THE MEETING IS DEDICATED TO THE 75TH ANNIVERSARY OF FAZLY ATAULLAKHANOV
SYSTEMS BIOLOGY AND
SYSTEMS PHYSIOLOGY:
REGULATION OF
BIOLOGICAL NETWORKS
HYBRID CONFERENCE
AUG 25-27, 2021
SCIENTIFIC PROGRAM
Illuminating the nature of complex
systems
SBPReports is the Open-Access Journal,
devoted to studies of complex biological
systems
SBPReports is a forum for in-depth
discussions between physicians,
biophysicists, biologists, mathematicians and
professionals
from related fields
SBPReports publishes articles, brief reports
and reviews both in English and in Russian
sbpreports.com
Our Scope
Self-organization at the level of molecules
and macromolecular complexes, molecular
mechanisms of biochemical reactions
Сell signal transduction and metabolic
networks, regulation of cell cycle, gene
expression and epigenetic regulation
Mechanisms of physiological and
pathophysiological processes at the levels
of cells, tissues, organs and organisms
Pharmacological research and diagnostics
sbpreports.com
SCIENTIFIC PROGRAM
AUGUST 25th, 2021
GMT+3
9:00-10:00 MAIN REGISTRATION
10:00-11:30 GRAND OPENING
11:30-12:30 L U N C H B R E A K
SECTIONS
12:30-16:30 BIOLOGICAL SYSTEMS OF THE
SUPRACELLULAR LEVEL:
HEMOSTASIS, IMMUNITY,
NEUROBIOLOGY (PART 1)
Chairs: Vitaly Volpert, France
Vladimir Kolyadko, USA
12:30-13:05 Simulation of the coagulation system,
Tool or Toy?
Coenraad Hemker
Maastricht University
the Netherlands
13:05-13:35 Construction of self-adaptive
biomaterials surface with high blood
compatibility
Qiang Shi
Changchun Institute of Applied
Chemistry, Chinese Academy of Sciences
China
13:35-14:05 Synergism between anticoagulation and
phototherapy to prevent the thrombotic
complications
Zhifang Ma
Changchun Institute of Applied
Chemistry, Chinese Academy of Sciences
China
14:05-14:35 Modelling of blood clotting in aneurysm
Vitaly Volpert
Institut Camille Jordan, University Lyon 1
France
14:35-14:50 C O F F E E B R E A K
14:50-15:20 Numerical and qualitative investigation
of the mathematical model of blood
coagulation with membrane reactions
Alexey Lobanov
Moscow Institute of Physics and
Technology
Russia
15:20-15:40 Inhibition of blood coagulation:
biochemistry, structural biology, and
translational applications
Vladimir Kolyadko
The Children's Hospital of Philadelphia
Philadelphia, USA
15:40-16:00 A mechanistic model for
thromboelastography
Anand Mohan
IIT Hyderabad
Sangareddy, India
16:00-16:30 In silico modelling of hemostatic
response: challenges and perspectives
Dmitry Nechipurenko
Center for Theoretical Problems of
Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia
16:30-17:50 FUNDAMENTALS OF LIFE:
PRINCIPLES OF FUNCTIONING OF
BIOLOGICAL SYSTEMS
(ANNIVERSARY SECTION)
Chair: Mikhail Panteleev, Russia
16:30-16:50 The end of hemostasis
Mikhail Panteleev
Center for Theoretical Problems of
Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia
16:50-17:10 Fazli – scientist, friend, Boss
Victor Vitvitsky
Center for Theoretical Problems of
Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia
17:10-17:30 Fazly’s scientific life in the Wild West
Richard McIntosh
University of Colorado Boulder
Colorado, USA
17:30-17:50 50 years in science: The Outcome
Fazly Ataullakhanov
Center for Theoretical Problems of
Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia
17:50-18:05 C O F F E E B R E A K
18:05-21:40 CELL DIVISION AND MOLECULAR
MOTORS
Chairs: Nikita Gudimchuk, Russia
Vladimir Volkov, the Neterlands
18:05-18:40 The tip of a growing microtubule and its
implications for polymer dynamics
Richard McIntosh
University of Colorado Boulder
Colorado, USA
18:40-19:10 Electron cryo-tomography provides
insight into the regulation of
microtubule dynamics by end-binding
protein assemblies
Vladimir Volkov
Delft University of Technology
the Netherlands
19:10-19:40 Mechanisms of microtubule dynamic
instability examined with Monte-Carlo
simulations and in vitro reconstitution
experiments
Nikita Gudimchuk
Center for Theoretical Problems of
Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia
19:40-20:10 Harnessing Dynamic Microtubule Ends:
lessons from reconstruction studies in
vitro
Ekaterina Grischuk
University of Pennsylvania,
Philadelphia, USA
20:10-20:20 C O F F E E B R E A K
20:20-20:50 Role of tropomyosin dynamics in
regulation of cardiac muscle in health
and disease
Andrey Tsaturyan
Lomonosov Moscow State University
Russia
20:50-21:20 Structure of super-relaxed myosin heads
in relaxed muscle
Natalia Koubasova
Lomonosov Moscow State University
Russia
21:20-21:40 The ratio of Tpm α- and β-chains in the
thin filament affects the actin-myosin
interaction
Salavat Nabiev
Institute of Immunology and Physiology,
Ural Branch of the Russian Academy of
Sciences
Russia
AUGUST 26th, 2021
GMT+3
9:30-13:00 METHODOLOGICAL ISSUES OF
BIOPHYSICS
Chairs: Vladik Avetisov, Russia
Anatoly Vanin, Russia
9:30-10:00 Oxidative modification of fibrinogen
molecules: structural and functional
aspects
Lyubov Yurina
N.M. Emanuel Institute of Biochemical
Physics Russian Academy of Sciences
Russia
10:00-10:30 Physical chemistry of dinitrosyl iron
complexes as a determinant of their
biological activity
Anatoly Vanin
Semenov Federal Research Center for
Chemical Physics, Russian Academy of
Sciences
Russia
10:30-11:00 Reversible aggregation and
deformation of RBC as determining
factors of blood fluidity control
Alexander Priezhev
Lomonosov Moscow State University
Russia
11:00-11:30 Biophysics in tissue engineering
Yury Rochev
Centre for Research in Medical Devices
(CURAM), National University of
Ireland
Ireland
11:30-12:00 Euler arches and Duffing oscillators a
few nanometers in size
Vladik Avetisov
Semenov Institute of Chemical Physics
of the Russian Academy of Sciences
Russia
12:00-12:30 How does viscosity help (!) the dynamics
of spatial self-organization of molecular
and supramolecular structures?
Konstantin Shaitan
Lomonosov Moscow State University
Russia
12:30-13:00 Computer Simulation of the Heart and
Machine Learning for Basic Research in
Physiology and Clinical Applications
Olga Solovieva
Institute of Immunology and Physiology,
Ural Branch of the Russian Academy of
Sciences
Russia
13:00-13:15 C O F F E E B R E A K
13:15-18:20 METHODOLOGICAL ISSUES OF
SYSTEMS BIOLOGY AND SYSTEMS
PHYSIOLOGY
Chairs: Svetlana Komarova, Canada
Vladimir Sulimov, Russia
13:15-13:45 Biophysical and biochemical properties
of biocrystal hemozoin produced by
malaria parasite
Oleksii Skorohod
University of Torino
Italy
13:45-14:15 Reimagining the interaction between
stress-induced glucocorticoids and
gastric ulceration: the importance of a
methodological approach
Lyudmila Filaretova
Pavlov Institute of Physiology, Russian
Academy of Sciences
Russia
14:15-14:45 Quantum docking
Vladimir Sulimov
Research Computing Center
Russia
14:45-15:00 PI3 kinase ligands LY294002, LY303511
and PI828 block coupling of the 5-HT2C
receptor with Ca2 + mobilization in a
PI3 kinase-independent manner
Ekaterina Dymova
Institute of Cell Biophysics, Russian
Academy of Sciences
Russia
15:00-15:45 Overcoming kinase inhibitor resistance
and oncogenic RAS signaling
Boris Kholodenko
University College Dublin
Ireland
15:45-16:00 C O F F E E B R E A K
16:00-16:35 Using Microwave radiometry for
measuring kinetic constants or New
metagenomic methods for drug targets
identification
Igor Goryanin
Cluster of Biological and Medical
Technologies of the Skolkovo Innovation
Center
Russia
16:35-17:05 Processes in the photosynthetic
membrane as an object of systems
biology
Galina Riznichenko
Lomonosov Moscow State University
Russia
17:05-17:35 Microgravity-induced bone loss: lessons
learned from systematic reviews and
meta-analysis
Svetlana Komarova
McGill Univeristy
Canada
17:35-18:05 A possible mechanism of ligand-
receptor binding of short peptides to
NaV1.8 channels: a novel approach to
development of safe and effective
analgesics
Ilya Rogachevskiy
Pavlov Institute of Physiology, Russian
Academy of Sciences
Russia
18:05-18:20 Application of machine learning
technologies in a non-invasive sensor
system for diagnostics of a human
functional state
Anna Zaytseva
Institute of Analytical Instrumentation,
Russian Academy of Sciences
Russia
18:20-18:35 C O F F E E B R E A K
18:35-21:15 BIOLOGICAL SYSTEMS OF THE
SUPRACELLULAR LEVEL:
HEMOSTASIS, IMMUNITY,
NEUROBIOLOGY (PART 2)
Chairs: Dmitry Nechipurenko, Russia
Grigorii Panasenko, France
18:35-19:10 A new look at the retraction
(contraction) of blood clots and thrombi
Rustem Litvinov
University of Pennsylvania
Philadelphia, USA
19:10-19:45 Multiscale studies of blood clot
mechanics
John Weisel
University of Pennsylvania
Philadelphia, USA
19:45-20:15 Mathematical modeling of
hemodynamics in the left atrium during
atrial fibrillation
Grigorii Panasenko
Jean Monnet University of Saint-Etienne
France
20:15-20:45 Couple morphogen-mechanical models
for tissue growth and organogenesis
Sergey Nuzhdin
University of Southern California
California, USA
20:45-21:15 Corticotropin-releasing factor (CRF) as
a mediator of pain response to stressor:
involvement of CRF receptors of
subtype 2, opioid receptors and
glucocorticoid receptors in CRF-induced
analgesic effect in rats
Natalya Yarushkina
Pavlov Institute of Physiology, Russian
Academy of Sciences
Russia
AUGUST 27th, 2021
GMT+3
10:00-11:50 PRACTICAL APPLICATIONS OF CELL
BIOPHYSICS: ERYTHROCYTES AS
CARRIERS OF DRUGS
Chair: Victor Vitvitsky, Russia
10:00-10:35 Red blood cells-based drug delivery:
new applications and current clinical
developments
Mauro Magnani
University of Urbino
Italy
10:35-11:10 Erythrocyte mediated therapy for rare
diseases: a complicated affair
Bridget Bax
St. George's University of London
United Kingdom
11:10-11:30 Development of an automatic device for
creating drug-loaded erythrocytes
Larisa Koleva
Dmitry Rogachev National Medical
Research Center Of Pediatric
Hematology, Oncology and Immunology
Russia
11:30-11:50 Mathematical modelling of erythrocytes-
bioreactors
Eugeny Protasov
Dmitry Rogachev National Medical
Research Center Of Pediatric
Hematology, Oncology and Immunology
Russia
11:50-12:05 C O F F E E B R E A K
12:05-15:10 GENOMICS AND BIOINFORMATICS
Chairs: Fazly Ataullakhanov, Russia
Artem Efremov, China
12:05-12:40 mRNA editing in soft-bodied
cephalopods as evolutionary adaptive
functional diversification
Mikhail Gelfand
Skolkovo Institute of Science and
Technology
Russia
12:40-13:15 Reverse genetics and biomedical models
Sergey Nedospasov
Engelhardt Institute of Molecular
Biology
Russia
13:15-13:45 Mechanical equilibrium of the cell
nucleus and its potential role in
regulation of chromatin structure
Artem Efremov
Institute of Systems ond Physical
Biology
China
13:45-14:00 C O F F E E B R E A K
14:00-14:30 Molecular aspects of screening
technologies in biodiversity
Alexander Gabibov
M. M. Shemyakin and Yu. A.
Ovchinnikov Institute of Bioorganic
Chemistry of the Russian Academy of
Sciences
Russia
14:30-14:50 Single-cell-resolution transcriptome map
of human, chimpanzee, bonobo, and
macaque brains
Ekaterina Khrameeva
Skolkovo Institute of Science and
Technology
Russia
14:50-15:10 Dynamics of chromatin folding: lessons
learned from single-cell and time-
resolved bulk Hi-C data
Alexandra Galitsyna
Skolkovo Institute of Science and
Technology
Russia
15:10-19:05 CELLULAR METABOLISM AND
ENERGETICS
Chairs: Victor Vitvitsky, Russia
Alexander Tikhonov, Russia
15:10-15:40 Virtual cell and theory of metabolic
control
Victor Vitvitsky
Center for Theoretical Problems of
Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia
15:40-16:05 Mapping Mitochondrial Activity in
Postmortem Human Brain
Eugene Mosharov
Columbia University
New York, USA
16:05-16:20 Experimental anticancer compound
TIC10 induces transformation of BT474
human breast cancer cells to stable
stress-state
Artem Mishukov
Institute of Theoretical and
Experimental Biophysics, Russian
Academy of Sciences
Russia
16:20-16:30 C O F F E E B R E A K
16:30-17:00 Calcium oscillations and autowaves in
cells
Valery Zinchenko
Institute of Cell Biophysics of Russian
Academy of Sciences
Russia
17:00-17:30 Structural and functional mechanisms of
regulation of light stages in
photosynthesis
Alexander Tikhonov
Lomonosov Moscow State University
Russia
17:30-18:05 Signaling through Sulfide
Ruma Banerjee
University of Michigan
Michigan, USA
18:05-18:35 Novel genetically encoded tools for
compartment-specific manipulation of
NADH/NAD+ and NADPH/NADP+
ratios in living cells
Valentin Cracan
Scintillon Institute
California, USA
18:35-18:50 The effect of antioxidants on the
dynamics of oxidative stress in human
sperm
Eugene Bochkov
Lomonosov Moscow State University
Russia
18:50-19:05 Dynamics of structural changes in
cryoprotective media for
cryopreservation of cells
Anna Ivanova
Lomonosov Moscow State University
Russia
19:05-19:20 C O F F E E B R E A K
19:20-21:20 BIOLOGICAL SYSTEMS OF THE
SUPRACELLULAR LEVEL:
HEMOSTASIS, IMMUNITY,
NEUROBIOLOGY (PART 3)
Chairs: Dmitry Nechipurenko, Russia
Irina Grigorova, USA
19:20-19:50 Design of potential anti-aggregatory
agents and their influence on human
platelets activation
Olga Demina
N.M. Emanuel Institute of Biochemical
Physics Russian Academy of Sciences
Russia
19:50-20:20 Wandering cells: dissecting spatio-
temporal regulation of B cell immune
response
Irina Grigorova
University of Michigan Medical School
Michigan, USA
20:20-20:40 The influence of blood clotting on
pulmonary circulation
Anastasia Mozokhina
Peoples Friendship University of Russia
Russia
20:40-21:00 Elevated shear rate is not specific to
arterial thrombosis, but also relevant to
hemostasis
Alexandra Yakusheva
Center for Theoretical Problems of
Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia
21:00-21:20 Effect of heparin on the formation and
healing of stomach ulcers in rats
Denis Sakhno
Pavlov Institute of Physiology, Russian
Academy of Sciences
Russia
NOTES
