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Laghari@pharmaMmdc
ENDOCRINOLOGY BCQS
Topics
Estrogen
Diabetes Mellitus
Oral Contraceptives
Drugs & Breast Feeding
Ergometrine
Oxytocin
PROLACTIN
Anti-Thyroid Drugs
Corticosteroids
Q1.The hormone which causes contraction of uterus & helps milk ejection is.
A-Prolactin
B-Oxytocin
C-FSH
D-LH
E-Estrogen
Q. 2 Oxytocin
A-It is responsible for ovulation
B-It induces milk injection
C-It produces milk
D-It regulates menstnal cycle
E-It is always given orally
Q. 3.Regarding oral contraceptives choose the CORRECT action.
A-It makes the cervical mucus thin
B-It causes contraction of uterus
C-It acts by inhibiting ovulation
D-It increases milk injection
E-Failure rate is 50%
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Q. 4.Regarding glutathione conjugation reaction.
A-It results in increased water solubility of substrate
B-Inactivation of highly reactive interned rate products takes place
C-Enzyme involved in this reaction is UDP glucronidal transferase
D-Corticosteroids are inducer of enzyme
E-End products are excreted in urine
Q. 5.Which of the following is long action glucocorticoid?
A-Prednisolone
B-Dexamethasone
C-Fludrocortisone
D-Triamcinolone
E-Hydrocortisone
Q. 6.Corticosteroids are contraindicated in the following condition.
A-Acute lymlaticg leukemia
B-Eczema
C-Angioneurotic edema
D-Osteoporosis
E-Rheumatic fever
Q. 7.Sulfonylureas:
A-Act by increasing insulin synthesis
B-Tends to produce weight loss
C-Can be administrated in combination with metformin
D-Are suitable drugs for diabetes in pregnancy
E-Are effective in correcting diabetic ketoacidosis
Q. 8.Which of the following statement about metaformin is CORRECT:
A-It commonly Causes hypoglycemia
B-It can be safely administrated to patients with hepatic & renal disease
C-It increase release of insulin
D-It commonly cause weight gain
E-It decreases enogenous glucose production
Anti-Thyroid Drugs
Q9.location of thyroid gland?
A-Below larynx and in front of trachea
B-Above larynx and in front of trachea
C-Lateral to larynx and in front of trachea
D-Non of these
Q10.T4 also known as
A-thyroxine
B-thyroid strom
C-triiodothyronine
D- triiodothyroxine
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Q11.which statement is true for Triiodothyronine
A-4 times more potent
B-Remain for short time in blood
C-93% secretion is triiodothyronine
D-all
Q12.when 2 Iodides enters into interior of cell known as
A-iodide assemblance
B-Iodide traping
C-iodide resonance
D-Iodide coupling
Q13.The combination of active iodide with thyroglobulin is called
A-Coupling
B-condensation
C-organification
D-accumulation
Q14.which of the following drug will trapped iodide
A.-Methimazole
B-Organic iodide
C-Carbimazole
D-Thiocyanates
Q15.which of the following drug will Inhibit hormone synthesis
A-Propylthiouracil
B-Iodides of Na & K
C- Nitrates
D- Perchlorates
Q16. goiter formation with prolonged treatment is side of.
A-Propranolol
B-sodium iodide
C- Propylthiouracil
D-Thiocyanates
Q17. Organic iodide
A-Inhibit hormone synthesis
B-Inhibit iodide trapping
C-Inhibit hormone release
D-Destroy thyroid tissue
Q18.conversion of T4 to T3 within the thyroid and in peripheral tissues is blocked by which drug?
A.methimazole
B.Propylthiouracil
C.Propranolol
D.Radioactive iodine
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ESTROGENS
19. Progesterone is secreted by:
A- Ovarian follicles
B-Corpus luteum
C- Granulosa and theca cells
D-All of the above
20. The major natural progestin is:
A- Estradiol
B-Estron
C- Progesterone
D- Estriol
21. Which of the following statements about progestins is True:
A- Progesterone is rapidly absorbed following administration by any route
B-In the liver, progesterone is metabolized to pregnanediol and conjugated with glucuronic acid.
C- Significant amounts of progestins and their metabolites are excreted in the urine
D- All of the above
22. Noncontraceptive clinical uses of progestins are following:
A- Hormone replacement therapy
B-Dysmenorrhea
C-Endometriosis
D- All of the above
23. Mifepristone :
A- Antiprogestin
B-Antiandrogen
C- Antiestrogen
D-Androgen
24. Actions of mifepristone (RU-486) include:
A- Inhibition of ovulation during the follicular phase by blocking hypothalamic-pituitary progesterone
receptors, which
Suppresses midcycle gonadotropin release
B-During the luteal phase, inhibition of progesterone action on the uterus, which induces prostaglandin release
from the
Endometrium
C- Termination of pregnancy by facilitating luteolysis, menstruation, uterine motility, softening of the cervix,
and Detachment of the embryo.
D- All of the above
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25. All of the following statements about oral contraceptives are true, EXCEPT:
A- The “combination pill” contains both estrogen and progestin
B-Ethinyl estradiol and mestranol are commonly used in oral contraceptives
C- The “minipill” contains progestin alone
D- The “triphasic pill” contains estrogen, progestin, and luteinizing hormine (LH)
ANTIDIABETIC DRUGS
26.Secretory products of pancreatic β-cells are:
A- Glucagon, proglucagon
B-Insulin, C-peptide, proinsulin, islet amyloid polypeptide (IAPP)
C- Somatostatin
D- Pancreatic polypeptide (PP)
27. Insulin is:
A- A glycoprotein with a molecular weight of 6000
B-A small protein with a molecular weight of 5808 having disulphide linkage
C- A fructoolygosaccharide
D- A catecholamine
28. Insulin is a polypeptide hence:
A- It is resistant to destruction by gastric juice
B-It is destroyed by gastric juice
C- It is not a polypeptide
D- It is metabolized immediately by cellular enzymes
29.Insulin causes reduction in blood sugar level by the following mechanisms, EXCEPT:
A- Increased glucose uptake in the peripheral tissue
B-Reduction of breakdown of glycogen
C- Diminished gluconeogenesis
D- Decreased glucose absorption from the gut
30.Which of the following is true for glucagon?
A- Stimulates gluconeogenesis in the liver
B-Stimulates the secretion of insulin by beta cells
C- Inhibits glucose utilization by skeletal muscle
D- Inhibits uptake of aminoacids by cells
.
31. Insulin can not be administered by:
A- Oral route
B-Intravenous route
C- Subcutaneous route
D- Intramuscular route.
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32. Sources of human insulin production are:
A- Recombinant DNA techniques by inserting the proinsulin gene into E. Coli or yeast
B-Postmortem insulin extraction from human autopsy pancreas
C- All of the above
D- None of the above
34. The primary reason for a physician to prescribe human insulin is that:
A- It has a faster onset of action than other insulins
B-It has a shorter duration of action than other insulins
C- It can be given to patients who have an allergy to animal insulins
D- It is more effective in preventing the complications of diabetes than animal insulins
35. Correct statements about crystalline zinc (regular) insulin include all of the following, EXCEPT:
A- It can serve as replacement therapy for juvenile-onset diabetes
B-It can be administered intravenously
C- It is a short-acting insulin
D- It can be administered orall
36. Diabetic coma is treated by the administration of:
A-Lente insulin
B-Glucose
C-Crystalline insulin
D- Oral anti-diabetic drugs.
37. Sulphonylureas act by:
A- Reducing the absorption of carbohydrate from the gut
B-Increasing the uptake of glucose in peripheral tissues
C-Reducing the hepatic gluconeogenesis
D- Stimulating the beta islet cells of pancreas to produce insulin
38. Currently used second-generation sulfonylureas include the following, EXCEPT:
A-Glyburide (Glibenclamide)
B-Glipizide (Glydiazinamide)
C-Glimepiride (Amaril)
D- Tolbutamide (Orinase)
39. Currently used oral hypoglycemic thiazolidinediones include the following, EXCEPT
A-Pioglitazone (Actos)
B-Rosiglitazone (Avandia)
C-Troglitazone (Rezulin)
D- All of the above
40. Thiazolidinediones act by:
A-Diminishing insulin resistance by increasing glucose uptake and metabolism in muscle and adipose tissues
B-Reducing the absorption of carbohydrate from the gut
C-Stimulating the beta islet cells of pancreas to produce insulin
D- All of the above
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41. Currently used alpha-glucosidase inhibitors include the following, EXCEPT:
A-Pioglitazone (Actos)
B-Acarbose (Precose)
C- Miglitol (Glyset)
D- All of the above
42. Alpha-glucosidase inhibitors act by:
A-Diminishing insulin resistance by increasing glucose uptake and metabolism in muscle and adipose tissues
B-Competitive inhibiting of intestinal alpha-ghucosidases and modulating the postprandial digestion and
absorption of starch and disaccharides
C-Reducing the absorption of carbohydrate from the gut
D- Stimulating the beta islet cells of pancreas to produce insulin
43. Potency of action of
A-Miglitol is six times higher than that of acarbose
B-Acarbose is more than that of miglitol
C-Miglitol and acarbose is equal
D- Oral hypoglycemic agents depend on the severity of hyperglycemia
44. Which of the following oral hypoglycaemic drugs stimulates both synthesis and release of insulin from beta
islet cells:
A-Glibenclamide
B-Phenformin
C-Buformine
D- Metformin
45. Currently used oral hypoglycemic biguanides include the following, EXCEPT:
A-Repaglinide (Prandin)
B-Metformin
C-Phenformine
D- Glipizide
46. The action of insulin is potentiated by:
A-Sulphonylureas
B-Glucagon
C-Biguanides
D- None of the above
47. Duration of action of:
A-Tolbutamide is more than that of chlorpropamide
B-Chlorpropamide is more than that of tolbutamide
C-Tolbutamide and chlorpropamide is equal
D- Oral hypoglycemic agents depend on the severity of hyperglycemia
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49. Biguanides are used in the following conditions, EXCEPT:
A-As a supplement to sulphonylurea, where it is insufficient to give good results
B-In over weight diabetics
C-To reduce insulin requirements
D- In case of hyperglycemic shock
50. Which of the following agents is/are important hormonal antagonists of insulin in the body?
A-Glucagon
B-Adrenal steroids
C-Adrenaline
D- All of the above
51. Glucagon is:
A-A glycoprotein with a molecular weight of 6000
B-A peptide – identical in all mammals – consisting of a single chain of 29 amino acids
C-A a fructoolygosaccharide
D- A small protein with a molecular weight of 5808 having disulphide linkage
52. Which of the following statements is FALSE?
A-Glucagon is synthesized in the A cells of the pancreatic islets of Langerhans.
B-Glucagon is a peptide – identical in all mammals – consisting of a single chain of 29 amino acids
C-Glucagon is extensively degraded in the liver and kidney as well as in plasma, and at its tissue receptor sites.
D- Half-life of glucagon is between 6 and 8 hours, which is similar to that of insulin
53. Glucagon can be used in the following situations, EXCEPT:
A-Severe hypoglycemia
B-Severe hyperglycemia
C-Endocrine diagnosis
D- Beta-blocker poisoning
54. Main complications of insulin therapy include the following:
A-Hypoglycemia
B-Insulin allergy
C-Lipodystrophy at an injection site
D- All of the above
Oral Contraceptive Kd Tripathiii
55.Which side effect of the oral contraceptive subsides after 3–4 cycles of continued use:
A.-Glucose intolerance B-Rise in blood pressure C- Headache D-Fluid retention
56. Oral contraceptive use increases the risk of occurrence of the following diseases except:
A-Hypertension B-Leg vein thrombosis C-Endometrial carcinoma D-Gall stones
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57.Concurrent use of the following drug is likely to cause failure of oral contraception:
A-Isoniazid B-Rifampicin C-Cimetidine D-Propranolol
58. Health benefits afforded by the combined estrogenprogestin oral contraceptive pill include the
followingexcept:
A-Reduced menstrual blood loss
B-Lower risk of fibrocystic breast disease
C- Lower risk of myocardial infarction
D- Lower risk of endometrial carcinoma
59. On stoppage of the combined estrogen-progestin contraceptive pill, fertility returns after:
A- 1–2 months
B-4–6 months
C- 6–12 months
D- Uncertain period
60. Centchroman is:
A- An oral contraceptive for women
B-An oral contraceptive for men
C-A mast cell stabilizer
D- A centrally acting muscle relaxant
61. The following has been found to act as a male contraceptive without affecting libido or potency:
A-Cyproterone acetate
B-Goserelin
C-Centchroman
D- Gossypol
62.78 The following contraceptive acts primarily by interfering with implantation of blastocyst:
A.-Gossypol
B-Centchroman
C-Combined estrogen-progestin pill
D-Phased pill
63.Select the tissue that is most sensitive to oxytocin:
A-Myometrium
B-Myoepithelium of mammary alveoli
C-Vascular smooth muscle
D- Renal collecting ducts
64. Actions of oxytocin include the following except:
A- Vasoconstriction
B-Increased water reabsorption in renal collecting ducts
C-Contraction of mammary myoepithelium
D- Release of prostaglandins from endometrium
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