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Sympathetic

The document discusses several alpha and beta adrenergic agonists including their side effects, symptoms of toxicity, adverse effects, food and drug interactions, and common uses. Pseudoephedrine, phenylephrine, midodrine, naphazoline, epinephrine, ephedrine, norepinephrine, and clonidine are described in tables with details about each drug.
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0% found this document useful (0 votes)
82 views7 pages

Sympathetic

The document discusses several alpha and beta adrenergic agonists including their side effects, symptoms of toxicity, adverse effects, food and drug interactions, and common uses. Pseudoephedrine, phenylephrine, midodrine, naphazoline, epinephrine, ephedrine, norepinephrine, and clonidine are described in tables with details about each drug.
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Stimulate SNS (Sympathetic Agonist/ Sympathomimetic)

Alpha 1 Side effects Symptoms Toxicity Adverse effect Food & drug interactions Uses and functions

Pseudoephedrine ▪ Restlessness ▪ fast heart rate ▪ agitation ▪ nervousness Avoid Caffeine intake, It is to relieve
▪ Nausea ▪ dizziness ▪ hyperactivity ▪ difficulty sleeping should not take with nasal congestion
▪ vomiting ▪ increased blood ▪ mydriasis ▪ stomach pain dihydroergotamine, caused by colds,
pressure ▪ tachycardia rasagiline, selegiline allergies, and hay
fever

Phenylephrine ▪ upset stomach ▪ irregular heartbeat ▪ ▪ nausea Avoid taking MAO Temporarily
▪ lightheadedness ▪ vomiting ▪ vomiting inhibitors relief’s stuffy nose,
▪ reduce blood flow to ▪ seizures ▪ headache, and sinus, and ear
your hands or feet nervousness symptoms
Midodrine ▪ numbness and ▪ blurred vision ▪ Hypertension ▪ slow heartbeat Should be taken Treats orthostatic
tingling ▪ difficulty urinating ▪ dizziness without food hypotension
▪ scalp itching ▪ Pounding in your ▪ fainting
▪ chills ears
Naphazoline ▪ Eye Pain ▪ increased sweating ▪ Hypertension ▪ stinging of the eye Avoid using alcohol or Decreases
▪ Changes in the ▪ headache ▪ bradycardia with ▪ watery eyes dizziness tobacco congestion,
Vision ▪ weakness dysrhythmia relieves allergies
▪ Severe headache ▪ hypotension and eye irritations.
Epinephrine ▪ Anxiety ▪ numbness on one ▪ blurred vision ▪ Dizziness Avoid Caffeine intake For bronchospasm,
▪ pale skin may occur side of the body ▪ pounding in ▪ Tremor asthma, cardiac
▪ trouble breathing ▪ decreased urination your neck or ▪ Palpitations arrest,
▪ sweating ▪ confusion ears ▪ nausea and vomiting anaphylaxis.
▪ cough with
foamy mucus
Ephedrine ▪ Anxiety ▪ Tachycardia • muscular ▪ High blood pressure avoid combination Treat hypotension,
▪ Headache ▪ cold sweat tremors ▪ Palpitations products that contains allergies, bronchial
▪ Nausea ▪ dilated pupils • convulsions ▪ Seizures ephedrine, asthma, and nasal
▪ Insomnia ▪ Death pseudoephedrine, congestion, to raise
▪ loss of appetite ephedra and caffeine blood pressure

Norepinephrine ▪ Slow heart rate ▪ excessive sweating • Should be ▪ Sudden Avoid Caffeine intake For severe shock,
▪ Confusion ▪ irregular heartbeat titrated to age- numbness/weakness/cold cardiac
▪ Nausea and vomiting ▪ intense headaches appropriate feeling in your body arrest
blood pressure ▪ Blue lips or fingernails
Stimulate SNS (Sympathetic Agonist/ Sympathomimetic)
Alpha 2 Side effects Symptoms Toxicity Adverse effect Food & drug Uses and functions
interactions

Clonidine ▪ Mental depression ▪ Nervousness ▪ Lethargy ▪ Stroke treat high blood


▪ swelling of the feet ▪ Agitation ▪ Miosis ▪ itching, scaling, severe pressure/
and lower legs ▪ Shaking ▪ slurred speech redness, soreness, or hypertension, ADHD,
▪ blistering, burning, ▪ Headache swelling of the skin opiate withdrawal,
crusting, dryness, vascular headaches,
or flaking of the glaucoma, ulcerative
skin colitis,
Tourette’s
syndrome,severe pain
in cancer patients
Epinephrine ▪ Anxiety ▪ numbness on one ▪ blurred vision ▪ Dizziness Avoid Caffeine intake For bronchospasm,
▪ pale skin may side of the body ▪ pounding in your ▪ Tremor asthma, cardiac arrest,
occur ▪ decreased urination neck or ears, ▪ Palpitations anaphylaxis
▪ trouble breathing ▪ confusion sweating ▪ Headache
▪ sweating ▪ cough with ▪ nausea and vomiting
foamy mucus

Ephedrine ▪ Anxiety ▪ Tachycardia • muscular tremors ▪ High blood pressure avoid combination Treat hypotension,
▪ Headache ▪ cold sweat • convulsions ▪ Palpitations products that contains allergies, bronchial
▪ Nausea ▪ dilated pupils ▪ Seizures ephedrine, asthma, and nasal
▪ Insomnia ▪ Death pseudoephedrine, congestion, to raise
▪ loss of appetite ephedra and caffeine blood pressure

Norepinephrine ▪ Slow heart rate ▪ excessive sweating • Should be titrated ▪ Sudden Avoid Caffeine intake For severe shock,
▪ Confusion ▪ irregular heartbeat to age- numbness/weakness/cold cardiac
▪ Nausea and ▪ intense headaches appropriate blood feeling in your body arrest
vomiting pressure ▪ Blue lips or fingernails
Stimulate SNS (Sympathetic Agonist/ Sympathomimetic)
Beta 1 Side effects Symptoms Toxicity Adverse effect Food & drug Uses and
interactions functions

Isoproterenol ▪ headache, dizziness, ▪ Chest Pain ▪ ▪ Upset stomach Caution in Containing Treats Heart
nervousness ▪ Flushing sulfites which may Block, Shock, and
▪ nausea ▪ Dyspnea provoke an allergic Bronchospasm
▪ blurred vision reaction in patients
with a sulfa allergy
Dobutamine ▪ Nervousness ▪ chest pain, ▪ Has a rare toxicity ▪ rise in the systolic blood contraindicated in use in patients with
▪ Palpitations ▪ headaches pressure patients with a decreased
▪ Nausea and vomiting ▪ tremors ▪ risk of rapid ventricular history of idiopathic contractility or
▪ nausea, and response hypertrophic sub- cardiac surgical
procedures leading
vomiting aortic stenosis
to cardiac
decompensation
Isoprenaline ▪ Nausea ▪ Angina ▪ ▪ Tachycardia Avoid coffees, teas,
▪ Vomiting ▪ arrhythmias ▪ Nausea, vomiting colas or chocolate
▪ Weakness ▪ Increased serum glucose
▪ Confusion ▪ myocardial necrosis
Norepinephrine ▪ Slow heart rate ▪ excessive sweating ▪ Should be titrated ▪ Sudden Avoid Caffeine For severe shock,
▪ Confusion ▪ irregular heartbeat to age-appropriate numbness/weakness/cold intake cardiac
▪ Nausea and vomiting ▪ intense headaches blood pressure feeling in your body arrest
▪ Blue lips or fingernails
Epinephrine ▪ Anxiety ▪ numbness on one ▪ blurred vision ▪ \Dizziness Avoid Caffeine For bronchospasm,
▪ pale skin may occur side of the body ▪ pounding in your ▪ Tremor intake asthma, cardiac
▪ trouble breathing ▪ decreased urination neck or ears, ▪ Palpitations arrest,
▪ sweating ▪ confusion sweating ▪ Headache anaphylaxis
▪ cough with foamy ▪ nausea and vomiting
mucus

Ephedrine ▪ Anxiety ▪ Tachycardia • muscular tremors ▪ High blood pressure avoid combination Treat hypotension,
▪ Headache ▪ cold sweat • convulsions ▪ Palpitations products that allergies, bronchial
▪ Nausea ▪ dilated pupils ▪ Seizures contains ephedrine, asthma, and nasal
▪ Insomnia ▪ Death pseudoephedrine, congestion, to raise
▪ loss of appetite ephedra and caffeine blood pressure
Stimulate SNS (Sympathetic Agonist/ Sympathomimetic)
Beta 2 Side effects Symptoms Toxicity Adverse effect Food & drug Uses and
interactions functions

Isoproterenol ▪ headache, dizziness, ▪ Chest Pain ▪ ▪ Upset stomach Caution in Containing Treats Heart
nervousness ▪ Flushing sulfites which may Block, Shock, and
▪ nausea ▪ Dyspnea provoke an allergic Bronchospasm
▪ blurred vision reaction in patients
with a sulfa allergy
Albuterol ▪ irregular heart rate ▪ swelling of your ▪ Increased heart ▪ Wheezing Can take this with or A bronchodilator
▪ shakiness throat or tongue rate (up to 200 ▪ skin rash without food. that treats
▪ dizziness ▪ hives beats a minute) ▪ trouble swallowing shortness of breath
Isoprenaline ▪ Nausea ▪ Angina ▪ ▪ Tachycardia Avoid coffees, teas,
▪ Vomiting ▪ arrhythmias ▪ Nausea, vomiting colas or chocolate
▪ Weakness ▪ Increased serum glucose
▪ Confusion ▪ myocardial necrosis
Norepinephrine ▪ Slow heart rate ▪ excessive sweating ▪ Should be titrated ▪ Sudden Avoid Caffeine For severe shock,
▪ Confusion ▪ irregular heartbeat to age-appropriate numbness/weakness/cold intake cardiac
▪ Nausea and vomiting ▪ intense headaches blood pressure feeling in your body arrest
▪ Blue lips or fingernails
Epinephrine ▪ Anxiety ▪ numbness on one ▪ blurred vision ▪ \Dizziness Avoid Caffeine For bronchospasm,
▪ pale skin may occur side of the body ▪ pounding in your ▪ Tremor intake asthma, cardiac
▪ trouble breathing ▪ decreased urination neck or ears, ▪ Palpitations arrest,
▪ sweating ▪ confusion sweating ▪ Headache anaphylaxis
▪ cough with foamy ▪ nausea and vomiting
mucus
Ephedrine ▪ Anxiety ▪ Tachycardia • muscular tremors ▪ High blood pressure Avoid combination Treat hypotension,
▪ Headache ▪ cold sweat • convulsions ▪ Palpitations products that allergies, bronchial
▪ Nausea ▪ dilated pupils ▪ Seizures contains ephedrine, asthma, and nasal
▪ Insomnia ▪ Death pseudoephedrine, congestion, to raise
▪ loss of appetite ephedra and caffeine blood pressure

Salmetarol ▪ runny nose ▪ shaking of a part of • Salmetarol ▪ swelling of the face, should not be used at treatment of
▪ throat irritation your body that you overdose throat, tongue, lips, or or around the time of asthma and COPD
▪ sinus pain cannot control eyes eating food and
▪ Nausea, vomiting ▪ excessive tiredness ▪ hoarseness avoid alcohol or
▪ headache ▪ difficulty swallowing tobacco
INHIBITS SNS (ADRENERGIC BLOCKERS/ Sympatholytic)
Alpha 1 Side effects Symptoms Toxicity Adverse effect Food & drug interactions Uses and functions

Alfuzosin ▪ headache ▪ dizziness ▪ hypotension ▪ Rash Inform the doctor if relaxes the muscles
▪ stomach pain ▪ lightheadedness ▪ difficulty swallowing or you are eating in prostate and
▪ nausea ▪ blurred vision breathing grapefruit or drinking bladder to allow
▪ fainting grapefruit juice while urine to flow more
taking this medication easily

Prazosin ▪ weakness ▪ drowsiness ▪ Toxic doses are ▪ fast, pounding, or reduced salt (sodium) treat hypertension,
▪ tiredness ▪ decreased reflexes ranging from irregular heartbeat diet it relaxes the blood
▪ headache ▪ fainting 285 mcg/kg to ▪ painful erection of the vessels so that
▪ nausea 1.7 mg/kg penis that lasts for hours blood can flow
▪ rash more easily
through the body
Terazosin ▪ tiredness ▪ dizziness ▪ hypotension ▪ Hives reduced salt (sodium) treat the symptoms
▪ back pain ▪ lightheadedness ▪ shortness of breath diet of an enlarged
▪ nausea ▪ blurred vision ▪ rapid, pounding, or prostate
▪ decreased sexual irregular heartbeat
ability

Alpha 2 Side effects Symptoms Toxicity Adverse effect Food & drug interactions Uses and functions

Mirtazapine ▪ Dry mouth ▪ flu-like symptoms, ▪ Mirtazapine ▪ Increased serum Avoid MAO inhibitors treatment of a
▪ Increased appetite fever, chills, sore overdose cholesterol major depressive
▪ Lack of energy throat, mouth sores, ▪ Drowsiness disorder
or other signs of ▪ Constipation
infection
INHIBITS SNS (ADRENERGIC BLOCKERS/ Sympatholytic)
Beta 1 Side effects Symptoms Toxicity Adverse effect Food & drug interactions Uses and functions

Propranolol ▪ Hypotension ▪ slow heartbeat ▪ hypotension ▪ swelling of the face, - Avoid alcohol. It treats Hypertension,
▪ bradycardia ▪ hypoglycemic throat, tongue, or lips Alcohol increases Cardiac, arrhythmias,
▪ fatigue seizure ▪ irregular heartbeat propranolol plasma Angina pectoris,
▪ depression ▪ restlessness ▪ blistering concentrations. Migraine headache
▪ hypoglycemia ▪ euphoria - Avoid natural
▪ insomnia licorice. Natural
licorice inhibits the
metabolism of
propranolol.
- Must be taken with
food

Atenolol ▪ cold hands or feet ▪ slurred speech ▪ can make ▪ trouble breathing Avoid using of alcohol Treats high blood
▪ tightness in chest ▪ unusual drowsiness, asthma or ▪ red rash and tobacco pressure/hypertension,
▪ sweating dullness, tiredness, COPD worse ▪ swelling of your throat reduce angina
weakness, or feeling or tongue
of sluggishness
Metoprolol ▪ nausea, vomiting ▪ dizziness ▪ Slows down ▪ heart failure Cardiac glycosides in treatment for angina,
▪ dry mouth ▪ trembling heart rate and exacerbation pleurisy root may heart failure,
▪ stomach pain make it difficult ▪ fatigue interfere the effect myocardial infarction,
▪ tiredness to breathe ▪ depression atrial fibrillation, and
▪ bradycardia hypertension
▪ hypotension
▪ bronchospasm

Beta 2 Side effects Symptoms Toxicity Adverse effect Food & drug interactions Uses and functions

Propranolol ▪ Hypotension ▪ slow heartbeat ▪ hypotension ▪ swelling of the face, - Avoid alcohol. It treats
▪ bradycardia ▪ hypoglycemic throat, tongue, or lips - Avoid natural Hypertension,
▪ fatigue seizure ▪ irregular heartbeat licorice. Cardiac,
▪ depression ▪ restlessness ▪ blistering - Must be taken with arrhythmias,
▪ hypoglycemia ▪ euphoria food Angina pectoris,
▪ insomnia Migraine headache

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