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Drugs in Heart Failure Zol 1

This document outlines the treatment and management of cardiac failure. It classifies drugs used to treat heart failure into several categories: inotropes to increase contractility like digoxin; ACE inhibitors like captopril and enalapril; ARBs like valsartan and losartan; diuretics like furosemide to reduce blood volume; and beta blockers like metoprolol and bisoprolol. It describes the pharmacokinetics, indications, and adverse effects of these drug classes. While beta blockers are important long-term for reduced ejection fraction, they can exacerbate symptoms in acute or decompensated heart failure due to dependence on sympathetic drive.

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71 views27 pages

Drugs in Heart Failure Zol 1

This document outlines the treatment and management of cardiac failure. It classifies drugs used to treat heart failure into several categories: inotropes to increase contractility like digoxin; ACE inhibitors like captopril and enalapril; ARBs like valsartan and losartan; diuretics like furosemide to reduce blood volume; and beta blockers like metoprolol and bisoprolol. It describes the pharmacokinetics, indications, and adverse effects of these drug classes. While beta blockers are important long-term for reduced ejection fraction, they can exacerbate symptoms in acute or decompensated heart failure due to dependence on sympathetic drive.

Uploaded by

vinoedhnaidu_rajagopal
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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DRUGS IN HEART

FAILURE
YEAR 2 COHORT 6
31st MAY 2021
• OUTLINE THE TREATMENT /
LEARNING MANAGEMENT OF CARDIAC
FAILURE
OUTCOMES • CLASSIFICATION OF DRUGS IN
HEART FAILURE
• DESCRIBE PHARMACOKINETICS,
PHARMACODYNAMICS,
INDICATIONS, ADVERSE EFFECTS
EXERCISE

DIET : DECREASE SALT / FAT INTAKE


GENERAL
MANAGEMENT
AVOID FOOD HIGH IN K

TREAT THE CAUSES: VALVES, CABG


INCREASE CONTRACTILITY
• DIGOXIN
• INOTROPES e.g. DOBUTAMINE
ANGIOTENSIN CONVERTING
ENZYME [ACE] INHIBITORS
• ENDS WITH “ PRIL “
• CAPTOPRIL
• ENALAPRIL
• PERINDOPRIL
• LISINOPRIL
ANGIOTENSIN II RECEPTOR
BLOCKERS [ARB]
• ENDS WITH „SARTAN‟
• VALSARTAN
• LOSARTAN
• TELMISARTAN
DIURETICS
• INCREASE URINE OUTPUT
• HENCE REDUCE BLOOD VOLUME  REDUCE
VENOUS RETURN
• SPIRINOLACTONE
• FUROSEMIDE (LASIX “LAST FOR SIX HOURS”)
FUROSEMIDE

CLINICAL USE SIDE EFFECTS


• Heart failure • Hypokalaemia
• Hypertension • Hypomagnesaemia
• Oedema • Ototoxicity
β BLOCKERS (END WITH „LOL‟)
• METOPROLOL
• BISOPROLOL
• CARVEDILOL
Heart failure — Beta blockers are an important
component of long-term therapy for patients with chronic
heart failure and reduced left ventricular systolic function,
as these drugs reduce the detrimental effects of excess
chronic catecholamine stimulation. However, beta
blockers may exacerbate symptoms in patients with acute
decompensated heart failure or in those with preexisting
myocardial dysfunction and borderline compensation,
since the maintenance of cardiac output in such patients
depends in part upon sympathetic drive. Hence, beta
blockers should not be administered as new therapy until
after heart failure is compensated

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