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CM KG M: Ukall 14 Consolidation 2 Height Weight BSA

This document outlines a chemotherapy regimen for a patient with UKALL 14. It details a consolidation cycle that is administered over 21 days. The regimen involves daily doses of Imatinib for Philadelphia positive patients. On days 1-5 of the cycle, the patient will receive intrathecal methotrexate followed by ondansetron, dexamethasone, cytarabine, and etoposide. Ondansetron is also administered after chemotherapy. Consolidation 3 will begin 3 weeks after the start of consolidation 2 once the patient's blood counts have sufficiently recovered.

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164 views2 pages

CM KG M: Ukall 14 Consolidation 2 Height Weight BSA

This document outlines a chemotherapy regimen for a patient with UKALL 14. It details a consolidation cycle that is administered over 21 days. The regimen involves daily doses of Imatinib for Philadelphia positive patients. On days 1-5 of the cycle, the patient will receive intrathecal methotrexate followed by ondansetron, dexamethasone, cytarabine, and etoposide. Ondansetron is also administered after chemotherapy. Consolidation 3 will begin 3 weeks after the start of consolidation 2 once the patient's blood counts have sufficiently recovered.

Uploaded by

Kena Ben
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Canterbury Regional Cancer and Blood Service (Haematology) Page 1 of 2

UKALL 14 Height cm
Consolidation 2 Weight kg
BSA m2

Cycle length: 21 days CBC Day 1 Limits Hypersensitivities/Allergies Agent Round


Date Cytarabine 10 mg
Destination: Hb Etoposide 10 mg
Antiemetics
Neuts > 0.75 x 109/L Domperidone 10mg PO QID
Plts > 75 x 109/L  Cyclizine 50mg TDS PO/IV
Reference: UKALL 14 trial protocol –v5.0 – 20/07/12 DOSE MODIFIED: No Yes

Day Date Time Agent Dose Route Instructions Doctor Nurse Check Start Stop
Continued for patients with Philadelphia positive disease. Continuous daily Imatinib, PO, aiming to
Continuous Imatinib
mg PO escalate to 600mg, if tolerated. This should be continued until transplant wherever possible. Prescribe
(Philadelphia +ve patients only) on regular medication chart or outpatient prescription.

1 Methotrexate 12 mg IT See separate intrathecal chemotherapy medication chart (C160016)

1 Ondansetron 8 mg PO Give one hour prior to chemotherapy


Dexamethasone 8 mg PO Give one hour prior to chemotherapy
Cytarabine 75 mg/m2 mg IV Bolus
Etoposide 100 mg/m2 mg IV In 500 mL sodium chloride 0.9 % over 1 hour
Ondansetron 8 mg PO
2 Ondansetron 8 mg PO Give one hour prior to chemotherapy
Dexamethasone 8 mg PO Give one hour prior to chemotherapy
Cytarabine 75 mg/m2 mg IV Bolus
Etoposide 100 mg/m2 mg IV In 500 mL sodium chloride 0.9 % over 1 hour
Ondansetron 8 mg PO
 Timing of intrathecal therapy can be moved +/- 3 days to allow administration on specific lists as per local and national guidelines
Consultant:
NZMC Reg. No:
Authorised by: Dr P Ganly Pharmacists: C. Innes / B. Harden March 2012
Review April 2016
Canterbury Regional Cancer and Blood Service (Haematology) Page 2 of 2

UKALL 14 Height cm
Consolidation 2 Weight kg
BSA m2

Day Date Time Agent Dose Route Instructions Doctor Nurse Check Start Stop
3 Ondansetron 8 mg PO Give one hour prior to chemotherapy
Dexamethasone 8 mg PO Give one hour prior to chemotherapy
Cytarabine 75 mg/m2 mg IV Bolus
Etoposide 100 mg/m2 mg IV In 500 mL sodium chloride 0.9 % over 1 hour
Ondansetron 8 mg PO
4 Ondansetron 8 mg PO Give one hour prior to chemotherapy
Dexamethasone 8 mg PO Give one hour prior to chemotherapy
Cytarabine 75 mg/m2 mg IV Bolus
Etoposide 100 mg/m2 mg IV In 500 mL sodium chloride 0.9 % over 1 hour
Ondansetron 8 mg PO
5 Ondansetron 8 mg PO Give one hour prior to chemotherapy
Dexamethasone 8 mg PO Give one hour prior to chemotherapy
Cytarabine 75 mg/m2 mg IV Bolus
Etoposide 100 mg/m2 mg IV In 500 mL sodium chloride 0.9 % over 1 hour
Ondansetron 8 mg PO
6 Dexamethasone 8 mg PO
7 Dexamethasone 8 mg PO

 Consolidation 3 to commence 3 weeks from the first day of consolidation 2 or when neutrophils > 0.75 x 109/L and platelets >75 x 109/L

Authorised by: Dr P Ganly Pharmacists: C. Innes / B. Harden March 2012


Review April 2016

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