent dispensing

Mechanical Coagulation Detection

• The original Amelung

• Reference method since the 70’s

• No optical interferences from lipemic, icteric or hemolysed

samples

DT 100: The best of both technologies

PART NUMBER DESCRIPTION PACKAGING

H02000 PACK DT 100 complete with starter kit, PC, Touch Screen Monitor 1

Consumables
DTW DT Wash 24 x 15 mL

Z04050 Destiny Cuvette Trays set of 100

DSF Destiny System Fluid 3 x 3.3 L

626060 1.5 mL Containers 100

242360 Stirring Magnet 10

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 Destiny Max™
High Throughput Coagulation Analyser
We introduce the latest high throughput Haemostasis analyser. It offers the best combination of existing and new technologies to provide operators
with unique features in a flexible, easy to use system. Destiny Max™ is the only instrument offering the choice of optical or micro-mechanical clot
detection with reliable cap piercing and result standardisation. The operational software is a state-of-the-art graphic user-interface. This provides an
intuitive, multitasking functionality and flexibility, enabling convenient operation with continuous sample processing.

Comprehensive reagent management Safety and ease of use Multiple Measuring Technologies

• 55 on board reagents with 50 in cooling area and 8 stirred position Results are independent of the type of sample tube and make validation Destiny Max™ gives you the flexibility to choose mechanical or optical
easier and faster clotting method.
• Real continuous loading with Positive identification
• Open and closed tubes combined on the same rack Multiple Measuring Technologies
• Monitoring of reagent volume, expiry and on board stability
• Convenient for all tubes including paediatric and Eppendorf • Chronometric, Chromogenic and Immunoturbidimetric
• Multiple vials of same reagent for high workload testing
• Guaranteed accuracy of sample volume • Wavelengths 340 nm, 405 nm, 635 nm, 705 nm

• Optimised walk-away capacity with continuous loading of samples, • Multiple simultaneous wavelength detection
reagents, cuvettes and system fluid and continuous unloading of solid and
• Reliable, accurate results on compromised samples - icteric, haemolytic and
liquid waste
lipemic using Mechanical Clot detection

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 Flexible Software and Result Management

• Intuitive touch screen ICON driven software

• True multitasking system

• Comprehensive quality assurance

• Complete traceability and software security

• Factor parallelism and reflex testing

• System standardisation of results using TriniVeriCAL

• Result integrity checking with ‘Blue Dye’ technology

• Real time system monitoring

Destiny Max™ Instrument and Consumables

PART NUMBER DESCRIPTION PACKAGING

M01000PACK Destiny Max™ complete with starter kit, PC, Touch Screen Monitor and Printer 1

Consumables
DPW20 Destiny Prowash 10 x 20 mL

Z04050 Destiny Cuvette Trays set of 100

DSF Destiny System Fluid 3 x 3.3 L

626050 Glass Vessel for Buffer/Reag./CaCl 20 mL 16

626065 Plastic Reagent Vessel 12 mL 20

626060 1.5 mL Containers 100

242360 PTT Stirring Magnet 10

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 Destiny Plus™
Medium Throughput Coagulation Analyser
The demand for rapid, accurate patient results from today’s clinician requires a complete solution for the Haemostasis Laboratory. The Destiny Plus™
represents the ultimate in the fusion of technology and economy for coagulation automation in the mid to large-sized, routine or specialty laboratory.
The unique combination of key features includes:

• Patented Ball Method Mechanical Testing technology

• STAT results on-demand in under three minutes

• IntuiTouch user-friendly software with integrated

reflexive testing

• Comprehensive test menu including clotting,

chromogenic and immunoassay analysis

Measuring Modes Ease of use

Mechanical Measuring Modes • Convenient for a variety of open primary and secondary tubes • Ability to manage multiple reagent lots and multiple calibration curves
Including paediatric draw tubes and Eppendorf; • Intuitive touch screen icon driven software
• TRUE mechanical measuring mode, the “Gold standard” -
multiple sample dilutions - parallelism studies
developed and perfected by Amelung • Simple maintenance
• Reagent management by volumes and number of tests remaining;
• Reliable, accurate results on compromised samples -
reagent expiration monitoring by label and on-board time;
icteric, haemolytic, lipemic and medicated
uninterrupted reagent refill
Optical Measuring Modes
• Continuous loading of samples, reagents, consumables and unloading
• Optical clot detection of liquid and solid waste: refill and empty without interruption
• Chromogenic assays of sample processing

• Immunoturbidimetric assays

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QC Features/Process Security Cost effective and economical

• Absolute sample verification by liquid level sensing probe; • Multifunctional cuvette tray ; partially used trays returned to start position
level sensing of reagents so that unused cuvettes can be used in next processing period

• Positive barcode identification of samples and reagents • Walk-away time >2 hours

• Westgard Rules • Minimal maintenance : 5 min per day, 30 min per week

• Levey-Jennings chart • No additional consumables

• Real-time on-line log

• Maintenance log printout with operator ID tag
• Access to instrument status from every menu

Destiny Plus™ Instrument and Consumables

PART NUMBER DESCRIPTION PACKAGING

H01000PACK Destiny Plus™ complete with starter kit and Printer 1

Consumables
DPW10 Destiny Prowash 12 x 10 mL

Z04050 Destiny Cuvette Trays set of 100

144005 Destiny Waste Tray (in instrument) 1

350361 Destiny Syringe - plunger tips 1 pack

626050 Glass Vessel for Buffer/Reag./CaCl 20 mL 16

626065 Plastic Reagent Vessel 12 mL 20

626060 1.5 mL Containers 100

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 KC4 Delta™ and KC1 Delta™
Semi Automated Coagulation Analyser
KC4 Delta™ and KC1 Delta™ are semi automated coagulation analysers with four or one test position(s), respectively, providing operators with a
compact easy to use system. KC Delta™ series instruments use micro-mechanical clot detection technology for clotting assays.

Technology Measuring
sur
u ing Features
F at
Fe a ur
u ess

• “Gold standard” mechanical

ical detection • Pre packed
acked single micro cuvettes with ball bearing for easy loading
• Pipette auto start testing • Store reagent ISI values for automatic INR calculation including calibration
curvess
• LCD display and optional printing of results
• Preparation and incubation area for samples and reagents
• Programmable test modes, single or duplicate testing
• Suitable for STAT and routine testing

• Test menu for PT, APTT, Fibrinogen, Factors

• Maintenance free operation

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KC4 Delta™ Instrument and Consumables
PART NUMBER DESCRIPTION PACKAGING

N04000PACK KC4 Delta™ complete with starter kit (H12 x L45 x W35cm) (6.4kg) 1

Consumables
Z04140 Strips of 4 packed micro cuvettes with ball inside cuvette for KC4 Delta™ 150 x 4

Z05111 Bulk cuvettes for KC4 Delta™ with balls packed separately in a ball dispensor 2000

Optional Printers
Z09165 Printer set KC4 Delta™ 230 /110 V 1

Printer Consumables
852015 KC Delta™ Thermal Printer Paper 1

KC1 Delta™ Instrument and Consumables

PART NUMBER DESCRIPTION PACKAGING

G05000PACK KC1 Delta™ complete with starter kit (H8 x L21 xW14cm) (1.2kg) 1

Consumables
Z05100 Bulk cuvettes for KC1 Delta™ with balls packed separately without ball dispensor 1000

Z01000 Ball Dispenser for Z05100 1

Optional Printers
Z09160 Printer Set KC1 Delta™ 230 /110 V 1

Printer Consumables
852015 KC Delta™ Thermal Printer Paper 1
 Notes

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