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Targeted Cancer Therapy Overview

The document discusses targeted cancer therapies, which are drugs that block cancer growth and spread by interfering with specific molecules involved in cell growth and cancer progression. There are two main groups of targeted drugs: monoclonal antibodies and small molecule inhibitors. Monoclonal antibodies target biomarkers on cancer cells and include drugs like bevacizumab and trastuzumab. Small molecule inhibitors target intracellular pathways and proteins, and include tyrosine kinase inhibitors and mTOR inhibitors like everolimus. The document also discusses cancer drug resistance through mechanisms like drug efflux and potential solutions being researched like silencing resistance genes with RNA.

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Naura
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176 views30 pages

Targeted Cancer Therapy Overview

The document discusses targeted cancer therapies, which are drugs that block cancer growth and spread by interfering with specific molecules involved in cell growth and cancer progression. There are two main groups of targeted drugs: monoclonal antibodies and small molecule inhibitors. Monoclonal antibodies target biomarkers on cancer cells and include drugs like bevacizumab and trastuzumab. Small molecule inhibitors target intracellular pathways and proteins, and include tyrosine kinase inhibitors and mTOR inhibitors like everolimus. The document also discusses cancer drug resistance through mechanisms like drug efflux and potential solutions being researched like silencing resistance genes with RNA.

Uploaded by

Naura
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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TARGETED

CANCER
THERAPIES
Ika Puspita Dewi
2
Pengobatan Kanker

Jens Martensson
3

https://www.youtube.com/watch?v=vKIRWY-LMYc
Jens Martensson
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Jens Martensson
5
Radiotherapy
https://www.youtube.com/watch?v=
_moypMx05Fw

Jens Martensson
6
Targeted Cancer
Therapies

Jens Martensson
Targeted cancer therapies are drugs
or other substances that block the
growth and spread of cancer by
interfering with specific molecules
involved in cell growth and cancer
progression.

https://www.youtube.com/watch?
v=K09xzIQ8zsg
7
Jens Martensson
8
Target
• Biomarkers
• Cell Pathways

Jens Martensson
Two main groups of drugs
• Monoclonal antibodies
• Small molecule inhibitors

9
Jens Martensson
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Jens Martensson
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Monoclonal Antibody

Jens Martensson
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Jens Martensson
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Avastin/
Bevacizum
ab

Jens Martensson
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Trastuzumab & Pertuzumab

Jens Martensson
15
Rituximab &
Obinutuzumab

Jens Martensson
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Small Molecule Inhibitor

Jens Martensson
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Tirosin Kinase Inhibitor
Lapatinib Sunitinib

Jens Martensson
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Jens Martensson
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Everolimus
Jens Martensson
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CANCER RESISTANCE

Jens Martensson
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Mekanisme
Resistensi

Jens Martensson
https://www.youtube.com/watch?list=PLTtwVKa4Pr03 22
--nuuuRNZcpU0_B1B5CB-&v=uHAx2IZF_IE
Jens Martensson
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Jens Martensson
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Drug Efflux

Jens Martensson
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https://www.youtube.com/watch?v=T8dZwSPr8i8
Jens Martensson
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Solusi? → tahap penelitian

Jens Martensson
Overcoming multidrug resistance in cancer
cells by silencing genes with RNA A Small Molecule Targeting Mutagenic Translesion
https://phys.org/news/2014-01-multidrug- Synthesis Improves Chemotherapy. Wojtaszek, et 27

resistance-cancer-cells-silencing.html al. Cell, June 6, 2019.


Solusi? → tahap penelitian

Jens Martensson
Overcome Cancer Cell Drug Resistance Using https://www.nibib.nih.gov/news-
Natural Products (Wang et al, 2015) events/newsroom/overcoming-multidrug-resistant-
https://www.hindawi.com/journals/ecam/2015/7 cancer-smart-nanoparticles
28

67136/
Jens Martensson
29
Thank You

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