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Assignment #2: BIOM5101F21

The document discusses electrophysiology of the heart and cell membrane potentials. It contains questions about analyzing EKG waveforms, calculating membrane potentials given ion concentrations and permeabilities, and factors that impact biosignal electrode recordings such as impedance.

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Aditi Biswas
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36 views4 pages

Assignment #2: BIOM5101F21

The document discusses electrophysiology of the heart and cell membrane potentials. It contains questions about analyzing EKG waveforms, calculating membrane potentials given ion concentrations and permeabilities, and factors that impact biosignal electrode recordings such as impedance.

Uploaded by

Aditi Biswas
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Assignment #2

BIOM5101F21
Question 2.1
Explain each waveform based on the electrophysiology of the heart given the condition.
For each wave form – estimate the heart rate assuming the standard scale shown.
a) 3rd degree AV block

1 second http://www.rnceus.com/ekg/thirdav.gif

b) Atrial Fibrillation

Scale

https://www.nottingham.ac.uk/nu
rsing/practice/resources/cardiolog
y/function/role_of_ecg.php
https://www.practicalclinicalskills.com/atrial-fibrillation
Question 2.2
A cell has a intracellular/extracellular ionic concentration of 12/145, 155/4, and 4/120 for
Na+, K+, and Cl-, respectively (mmol/L).

a) Assuming cell membrane permeabilities of 2e-8, 2e-6, and 4e-8 for for Na+, K+, and
Cl-, respectively (cm/s), what is the resting transmembrane potential.

b) Assuming cell membrane permeabilities of 2e-5, 2e-6, and 4e-8 for for Na+, K+, and
Cl-, respectively (cm/s), what is the resting transmembrane potential.

c) What changed between the scenario in (a) and (b)? What did that change result in?
Can these changes be related to action potentials?

d) Explain how these potentials relate to the potentials observed during the various
phases of an Action potential.
Question 2.3
• Electrode-skin impedance is a major determining factor for
the quality of biosignal recordings. A lower electrode-skin
impedance is desired, which can be achieved in a number
of different manners, including skin-preparation.

• A larger electrode that has a larger contact surface area will


have a lower electrode-skin impedance (resistance is
inversely proportional to the cross-sectional area).

• Should biosignal recordings use really large electrodes (or


really small electrodes)? Explain your reasoning.

• What about the reference electrode?

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