Bio. Stat. & Applied Stat. 2021 2 semester, DR. Y.M.
nd
Regression and Correlation” Exercises”
[1]An experiment was conducted to study the effect of
increasing the dosage of a certain barbiturate on sleeping
time. Three readings were made at each of three dose levels.
Sleeping Time (Hours) 4 6 5 9 8 7 13 11 9
Dosage (μM/kg) 3 3 3 10 10 10 15 15 15
What is the predicted sleeping time for a dose of 12 μM/kg?
Place a 95% confidence interval for β1.
Solution
̂ = 3.38 + 0.495x
𝒚
At x=12
̂ = 3.38 + 0.495(12) = 9.32
𝒚
95% C.I. for β1:
b1 = 0.495 , t0.025 , 7 = 2.365
̂
𝒚 4.865 4.865 4.865 8.33 8.33 8.33 10.805 10.805 10.805
ei = - 1.135 0.135 0.67 -0.33 -1.33 2.195 0.195 -1.805
̂ -
𝒚 0.865
y
SSE=12.495 “using calculator” , MSE = 12.495/7 =1.785
Sxx = 218 “ using calculator “
𝟏.𝟕𝟖𝟓
0.495 ± 2.365 * √
𝟐𝟏𝟖
(0.2809 , 0.709)
1
Bio. Stat. & Applied Stat. 2021 2 semester, DR. Y.M.
nd
[2] In a study of the relationship between amphetamine
metabolism and amphetamine psychosis, six chronic
amphetamine users were given a psychosis intensity rating
score. Plasma amphetamine levels (mg/ml) were also
determined for these patients.
Psychosis Intensity Rating (y) 15 40 45 30 55 30
Plasma Amphetamine (mg/ml)(X) 150 100 200 250 250 500
Determine the correlation coefficient. Is there a
significant correlation between intensity rating and
plasma amphetamine level? Test Ho : 𝜷𝟏 = 𝟎
Solution
r = -0.0472
Test:
Ho : there is no correlation coefficient between intensity
rating and plasma amphetamine
Ha : there is a significant correlation between intensity rating
and plasma amphetamine
𝒏−𝟐 𝟒
Tc = r√ = -0.0472 √ = -0.0945
𝟏−𝒓𝟐 𝟏−(−𝟎.𝟎𝟒𝟕𝟐)𝟐
t0.025,4 = 2.776
Reject Ho if | -0.0945 | ≥ 2.776
Can’t Reject Ho
there is no correlation coefficient between intensity rating
and plasma amphetamine.
2
Bio. Stat. & Applied Stat. 2021 2 semester, DR. Y.M.
nd
Test Ho : 𝜷𝟏 = 𝟎
H0 : 𝜷𝟏 = 𝟎 Ha: 𝜷𝟏 ≠ 𝟎
b0 = 37 , b1 = -0.0047
t0.025,4 = 2.776
MSE= 242.2
Sxx = 97083.33
−𝟎.𝟎𝟎𝟒𝟕
Tc = = -0.094
𝟐𝟒𝟐.𝟐
√
𝟗𝟕𝟎𝟖𝟑.𝟑𝟑
Reject Ho if |-0.094| > 2.776
Can’t Reject Ho , 𝜷𝟏 = 𝟎 , the model is bad fit
[3] An investigator studying the effects of stress on blood
pressure subjected nine monkeys to increasing levels of
electric shock as they attempted to obtain food from a
feeder. At the end of a 2-minute stress period blood
pressure were recorded.
Blood pressure (Y) 125 130 120 150 145 160 175 180 180
Shock Intensity (X) 30 30 30 50 50 50 70 70 70
Determine the regression line relating blood pressure to
intensity of shock. Test Ho : 𝜷𝟏 = 𝟎
Solution
b0 = 85 , b1 = 1.33
̂ = 85 + 1.33x
𝒚
3
Bio. Stat. & Applied Stat. 2021 2 semester, DR. Y.M.
nd
H0 : 𝜷𝟏 = 𝟎 Ha: 𝜷𝟏 ≠ 𝟎
t0.025,7 = 2.365
MSE= 26.2
Sxx = 2400
𝟏.𝟑𝟑
Tc = = 12.73
𝟐𝟔.𝟐
√
𝟐𝟒𝟎𝟎
Reject Ho if | 12.73 | > 2.365
Reject Ho , 𝜷𝟏 ≠ 𝟎 , the model is good fit
[4] The following table gives grade point average at the end
of the first 2 year of basic sciences and scores on National
Boards (NBS) Part 1 for 12 medical students:
GPR (X) 3.35 2.37 3.13 3.10 1.94 3.00 2.85 1.96
2.98 2.55 2.23 1.95
Score (Y) 620 445 445 560 295 570 415 430
560 515 430 435
Determine the correlation between GPR and NBS. Is the
correlation significant? For GBR of 3, what is the predicted
NBS? Test Ho : 𝜷𝟏 = 𝟎 Place 95% confidence interval for β1.
Solution
r=0.7543
Ho : there is no correlation coefficient between GPR and
Score
Ha : there is a significant correlation between GPR and Score
4
Bio. Stat. & Applied Stat. 2021 2 semester, DR. Y.M.
nd
𝒏−𝟐 𝟏𝟎
Tc = r√ = 0.7543 √ = 3.633
𝟏−𝒓𝟐 𝟏−(𝟎.𝟕𝟓𝟒𝟑)𝟐
t0.025,10 = 2.228
Reject Ho if | 3.633 | ≥ 2.228
Reject Ho
There is a significant correlation between GPR and Score
̂ = 131 + 132x
𝒚
At X=3 , 𝒚
̂ = 131 + 132(3) = 527
H0 : 𝜷𝟏 = 𝟎 Ha: 𝜷𝟏 ≠ 𝟎
b0 = 131 , b1 = 132
t0.025,10 = 2.228
MSE= 3858
Sxx = 2.9166
𝟏𝟑𝟐
Tc = = 3.63
𝟑𝟖𝟓𝟖
√
𝟐.𝟗𝟏𝟔𝟔
Reject Ho if | 3.63 | > 2.228
Reject Ho , 𝜷𝟏 ≠ 𝟎 , the model is good fit
C.I.
5
Bio. Stat. & Applied Stat. 2021 2 semester, DR. Y.M.
nd
𝟑𝟖𝟓𝟖
132 ± 2.228 * √
𝟐.𝟗𝟏𝟔𝟔
(50.967 , 213.032)
[5] In a study on the elimination of a certain drug in man, the
following data were recorded:
Time in Hours (X) .5 .5 1 1 2 2 3 3 4 4
Drug Concentration (μg/ml)(Y) .42 .45 .35 .33 .25
.22 .20 .20 .15 .17
What is the predicted drug concentration after 2 hours? Test
Ho : 𝜷𝟏 = 𝟎. Set a 99% confidence interval for β1.
Solution
̂ = 0.43 - 0.0743 x
𝒚
At x=2 , 𝒚
̂ = 0.43 - 0.0743(2) = 0.2814
H0 : 𝜷𝟏 = 𝟎 Ha: 𝜷𝟏 ≠ 𝟎
b0 = 0.43 , b1 = -0.0743
t0.025,8 = 2.306
MSE= 0.001404
Sxx = 16.4
−𝟎.𝟎𝟕𝟒𝟑
Tc = = -8.03
𝟎.𝟎𝟎𝟏𝟒𝟎𝟒
√
𝟏𝟔.𝟒
Reject Ho if | -8.03 | > 2.306
6
Bio. Stat. & Applied Stat. 2021 2 semester, DR. Y.M.
nd
Reject Ho , 𝜷𝟏 ≠ 𝟎 , the model is good fit
t0.005,8 = 1.86
𝟎.𝟎𝟎𝟏𝟒𝟎𝟒
99% C.I. : -0.0743 ± 1.86 * √
𝟏𝟔.𝟒
(-0.0915 , -0.057)