Exp no:1
Cardiogenic Pulmonary Edema.
Dt:
           Name: M.kalayan                                    Age: 88yrs
           Sex: Male                                           IP No:1603183
           DOA:29-09-2020                                     DOD:05-10-2020
           Chief Complaints:
                 Overwhelming of pulmonary edema is difficulty breathing,
                 Coughing up blood,
                 Excessive sweating,
                 Anxiety, and
                 Pale skin.
           History Of Present Illness:
           A 88yr male patient was prepared with complaints of wheezing , shortness of
           breath and altered sensorium since 20days. He had history of fever with
           thrombopenia one month back, followed with altered behaviour. He is non
           alcoholic, non smoker and takes mixed diet. From 3 days his urine output was
           decreased and constipation was observed.
           Patient was conscious. He is pallor and pedal edema was obeseved up to Knees.
                 On physical examinations his vital signs were
                 BP:130/50mmHg,
                 PR:100beats/min,
                 RR: 20cycles/min,
                 CVS: S1S2+
                 RS: Creps,Rhonchi
                 CNS: Consicous,coherent and occasionally talks irrelevantly.
  Abdomen: Distension and Suprapublic dullness.
  CT brain scan showed age related diffuse cerebral atrophy.
  2D echo cardiography showed maildly dilated RA and RV, mild TR with
   PAH.
  Ultrasonography reported moderate hydrouretero nephrosis.
 Problem list:
          Cardiogenic Pulmonary edema
CURRENT MEDICATIONS:
   DRUG            DOSE       FREQUENCY        ROUTE          START DATE       STOP DATE
Inj.Optineuron     2amp           OD           Ⅳ            29-09-2020       04-10-2020
Inj.Bactrimfort    3gm             BD          Ⅳ            30-09-2020       04-10-2020
e
 Inj.Pantop        1amp            BD           Ⅳ           30-09-2020       01-10-2020
Neb.Asthalin                   2nd hourly                   30-09-2020       01-10-2020
Neb. Duolin                   6th hourly                    30-09-2020       01-10-2020
Budecort
Tab.Azitral        500mg         BD                PO       01-10-2020       04-10-2020
Tab.Synasma        400mg         BD                PO       30-09-2020       03-10-2020
Tab.Amifru                       OD                PO       01-10-2020       03-10-2020
Tab.Dytor          10mg          OD                PO       02-10-2020       04-10-2020
Tab.Benformat      1 tablet      OD                PO       03-10-2020       O4-10-2020
plus
Tab.Pantop         40mg            OD              PO       02-10-2020       04-10-2020
      SUBJECTIVE AND OBJECTIVE EVIDENCE:
                       Patient was presented with complaints of wheezing, shortness
                        of breath.
                       Decreased urine output and constipation.
      Current medications:
             Inj.Bactrim forte 3gm/BD/Ⅳ
             Neb.Asthalin 2nd hourly
             Neb.Duolin Budecort 6th hourly
             Tab.Azitral 500mg/BD/PO
             Tab.Synasma 400mg/BD/PO
    Tab.Dytor 10mg/OD/PO
ASSESSMENT:
  Etiology: Congestive heart failure.
  Risk factors:
              Left ventricular failure.
              History of lung disease, such as tuberculosis, chronic obstructive
               pulmonary disorder. (COPD).
              Kidney failure.
              Vascular disorders.
EVALUATE NEED FOR THERAPY
   (EVALUATE CURRENT OR NEW THERAPY)
Cardiogenic Pulmonary edema:
          Yes patient needs therapy to reduce symptoms and prevent possible
complications like pulmonary hypertension, acute heart attack, cardiogenic
shock, arrhythmias, electrolyte disturbances, respiratory arrest.
                      PLANNING
RECOMMEND DRUG TREATMENT (DRUGS TO BE AVOIDED;
FURTHER TESTES)
          The effective dose of Amifru (Furosemide) is 40mg 1tablet daily.
           But it was not given in the prescription.
          When Asthalin or the Duolin given with diuretics like Furosemide
           and Torsemide causes hypokalemia. So Ipratropium bromide
           500mcg 1 unit dose vial can be administered 3 to 4 times a day.
Goals of therapy:
    Reduce symptoms.
    Reduce the fluid in the lungs.
    Improve gaseous exchange and heart function.
                    PATIENT EDUCATION
Azithral(Azithromycin):
    Take the tablet once daily in the morning.
    Take low-sodium or low-salt diet, potassium supplements, and
    potassium-rich foods like bananans, raisins, and orange juice in your diet.
  Duolin with Budecort:
       Twist open the top of one unit dose vial and squeeze the contents in
       the nebulizer reservoir.
       Connect the nebulizer reservoir to the mouthpiece.
       Connect the nebulizer to the compressor.
       Sit in a comfortable, upright position; place the mouthpiece in your
       mouth and turn on the compressor.
       Follow the instructions provided to add the solution to the nebulizer
       and inhale the aerosol using the nebulizer.
       You should use your nebulizer continually for as long as your doctor
       recommends.
Pantoprazole:
    Take the medicine at same time each day.
    Swallow this medicine as a whole, do not crush or chew the tablet .
    Take it 30min before meal, if it upsets your stomach then take it with
    food.
DRUG THERAPY PROBLEM WORK SHEET:
Type of problem               Possible Cause                    Comment
Needs different drug         More effective drug       Ipratropium bromide 500mcg 1 unit
product                      available.                dose vial can be administered 3 to 4
                                                       times a day.
Adverse drug reaction        Unsafe drug for patient   Azithromycin reacts with the pyridoxine
                                                       and decreases the level or affect of
                                                       pyridoxine by altering the intestinal
                                                       flora, so dosing space is required.
       PHARMACEUTICAL CARE PLAN
       1.Medical problem list: Drug Interaction
       Current drug regimen: Azithromycin reacts with pyridoxine.
       Drug therapy problem: Decreases the level or affect of pyridoxine by
       altering the intestinal flora.
       Therapy recommendations: Dosing space is required for 2hrs.
       2.Drug therapy problem: Wrong Dose
       Current drug regimen: Azithromycin 500mg BD
       Therapy goals/ Therapy end points: To reduce the infection.
       Therapy recommendations: Azithromycin 500mg orally as a single
       dose on the first day followed by 250mg upto 2 or 5 days.
3.Drug therapy problem: wrong dose
Current drug regimen: Bactrim forte 3gm iv
Therapy goals/ therapy end points: To reduce the infection.
Therapy Recommendations: Bactrim forte of 8 to 10 mg/kg given in 2
or 4 equally divided doses through for every 8 or 12 hours for upto 14 days.
REFERENCES:
   1.  www.webmd.com/.../mono-3223azithromycin+250%2F500+MG+..
   2. www.medindia.net/doctors/drug_information/doxofylline.htm
   3. www.healthkartplus.com/details/drugs/58409/amifru-40mg
   4. www.healthkartplus.com/details/drugs/64284/dytor-plus-10mg
   5. www.drugs.com/pantoprazole.html
   6. www.mayoclinic.org/disease.../pulmonary-edema/basics/.../con-200224
   7. www.nlm.nih.gov/medlineplus/ency/article/000140.htm
   8. Reference.medscape.com/drug-interaction checker
   9. http://www.inhousepharmacy.biz/p-630-duolin-inhalation.aspx
   10. https://www.nhlbi.nih.gov/guidelines/asthma/