DNA•STRIP Technology
Reliable diagnostic assays
for your convenience
On basis of the approved DNA•STRIP technology we offer you a broad range
of test systems for the determination of human genetic and microbiological
parameters.
Your benefits
• Reliable
• Highly sensitive and specific
• Cost-efficient
• User-friendly
• CE-marked
DNA•STRIP Technology
Assay principle DNA/RNA- Free Amplification Denaturation Sample preparation
DNA•STRIPs are coated with specific probes which are extraction from DNA/RNA Starting point of the analysis is a specimen from
the specimen
complementary to the amplified nucleic acid (amplicon). which the nucleic acid is extracted. The nucleic acid
After denaturation the single-stranded amplicon specifically is selectively amplified in a subsequent PCR reac-
binds to the probes (hybridization) and is visualized in a tion. Since single-stranded nucleic acid is required
subsequent enzymatic color reaction. As a result a specific for the next step, amplification is followed by a
banding pattern develops on the DNA•STRIP. This proce- denaturation step.
dure can be performed manually or can be automated.
Hybridization Conjugate binding Colour formation Evaluation
GenoType
DNA•STRIP
with developed 2
3
bands
DNA•STRIP Streptavidine
with specific
probes
Alkaline
phosphatase
Benefits of using the DNA•STRIP technology Internal controls ensure valid results Evaluation
Reliable: Internal controls document valid results and secure User-friendly: In contrast to conventional methods, the The combination of specific amplification and hybridization The evaluation of the DNA•STRIP can easily be performed
safe and impeccable test procedures. Thus, a high diagnos- DNA•STRIP technology saves valuable time and can guarantees a high level of diagnostic reliability. Internal by aligning it to a template. Consult the corresponding
tic reliability is guaranteed. easily be integrated in your laboratory routine. controls ensure valid results: package insert in order to interpret the banding pattern.
The genotype or microbiological organism present can thus
Highly sensitive and specific: The chosen targets of the CE-marked: No need for elaborate validation studies. • All DNA•STRIPs: The Conjugate Control documents the be reliably identified.
different test systems ensure high specificity combined with efficiency of the color reaction.
maximum sensitivity.
• Microbiological DNA•STRIPs: The additionally integrated
Cost-efficient: Only minimum technical equipment is need-
Universal or Amplification Control shows that the test
ed for processing. This allows for a cost-effective imple-
was performed correctly.
mentation in all laboratories.
• Human genetic DNA•STRIPs: Gene site-specific
Sensitivity Controls confirm the sensitivity of the hybridi-
zation reaction. If hybridization took place under unspe-
cific test conditions, this is documented by the Specificity
Control.
Tests based on the DNA•STRIP technology
Human Genetics
ThromboType
®
Factor V Leiden, Factor II G20210A
ThromboType plus
®
Factor V Leiden, Factor II G20210A, MTHFR C677T, A1298C
GenoType CVD Eight different thrombophilia-associated mutations
GenoType MTHFR Most important MTHFR polymorphisms
GenoType ApoE Alleles ε2, ε3, ε4 of the ApoE gene
GenoType PAI-1 Most important PAI-1 polymorphisms
GenoType HH Hereditary hemochromatosis
GenoType AAT Alpha-1-antitrypsin deficiency allele
GenoType LCT Most important polymorphisms of the lactase gene
GenoType SugarTol Polymorphism in lactase gene C-13910T and 3 polymorphisms in aldolase B gene
Microbiology
GenoType MTBC MTB complex differentiation from culture
GenoType CMdirect MTB complex, NTM differentiation from clinical specimens
GenoType Mycobacterium CM MTB complex, NTM differentiation from culture
GenoType Mycobacterium AS Further NTM differentiation from culture
GenoType NTM-DR NTM differentiation, resistance to microlides and aminoglycosides from culture
GenoType MTBDRplus MTB complex, resistance to rifampicin/isoniazid from clinical specimens and culture
GenoType MTBDRsl VER1.0 MTB complex, resistance to fluoroquinolones/aminoglycosides/cycl. peptides/
ethambutol from clinical specimens and culture
GenoType MTBDRsl VER2.0 MTB complex, resistance to fluoroquinolones/aminoglycosides/cycl. peptides from
clinical specimens and culture
GenoType LepraeDR M. leprae, resistance to rifampicin/ofloxacin/dapsone from clinical specimens
GenoType Staphylococcus S. aureus, S. epidermidis, further S. spec., mecA, PVL from culture
GenoType MRSA S. aureus, S. epidermidis, mecA, mecC, PVL from culture
GenoType HelicoDR H. pylori, resistance to fluoroquinolones/clarithromycin from clinical specimens and culture
GenoType EHEC Shiga toxins, virulence factors from culture
GenoType Enterococcus Species differentiation, resistance to vancomycin from culture
GenoType BC grampositive Gram-positive bacteria from blood culture
GenoType BC gramnegative Gram-negative bacteria from blood culture
GenoType CDiff C. difficile, toxins, deletions in tcdC, ribotype 027 from clinical specimens and culture
micro-IDent
®
5 periodontopathogenic bacterial species
micro-IDent plus11
®
11 periodontopathogenic bacterial species
L_JN0419002_0219
Hain Lifescience GmbH
Hardwiesenstrasse 1 | 72147 Nehren | Germany
Tel.: +49 (0) 74 73- 94 51- 0 | Fax: +49 (0) 74 73- 94 51- 31
E-Mail: info@hain-lifescience.de | www.hain-lifescience.de
