1.
(a) The diagram below in Figure 5 represents the sequence of events that occur
                in the cell cycle.
                                                                        cell division
                                                                        cytokinesis
                                   Cell
                                  Cell
                                   cycle
                                  cycle
                                            Figure 5 . the cell cycle
                      With reference to the diagram shown in Figure 5. State the event with:
                            (i)     Longest phase
                            (ii)     Outline the stages involved in cell division in the cell cycle :
                                                                                                   [4 marks]
      (b)           During development of the female gametes in a process called oogenesis, primary
                    follicles are produced which undergo partial completion of meiosis I until puberty,
                    which will then continue meiotic division to a point which then develop into mature
                    Graafian follicles encouraging ovulation.
            (i)         Explain what is meant by ‘homologous pairs’ of chromosomes                [1 mark ]
            (ii)        The primary follicles in the ovary develop in the female foetus in pregnancy to
                        the point of Prophase I of meiosis until puberty.
                        Draw an annotated diagram showing the stage of Prophase I of meiosis of the
                        developing the primary follicles.                               [4 marks]
            (iii)       Draw a diagram of the ovum at the point of ovulation. State the chromosome
                        number of the ovum at this point.                                 [3 marks]
            (iv)        Describe TWO events that occur in meiotic division that encourages genetic
                        variation in organisms.                                         [4 marks]
                                                                                           Total 15 marks
2.   (a)    Explain the difference between ‘gene’ and ‘allele’                    [4 marks]
     (b)     Mary has the genotype (Bb) that codes for black hair and her husband has the
             genotype (bb) that codes for brown hair.
             Using a genetic cross diagram, determine the ratio at which their offspring will
             obtain black hair vs. brown hair.                                     [5 marks]
     (c)   (i)    Define the term ‘mutation’                                       [ 1 mark]
           (ii)   Using a named example, explain how minor changes in the genetic sequence
                  can contribute to disease.                                     [5 marks]
                                                                            Total 15 marks