Scribd
Upload
94 views18 pages

Pharmacognosy & Phytochemistry-II: Basic Metabolic Pathway

The document summarizes two basic metabolic pathways: 1) The shikimic acid pathway, which is a seven step pathway that converts phosphoenolpyruvate and erythrose-4-phosphate into chorismate. Chorismate is then used to synthesize aromatic amino acids like phenylalanine, tyrosine, and tryptophan. 2) The mevalonic acid pathway, which is a ten step pathway that converts acetyl-CoA into isopentenyl pyrophosphate and dimethylallyl pyrophosphate. These molecules are used to synthesize terpenes, steroids, and carotenoids.

Uploaded by

Abdul Munaf Ali Nasir
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
94 views18 pages

Pharmacognosy & Phytochemistry-II: Basic Metabolic Pathway

The document summarizes two basic metabolic pathways: 1) The shikimic acid pathway, which is a seven step pathway that converts phosphoenolpyruvate and erythrose-4-phosphate into chorismate. Chorismate is then used to synthesize aromatic amino acids like phenylalanine, tyrosine, and tryptophan. 2) The mevalonic acid pathway, which is a ten step pathway that converts acetyl-CoA into isopentenyl pyrophosphate and dimethylallyl pyrophosphate. These molecules are used to synthesize terpenes, steroids, and carotenoids.

Uploaded by

Abdul Munaf Ali Nasir
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 18

Basic Metabolic Pathway

UNIT -01 (B.Pharmacy 5th semester)


Pharmacognosy & Phytochemistry-II
Collection of all screen shots of “Solution-Pharmacy” YouTube classes of Pharmacognosy-II
1 2 3

4
6 5
7
10

11

13

p-Hydroxyphenyl pyruvic acid

Reductive transamination 14
9
12

Shikimic Acid Pathway


Shikimic Acid Pathway
Steps Type of Reaction Enzyme
1 Aldol Codensation 3-Deoxy- D arabinoheptulosonate-7-Phosphae synthase (DAHP synthase)

2 Cyclization 3- Dehydroquinate synthase (DHQ synthase)


3 Dehydration 3- dehydroquinate dehydratase
4 Reduction Shikimate dehydrogenase
5 Phosphorylation Shikimate Kinase

6 Condensation with PEP and Enolpyruvyl Shikimate-3-Phosphate synthase (EPSP synthase)


dehydration
7 Elimination of Phosphoric acid Chorismate Synthase
8 Amination Anthranilate synthase
9 Conjugation with serine Tryptophan synthase
10 Claisen rearrangement Chorismate mutase
11 Decarboxylation and Dehydration Prephenate Dehydratase

12 Reductive transamination Phenylalanine aminotranferase


13 Oxidative decarboxylation Prephenate Dehydrogenase
14 Reductive transamination Tyrosine aminotranferase
Mevalonic Acid Pathway
Steps Type of Reaction Enzyme
1 Codensation Acetoacetyl CoA thiolase
2 Aldol condensation 3- Hydroxy 3-Methyl glutaryl CoA Synthase (HMG-CoA synthase)
(Synthesis of HMG-CoA)
3 Reduction of HMG-CoA 3- Hydroxy 3-Methyl glutaryl CoA Reductase (HMG-CoA reductase)
4 Phosphorylation Mevalonate Kinase
5 Phosphorylation Phosphomevalonate Kinase

6 Decarboxylation and Pyrophosphate-Mevalonate Decarboxylase


Dehydration
7 Isomerisation Isopentanyl pyrophosphate Isomerase
8 Condensation (Synthesis of Geranyl pyrophosphate Synthase
GPP)
9 Addition of IPP to GPP Farnesyl pyrophosphate synthase (FPP synthase)
10 Addition of IPP to FPP Geranyl Geranylpyrophosphate synthase
(Synthesis of GGPP)
11 Addition of FPP to FPP Sqalene Synthase
(Synthesis of Sqalene)

You might also like