Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices
Pharm 201L
Name: De Jesus, Esmeria, Estanislao Group: 05
Year/Section: Q2A Final Rating:
PREPARATION No. “16”
“AROMATIC ELIXIR”
A. WRAP-UP GUIDE QUESTIONS:
Synonym/s: Simple elixir
Uses of Preparation: Flavoring agents. solvents or vehicles for drug preparation
Method/s of Preparation used: Simple solution
Method/s of Administration: Oral Administration
Packaging material/s used in the preparation: Amber bottle
Particular Equipment (if any): Beaker, Dropper, Funnel, Filter paper, Graduated cylinder
Ideal temperature and storage conditions: Stored in a tightly closed, light resistant container
away from direct heat and sunlight.
Description of Finished Product: Cloudy or yellow-green, sweetened hydroalcohol liquids
intended for oral use containing flavoring substances or active medicinal agents.
B. Facsimile label:
Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices
Pharm 201L
Formula based on preparation:
Raw Materials Quantity Physical Appearance Uses
Orange oil 0.072 mL It is a yellow to Orange oil is a
reddish-yellow liquid with powerful and natural
the characteristic odor of solvent.
orange peel and may Antimicrobial
become cloudy when activity, pain relief,
chilled. and anticancer
properties.
Lemon oil 0.018 mL Yellow or yellow-green As an ingredient that
liquid. Gives it its fights exhaustion,
distinctive lemony aroma. helps with
depression, clears
your skin, kills
harmful viruses and
bacteria, and reduces
inflammation.
Coriander oil 0.0072 mL It is an almost colorless to Used in antibacterial
pale yellow liquid with a formulations due to
characteristic odor, its ability to fight
reminiscent of linalool. foodborne illnesses
and hospital-acquired
infections
Anise oil 0.0018 mL Has a clear light to pale It is used as an
yellow color with a antispasmodic and
characteristic potent antiseptic and for the
aroma. treatment of cough,
asthma, and
bronchitis.
Simple syrup 11.25 mL Brownish hue, thick and Used as vehicles for
sweet liquid drugs such as
antibiotics,
Antihistaminic,
antitussives, and
vitamins.
Talc 1.35 g Translucent to opaque Used as an anticaking
with colors ranging from agent to improve
whitish-grey to green with powder flow in tablet
a vitreous and pearly compression.
luster
Alcohol 7.401 mL Liquid colorless Used as a solvent and
preservative in
Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices
Pharm 201L
pharmaceutical
preparations.
Purified water, qs.ad 30 mL White crystalline solid, Used as raw material,
almost colorless liquid ingredient, and
with a hint of a blue, solvent in the
colorless gas processing,
formulation, and
manufacture of
pharmaceutical
products, active
pharmaceutical
ingredients
C. Calculation(s):
Ingredients Original amount Computed amount
Orange oil 2.4mL 0.072 mL
Lemon oil 0.6mL 0.018 mL
Coriander oil 0.24mL 0.0072 mL
Anise oil 0.06mL 0.0018 mL
Simple syrup 375mL 11.25 mL
Talc 45g 1.35 g
Alcohol 246.70mL 7.401 mL
Purified water, qs.ad 1000mL 30 mL
To make 1000mL 30mL
Solution:
2.4 mL / 1000 mL = x / 30 mL = 0.072 mL
0.6 mL / 1000 mL = x / 30 mL = 0.018 mL
0.24 mL / 1000 mL = x / 30 mL = 0.0072 mL
0.06 mL / 1000 mL = x / 30 mL = 0.0018 mL
375 mL / 1000 mL = x / 30 mL = 11.25 mL
45 g / 1000 mL = x / 30 mL = 1.35 g
Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices
Pharm 201L
246.70 mL / 1000 mL = x / 30 mL = 7.401 mL
1000 mL / 1000 mL = x / 30 mL = 30 mL
D. Attachment(s) of actual laboratory activity: (if any)
Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices
Pharm 201L
ASSIGNMENT
1. What are the similarities of aromatic elixir to aromatic water?
- Aromatic waters are clear aqueous solutions saturated with volatile oils or other
aromatic or volatile substances. Elixirs are sweetened hydro-alcoholic (water and
alcohol) liquids for oral use. Alcohol and water are used as solvents when the
drug will not dissolve in water alone.
2. What is the solvent that is a highly toxic agent used in antifreeze solutions in 1938,
resulting in the death of 100 people due to poisoning?
- “Elixir Sulfanilamide incident.” In 1937, over 100 people died after taking a
liquefied version of a common antibiotic that was sweetened with diethylene
glycol.
3. What are the primary solvents of elixirs?
- Their primary solvents are alcohol and water, with glycerin, sorbitol, and syrup
sometimes as additional solvent and/or sweetening agents.
4. Give an example of a commercially available elixir dosage form.
- digoxin
- antihistamine
- phenobarbital
