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Drug Interaction Sa

This document contains a self-assessment test on drug interactions with 11 multiple choice questions. The questions cover topics like which drugs have their absorption reduced by antacids, why cimetidine interacts with more drugs than ranitidine, which enzyme exhibits genetic polymorphism, which drug is not known to interact with St. John's Wort, how miconazole oral gel interacts with warfarin, examples of enzyme inducers and inhibitors, examples of pharmacodynamic and pharmacokinetic drug interactions, drugs that can interact with aspirin to cause bleeding, and which drug is unlikely to interact with grapefruit juice.

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ShahabWassi
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318 views3 pages

Drug Interaction Sa

This document contains a self-assessment test on drug interactions with 11 multiple choice questions. The questions cover topics like which drugs have their absorption reduced by antacids, why cimetidine interacts with more drugs than ranitidine, which enzyme exhibits genetic polymorphism, which drug is not known to interact with St. John's Wort, how miconazole oral gel interacts with warfarin, examples of enzyme inducers and inhibitors, examples of pharmacodynamic and pharmacokinetic drug interactions, drugs that can interact with aspirin to cause bleeding, and which drug is unlikely to interact with grapefruit juice.

Uploaded by

ShahabWassi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Drug Interactions Self Assessment

1. Drug Interaction MCQs

For the following multiple choice questions please select one correct answer.

1. Please enter your name

2. Which of the following drugs would have its absorption significantly reduced by the
co-administration of an antacid ?
j
k
l
m
n Warfarin

j
k
l
m
n Ketoconazole

j
k
l
m
n Fluconazole

j
k
l
m
n Terbinafine

j
k
l
m
n Acyclovir

3. Cimetidine interacts with more drugs than ranitidine because;


j
k
l
m
n Its is subjected to greater first pass metabolism

j
k
l
m
n It is a more potent enzyme inducer

j
k
l
m
n It is a more potent enzyme inhibitor

j
k
l
m
n It has better oral absorption

j
k
l
m
n The dose administered is higher

4. Which of these enzymes exhibits genetic polymorphism in humans ?


j
k
l
m
n CYP2E1

j
k
l
m
n CYP2D6

j
k
l
m
n CYP2B6

j
k
l
m
n CYP3A4

5. Which of the following drugs is not known to interact with St John’s Wort ?
j
k
l
m
n Digoxin

j
k
l
m
n Cyclosporin

j
k
l
m
n Warfarin

j
k
l
m
n Saquinavir

j
k
l
m
n Ciprofloxacin

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Drug Interactions Self Assessment
6. Miconazole oral gel interacts with warfarin due to:
j
k
l
m
n Additive anticoagulant effects

j
k
l
m
n Miconazole inhibits renal excretion of warfarin

j
k
l
m
n Miconazole antagonizes the anticoagulant effects of warfarin

j
k
l
m
n Miconazole inhibits hepatic metabolism of warfarin

j
k
l
m
n Miconazole reduces the absorption of warfarin

7. Which of the following is NOT an enzyme inducer ?


j
k
l
m
n Rifampicin

j
k
l
m
n Phenytoin

j
k
l
m
n St John’s Wort

j
k
l
m
n Carbamazepine

j
k
l
m
n Valproic Acid

8. Which of the following is NOT an enzyme inhibitor ?

j
k
l
m
n Cimetidine

j
k
l
m
n Fluoxetine

j
k
l
m
n Norfluoxetine (a metabolite of Fluoxetine)

j
k
l
m
n Diazepam

j
k
l
m
n Erythromycin

9. Which of the following would you classify as a pharmacodynamic interaction?


j
k
l
m
n Serotonin syndrome due to paroxetine and clomipramine

j
k
l
m
n Bradycardia due to fluoxetine and metoprolol

j
k
l
m
n Increased phenytoin plasma concentrations due to fluoxetine

j
k
l
m
n Increased bleeding due to cimetidine and warfarin

j
k
l
m
n Lithium toxicity due to addition of diclofenac

10. Which of the following can interact with aspirin causing bleeding ?

j
k
l
m
n Valerian

j
k
l
m
n Liquorice

j
k
l
m
n Kava

j
k
l
m
n Saw Palmetto

j
k
l
m
n Ginkgo Biloba

Page 2
Drug Interactions Self Assessment
11. Which of the following drugs is unlikely to interact significantly with grapefruit
juice?
j
k
l
m
n Felodipine

j
k
l
m
n Simvastatin

j
k
l
m
n Cyclosporin

j
k
l
m
n Cisapride

j
k
l
m
n Paroxetine

Page 3

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