Graduation Book
Graduation Book
+91 8075798297
ashwinnsuresh@gmail.com
May 2019
Pharmaceutical Predictive Analysis
Ashwin Suresh T UG User Experience Design Graduation Project 2019
1.1
― Edward De Bono
Beliefs
1.1
Preface
Thank you mother, father, brother, sister, brother-in
law and Mira. I am what I am because of you and
without you I am nothing.
Most of the adventures recorded in this book This project revolves around the
really occurred. Although the main intention pharmaceutical industry and most of the
of the book is to help the batches that come industries stakeholders, this was chosen to
after to learn to see good from bad, right be the domain I work with due to the level
from wrong and learn from my experience, it of impact the industry has and the sudden
can also be used as a yardstick to measure surge of technology front, human centered
my growth as a designer and human being, innovations and by participating in this
although that is highly discouraged. innovation and bringing new found meanings
and end desirables, impact can directly be
Although my book is intended for the education translated to the end consumer.
and entertainment for boys and girls, I hope it
will not be shunned by men and women.
Acknowledgments
Table of 1. Introduction
content 1.1 Sponsor 16
1.2 Methodologies 20
1.3 Blue sky thinking 24
1.4 Domain and initial brief 26
2. Literature study
3. Empathize
Fig 2 29
The industry stagnating.
Fig 3 32
Epidemic outbreak growth
Fig 4 37
Increasing demand for NCD’s
Fig 5 38-39
Lfetime of a drug
Fig 6 40
Increasing demand for generics
Fig 7 47
As per a survey conducted on pharmaceuticals by IS Reports.
Fig 8 50
Foundation for Assuring an Ongoing State of Control
Fig 9 55
Factors affecting lack of supply
Fig 10 114
Information Architecture
Fig 11 115
Hero Flow
Fig 12 117
A visual representation of contextualization of data
XO’s 108-109
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
Acknowledgments
Thank you mother, father, brother, sister, brother-in
law and Mira. I am what I am because of you and
without you I am nothing.
I want to express my gratitude to my mentors I would like to also thank the family I was a part
Karma Bhutia and Wricha Mishra for providing of in MIT, sharing moments of joy and helping
their unconditional support and guidance through- make my experience truly memorable. These
out the process, the panic and the successes. Your are friends I have made for life.
confidence helped me find mine.
My family has provided me with more than
I would like to thank the team at Honeywell HUE a thank you can say, from believing in me to
PMT Bangalore in making me feel at home, sup- exercise my passion for design and helping me
porting me with their interest in my work and help- stay in my path.
ing me achieve clarity in my work. The last three
months have been a very inspirational experience
which I will carry with me for the rest of my career. For your love and support TM.
I had the opportunity to use my skills and learn a
lot more.
Shout out to
My batchmates
Varun Prabhakar Mr. Shelly Antony
Dawa Pakemon Mr. Muthu Kumar Twisha Mehta
Ankit Mr. Hari Babu Akilan Nagarajan
Simran Tandon Mr. Gopakumar Vrajesh Pithadiya
Arundhati Man- Rohyn Rajesh
mode Intermed Phar- Advit Mohunta
Geethu Sebastian maceuticals Veersingh Gaikwad
Yuhina Aditya Menon
Akshay Khandel- Harsh K Mittal Rohit Kolhatkar
wal Shivangini Dasgupta
Bimal Rajappan Chitvan Patel
Maithili 507 Neeraja Kulkarni
Rujuta Shah Soham Putran
Narendra Singh Naomi Rohila
Neha Shetty Janmajeaye Daroz
Kabir Chaturvedi
13
Introduction
Ashwin Suresh T UG User Experience Design Graduation Project 2019
1.1
HTS and HUE
The sponsor
Honeywell Technology Solutions is a technology
Honeywell centric solution vertical of Honeywell
international. HTS started by Ramesh
Krishnamurthy started out as a relatively small
team working out of India. Now it has grown
to occupy prominent space in multiple cities. I
had the opportunity to work in the Bangalore
campus 2 which was a recent (relatively) setup.
The team
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
Aspirations
Foreword
Sub heading
Suresh
There are manyVasudevan
variations of passages of Lorem
Zonal Manager
Ipsum available, Elder Pharmaceuticals
but the majority have suffered Ltd.
Consultant Marketing and Sales of
alteration in some form, by injected humour, or ran-
Subject
domised words .Matter Expert
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
1.2
Methodology
A literature review is both a summary and ex- Requirements Analysis is the process of defin- In simple term, ‘user study’ means a study of
planation of the complete and current state of ing the expectations of the users for an appli- the users of information. It deals with the kind
knowledge on a limited topic as found in academic cation that is to be built or modified. Require- of information required by the user, the ways
books and journal articles. There are two kinds of ments analysis involves all the tasks that are and means used for searching for the required
literature reviews you might write at university: one conducted to identify the needs of different information, the use of the information, the use
that students are asked to write as a stand-alone stakeholders. Therefore requirements analy- of the information obtained, the satisfaction/
assignment in a course, often as part of their train- sis means to analyze, document, validate and dissatisfaction arising from the use of informa-
ing in the research processes in their field, and the manage software or system requirements. tion obtained, the flow of the information and
other that is written as part of an introduction to, High-quality requirements are documented, the relationship of studies.[119]
or preparation for, a longer work, usually a thesis actionable, measurable, testable, traceable,
or research report. [128] helps to identify business opportunities, and are
defined to a facilitate system design. [118]
Affinity diagrams are a great method to help you Taking a Guided Tour through the home or A Survey is defined as a research method used
make sense of all your information when you have workplace of the person you’re designing for for collecting data from a pre-defined group of
a lot of mixed data, such as facts, ethnographic can reveal their habits and values far better respondents to gain information and insights
research, ideas from brainstorms, user opinions, than talking to them on the street. [132] on various topics of interest. Surveys have a
user needs, insights, and design issues. [129] variety of purposes and can be carried out in
many ways depending on the methodology
chosen and the objectives to be achieved. [133]
Wireframing is a way to design a website service Information architecture (IA) is the structural Stakeholder mapping is a collaborative process
at the structural level. A wireframe is commonly design of shared information environments; of research, debate, and. discussion that draws
used to lay out content and functionality on a the art and science of organizing and labelling from multiple perspectives to determine a key
page which takes into account user needs and websites, intranets, online communities and list of. stakeholders across the entire stakehold-
user journeys. Wireframes are used early in the software to support usability and findability; er spectrum. Mapping can be broken. [131]
development process to establish the basic struc- and an emerging community of practice fo-
ture of a page before visual design and content is cused on bringing principles of design, archi-
added. [130] tecture and information science to the digital
landscape.[1] Typically, it involves a model or
concept of information that is used and applied
to activities which require explicit details of
complex information systems. These activities
include library systems and database develop-
ment. [134]
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
Brainstorming
Pharmaceutical Industry
Bespoke drugs
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
Prominent domains
Optimizing drug discovery
Lack of supply of medicines
Unqualified PHC providers
Counterfeit and substandard drugs
Trial subject monitoring and adherence
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
1.4 Domain
After pitting impact with
accessibility to users the following
domain was chosen.
Pharmaceutical Production
Initial brief
Literature study
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
2.1
Introduction
Background
The pharmaceutical industry is one of the most These new molecules have a lifetime that will
information regulated industries among the list which in- be discovered later on but once the patent for
cludes oil and gas industry, air transportation a new medicine has ended, any competitor with
industry, electric power supply etc. This makes intent can replicate the same medicine, this
it very important for the stakeholders of the saves them the trouble of conducting R&D and
country to promote the regulation and make the cost but at the cost of losing a huge chunk
sure that the drugs produced are meeting stan- of the market due to consumer loyalty and
dards set by them and other industry players. trust.
There are multiple types of pharmaceuticals, This generic drug has reduced cost helps in
The overall revenue of the phar- they can be categorized as R&D and produc- making the medicine more accessible to a large
maceutical indistry is $1,13 billion, tion, Production only and R& D only facilities. All pool of the population.
this revenue has grown but so drugs are made of an active ingredient called
the Active Pharmaceutical Ingredient.[41]
has cost of R&D and regulations.
Most pharmaceuticals are tar- Regulation
geting emerging markets due to For R&D facilities the major activity is to con-
their huge population. [41] duct research and to find new ways to treat a Due to the nature of the product, as discussed,
disease or new diseases to target with existing regulation is not mandatory, in making sure
medicines. R&D is the biggest expense in the that people get equitable and effaceable
pharma industry as it takes upto $2 Billion to healthcare. This considered there are a few
discover and develop new medicine and to un- organizations that standardize the product
derstand it’s safety and efficacy in treating the and some organizations that check it’s quality.
targeted disease. These will be discussed in detail in the coming
pages.
With a global revenue of over $1,143 Billion In emerging economies, where the market is huge, market share
dollars the pharmacetical industry is one of the wise there is a huge disparity in this ranking due to the huge
biggest revenue reapers when compared to market share of generic medicine and with many patents going
other industries. But regardless of their revenue out of their patent lifetime. These players mentioned above are
growth, due to the exuberant expenditures, the continuously renewing their policies, programs and market strat-
industry still fails to show margin and is stag- egy to occupy maximum parts of the emerging markets.
nating Lets look at how this revenue is distribut-
ed in the industry.
Top Pharmaceuticals
Pfizer
Johnson & Johnson
Roche
Abbvie
Amgen
Novartis
Gilead Sciences
Sanofi
Fig 2
BristolMyers Squbb The industry stag-
nating.
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
2.2
High level factors affecting the Patient to doctor ratio
Determining health of a nation
health of a The health of a country is a very important WHO identifies patient to doctor ratio as a key
factor in deciding where changes have to be factor while discussing equitable healthcare.
nation made, funding has to be done and initiative The provision of good primary, emergency
have to be taken. There are multiple segments and general healthcare can reduce the cost
of health like economic health, financial health, born by the country in unnecessary healthcare
healthcare provisions etc. provisions. In many developing countries we
can see that not only is the patent to doctor
For our purposes lets focus on the healthcare ratio very low there is also a huge disparity
part of the subject. Without getting too gritty between the number of treatment facilities
To look at why pharmaceutical with the details some of the infrastructure available and the infrastructure in those.[1]
matters, we need to look at surrounding goof healthcare are-
how a countries health is
measured and map the impact Provider availability
A doctors education is expensive and time
of pharmaceutical in these Health coverage
consuming and the rural sectors neither pay
parameters.
Availability of medicine
well nor give them the benefits that the private
Overall expenditure
sector gives. This is why we can see that the
Mortality rate
majority of doctors are engaged in private
Care provision and infrastructure availability
practice which makes the situation worse in
Limitations
rural areas.[1]
Partnership
Providing equitable access to people-centered
care
But providing diagnosis of life threatening diseases is The readiness and continuous updating of these epidemics
pointless if there is no medicine to cure it. in the market is very important to manage production to
meet market need. If not for purely humanitarian reasons, it
will at least help pharmaceutical companies gain edge over
By being at the forefront of healthcare
pharmaceuticals manufacture some of the competition and predict epidemics and plan accordingly.
most important products and innovate in areas
that help us by not only keeping the individual
safe but extending to it societies and countries. MERS, H1N1, swine flu, chikungunya, Zika: Another virus
They help us in collectively maintaining out with a peculiar name always seems to be right around the
heard immunity by providing us with vaccines corner, threatening to become a pandemic.
and reduce reduce the mortality rates by
innovating in pediatric medical products, they Over the past decade, the World Health Organization has
help us prolonging our lives instead of us dying declared four global health emergencies. Two of them
due to a common cold (shoutout to Penicillin) were in the past two years: the Ebola epidemic in West
[2] Africa and the Zika outbreak that’s spread through the
India is a country where almost 70% of the Americas. But emergence are taking it to an extreme,
population live in rural settings and as a even small epidemics like social diseases due to climatic
developing nation like many other BRIC and environmental change can be deadly, especially is
nations needs access to healthcare to be equal unforeseen. [127]
amongst the most extreme of conditions. [1]
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
(a) (b)
3000 - 3000 -
Disease richness
No. of outbreaks
2000 - 2000 -
- 175 Human specific
- 150 Zoonose
1000 - 1000 -
- 125
- 100
0- 0-
1980 1990 2000 2010 1980 1990 2000 2010
(c) (d)
3000 - 3000 -
No. of outbreaks
fungi
2000 - 2000 -
parasites
Vectorborne
Prorozoans
Non-Vectorborne
1000 - viruses 1000 -
Bacteria
0- 0-
1980 1990 2000 2010 1980 1990 2000 2010
Fig 3
The global number of human infectious diseas outbreaks and richness of casual diseases, from 1980 to 2010. Epidemic out-
Outbreak records are plotted with respect to (a) total globaal outbreaks and total number of disease breaking break growth
[127]
outbreaks in each year (b) host type (c) pathogen taxonomy and (d) transmission mode | The Royal Society
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
2.3
Suspicions
Case study
Approximately 1.6 million Africans died of The Trade Related Aspects of Intellectual
Dying from malaria, tuberculosis and HIV-related illnesses Property Rights (TRIPS) regulation of the
in 2015. These diseases can be prevented or World Trade Organization (WTO), in force
lack of treated with timely access to appropriate and since 1986, curtails the right of companies to
affordable medicines, vaccines and other manufacture generic drugs, forcing countries
medicines health services. But less than 2% of drugs to rely on brand-name products. However, the
consumed in Africa are produced on the WTO in 2006 granted developing countries
continent, meaning that many sick patients a 10-year waiver to manufacture generic
do not have access to locally produced drugs drugs using the intellectual property rights
and may not afford to buy the imported ones. of big pharmaceutical companies overseas.
Source:
Despite US objections, the waiver, which expired
Africa Renewal Magazine [135]
Without access to medicines, Africans are this year, was extended until two-thirds of
susceptible to the three big killer diseases on WTO members decide to remove it. Experts
the continent: malaria, tuberculosis and HIV/ believe that is unlikely to happen, as the US
AIDS. Globally, 50% of children under five appears to be the only big country insisting
who die of pneumonia, diarrhea, measles, on its removal. o produce medicines, a country
HIV, tuberculosis and malaria are in Africa, must abide by Current Good Manufacturing
according to the World Health Organisation Practices (CGMP), which are enforced by the
(WHO). The organisation defines having access United States and other governments to ensure
to medicine as having medicines continuously the quality of manufacturing processes and
available and affordable at health facilities that facilities. Many African countries do not have
are within one hour’s walk of the population. the technical, financial or human resources
required for high-scale drug production.
Reprements
Image
A primary healthcare facility
in Africa
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
2.4
Changing
Companies are more focuses on innovation Typically market study has been done to
marketscape and bringing technology into the process or understand growth of the market from
manufacturing. An are that has seen a lot a yearly or quarterly perspective and to
of attention from the FDA and independent identify the course of action for the next
publishers is continuous manufacturing in time period until the market is assessed
pharma. The disease scape is also changing. again. The new market scape provides
With the demographic data changing due opportunities to market researchers
to better lifestyle, rarer disease turn up and and producers to communicate and
diseases and demands have been fluctuating continuously improve their knowledge
very often. This new market needs addressing and opportunities in the market.
The market has been changing from not only market researchers but
interms of production shifting production to see what can be done about the
to high growth regions and the changes occurring.
consumption trend changing
rapidly. The kind of diseases
treated is also shifting leading to As providers, the pharmaceutical companies
that will always be a cornerstone in mitigating
a different type of epidemic.
epidemics/outbreaks and providing accessible
healthcare, they have the recently brought up
responsibility of being on top of the market
chain are visualizing change before change
happens. The ability to deal with certain
adverse scenarios and their ability to use data
to its fullest defines differentiation in todays
market.
Increasing NCD
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
Basic Drug Pre- Clinical Phase one Phase two Phase three
Research Discovery Clinical Testing
Fig 5
Lfetime of a drug
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
When a company utilizes it’s revenue and other The market share for generics is ever-
resources in developing new medication, that growing with the rate of population growth
medication is usually subjected to a patent in some developing countries like India. This
which runs for anywhere between 3 to 15 years presents a unique challenge and opportunity
depending on the complexity of the product for manufacturers to increase production
and the resources and time taken to develop locally. Indian pharmaceutical companies
it. During this period of protection that the are already well positioned in some of the
new drug has, no other company or player generic pharmaceutical markets of developed
is allowed to release the same product in the nations. This is due to product development
market under their brand name. Generic drugs skills through advanced technological
are usually much less expensive than branded capabilities, and low-cost manufacturing.
drugs due to factors like, negligible development Ranbaxy (now Sun Pharma) was the first Indian
cost for competitors, huge competition etc. pharmaceutical company to recognize and
When we go from brand to generics it changes take advantage of the generics market. After
from a sellers market to a buyers market. [86] the acquisition by Sun Pharma, the company’s
net worth in 2015 was around $4 billion. [86]
Fig 6
Increasing demand
for generics
40 Pharmaceutical Predictive Analysis
MIT Institute Of Design
Threat to production
Even though India is not hit by the lack of To create the supply for the sheer volume
supply too hard, places like China and US are of need for generic drugs with the bottom
really facing issue due to reasonable regulatory line also diminishing is not realistic for many
practices. manufacturers who have the capacity and
interest to produce these generic versions of
Currently US has about 200 drugs in the list medication. With increasing pressure from
they make on drug shortages. the government to produce volume and still
abide to standards of product, it is not at all
The Chinese generics market grew at a CAGR economically wise to for producers to venture
of 16.4% between 2006 and 2010 to $19.6 into generics. [44]
billion. In 2010, 95.3% of its prescription drug
sales, by volume, were generics. As previously The cost of branded drugs vs the cost of
mentioned, the Chinese generics market is generic clearly show us that the same process
expected to reach $80 billion in 2017 and intensive product sells for a much lower margin.
become the largest generics market in the This means that to hit significant profit margins
world. Generic drug sales currently account for generics need to be produced in bulk which
65% of pharmaceutical sales, by value, in the takes up the production capacity which can be
country. China and India now account for 25% utilized to make branded medicines that have a
of the global generics market, and demand in significantly higher margin.
these countries is expected to remain strong
for the foreseeable future. China consumed This paradox of cost is affecting the
roughly 19.2% of the global demand for generic approachability to generic market by pharma
active pharmaceutical ingredients (API) in 2008, manufacturers. They need to maintain quality
making it the second-largest consumer of APIs at the same standard which is not viable and
after the US. [86][91] higher recalls have been happening in this
space. They have also started increasing
prices due to the shortage in this market, which
completely deteriorates the value provided by
generic medication.[44]
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
2.6
Type of manufacturing
Current
There are two types of manufacturing that is Process manufacturing
production seen in any industry, discrete manufacturing
and process manufacturing. The pharma indus- Process manufacturing is the production of
practices try follows a practice known as discrete manu- goods by combining supplies, ingredients or
facturing. raw substances using a formula or recipe.
Examples of process manufacturing goods
The type of production process they follow is include food, beverages, refined oil, gasoline,
called bulk production where inputs, in this case pharmaceuticals, chemicals and plastics.
API, excipients and other resources are input in
bulk quantities and are processed using re-
Currently the industry practic- quired machinery. This process has been used
es Process manufacturing with for the last 50 years and has seen commend- Batch production
batch production practice. This able growth in terms of semi automation, this
is the maximum this type of production can go Batch production is a technique used in man-
has not changed in the last
to in terms of automation due to the heavily ufacturing, in which the object in question is
50+ years. fragmented process, that we will discuss in the created stage by stage over a series of work-
coming sections. stations, and different batches of products are
made. Together with job production and mass
This bulk process, since not fully automated re- production it is one of the three main produc-
quired many staff to ensure that the plant and tion methods.[88]
all the production is running smoothly and with-
out any hiccups. Everything is done manually.
Pro’s Con’s
01. Modest setup costs 01. Long shut down and maintenance time
04. Very low production cost if run at full 04. High operational cost
optimization.
05. Low levels of maximum possible optimization
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
These are the types of final drug forms (FDF) In the current production type which was
available in the market right now- batch production, the process dictates the
equipment used. If we take an example of
Oral tablet FDF, there are three types of production-
Injectable
Liquid 01. Direct compression
Cream, gel, liniment, or balm, lotion or ointment 02. Wet granulation
Patches 03. Dry granulation
Aerosols
Capsules
In this book, there i=will be a
prominence of tablet as the final A single product like Ranbaxy can be made
drug form. Instead of identifying available in multiple forms based on mechanisms
it as a limitation, it was identified of treatment.
as a starting point provided final
output is scalable.
Drugs can be purchased over the counter
(OTC) or as prescription based medicine
depending on the components, it’s effects
and the regulatory system dealing with the
particular product. OTC drugs can be bought
without a prescription, from any pharmacy
but prescription based medicine needs the
prescription to be shown.
These CMO’s often work on a batch to batch 07. Easy augmentation of supply
basis (quantity based) or they could be
contracted for an API quantity or a long term
(time based) operations. They can work on
end to end production or selected parts like
API manufacturing or FDF (Final Drug Form).
The more number of CMO’s the pharmaceutical
has for a particular process, the more time is
required for production, more the risk and more
complex the production management becomes.
Pro’s
With any contractor you can expect some level According to World Journal of Pharmacy and This risk is now a part of the contract and is
of challenges. It holds true for this industry as Pharmaceutical Science (WJPPS) for CMO’s being paid for while signing contracts by the
well but presents risks in the life science field working out of a different country some client.
whose consequences are huge. Some of the additional challenges may be-
high level problems identifies are listed below- How is this a good process of manufacturing
Language and meeting bottom line?
Time Zones
Quality control and the lack of it subsequently
Cultural differences
leading to process shut down and rejections
that is very expensive Corruption and local politics
Exploitation of MNC’s
Accountability
2.8
Types of frameworks Quality systems
Frameworks
Due to the high level of human intervention in the
for Quality by process it is important to have a framework for
Design
Laboratory
processes and forr final output. Let’s explore the
existing ones.
Quality System
Most countries will only accept import and sale Pharmacopoeias ensure end outcome quality
of medicines that have been manufactured to measurements by pitting outcomes with standards.
internationally recognized GMP. Governments This is useful in measuring no only your drugs
seeking to promote their countries’ export of adherence but al helps in continous improvement of
pharmaceuticals can do so by making GMP your processes to reach desired goal or standard.
mandatory for all pharmaceutical production and by
training their inspectors in GMP requirements.
Pharmacopoeias use science and evidence
based knowledge to standardize many
Good manufacturing practice (GMP) is a system prescription and over the counter drugs.
for ensuring that products are consistently Every country has it’s oun pharmacopoeia for
produced and controlled according to quality example India has the IP USA has the USP.
standards. It is designed to minimize the risks
involved in any pharmaceutical production that Some of the major pharmacopoeias are the
cannot be eliminated through testing the final USP, JP and BP.. In addition to developing
product. This system specifies on the processes standards for medicines, food ingredients,
equipments and peripheral measurements to and dietary supplements, pharmacopoeias
ensure quality in which case the quality of the also participates in various activities that help
output should be a given. [115] in providing primary care like awareness and It is important to note
safety initiatives; verification programs that however that the IP does
help ensure the quality and purity of dietary not regulate all aspects of
supplements and pharmaceutical and dietary production, in reality it deals
supplement ingredients; pharmacopoeia with a few aspects (Formula,
education programs that offer instruction on molecular sizing, delivery
how to meet official USP standards, among mechanism to name a few)
other related topics; and global assistance and there is a lot of room for
initiatives that work to improve drug quality generic producers to bring
and appropriate use of drugs in developing their own innovation into play.
countries.
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
2.8.2
Good
Manufacturing facilities must maintain a clean and hygienic manufacturing area.
manufacturing
practices Manufacturing facilities must maintain controlled environmental conditions in order to
prevent cross-contamination from adulterants and allergens that may render the product unsafe
for human consumption or use.
All critical processes are validated to ensure consistency and compliance with specifications.
A list of some topics that the Cur-
rent Good Manufacturing Process. Manufacturing processes must be controlled, and any changes to the process must be evaluated.
Changes that affect the quality of the drug are validated as necessary.
Instructions and procedures must be written in clear and unambiguous language using good
documentation practices.
Records must be made, manually or electronically, during manufacture that demonstrate that
all the steps required by the defined procedures and instructions were in fact taken and that the
quantity and quality of the food or drug was as expected. Deviations must be investigated and
documented.
Records of manufacture (including distribution) that enable the complete history of a batch to be
traced must be retained in a comprehensible and accessible form.
A system must be in place for recalling any batch from sale or supply.
Complaints about marketed products must be examined, the causes of quality defects must be
investigated, and appropriate measures must be taken with respect to the defective products and to
prevent recurrence.
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
2.9
Strategizing production
So what do I
As he final step to production, pharmaceuticals Both qualitative information and quantitative
produce? need to look at the portfolio of drugs they information is collected to form insights on
manufacture and identify which ones to market trends.
produce. Now this can depend on a lot Third part platforms are expensive to say the
of factors like type of medicine, seizable least and that does not cove the expense of
addressable market, disease category and getting in house talent to curate reports. This
market demand of the drug. This study is is a waste of potential that only happens
usually conducted by the market researchers in because data is inaccessible.
collaboration with pharmacies and hospitals.
Now that we know how Using the market data that they collect they
manufacturing happens, lets bring about schemes, packaging design, colors,
dive into understanding how pricing and most importantly, take decisions on
what to produce. This industry has very distinct ways of
from the extensive portfolios
market research and some of that include
pharmaceuticals choose what to
understanding prescription sales, intent of
produce. This is based on their requirements and their purchase and epidemiology data to gain early
level of funding but the sample size is notable warnings and react to the market.
as very low. Often due to funding and reach
reasons. The resort to their party platforms to
conduct their market research for them and
then curate that data and forecast the same
days, weeks, months or quarters depending on
their scale of study.
Fig 9
Factors affecting lack of
supply
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
2.10
Insights
01 02 03
Insights from the secondary
research that was done on the There is going to be an Pharmaceuticals mostly A facility employs a huge
topic. increase in the production outsource their production number of people to make
of tailored medicine which to CMO’s who usually handle it productive to operate, this
is suited for a particular multiple such pharmaceutical. means the cost of staffing
category or patients A pharmaceutical may even cuts into potential profits
according to multiple have up to 200+ CMO’s and
characteristics. CMO’s can be catering to tens
of pharmaceuticals depending
on the scale.
04 05 06
The processes are isolated A lot of communication The nature of production
and data collected needs happens between makes the process one of
tome to process pharmaceutical and CMO’s the lengthiest production
processes seen amongst
similar outputs, it can
sometimes take up to 180
days of holding time too get
the product ready.
07 08 09
The manual input is very Transferring paperwork and No proper systems exist to
repetitive and could be documents from different ensure that batch recalls
automated with the right CMO to the pharmaceutical are handled objectively and
process. for final evaluation is a time everyone is made aware that
and labor intensive task. whatever medicine is being
taken falls under a recall.
10
Regulations are going to
increase in previously loosely
regulated countries like India
and China.
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
Empathize
Immerse learning and knowledge sharing sessions with
industry experts and field visit to production facility
Ashwin Suresh T UG User Experience Design Graduation Project 2019
3.1
Expert interviews Guided tours
Research
Though the crux of Inspiration phase is talking A Guided Tour is a great method to employ
methodology with the people you’re designing for, you can when you’re in the field. Immersion is one of the
gain valuable perspective by talking to experts. primary ways we learn about the people we’re
Experts can often give you a systems-level designing for. Having one of them give you a
view of your project area, tell you about recent Guided Tour of their home, workplace, or daily
innovations—successes and failures—and offer activities will reveal not just the physical details
the perspectives of organizations like banks, of the person’s life, but the routines and habits
governments, or NGOs. You might also look to that animate it.
experts for specific technical advice.
9 hour tour and informal interviews
50-90 minutes Loosely based on interview guides
Based on interview guide All stakeholders on the shop floor
Marketing and Market Research staff of
pharmaceutical companies Challenges
3.2
Themes Probes
Interview
A day in the life What does a manufacturer do?
guide Roles and responsibilities What kind of drugs do you produce?
About their company Do you design and test the drugs you produce?
Role of production and your impact on it What entails a contract? Is it standard or does it differ?
Your role in production planning Demand for generic medication?
Communication between teams What exactly happens in the supply chain? How does demand
Generic medication affect the chain?
Current production practices How does a factory operate? How many people are employed
An overview on the high level
View on quality and regulation under what designation?
questions asked during the expert
interview. These are categorized future of communication and production What are the roles of each designation?
into themes and leading Communication between roles?
questions. This is a general guide, How much is the production dependent on human intervention?
which is modular enough to How does production change according to drug formula?
contextualize for stakeholders. When was the last time production practices were revised?
How long does it take for one batch to get produced? Including
break time.
What resources are needed other than human?
How often does quality of a batch get checked throughout the
process?
How does rejection of a sample happen? How often do you see
batches getting rejected?
What kind of monitoring systems are used?
Documentation of process and analysis
Any points where you feel you could improve?
How do you think technology can transform the way you produce?
Any apprehensions?
62 Pharmaceutical Predictive Analysis
MIT Institute Of Design
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Insights
01 02 03
Insights from the expert
interviews that was done on the Low profit margin Bulk purchase of API Maximizing efficiency
topic.
The current production Buying raw or starting The north star for production
practices cannot be material in volume is good is turnaround time and others
sustainable due to the low because they give the buyer include bottom line, quality
margin of profit they give bargaining power, this optimizing production for
when compared to the cost of reduces the cost noticeably maximum efficiency, capacity
production in large quantities and hence improves the to produce volume and
where the margins are bottom line. manpower utilization
justified”
04 05 06
Variable quality within same Over hiring No planning based on cur-
batch rent info
Most manufactures end up
All pharmaceuticals are very employing more people than Pharmaceutical companies
serious about their quality required, optimizing human are investing in advancements
as an organization buy very resource is much needed as and data informed decision
often production quality isn’t it takes up anywhere from making. Preemptive disease
met and sometimes its swept 30% to 50% of total cost in outbreaks identification better
under the rug and sent to production prepares the manufacturers.
market anyways. Fragmented
data is difficult to use
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
3.3
Sub heading
Factory
Work needs to be done in this situation, they Educating, training and continually maintaining
visit treat the production of pharmaceuticals like the
production of cement, putting their unprotected
competency of workers quickly will be a huge
boon in terms of reduced risk to the product.
hand into the vessels, touching the material, This will also have effects on the productivity of
sneezing into the final product. Human contact workers. Overall the process is very fragmented
needs to be reduced to a minimum, the entire and a lot can be done to reduce ambiguity,
process takes time because the production is risks and unpleasant surprise in the production
not flexible and this leads to a large turnaround process.
time. In a continuous process, let’s say, the
capacity of the equipment is virtually non-
A summary of the factory visit existent. The same batch size that takes maybe
done as a part of the project. 3-4 rounds using the current process of batch
The details of he visit are not manufacturing could be done in a couple of
hours, without the need for human intervention Some factors that were looked at where
disclosed to maintain discretion
or initiation and setup. This report presents the communication, patterns of engagement,
of the facility and the facilitators. current scenario in a small capacity factory problem solving, life in the day of and roles and
which is approved by the WHO. Data needs responsibilities.
to be utilized to make a wiser more careful
decision and loss of productivity in the process
needs to be reduced.
04 05 06
The production has reached As a new plant is set up, The API for a drug is very
maximum capacity. It has safety training and reskilling close to expiry date. There
been optimized and no more workers to maintain safety is is bulk of API but the market
can be produced by API still required. does not demand the product.
remains as excess.
How does training in each such Do you still use up the API?
How is the API used and what scenario work?
happens to the production
process?
The contract worker Changing equipment to keep
the process moving
68
Quality testing compressed Process supervisor
tablets
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
Insights
01 02 03
Insights from the factory vis-
it that was done to gain insider Education level Equipment limitation Maximizing efficiency
experience.
Workers have a very low level Production is highly The north star for production
of education and training dependent on the capacity of is turnaround time and others
equipment, in case of large include bottom line, quality
orders, multiple rounds of the optimizing production for
process have to be done maximum efficiency, capacity
to produce volume and
manpower utilization
04 05 06
Risk of contamination Capacity based equipment Contract unskilled workers
07 08 09
Shut down times Silos of data Up-rooting equipment
Huge stop times even Silos of processes present The plant was set up years
between batches of the lengthy production time, ago and the machinery has
same drug for cleaning and typically it takes 2 to 3 days not changed since then. This is
calibration purposes. for a single batch (200kg) of due to the expenses incurred
material to be converted into in changing equipment so this
deliverable packages. This will be a challenge.
also silo’s the data that is
collected if it is.
10 11 12
Large footprint Repetitive tasks Outcome based
measurement of efficiency
The machinery is so large Repetitive tasks like loading
because the nature of the material and making boxes Efficiency is measured by
process requires machines to are still assigned to humans outcome, but the outcome is
have large capacity so that extremely variable for each
volumes can be produced. product, some products take
2 hours to dry while some
take 4 hours, but turnaround
time is what supervisors use
to brag about efficiency.
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3.4 Pain points
Manufacturing organizations 1. Optimizing resources used in 1. It’s very difficult to keep track of “We need to have an interna- Reducing the operation-
functioning plant all the workers tional presence and make it al costs can lead to better
2. To oversee which contracts to 2. Upskilling workers is a remedial into newer markets as quickly bottom line, this can motivate
take on and which ones not to and difficult task big pharma to participate
and effectively as possible.”
3. Set realistic goals for produc- 3. The operations run at less than more in the generic market.
tion 70-75% efficiency
4. Improve bottom line 4. Changing equipment to suit
5. Maintain pristine working automation or data reading is
conditions highly disregarded due to expens-
es incurred
Operator 1. Operate plant optimally and 1. Training new workers is an issue “I am the operator and the Manual initiation and set-
plan resources for maximum because of the lack of knowledge technician, if something goes up of process work is not
productivity 2. Transferring knowledge is hard, wrong then I have to quickly efficient, they can also learn
2. Oversee all worker tasks and but needed with closing gap of from data being generated
fix it. I train other people by
give training retirement age. by the machine and optimize
3. Planning and optimizing 3. Frequent training inhibits their putting them in situations that their tasks.
production according to market job performance need fixing and guide them
data 4. They are involved in a lot of through it. I need to train
4. Mitigate risks and loss during physical work that could be easily them because I’ll be retiring
processes automated, like cleaning equip- soon.”
ment.
Process supervisor 1. To monitor and initiate pro- 1. No data is smartly utilized from “We have to sometimes utilize Why can the equipment
cesses when required fragmented process, so they have the same equipment 3 to 4 be smarter? We have been
2. To closely manage staff un- to judge efficiency on outcome times to produce according seeing self cleaning ma-
der them and not the process chines become a reality, can
to the market demand. This
3. Participate in training new 2. Mitigating risk while having this be implemented here?
workers quick turnover time is difficult makes it risky to lose one day
4. Maintain, optimize and make 3. Optimizing equipment process in cleaning.” Enabling data and
the process more efficient with the capacity limited equip- retrievability of information
5. Ensure fast turnover time ment is hard of the process and using this
6. Ensure optimized production to conduct analysis and gain
insights into what can be
done to make outcome better.
Plant supervisor 1. To ensure that the plant is opti- 1. To maintain all systems required “Production is not at all cor- Reducing the operational costs
mized to maintain processes, to ensure rect. Why do I need to clean can lead to better bottom line,
2. Maintain important systems all processes between production of same this can motivate big pharma to
for plant health such as HVAC, 2. Keep all production practices to participate more in the generic
drug?”
storage etc a set standard of GMP market.
3. To co-ordinate with field techni- 3. Maintain safety of operation
cians and communicate needs and lessen stop time.
4. Evaluate processes being done
5. Ensure data is collected
Safety staff 1. Train and maintain competen- 1. Creating awareness is not “How can I communicate effec- Predictive maintenance and
cy of all safety staff and field enough, the one time training tively with people who cannot smarter machinery can help in
engineers they get does not ensure safety in speak my language. This is a reducing the risk and burden of
2. Maintain safety of the plant the workplace having to clean and maintain
bad way of training.”
and engineers 2. Individuals are responsible for equipment redundantly.
3. Do regular checkups of equip- their own safety
ment used and maintain them 3. Getting people in order is a “Safety is not managed, it’s Reduce the need for regular
4. Treat every equipment individ- challenging task more like troubleshooting. That check ups, these checkups are
ually and maintain them individ- can be very expensive in manu- a waste of time as you end up
ually facturing.” guessing and then trying to test
your guess.
Quality Analysts 1. Train and maintain competen- 1. To ensure loss is minimized “We have to make it look like Control of information is re-
cy of all safety staff and field while trying to improve quality there is no loss. We cant even quired, no manufacturer can
engineers 2. Accumulating paperwork is not account for the loss, so we tidy up the books because med-
2. Maintain safety of the plant stored or digitized, they cannot icines are about life or death,
spread it across batches of the
gather any insights from the BMR and such practices and risks
same drug.” must be stopped. Automat-
ing the process can remove
all risk involved in production .
Permanent worker 1. To assist the operator in do- 1. It is difficult to reduce the Problems with the current pro- Training can be done in re-
ing manual work like lifting and contact they have with the duction practices: gional languages with practical
shifting material The worker is not trained experience, even if the first 2
2. Reducing human error in the 2. Due to working and environ- days of employment are spent
properly
process mental factors, a lot of invisible in practicing, this will affect the
3. Learning quickly and deeply loss is incurred Analyzing the utilization and level of risk and also be a good
Reduce loss during processes 3. Unionizing workers are a intermediate processes rep- measure of competency.
huge threat to production resent the threat of loosing
material
The process needs to be
Temporary worker 1. Assist the production process 1. Understanding and knowing Due the seasonality of work
closely monitored
in mainly secondary areas where to be is difficult and the extreme lack of educa-
2. Understand and learn tasks 2. A lot of the time they are Reduction of risk in such a tion they have, more immerse
to be done over-hired so they are not pro- production practice is very and practical ways of training
3. Be ready for whatever work ductive 40% of the time difficult due to the nature of needs to be provided.
that needs to be done 3. Upskilling and competency the process
4. Upskill themselves to take on measurement is non existent It would also help us to identify
more tasks 4. Mitigating risk without proper areas for upskilling workers
5. Reduce error to a minimum training is an insurmountable
task
High level managers 1. To ensure that plants bottom 1. Close monitoring of pro- “We do not closely monitor Make it possible to pres-
lines re met cess is not possible due to the the process, we just expect ent and utilize data on plant
2. Strategist COGS fragmentation, so they assess outcomes and then look back- working to help them ret-
3. Ensure minimal loss of ma- production based on outcome rospect and optimize the
wards.”
terial 2. No actionable insights are productivity of operations
4. Reduce human intervention provided
and possibility of risk whenever 3. Ensure that all documents
possible. can clear Foreign Supplier 4.
5. Ensure plant runs optimally Verification Program (FSVP)
requirements
5. Questioning losses is hard
when data is approximated
74
MIT Institute Of Design
Human resources 1. Keeping track of all the 1. Inability to track the workers “ It gets very difficult to man-To make it possible for HR
working staff and identify them age people productivity, they department to gather data and
2. Reduce the amount spent on 2. Redundant process of super- always find a way to slack off. closely manage each workers
production vising PPE usage productivity
Something that could be done
3. Comply to employment reg- 3. Funding and sourcing salary
ulations for workers is hard in 30 min takes an entire day.”
4. Supervise the workers adher-
ence to safety requirements
Market researcher 1. To see what product and at 1. No continuous data “We need data because pro- Make a tool that does not
what capacity the company has 2. No demographic data duction depends on market require them to invest more in
to produce for the next range 3. No objective data coming analysis. No continuous data operations but will give them
of batches from end consumers continuous real time and veri-
is gotten.”
2. To understand the need in 4. No trust in data as it is not fied data that will help mobilize
the market verified within itself market research faster.
3. Be continuously updated with 5. No able to show proof while
qualitative and quantitative communicating production
insights requirements
4. Gain insights by communicat- 6. Improper communication
ing with third party providers 7. Lack of funding to cover
huge areas, this reduces sam-
ple size
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3.5
Workshop and
brainstorming
session
Presentation of factory
visit withing 48 hours
of visit
Insight formation
Brainstorming and
insight formaation
77
Smart retrofitting Predictive production Continuous manufacturing
3.6 Concept
Retrofitting existing factories Using Real World Data to Introducing equipment and
ideation to enable data collection and estimate and plan production automation tools to bring
Ideation and high level evaluation
automated BMR filling. according to current scenario, continuous manufacturing to
from insights gained
thus reducing need gaps pharma.
Using AI and OCR to take Using existing PLC’s and edge Reduce invisible COGS when
existing paperwork collection devices to collect data about it comes to over hiring and
methods and allowing them to process maintaining plant productivity
be digitized. using RFID, smart cameras
and mobile platforms.
79
Quick tracking Immersive upskilling Continuous improvement
Providing a platform to enable AR VR and web based train- Introducing continuous im-
FDA and regulatory bodies ing modules to accustom provement with data collect-
to quickly identifying deviant and quickly upskill workers to ed. Data centered continuous
and bad drug using electronic reduce knowledge gaps. improvement platform.
BMR and block-chain.
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Build
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
4.2
Study method
Understanding
Questionnaire Informal interviews
the user The need for a questionnaire is to validate the concept and gain This helped me focus on the core values that I
insights into current process and needs. can provide as a product and hear the intensity
of the pain point which was missing in the
Goal questionnaire.
To identify current tools they use in understanding market
How often do they use these tool? If periodically, what defines Target populous
the periods? Market researchers
The objective of this section was
How does your research affect production, how often and after Pharmaceutical market research groups
to understand the users wants,
what period? Pharma companies
needs, challenges and what tools
they use to overcome them. What activities are in place to ensure market research is sound? Ex-Pharma company workers
Are they proactive or reactive? Why?
How soon can they use their insights? These are not published as they were requested
What do they imagine the future of market-scaping to be? to be off the record.
Target populous
Market researchers Co creation session
Pharmaceutical market research groups One potential user was kind enough to spend
Pharma companies some time with me to explain the process of
Ex-Pharma company workers market research and how it is bespoke for
each company.
Co creation studies
The idea of co-creation is to unleash the creative
energy of many people, such that it transforms
both their individual experience and the
economics of the organization that enabled it.
3 days
The idea was presented to them and we started with
information architecture and led all the way to wire
frames (they were exceptionally good)
Challenges
Image
4.2.1
To keep the consumer at the cen- To gain competitive advantage
What does ter of their process
To gain competitive advantage, companies
market try to maximize on potential market growth.
Market research is used by pharmaceutical This works on multiple levels as market can
research help companies to connect with their end only filled with competition and the more the
consumers and understand their pain points, competition they push their own power outside.
you achieve? apprehensions, any side effects and their
needs. It helps answer very qualitative Market research here is used to scope out the
questions for the company that helps it adjust market. The market i continuously changing as
it’s production, research and development. his is a need based market and the needs need
to be identified right down to the source. This
A brief look at the reason why A new trend that is seen in this industry is forces the companies to need iterations a lot
market research is done in a user centered approach to designing and and for good reason
pharmaceutical companies. producing drugs.
Usually the data that is taken from history both Market research especially when launching
near and far is used to take decisions on the and post marketing studies are usually done to
upcoming production cycle, this is because of scope the public perception and performance
the fact that the nature of the reports are that of the medicine. This performance data is
way. For example ICMR is data of 20117 and based on multiple factors like sales, demand
2016 have to be used to predict the production etc. A products performance is very important
for 2018 not because of the limitation of the to identify the value in continuing production.
company but due to the fact that tools are not
available to get current data to iterate on the
planning of production.
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
4.2.2
Forecasting production plan Strategize production activities
How does
Putting ll your eggs in one basket is never
it affect a good idea, but neither is diluting your
Market research is used to forecast the demand interests. It is therefore important for these
production? of certain product and this demand is directly pharmaceuticals to identify certain key
translated in this industry by planning the directions using market research and utilize
production of certain products and prioritizing this method to effect production to be more
certain products over others. This is especially efficient and have more impact in the market.
true for companies that are larger than
average, they typically have hundreds of
products and discoveries under their portfolio
A brief look at the reason why with multiple drugs in a segment but it is
market research is done in important to focus on what to produce and the
pharmaceutical companies. more localized you can focus that the better it
is for the planning and the market.
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
4.2.3
List of stakeholders
Who are the
Production Manager Potential users of the product Targeted devices
stakeholders? Market Researcher Production Manager Primary
Sales and Marketing Market Researcher Web app
Sales and marketing Mobile app
Pharmaceutical
Physicians
Patients
Insurance providers
Diagnostic centers
Pharmacy’s
CMO’s
Data pools
Stakeholder mapping
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4.2.4
Methodologies used
Survey design
Survey/ Questionnaire Target
and results
A questionnaire was the perfect tool to quickly get • Target populous
answers and subjects without being too boring or • Market researchers
intrusive into this bespoke industry. • Pharmaceutical market research
groups
• Pharma companies
• Ex-Pharma company workers
Online surveys were the chosen mechanism
and the tools used was Google analystics which
In order to gain surface level is a survey and subsequent analytics platform
speaking points and subjects to developed by Google. It has a clean user interface
study, a survey was designed. and is easily approachable.
This would further prove to
be extremely useful in the co The content of the survey is discussed in the
creation sessions that were done results section but the goal was to--
further along the line.
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
Results of
survey Professions Companies Market type
Medicine types
Antibiotic
Analgesic
Branded Generics
Bronchodilators
New Molecules
Anti-Histamines
Generics
Antacid
Specialty
Anti-Inflammatory / Steroids
Hormones
Vaccines
Sedatives
Anti Spasmodic
Cancer injectable and orals
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4.3
IMS or IQVIA SMSRC
Discovering
IQVIA also known as IMS before going through SMSRC is a very popular tool used by market
tools they use a merger and acquisition is a tool that is researches that supplied data and analytics to
used by market researchers which also uses multiple industries in a bespoke manner. In the
real world data to give actionable insights to pharma industry they carry out internal ales
customers. research and prescription analysis to determine
market need and distribution.
They use goth tool wise frameworks and on
demand frameworks which give more flexibility
to customer than most others.
Pharmacy data
Surveys ICMR
Surveys are sent out to multiple stakeholders ICMR is an organization that provides data
in their business, some of them include internal and reports on epidemics, demand and other
teams, patients, doctors and physicians, and information that if not directly indirectly relates
pharmacies. This is a very important toolbor and changes production patterns.
understanding some level of qualitative
sentiment across of the company or medicine. They put up reports yearly and this is great
information for forecasting and studying but no
Some drawbacks of survey is the time real world data is provided.
required to get a good sample size and the
investment required to not only onboaard
participants and reward their participation
but also for staff to go around to each and
every market and conducting surveys.
Image
A view of ICMR
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
4.4
Jobs To Do 01 02 03
Results curated from survey to
understand the use. To be updated with To be aware of any epidemic, See how they stack up with
information of their interested predict it and react in time to their competitors in very
fields. reach market to fill need gaps. localized markets.
News, daily updates on Epidemic detection and Market share analysis tools
areas of their liking marked insights (Cross verified) gained from stock market,
according to keyword, Internal based on demographics, news & articles, local market
news publishing tools. geographical and any purchasing trend, competitor
associated disease and pricing data.
product matches.
04 05 06
Get sales, prescription and Have a set of insights that are Gain knowledge on local
distributor data on localized actionable and match with demographic, geographic and
areas. their particular profile. climatic conditions quicker.
The mentioned data gotten A part of the platform has to Real world data on
from “data partners” be dedicated to specifying demographic based diseases
the profile, products range and illnesses faced, qualitative
with targets(biological factors from healthcare
targets, demographic target, providers, data from end
symptoms or associate consumers of their adherence,
disease targets, diagnosis qualitative data about why.
targets etc.), markets
targeted, type of features
98 Pharmaceutical Predictive Analysis they require, etc
MIT Institute Of Design
07 08 09
Understand public, hospital Gain insights and not have to Gain real world data of
and healthcare provider do it themselves multiple markets, national and
perception of drug. international.
Periodic surveys that improve All tests that are required are Split data when required
the healthcare provider data done automatically and the according to countries, states
that, using search and trends user gains insights and can and regions as micro as
data, using social media data. always check the math that possible, EMR data if present.
was done, these insights have
to be matched with other
historical data.
10 11 12
Gain in-depth knowledge Coin and customize reports Gain knowledge on local
for each type of disease, that they would need. Eg: If demographic, geographic and
regarding their sources and they want to compare sales climatic conditions quicker.
the are and examining further. of x, y and z drug with respect
How? to time they should be able to How?
create that.
Disease matched data, for Real world data on
dengue the water source How? demographic based diseases
would be important to and illnesses faced, qualitative
A part of the platform is
make correlations, for food factors from healthcare
dedicated to analysis tools , it
poisoning you can target providers, data from end
contains epidemic and growth
certain restaurants and then consumers of their adherence,
analysis and also a space for
gain data of anyone who goes qualitative data about why.
generating custom reports
there and then understand
and visualizations which you
how many more will come
can download share and doc-
with a level of uncertainty. 99
ument.
Ashwin Suresh T UG User Experience Design Graduation Project 2019
4.5
PERSONA
Kirsten M Goals
PERSONA
Researcher 1. Convey market needs to the production 1. Collaborating with multiple third party pro-
team viders is exhausting
2. Make sure that deadlines are set for set 2. All the reports are already old, predictive
deliverables tools leave a huge gap of failure
3. Keep bottom line up and ensure costs are 3. Expensive to employ people to gather local-
optimized ized data
4. Communicate with sales and production 4. Relying on third party only because of op-
5. To identify gaps and potential market take- erational expense and not talent
overs 5. Very limited voice in decisions making
6. Make reports to convey decisions back- impaired by the lack of funding for current
Neeraj Kulkarni
ground support data
Sanofi, Mumbai
B.Pharm
5 years of experience
28 years old
Goals
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
PERSONA
Supervisor 1. To ensure that the plant is optimized 1. Monitoring systems and coordinating with
2. Have conversations and communicate ef- people parallelly can be tasking
fectively with market researchers 2. He/she cannot keep track of all the workers
3. To co-ordinate with operators and workers 3. They have no means of benchmarking pro-
4. Evaluate processes being done duction objectively
5. To fill in the BMR 4. Any change they make is not communicat-
ed properly and they are not able to have a
conversation
5. Currently operating on we say-you execute
model
Ranjan P Goals
PERSONA
Manager 1. Ensure costs for market research is down to 1. Changing according to market required too
a manageable amount much investment and the return is ambigu-
2. Analyze the production and communication ous
channels 2. They can only afford 1 or 2 third party ser-
3. Ensure tools are given when capable and vices
necessary 3. Value for money is not there due to the
4. Acquire as much of the need gap in the very small sample size
industry as possible
Natelie Stewart
Goals
Sanofi, India
M.Pharm 1. Have a huge sample to study from
30 years of experience 2. Aggregate and reduce the number of exter-
45 years old nal dependencies the pharma company has
3. Continuously update themselves and their
company of need gaps
4. Convert processes into highly actionable
steps
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
PERSONA
Manager 1. Realize and communicate value of tools to 1. Communicating and setup for multiple
manager and rest of the decision makers accounts individually is hard
2. Setup and supply all teams to all plants(in 2. Training is a huge setback in some cases (if
case of MNC) to standardize processes the software is too complex)
3. Develop personal relationships and plans 3. Communicating value for individual
with the service providers stakeholders is extensive and sometime
4. Reduce learning curves by providing they need to try it to guarantee a service
training or reducing inputs
4.6.1
How might
we’s
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
INDICATOR ISSUE/INSIGHT
4.5.3
XO’s - XO1_Reduced number of resource
utilized
Too many resources including third party resources and expert staff
are used which makes it unapproachable for many producers.
Experience
Outcomes
XO2_Increased Collaboration Due to the isolated nature of market research, not many stakeholders
are involved in the process of decision making.
XO3_Faster Mobilization of Research The timeliness for gaining information from a pharmacy for example
is too much. This leads to lots of wasted time and iteration is not a
possibility that is entertained
XO4_Improved precision of Decision The data used in many reports is projected from last year or the year
making before and used to predict and plan production for the upcoming
year, the range for deviation is too long.
XO5_Decreased cost of research In order to gain better data and clarity about localized consumer
patterns, it gets very expensive and impossible to access.
XO6_More iterative and adaptive Due to the painpoints mentioned above, it is crucial that researchers
production are spot on and the predictions cannot change very much, this is very
limiting and not flexible.
Market Researcher Contract specialists and specialty Reduce number of resources required by
organizations to conduct isolated parts of 50%.
Pharmaceutical
market research and the collate the data.
All stakeholders Stakeholders are touched and informed By bringing multiple stakeholders on
at multiple stages of research and the same platform, we make decision
important stakeholders are ignored till all making by default more informed and
plans are set. collaborative.
Market Researcher The data takes month(s) to get collected Reduced time for market research by
and then it has to be manually formulated 80%
Pharmaceutical
and insights need to be gained form that
very limiting pool.
Market researcher The decision is made on a very small Precision in prediction improved by 50%.
sample size when market research is
Patients
done, this means the decisions have a
Pharmacies and HCP huge possibility of having shortcomings.
Market Researcher If companies do strive for more and Bigger sample size possibilities and
better data, i gets expensive to collect. richer data pool.
Pharmacies
Patients Market research is mostly done when Iterative culture is brought to the
there is a desperate need, which is not industry with respect to market research.
Pharmacies and HCP’s
good for patients, epidemic mitigation
WHO and National Health Safety Systems and general market need gap filling.
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4.5.4
Brief
What is the
Solving the problem of lack of localized and For this the tool needs to be
solution? proactive actionable insights on the population • Modular
that is affecting the marketing and production • Scalable
due to the alleged westernized data they
• Unbiased
work on. How can the events of the ever
changing world going to affect manufacturing? • Smart
[117]
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4.5.5 Revised
system
Input
Output
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4.7
Information
Architecture
Fig 10
Information
Architecture
Hero Flow
Get updated See updates on vision products *
Create activities based on insights Create activity based on discussion and need
Do activity
Fig 11
Hero Flow
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4.9
The need
Framework for
It is important to give a framework and a way If I tell you that 2 million tablets of Paracetamol
data of working for data . This is due to the fact that was produced today, I need more context. With
without a framework, data cannot be curated information like comparisons (how many were
utilization and or cross verified and vetted. Without going into made yesterday), change (what changed in
detail, a brief discussion of how data works is the way I produced that it may have lead to
collection discussed here. change), relational context (market yesterday,
today and tomorrow) and what is it supposed
to be (a set standard learn from multiple such
processes), only if I have all this information I
am able to say if the production was good or
How will this data be used? How bad, how bad was it and what can be changed.
will the end user discover and be
able to use the data? This is the process of continuous improvement,
and for branded generic manufacturers, the
edge they have when it comes to voice in
market depends on their competitive edge.
Data sources
Fig 12
A visual rep-
resentation of
contextualization
of data
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data Social study Social media activity/ Sentiment All social media channels
analysis/ Public perception
Internal sales data (Hospital sales) Patient charts, hospital attached pharma
POS, EMR
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
data Treatment data Patient treatment lifecycle data Patient Charts, EMR
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4.10
Insights Investigate
Initial features
This feature includes insights from the data we It is not possible to make all correlations on the
included collect and correlate. This is a visual dashboard first go without testing and getting OVOC’s. In
style feature from which the user can deep dive order to provide users the flexibility of using
into certain sections to get informed about the the data pool we have to their advantage, we
particular section. give them a tool which they can use with a few
simple steps that can bring them insights from
This works on multiple levels, as identified from any correlated parameters.
the user during co-creation. It is important to
have levels which start from their company This can bridge gaps and give us insights into
data to their products and to diseases they are the kind of data users are looking for.
targeting as market opportunities.
Collaborate
Image
Making the Infor-
mation Architec-
ture
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4.11
Design
principles
01 02 03
04 05 06
07 08 09
BREAK THE CHASM VISUAL MORE THAN TEXT Overviews and drill-downs
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4.12
Workflow 01
ADVANCED MARKET DATA
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Workflow 02
COLLABORATIVE DECISION
MAKING
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Workflow 03
COMPETITIVE EDGE
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Workflow 04
EPIDEMIOLOGY ANALYSIS
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4.13
Wireframes
With the information architecture
and the workflows. These
workflows helped me identify the
touchpoints of screens.
Fig
How to make like
this and scram till
you scream.
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Workflow 01
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
Workflow 02
Workflow 03
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
Workflow 04
Mobile wireframes
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Visualize and validate
Ashwin Suresh T UG User Experience Design Graduation Project 2019
5.1
Hypothetical
branding
Lgo
Type
Usage
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Mood board
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
5.2
Design
Elements
Icon fills
navigation overlays
Button colours
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Mobile Web
Design
elements
Secondary
Secondary
Navigation
Primary
Primary
Cards
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Design
elements
Inter UI
ABCDE Web typography
12345
Title
Typography
Card title
Bold / Medium / Regular
Body
Mobile typography
Title
Card title
Body
Data
visualizations
KPI
Drill downs
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5.3
Home
Visual
Design
The home screen acts as a divergent point to all other parts of th platform. The
KPI for the home screen is for the user to go through workflows . Use cases
were discussed and a Pinned to Home option was discussed to reduce the time
taken by users to reach certain drugs they need to check very often.
Drug overview
A drug overview takes multiple KPI’ s that is looked for in a drug by the users
and presents them all in the first fold, as you can see there are categorized drill
downs available for more details.
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Disease overview
Similar to the drug screen, the disease part of the platform shows the user details
and updated information about diseases. But the details are for a secondary level of
information. In order to provide a birds eyed view of the diseases KPI to the user he
can learn much more, much faster.
Segment ovverview
A segment is usually targeted for growth stats so that need gaps and expansion in the
segment can be made with more confidence and clarity, so it is important to show growth
information and important KPI to prevent cognitive overload.
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Generative Insights
Generative insights is a section dedicated to help users fill gaps in information and
identify potential data that they need which was not provided. This comes from the
use case that we might not be able to provide all the information a user looks for.
So inorder to know what is important and gain quicker insights into their needs this
section is used.
Epidemic Study
A section dedicated to investigate growth of epidemics, here the user can choose a
disease and opt for a market to study an d have drilldowns and key stats
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Activity overview
A primary screen that acts to give an overview of all planned activities with
basic tab filter to reduce searching and identification time.
Activity setup
The scheduling part of the activity segment of the platform, this is the section where
you use the insights to make them actionable.
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Mobile application
This is just a visual walk through of the mobile platform. The platform is yet
to be fleshed out end to end. The main objective here being the dark mode
visualization.
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5.4
Methodologies used Learnings
Usability
Heuristics Content
testing
An expert analysis done to look at the platforms • Content is classified and clustered
usability using a functional point of view. according to co creation session,
usage patterns will dictate what
needs to be adjusted in the KPI.
• A potential would be opened if
usability tests with eye tracking was
This an evaluation method developed by NN
possible. This could open the world to
group to provide parameters as determinants
information privatization.
Usability study was conducted to measure the general usability hygiene of the
after the platform was product you build. The parameters provided
prototyped, this is due to the there are extrapolated and contextualized
Visualizations
according to my requirements.
simple fact that i as a designer
am not a domain expert and can The content of the heuristic is discussed in The visualizations styles used especially
only judge it with the lens that i the results section but the broader themes of when it comes to data representation
have built to see the world with. judgment are- were accurate in terms of the styles used
and the visual treatment helped them
stand out.
• Text needs to be reduced
• The colors need to be maintained
Content
• S tatus needs to be more prominent
Visualization
Navigation
Interaction
Guidance
Guidance
System status
Default options/ reduced tasks As a quick tip, guidance needs to be
always made easily accessible, including
a chatbot option or some sort of quick
help and guidance will help make
the experience smoother and more
satisfactory with information structuring
as a constraint.
164 Pharmaceutical Predictive Analysis
MIT Institute Of Design
Navigation Interaction
The navigation had two levels to it, this The interactions were limited to tap and
provided clear and concise information drag on the website and touch and drag
delivery, the navigation was a repeated on the phone and table adaptations. This
pattern both in the primary and was limited due to the level of gesture
secondary stages of it. knowledge possessed by the users or
It was approached differently in this perceived to be possessed by the users.
product because of the fact that most This is subject to change after user study.
users would have a learning curve, so it
is important to give an expanded view Micro-interactions need to be added
of the primary menu options, this can be • Working on success messages,
permanently hidden and the platform error messages, off line modes and
can be used without to help reduce unavailable data modes need to
clutter for expert and learned users. be better established. These need
to further reinforce the existing
interaction and information delivery.
System status False interactions need to be reduced
• This needs to happen by limiting the
Although present, multiple levels of color options, sometimes user might
status, especially in form fillings need to perceive a blue highlight as a hyper
made more evident and obvious. link due to the similarity in treatment.
Default
Taking a scenario or a use case such This could be pre sorted, pre selected
as “If I am from India, I want only that options or pre zoomed maps to give
markets information, so that needs to lesser of a task and reduce the friction
be default”, it is easy to understand why between information identification and
giving a scalable service to regional, learning.
national and international producers
needs a level of default options set in
place.
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Methodologies used
VIMM Learnings
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Methodologies used
In order to further understand the the shortcomings • Don’t undermine their UX abilities- When they
and areas required to be worked on, it was extremely suggest or have opinions on the user experience
important to understand the users side of things in of the product it is important to keep in mind to
not sun, debate or undermine their opinion and
a qualitative “why” centered way. If this platform ws
cast it against an experts to see the validity of
to move forward then these are important questions
the opinions.
that need to be answered. This also analyses the • Learn patterns of intent (the users wanted a
contextual nature of the multiple tasks and the open hover on explanation they wanted this to
ended nature of the study helps in providing deeper be sure of their destination and they kept hover-
knowledge than any of the alternatives. ing hoping for a trace window)- The us-
ers may choose different routes of navigation or
will be expecting certain outcomes, thy to under-
It provides us with an opportunity to immerse into
stand those expectations.
the users context, their apprehensions and their • Probe only when necessary, let them do the
opinions. talking- In a think aloud it is more important
to listen than to ask, when we ask the user cer-
tain clear questions, they might develop a bias
which will taint the study and result rendering it
As of last record, the sample size is 3 users, this useless.
will improve as new user recruitments happen and
the study will improve in better testing condition
Key takeaways
Target and inclusion Probes were used only when extremely necessary, for
example when the user is clueless about where or how
Due to the niche target audience, it was a to navigate and complete a task, when the user makes
tricky task to define users to use for the repetitive mistake etc. These questions are the onus
study, the more picky we geet, the lesser of the usability expert present to find contextually
insights we have to cross validated but appropriate and probe accordingly.
the broader the classification the more
diluted the insights become. It was finally
chosen to recruit the participants of the
Setup link was shared with them. They were instructed
questionnaire due to their introduction
to help my process by providing me with proof of
to the topic and their expertise in the
industry. testing, this was due to the fact that many of them
reported screen recording and/or screen sharing as a
Characteristics like complex activity that due to the time constraints they
Demographic found hard to comply to (due to this constraint the
Tonality
nature of the study was changed from think aloud to
Regionality
retrospective).
were discarded as potential filtering
mechanisms
Users were given link to the prototype that was
and Job roles prepared, the prototype is still under construction and
Level of experience is subject too representational change post user study.
Domain Knowledge
were given more importance
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Method Method
Method of gaining insights • Users reported a severe level of stress due to the timeline for
Though the initial plan was modeled informing them
after an ideal usability analysis the users • Users were above 50 and some were retired and many were
were kind enough to allow me to engage retiring soon
them in conversation post them using • Users reported a level of complexity when they tried to access
the site for the tasks, for proof of test the same parts of the insights section
and due to the limitation (of time and • Navigation is not easy for them, they report as being confused
resource utilization) they were further by where they were
instructed to be on call while they carried • The users felt like the information was very new to them, with
out the task. further probing they felt that there was a clear learning curve.
This they reported was due to them never experiencing such a
product.
• One user expressed his need to be trained to handle such a
Briefing
software.
6.1
Business
model
Customer relationships
Customer relationships
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
6.2
Scalability Unified framework
So what does
The platform needs to identify ways to A unified framework for data collection needs
the future look integrate multiple third party manufacturers to be done so that we can convert multiple data
and present that data and also work at touchpoints and be able to read and collect
like? multiple tiers of the industry as having multiple that data and see what is missing and discard
KPI needs. The platform needs to be able to bad data. As of now there is no single data
scale their data pool in terms of tier 2 and framework for EMR’s and billing information,
3 cities and identify unique touchpoints of the system needs to be able to adapt to this
measurements in these localities. situation.
7
Concluding
thoughts
Although my experience in Honeywell has not Although this project admittedly does end
been concluded yet, it has been nothing short off at a cliffhanger, the rest of the journey of
of eventful till now. I started this journey with validating the design decisions need to be met
a goal in mind, to understand and adapt to a in order to bring it closer to completion. That
culture that I have never experienced before, will require funding and recruiting users and
MNC’s have this rapport of being strict and on SME’s, which although reachable, is a topic for
flexible and although that was not half true another day. Anybody who is interested in the
and the experience was extremely forgiving, I project is free to email me and I will be more
got to learn how to adapt to that a completely than willing to walk you through it.
different setup.
With the right funding and the right people
I got to work in a domain that is very close to working on this concept and my willingness to
my heart and so crucial in the economy, I am unlearn all of my insights, I feel this platform
glad to have tried to make a change and see has a future in aiding decision making in the
my progresses from where I started been I had pharmaceutical production circle.
nothing to where I stand now with a product
That I can test with potential consumers. This
project has helped me in going through each
stelp of the product design pipeline and it a gift
that keeps on giving.
8
Through college
The journey
MIT Institute of Design has been a wonderful There are many variations of passages of Lorem
till here journey that changed my life, I would argue, for Ipsum available, but the majority have suffered
the better. The first time I had lives so far away alteration in some form, by injected humour, or
from home and many more firsts made this an randomised words which don’t look even slight-
opportunity that is a gift that keeps o givng. All ly believable. If you are going to use a passage
the friends I made, all the criticisms faced and of Lorem Ipsum, you need to be sure there isn’t
the fights fought have made me stronger. anything non-characteristic words etc. sn’t any-
thing non-characteristic words etc.sn’t anything
The cultural diversity of MIT Institute of design non-characteristic words etc. If you are going to
makes it easy for you to lose your judgment, use a passage of Lorem Ipsum, you need to be sure
The last four years of nurturing it makes it easy for you to be in control of there isn’t anything non-characteristic words etc.
my creativity finally finds a your life, be disciplined and also gives you the
stage to be presented. This is opportunity to stand back and wonder how
your room got so dirty. There are many variations of passages of Lorem
great responsibility but also,
Ipsum available, but the majority have suffered
it gives you an opportunity alteration in some form, by injected humour, or
to explore with people in the As a part of the first batch of under graduate randomised words which don’t look even slightly
industry guiding you. A designers User Experience design learners who would be believable. If you are going to use a passage of
graduation project prepares them graduating. it is a responsibility on us to prove Lorem Ipsum, you need to be sure there isn’t any-
for the industry. to the college that this is a valuable UG field thing embarrassing hidden in the middle of text.
but also in setting examples by leading and All the Lorem Ipsum generators on the Internet
sharing. tend to repeat predefined chunks as necessary,
making this the first true generator on the Inter-
net. It uses a dictionary of over 200 Latin words,.
What is design?
Articulating
Design is a form of using common sense to My inspiration
UXD elevate problem solving. with a set of tools. It
is always considered as the last mile of the Apart from my seniors, faculties and peers,
process of building anything be it a product, a there have been a few organizations who are
service or a movement. It a value addition tool evangelizing the industry and it is great to see
that improves on any given idea. Design can that they are not only spreading awareness
be practiced anywhere for anything. and 80% but also helping other designers grow with the
of tools are easily accessible to people with no tools they provide. For examples, Ideo- a global
formal design education. design thinking consultancy founded by the
Kelly duo is an industry leading voice in the
User Experience Design was As long as you build the confidence to be market.
established in MIT Institute of creative, the potential of fearless creativity can
Design since 2016 but as a Post be unlocked.
There is so much innovation happening in
Graduate discipline. Since 2016,
companies like AirBnB with them being a design
the course was reinvented and led organization to smaller startups taking up
retrofitted to suit a full 3 year Being a generalist really helps out in this field the design first approach to product building
Under Graduatee program.. of work, is my opinion as it helps you correlate and innovation incubation. Design has a bright
information and inspirations to tie up things future ahead of it.
thaat have no corelations.
Fig 1
Elements of UX by jessie James
Garrett
183
9
In retrospect
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
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11
Appendix
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
Purpose Step 1
Co-Creation
Briefing
study Co creation session is a very effective way
that was identified for both exploratory and
conclusive design research study The participant was briefed using the presentation
A 3 day workshop I have prepared for the SME’s. This was used
This tools was used to hint at the deeper needs for the the user to be quickly on-boarded and
of the user and was successful in doing so. It knowledgeable about the solution and the process
also acted as a starting point to formulate and followed till now.
validating earlier findings and insights.
Any of their questions were answered and their
Due to the Greenfield nature of the project understanding was objectively judged.
it was near impossible to d research in the
given timeframe and formulate things such
as data points.
Step 2
I would like to extend my gratitude to After the briefing and casual conversation
Mr.Suresh Vasudevan, his 21 years of revolving around the subject matter and their
experience in the feild of pharma and his experience in the field, I had to set certain
background in BA.Economics and his title as expectations as far as the outcome of the study is
a Zonal manager and the journey till there concerned.
proved to be crucial in my research and the
project would not have taken shape without
him and his patience.
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Ashwin Suresh T UG User Experience Design Graduation Project 2019
Step 4
The results were studied and the study was used All the details including subjects like what are the
to extrapolate larger themes of features and different types of epidemics, what are the different
information that needs to be segregated. This subdivisions needed etc are directly translated into
could be considered as a reverse engineered card the information architecture.
sorting. This information was then presented to the
user and the second round started.
results 3.
4.
Company
What kind of disease does your company manufacture medicines for?
5. Type of medicines you produce?
6. What market do you cater to?
7. Does your company actively conduct market research?
8. How does this study help?
9. How often does his research happen?
10. How important is market research in deciding production?
11. Does it directly affect production planning?
12. What tools do you currently use for market research?
13. How effective are the tools mentioned below?(Certain tools mentioned below with an add other
option)
14. How important are the following factors for deciding what is to be produced?
15. How long are the decisions effective for?
16. Do you often resort to third parties in conducting research?
17. Rate some obstacles based on their level of impairment.
18. Any other obstacles you face
19. How adaptive are you and your team to new technology?
20. What according to you is the future of the tools you use for market research?
I understand that there are 20 questions but the users were comfortable enough to have 100%
completion.
200
201
202
203
Statement of originality
I, Ashwin Suresh, student of MIT Institute of Design, Pune (Maharashtra) for the year 2017-18, hereby declare that the
contents of this thesis is my own work and it contains no full or substantial copy of previously published material. I
certify that all data, figures and assistance of any other for received in preparing this thesis and sources have been
acknowledged. All the material about Honeywell has been approved by the company.