Amoebiasis
is a parasitic infection of the intestines caused by the protozoan Entamoeba
histolytica, or E. histolytica
It causes diarrhea and colitis. Spread of infection from the intestine can result in
liver abscess (via haemato-genous dissemination).
Etiologic Agent
Entamoeba histolytica lives in the intestines of infected people.
Entamoebae are a group of single-celled parasites (living things that live in, or on,
other living organisms) that can infect both humans and some animals.
There are at least six species of entamoeba that can infect the human gut but only E.
histolytica causes disease.
Mode of Transmission
Transmission occurs via the fecal–oral route, either directly by person-to-person
contact or indirectly by eating or drinking focally contaminated food or water.
Sexual transmission by oral-rectal contact is also recognized especially among male
homosexuals.
Vectors such as flies, cockroaches and rodents can also transmit the infection.
Incubation Period- The average incubation period is 2–4 weeks. Patients may, however,
present months to years after the initial infection.
Period of Communicability- Cases are infectious as long as cysts are present in the feces.
In some instances, cyst excretion may persist for years.
Signs and Symptoms
Acute amoebiasis can present as diarrhea or dysentery with frequent, small and
often bloody stools.
Chronic amoebiasis can present with gastrointestinal symptoms plus fatigue, weight
loss and occasional fever. Extraintestinal amoebiasis can occur if the parasite
spreads to other organs, most commonly the liver where it causes amoebic liver
abscess.
Amoebic liver abscess presents with fever and right upper quadrant abdominal
pain.
Diagnostic Procedure
stool sample is sent to the laboratory and examined under a microscope. Ideally,
three stool specimens from different days should be examined.
blood test that looks for evidence of E. histolytica infection in your blood
biopsy taken at colonoscopy and examined under the microscope can show the
parasites
Treatment Modalities
Amoebic dysentery
tinidazole PO
Children: 50 mg/kg once daily for 3 days (max. 2 g daily)
Adults: 2 g once daily for 3 days
metronidazole PO
Children: 15 mg/kg 3 times daily for 5 days
Adults: 500 mg 3 times daily for 5 days
• If there is no laboratory, first line treatment for dysentery is for shigellosis.
Oral rehydration salts (ORS) if there is risk of, or if there are signs of dehydration
Amoebic liver abscess
• tinidazole PO: same treatment for 5 days
• metronidazole PO: same treatment for 5 to 10 days
Nursing Management
Observe isolation and enteric precaution
Provide health education about:
Boil water for drinking or used purified water
Wash hands before and after defecation or when handling foods
Provide optimum comfort
Bland diet without cellulose or bulk-producing food should be maintained.
Prevention
public education on the importance of personal hygiene
public education about the importance of hand hygiene after defecation and before
preparing or eating food
providing information to intending travellers about the risks involved in eating
uncooked vegetables and fruits and drinking potentially contaminated water
public education about the possibility of transmitting the disease via sexual contact.
protecting public water supplies from faecal contamination
investigating the food preparation practices of any implicated local food premises
boiling and purifying water before consumption in endemic areas.