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Clomiphen Citrate

Clomiphene citrate works as an antioestrogen by competitively blocking oestrogen receptors in the anterior pituitary gland, removing the negative feedback of oestrogens on gonadotropin secretion. This stimulates the release of FSH and LH and induces ovulation, making it useful for treating infertility due to ovulation failure. Common side effects include polycystic ovaries, multiple pregnancy, hot flushes and headaches.

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Salon Lamichhane
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21 views1 page

Clomiphen Citrate

Clomiphene citrate works as an antioestrogen by competitively blocking oestrogen receptors in the anterior pituitary gland, removing the negative feedback of oestrogens on gonadotropin secretion. This stimulates the release of FSH and LH and induces ovulation, making it useful for treating infertility due to ovulation failure. Common side effects include polycystic ovaries, multiple pregnancy, hot flushes and headaches.

Uploaded by

Salon Lamichhane
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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1.

Explain the mechanism of action of Clomiphen


citrate. Mention their uses and side effects.
ANS;
MOA;
- Antioestrogenic effect
Clomiphene citrate (pure antagonist) === competitively
blocks oestrogen receptors (ERα, ERβ) in anterior
pituitary====opposes/abolishes negative feedback effect of
oestrogens(mainly), also progesterons ===stimulates
gonadotropin secretion (increases FSH and LH) === induces
ovulation.
USES;
- Infertility due to failure of ovulation.
- Aid in in-vitro fertilization with failure of ovulation.
- Assisted Reproduction Therapy (ART) and gamete
intrafallopian transfer (GIFT) technique.
- Male infertility; oligozoospermia; increase sperm count,
testosterone secretion.

SIDE EFFECTS; polycystic ovaries, multiple pregnancy, gastric


upset; others; hot flushes, headache, loss of hair,
hyperstimulation syndrome, wt. gain, breast discomfort etc.

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