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USP Loss On Ignition

This document provides instructions for performing a loss on ignition test to determine the percentage of a test material that is volatilized and driven off under specified conditions. The test involves accurately weighing a sample, igniting it in a crucible at a designated temperature and time, allowing it to cool, and reweighing to calculate any loss of mass. The individual monograph being tested may specify variations in pretreatment, equipment, temperature, time, or number of ignition cycles. The purpose is to perform a nondestructive test to quantify components of a substance that can be volatilized.

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1K views1 page

USP Loss On Ignition

This document provides instructions for performing a loss on ignition test to determine the percentage of a test material that is volatilized and driven off under specified conditions. The test involves accurately weighing a sample, igniting it in a crucible at a designated temperature and time, allowing it to cool, and reweighing to calculate any loss of mass. The individual monograph being tested may specify variations in pretreatment, equipment, temperature, time, or number of ignition cycles. The purpose is to perform a nondestructive test to quantify components of a substance that can be volatilized.

Uploaded by

moriz52
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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6/24/2020 General Chapters: <733> LOSS ON IGNlr lo N

U.S PH AR MA CO PE IA
Search USP29

{ 733 ) LOSS ON IGNITION


This procedure is provided for the purpose of determining
the percentage of test materia l that Is volatili zed and driven
orf
under the conditions specified . The procedure , as genera
lly applied , is nondestructive to the substance under lost;
howovor,
the substance may be converted to another form such as
an anhydride.
Perform the test on finely powdered material, and break
up lumps, if necessary, with the aid of a mortar and pestle
before
weighing the specimen. Weigh the specimen to be tested
without further treatment, unless a preliminary drying at a
lower
temperature, or other special pretreatment, is specified in
the individual monograph . Unless other equipment Is design
ated In
the individual monograph , conduct the ignition in a suitabl
e muffle furnace or oven that Is capabl e of maintaining a
0
temperature within 25 of that required for the test, and
use a suitable crucible, complete with cover, previously ignited
hour at the temperature specified for the test, cooled In a for 1
desiccator, and accurately weighed .
Unless otherwise directed in the individual monograph, transfe
r to the tared crucible an accurately weighed quantity, in
the substance to be tested, about equal to that calculated g, or
by the formula:

10 / L,
in which Lis the limit (or the mean value of the limits) for
Loss on ignition, in percentage . Ignite the loaded uncovered
0
crucible, and cover at the temperature (±25 ) and for the
period of time designated in the individual monograph. Ignite
for
successive 1-hour periods where ignition to constant weight
is indicated . Upon completion of each ignition, cover the
crucible , and allow it to cool in a desiccator to room temper
ature before weighing.

Auxiliary Inform ation- Staff Liaison : Horacio Papo,2, Ph,D


,
Expert Comm ittee: (GC05) General Chapters 05
USP29 -NF24 Page 2704
Phone Number : 1-301-816-8319

http://ftp .uspbpep .com/v29240/usp29nf24s0_c733 .htmlllus


p29nf24 s0_c733 111

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