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Dengue

The document summarizes the pathogenesis of dengue virus infection. It begins with environmental and host factors that predispose to infection by Aedes aegypti mosquitos carrying the dengue virus. After a 3-14 day incubation period, the virus disseminates through the bloodstream and stimulates immune cells. The virus ultimately infects liver and spleen cells, causing apoptosis. This can lead to hepatosplenomegaly and thrombocytopenia, hallmarks of dengue hemorrhagic fever. Capillary leakage of fluid into tissues then causes dangerous complications like shock that can be life-threatening without treatment.

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Kathleen Dimacali
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253 views4 pages

Dengue

The document summarizes the pathogenesis of dengue virus infection. It begins with environmental and host factors that predispose to infection by Aedes aegypti mosquitos carrying the dengue virus. After a 3-14 day incubation period, the virus disseminates through the bloodstream and stimulates immune cells. The virus ultimately infects liver and spleen cells, causing apoptosis. This can lead to hepatosplenomegaly and thrombocytopenia, hallmarks of dengue hemorrhagic fever. Capillary leakage of fluid into tissues then causes dangerous complications like shock that can be life-threatening without treatment.

Uploaded by

Kathleen Dimacali
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Precipitating

Environmental conditions (open spaces with water


Predisposing pots, and plants)
Geographical area – tropical islands in the Immunocompromise
Pacific (Philippines) and Asia Aedes
aegypti (dengue virus carrier): 8- Mosquito carrying dengue virus
Soldier
12 days of viral replication on
Sweaty skin
mosquitos’ salivary glands

Bite from mosquito (Portal of Entry in


the Skin)

Allowing dengue virus to be inoculated


towards the circulation/blood
(Incubation Period: 3-14 days

Virus disseminated rapidly into the blood


and stimulates WBCs including B
lymphocytes that produces and secretes
immunoglobulins (antibodies), and
monocytes/macrophges, neutrophils
Antibodies attach to the viral antigens,
and then monocytes/macrophages will
perform phagocytosis through Fc receptor
(FcR) within the cells and dengue virus
replicates in the cells

Recognition of dengue viral antigen on


infected monocyte

Entry to the Entry to the


spleen bone marrow

Release of cytokines which consist of vasoactive


agents such as interleukins, tumor necrosis factor,
urokinase and platelet activating factors which
stimulates WBCs and pyrogen release

Dengue
Virus ultimately targets liver Cellular direct destruction and
and spleen parenchymal cells infection of red bone marrow
where infection produces precursor cells as well as
apoptosis/cell death immunological shortened platelet

Hepatosplenomegaly Thrombocytopenia

Dengue Hemorrhagic

Increase number and size of the pores in the


capillaries which leads to a leakage of
fluid from the blood to the interstitial fluid
(capillary leakage) of the different
Pleural effusion
Ascite

Complications:
Intense bleeding
Recovery
Pulmonary Edema
Shock
Very low blood
pressure
Liver cirrhosis
Death

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