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Intramuscular Injection

Intramuscular injection, or IM injection, involves injecting medications directly into muscles using a needle. It has rapid absorption and onset of action compared to oral or subcutaneous routes. Some advantages are bypassing first-pass metabolism and allowing administration of large drug volumes. However, it requires expertise to administer properly and risks include pain, anxiety, and inadvertent injection into the wrong site. IM injection is used for antibiotics, vaccines, hormones, and other soluble drugs that need rapid absorption during emergencies.

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482 views2 pages

Intramuscular Injection

Intramuscular injection, or IM injection, involves injecting medications directly into muscles using a needle. It has rapid absorption and onset of action compared to oral or subcutaneous routes. Some advantages are bypassing first-pass metabolism and allowing administration of large drug volumes. However, it requires expertise to administer properly and risks include pain, anxiety, and inadvertent injection into the wrong site. IM injection is used for antibiotics, vaccines, hormones, and other soluble drugs that need rapid absorption during emergencies.

Uploaded by

Blazy Inhumang
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Intramuscular injection

  A method of installing medications into the depth of the bulk of specifically


selected muscles.
 Administered at 90-degree angle with a 22 to 25 gauge, ½ -to-1inch needle.

Dosage form: Parenteral

Bioavailability: 75≤100%

Examples:

 Antibiotics- Penicillin G benzathine, Streptomycin

 Biologicals- Immunoglobins, vaccines, and toxoids

 Hormonal agents- Testosterone, medroxyprogesterone

Any drugs that are nonirritant and soluble may be given IM during an emergency
scenario.

Advantage and disadvantages

ADVANTAGES DISADVANTAGES

 Rapid and uniform absorption of  Expert and a trained person are


the drug, especially those of the required for administrating the
aqueous solutions. drug by IM route.

 Rapid onset of the action  The absorption of the drug is


compared to that of the oral and determined by the bulk of the
the subcutaneous routes. muscle and its vascularity.

 IM injection bypasses the first-pass  The onset and duration of the


metabolism. action of the drug is not adjustable.

 It also avoids the gastric factors  In case of inadvertent scenarios


governing the drug absorption. such as anaphylaxis or
neurovascular injuries,
 Has efficacy and potency
intravenous (IV) assess needs to be
comparable to that of the
secured.
intravenous drug delivery system.
 IM injection at the appropriate
 Highly efficacious in emergency
landmarks may be difficult in a
scenarios such as acute psychosis
child as well as in patients
and status epilepticus.
requiring physical restrain.
 Depot injections allow slow,  Inadvertent injection in the
sustained, and prolonged action. subcutaneous plane of the fascia
can lead to delayed action of the
 A large volume of the drug can be
drug.
administered compared to that of
the subcutaneous route.  Painful procedure.

 Suspensions, as well as oily drugs,


cannot be administered.

 Can lead to anxiety in the patient,


especially in children.

 Self-administration of the drug can


be difficult.

 The precipitation of the drug


following faster absorption of the
solvent may lead to delayed and
prolonged action of the drug.

 Unintended prolonged sequelae


following delayed drug release
from the muscular compartment.

 Need for temporary restraint of


the patients, especially in cases
with children.

References:

Bioavailability of Drugs. (2011, September 4). HowMed. Retrieved September 10, 2021

from http://howmed.net/pharmacology/bioavailability-of-drugs/

Gutierrez, J. J. P., & Munakomi, S. (2021). Intramuscular Injection. In StatPearls

[Internet]. StatPearls Publishing. Retrieved September 10, 2021 from

https://www.ncbi.nlm.nih.gov/books/NBK556121/

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