aIDVWav4 3c LLNALSISW IS MVDIGAW LLNAISISY MULNAd lo leg lee the elem a a NOSATVHIW VINVAPYINIGV TA, NVADYVW NIXD IV rewoupa redaay us rivoraaw LinasCUVANT INTRODUCTIV Jan Baptista van HELMONT, 1707 La fiecare inceput de an, tofi cei preocupati de problema medicamentului lator si din cataloage a unor substanfe consi- au loc ia «lumea medicament fat st concepem acest manual, completat ga domeniu, GHID DE FARMACOLOGIE, elaborat de aceeasi ‘ALL, 2011), in linit mari, manualul se axeaz8 pe planul stabilit in ghidul ied respectind curicullum aprobat de M.E.C-T. actualmente consti din structurarea materiei de invaigimant farmaceutic — unde fiecare dintre ele se studiaza separat in cate in programul de invitmant pentru asistenti medicali general , desi contopite intr-un singur modul, reprezinta trei Ye diterite FARMACOLOGIE GENERALA (pentru asistent medical generalist rodulal 12, competent 1 si pentru asistent medical de farmacie anol 1, modulul X1). 2. FARMACOTERAPIE (pentru asistent medical generalist anul I, modulul 12, competenta 2 si pentru asistent medical de farmacie anul Il, modu- lV), 3. FARMACOTOXICOLOGIE (pentru asistent medical generalist anul 2, competenta 3 gi pentru asistent medical de farmacie anu relansarea acestei lucrari pe care le consideram fundamentale. macologie am pornit de la doua premize,Inspro ur gzeouorioe ozeo ojsuawivoipau puratsd s0jajaqe1 B pNOW PULIOY o-nu! paumnaistoo 1S rativoipaur P arENSIUNUpE op FAIZBAMIoU EPOLaU BD adTUE -aapsues ayauaysts 21dsop inyryesBered vazeyoazop BIlin yey9pIstoOD Wy youd ap tourexe nun [raped Ut axenyex2 2p yootqns a1m -rysu0s AN axeo sep (jALyeoride 19 ynsoyoeseD uLad EININ ap tIgasoap wEIApISuOD 6) exejuauunjdns gxmgaj 0 ap eqzoa a4s9 go exluate [apise puLsene ‘o|ta yeu Bx=H| (Soyooeuse3 ap vynotano uy sede nu yornadeza we 9p dios un na s1s98 wre-2 “ans e] a1voyz9ja1 ajapesesed 2oor209p “ISMo], IM] BayesTxojduuoo eo UE WOU jquiesue uy zens 19 yejozy ay nu ES MN|MIUaLUVOIPaNE IREpRUS IOUT ‘poyentjeas 1S oyuouteorpaur azjuy wraz9U0D TEU erNIEBay 0 az9z1[E4 -eyen nun apse “vot fps Aaya 29 natuad “nupour janiu op aiojooeauses ap jenueur un nantied coud aysoow ay801 sttused we-2N, “«o[Suoag NUNSE UL ERNades9) eIBOVENSY 19 yeyo|duoo use] pz [MIONdeD ~«ayuasgOZIYDS UE woRNadesD) wYBayEAyS> WET ‘sul BS joidne sonioyssdnue elsoBa1e> wip ojaseuSoxd op gues pupusi “Zz ynjordva nayua, “«pes9ua8 uy “yezeqdoau uy yo nadess wIBayeANS> Aneuinzornyn jryesered no wrajdusoo 1s0g © gt injoudes rer «(VETS) ATH rjaajut ur gopinadesay eyfayengy wzowis uRUozosd ws (Jue HAIN UIP alte -psapisuoa {9 9jasaxSoxd na) ajestAonariue forieoypeuw fuspeo Ul ° yniapisuos we ¢{ [njoudeo P7] ~«experuasa yyeyiaye wounjsuax.edyy wy wan -advsay wySayeng» “eaisuovodiq.iue vibeorpow e] 221 «oypaesoyu [mOepUy UE gonnadesay wySaywangy wengpe arso vorUIayos! 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Cu titlu de curiozitate, enumerim si alte c&teva medica- mente care NU mai apar in nomenclatoarele ultimilor 2 ani din Romania si pe care — bineinteles ~ le-am exclus gi noi din acest volum : amobarbital, astemizol (Hismanal®), Calmogastrin, Centrum Junior, Cisaprid, Cisrelax, clorpromazini (Plegomazin), Cofedol®, Ecoflorina, Eurovita + E forte, Gelusi comicind, Lizadon , meprobamat, mequitazina (Primalan®), Napoton, prazosin (Minipress®), Regulax®, tioridazina, terfenadina (Histadin®), Uleerotrat etc. ete, La vitamine am addugat sursele naturale principale pentru fiecare din- te ele, pentru a sublinia importanga si rationale (ceea ce ). Am vitamina B,, (acidul paraaminobenzoic), vitamina B,, (acidul orotic), vita- mina B,, (acidul pangamic) si vitamina B,, (casinovita B, Am acordat explie: mentare in legatura cu medicafia an si anticoagulanta, atat de mult utilizatd in epoca noastra, Am introdus la capitolul 18, in legaturd cu agenii imunosupresori, con- ceptul de boalé autoimund incluzdnd notiuni referitoare la domeniile ,self* si snon-self*, Am dat o dezvoltare mai mare medicatiei imunostimulante si irombotica supresoare pentru csi progresele in aceste domenii sunt remarcabi special in problema rejetului de transplant de organ. In legitura cu acest ca tole, am considerat necesara o seurtincursiune in domeniul imunitagii me ate umoral gi al imunitatii mediate celular, Progresele considerabile ealizate in domeniul medicatiei antiretrovirale ne-au obligat la completari substantiale ale acestui capitol. Datorita unor ase neniea progrese, sansele de supraviejuire in infectia HIV au crescut considera- sticul imediat fiind mult ameliorat. denumirile comerciale sub care nu mai apar uncle medicamente in circulatie. Spre exemplu preparatul Rudotel® NU mai apare sub folosité denumizea comund internationala, medazepam. ‘Am introdus la cap.7 maerogoli si unele eubiotice care in prezent au o uti- lizare din ce in ce mai larga. Am completat eapitolul 11- MEDICATIA DERMATOLOGICA cu pro- duse utilizate fn tratamentul psoriazisului Data fiind larga raspandie si larga utilizare a suplimentelor alimentare, am adaugat la fiecare capitol si cdteva din aceste produse, despre care eredem MANUAL DE FARMACOLOGIE c@ clevii trebuie s& ia cunostintS, chiar dacd nu apartin «tezaurului clasic» de medicaments. In fond, asistent al si asistemtul de farmacie trebuie si fie la curent cu actualititile din vastul domeniu al medicamentul ‘Tinand seama de abundenja de medicamente gi de numeroasele substanfe cou potential toxic (dintre care o buna parte se bucuri de libera circulatie) am dat o mai mare dezvoltare capitolului 32 TOXICOLOGIE (INTOXICATIL ACUTE), ‘Am procedat la ilustrarea capitolului 33. ~ TOXICOMANIILE, (DROGURI, STUPEFIANTE, NARCOTICE) cu imagini referitoare la unele surse de substanfe aparjindnd acestei grupe. Un spatiu marit si informagii mai ample sunt acordate pentru drogurile etnobotanice din acelasi capitol ‘Am imbogatit iconografia lucrarii cu figuri pe care le-am considerat suges- tive pentru aprofundarea materialului expus in text. Urmand exemplul a numeroase luerdri de larga circulatie, publicate atat fara noastra cat si in strdinatate, am introdus dublarea in limba englezi a rilor, sia unor grupe de medicamente. Cu atat mai mult cu ct suntem marto- rif unui adevrat wexod» de cadre medico-sanitare de la toate nivelurile, ple- cand din fara noastra ca s& lucreze pe baz de contract in alte yari ale Uniun Europene, Respectind noi, suntem recepti i alte lucrari concepute de i referitoare la acest volum. principiu pe care lam enuntat la orice observatii si sus Autorii NOTA. Atragem atentia c& NU toate datele din aceasta lucrare trebuie memo- rate, ele putind fi oricénd gt te in cataloage de medicamente, agende medicale, ajele produselor farmaceutice ete tore aflate ina lasificarea ATC este pretios pentru incadrarea unei iat dar NU enevoie ‘memomeduri, prospecte Astfl, codul medicamentelor fe pentru o prezentare ordonata a practica nu devine necesar. asi greutatea formelorsoso yminsai ut weiuozasdas 180g ‘pp BoroTe ese NO “IWa|BAq ‘OSEOIDI-OUT| noye Jojayeiour ednsB urp ‘o1[eaU s9}oeIeD 9 oLeUIYD WAULA|D ~ ‘MIg]ED = ED ‘uerBeyosoonse8 xn|Ja1 9p v[B09 = TOA 9p pores jong = yoIUOIDw (QS “aa “IN ‘BH “tg 21298 aperour ap tangs mo 18 (ermasa9e wdusoo 18) uasie no veiporxoruT UE 1OpHUE = oUSIN HUY YsHU = TYE (@rBesourey nes oruraypst) jesqas99 se]nasea yUapIsoe = (78Ua"gI] 2YOUS = JAV sAOIE = AV =d1¥ (Be — syeynsuos 2yeroyeu ajaun wy) wBnUE = (Bre nes) Bry (ov = areynsuoe afeqsaqeur ajoun uw) dioonue = Cove nes) “ory 0) pwonwoyDuD = DAV 7x0-OUrBIn|S wzEU -quresuen suntuouls #6 oujumuap woupa, “(LTV Wop arind reur rep) apestA jedoq uy ginoses9 pt 4398 UL B[BULI0U axBOTBA) 10) nredst = 1SV ainoe 2 {yarn ap 90) autluoa auto sep ‘NCL no areoiguuase a1zauodutoo purge ‘eBid ejnoojoun no otafonu pioe ~[FINY 222/8w2"Q)] a1a}9NUOGL PIDE = NIV = PAV = poranaidownnn( ezeurwinsuen suruouts 18 arrumusp e499, "9 ‘oqsod) ajeuta ainoe ajouneday s JOU axzo]PA) JOVBIOGE| 2p 1821 yedoy punyzus -"yzesaysuENOUNU-UIUELE = [TY ‘9Seox29|n1]UE a}UaUTEDEpOUL aSeOr -2uanu uy mags ap BULIOY gas 11 rou oyuNny quouoye ~NUGTTUNE = TV ‘9 uoxoudu “tuv9|xojous “u1seYewsopur“u2sozdnq! awwoupuiau ad = [pzaouyf qi] una {vais €] upuegop renayap -ounuis jnuospuis = f78u2-q1) awosputs Aouaroifepounuaur pasinbo0 = SLY ‘ol0jsoptpurzouape pioe = dav -uadorpiq ap tanae3] eAMEBoI 2p aperdayy,“su10}s0q proe 18 (ezoqLIFNO[S prusuaid eze9 0 oe uruen® nes UlUape) RolULINd Rzeq O-NUIP 1S 3]9P!09JINN“Podans as 210: Insuos uy EUs ENeIBD e905 2 -nuau ap pupiadas ‘¢-, puny puoqeo o “yopsred ROP 229 FoON2 2109 (2p je Enop) eleproayfoq IS preUarEoNG YULIOG 2p ‘ynaayous no jayonu plow = (eA 222}8u2'qy) 212}9nUOgHxO()>p PI9® = NAV 3 noe wud areangimy 18 axjuare 2p uo4yap ioyap wonuari9 = GHA rode eriquosqeanas pag> {nuowoy = [18u0'q) suowioy aneapuun = HAW un ‘gpwos 0 : xa) a9] ad supe a1e9 “ges = [pzxoungf gy] aanauep e (exeop.oque ez1yodty ap ry21095) don, -oonioaouaxpe ynuowtsot| = /7839'q1) auouoy 2idousoonuovoUe4pe = HIOW ‘YH vot2onpoud uy yoeysodut fox un ae aun “J wussuojrfue ut J wursuoyrsue PUNO|sUEN BS (Va) loutsUorOIBUE ajsianuon ap vwnr2ua = ((jSu2r9}] auidzu9 uotssasueD UIsus}or3uo = IOV (aooque = aymyasuoa ayessyew ajoun uy) ploe = (9e nes) “9y [sjoquds puv suduossn ‘suoynisasgqy] PANTOANIS 8 AWINOUV ‘TAGIATAAV{n ding, avand gi importante roluri functionale [ cap. 8, § 8.5]. In tera- apie) se utilizeaz sub forma de saruri Cap. (sau cap.) = capitolut caps. = capsule, ~ forme farmaceutice orale solide, in care medicamentul (pul- bere, substanté semisolid’ sau lichida) se afl bil din gelatina sau amidon, de forma cilindricd sau ovalaré, uneori preva- ut cu un eapacel, CID = (sindromul de) coagulare intravascular diseminaté = sindrom hemo- tagic sever cu stare toxicoseptie4, trombocitopenie si — frecvent ~ fibrino- liza asociata Cl = clor, ~ element chimic cu caracter nemetalic, din grupa halogenilor, eu valenga variabi V sau VII), masa atomica 35,5, avnd rol important oral (ORS = oral rehydration salts Ib.englez2) Clor= clearance-ul creatininei endogene = valoarea care exprima volumul tual de plasma epurat de creatinina in decurs de un minut, Normal laa 100-130 ml/minut. Este un parametru deoscbit de important in evaluarca stadiului in care se afl un bolnav cu insuficienta renala cronicé deoarece permite aprecierea numarului de nefroni rimasi functional CO = oxid de carbon, monoxid de carbon [a NU se confunda eu dioxidul de carbon (CO,) > mai jos}. Este un gaz extrem de toxic, fixaindu-se pe hemo- lob dus stabil, carboxihemoglobina. (CO-Hb). ‘Co= cobalt, element metalic intrand in compozitia vitaminei B,, (= ciancoba- lamina), CO.Hb = carboxihemoglobina = compus stabil toxic al CO cu hemoglobina, care astfel este impiedicata si-si exercite functia de transportor labil al O, expirat este in concentratie de 3 %, compr. = comprimate,- produse farmaceutice solide in forma de discuri mici sau ovale. ‘cone, = concentrat (solutie concentrat COX-1 ji COX-2 = ciclooxigenaza | si er = eronie .solufie-mama") looxigenaza 2 MANU FaRn Cr= crom, ~ element chimie cu caracter metalic, cu valenta vs LV, V, VI), cu masa atomics 52, avand in organism rol de oligoelement [> cap&, § 8.5] CT =con tomography [tb.engl,] = tomografie (axiala) computerizata ~ examen imagistic radiologic de profunzime, care poate fi efectuat nativ (= simplu) sau cu un mediu de contrast (o substanga radioopacd). Ctrind (sau ctrind) = contraindicatii (sau contrai -a comuna international ‘w= 100 ml 1b. englezd ACE) = enzima de conversie a angiotensinei | in angioten- II care are rol in mecanismul hipertensiunii arteriale. Medicamentele care blocheaza aceasta enzima (captopril, enalapril) au indicatie in trata~ ‘mentul HT si al edemului pulmonar act. ECG sau EKG = electrocardiograma EEG = electroencefalograma nosorbent assay {Ib.engl] = testul de aturate,- proba de laborator prin care se pun ‘anticorpii din organism aparuti in urma patrunderit unor agenti indu-se cenzime specifice marcate, Acestea actioneaza asupra unui imunoreactant si in caz de prezenta a anticorpilor cercetati - determina schimbarea de culoare a mediului din vasut unde se desfasoara react Ex. (sau ex) = spre exemplu ‘extern (pentru medicamente, uz extern) din produse vey ichida), extracte 3) si extracte uscate (de con: valent, masa atomica 19, avand in organism rol de oligoelement (component al smaltului dentar) [> cap, § 8.5] FAS = fosfataza alcalina serica ~ enzima folosita ca test de laborator, prin dozare in serul sanguin. Are valori crescu pro-Is-g § ‘geo €] rerouwosoew ws nnd op [Os WstEBL0 UL puyae “pz BoIMOFE eseaK ‘WUaLEAIg ‘oseOTS}-OUNED;E sojoreiau edad wip ‘o1yerau saroesw9 no omy quaLta|2 — “nizousEUH = BA sdups atid {© [e [Qe] xowodsun ap wrlouny ruyydapus ayeod your 8. Japise a1e9 gH fe 21K01 1 [LgeIs TepIXo snduioo = wuIgo/Zou1ay:0W! = GENOW rolueysqns v (gueyno9jour ese nes) yorUOye eset i O1 x 1p/Sur spjmuasoy yep y7~a]nope9 28 1FiNJ08 UY afureysqns eiua]ea no BIEZIAIp a}s9 (gsP|NDd|oUE Nes) YorUNOLE YSEUL TOxED e ‘piuejsqns o-nuyp fur us eareinues = (\iuayearypor[iar nes) yuayearyoor|tut = bur ({enwew er8osojoy as 16 eztuns -oud 2359) exesqitva wzop no zore[eyU = [/8U2"Ql) 4epOyLa asop pasoiou = IV qu xejnogjou arenas no puLredoy = uuodoy syBtam anpnoapou Mo] = AIN'T pourds-oxqai99 mynxe = ybaur jnunfuy 20yaa}0xd noSmeur un japse puyAsuod ‘se|Mpeuttsod 16 jwsqai201104 ‘ueiprouyeseqns jnrieds 18 unoaud seunpuodo nyeuea “{eaqere9 xeMoINUA nuioysts ajdusn azeo zea 18 yuamedsuen pryoH] = UeEPIEIOTEIe9 PIYD!] = AIT praoureyy equi uy = SURAT GT ‘yzaj8us equay uy = 1800-q] totieipes wumistuio vore[nuins ud yuan] ¥ oaeonynduue = [78u9 — ‘po! = | ‘yjeoue ounisuayiodiy — VLH ee -duosuensionay oySoumnu 25 eunyzue ‘earenuadored wiajdoo tf axe9 euIZUD © pugpasod ‘seputaouiar exjrurey usp auied 9984 “(VCS Imusse) auBwIN aluaroyapounu insnata = (78u2'q)] snaza Couaroyfepounuu uowny = iH IZIODLLYODOINTD INOWYOH “Ce'bl § “HL “deo & pluafin aseur op lems ut jeioads ut “t}eopur asvos aunt no “at eqursefur proonsoo00n|3 = uoz!090UpIY ap yeUDONs!WaY = HH jesoquored 2jeo od sywisuen) 5 onnedoy smata — ADH 2uNSeS mnynons ye yue}oduN ywouodwIO ~ LuprYsO|D pI9e = OH (eqeraquared ozo od snuusuen) gy ounedoy snata = ARH, Moojout arV9015 us 391) 2p wore un aurfuod 18 wesIxo ap jIgisianar roLodsuen ais “en20NLe WIP ngor jnyusuiid yzeouoy aueo yumoudopmaut = guigoyBouray = (@BH Nes) H (eper0-1e99} 2]29 2d stursuen) y onnedoy sata = AV uruoyorss = euruserdinuxoupiy-s = LHS “eynasaxo suojea ue aunyedat| uy ‘uinues jnsas ut axvzop utd “10) -ez0qp] 9p 159) HHISO}O} BUNIZUD —“ezepdodsuen juTeMyFEUS = (14) 199 Sun ngoulueEMes pide = /78u2 ‘QJ prov statyngounu ous = VEY ‘WUDLIeAO JOH[ADHOY eaTeAMyeUE I woLBUHIOY PUIID}Dp 91>U13} BL (@nurejeiodiy 2p ywr01098 ayso a1vo Wonnopeuo’ twouoy ap [2wouoy Bus payed] ates0q4]9 9p n{ns0}985 EoUYloe Qs) BIBOLIOVUE wZLjOdiY ap wI919—s amejaUINs-ojnoq[o} {UCULIOY = (78H2"g] ~ suOMAOFY BuopRUNS 2121104) HSA joy = (nes) Ly eoqwauenue ‘asnposd aseorouunu uy oySose8 os o1seuusey uy [16 § “6 deo Wy s'g § 'g deo €] areinjpownut aunzu9 soun & 1S rauigoFFoUey wr11Zoduto> ut RMU “UAL -2y2084]0 wueyiodusy nun jnjor wisiueBIO uy pupae “9g PO]WoIR eSB “(LA res 111 “I1) BHQRHEA wiuayer ‘oyperour spioese9 no ofuHIYD UAWi9|> — ‘oy) = 24 TOV NAV verona TSSTTAVHIN VIN) WIGVIA NVIDUV NTSCRIN MARCEAN, Vial in biologie (inclusiv pentru cantitat se calculeaz8 dupa formula mei mmol/l = sna ‘masa atomicd (au masa moleculara) a substanfel Mo = molibden, ~ element chimic cu caracter metalic, valenta varial 1V, V, VI), masa atomicdl 96, avand in organism rol de oligoelement. ‘Na = natriu = sodiu, ~ metal alcalin monovaient, masa atomica 23, organism, in natura si in unele uleiurile vegetale, mierea ete.) NaCl = clorurd de sodiu = sare de consum. NaHCO, = bicarbonat de sodiu = substanta prezenta in plasma, cu rol in menfinerea echilibrului acido-bazic al mediului intern, facdind parte din (ex. : in coma acidocetozica din diabetul zahara NN = nou-nascut = sugarul in primele 28 de zile de viata. NPEV = nutritic parenterala endovenoasa (0, = oxigen, ~ element gazos cu masa atomic procedurile de reanimare cardio-respiratorie, sub forma de inhalatii pe ‘mase3, prin sonda nazofaringiand sau sonda endotraheala ete. (OMS = Organizatia Mondiala a Sanacaqii ORL = otorinolaringologie OTC = over the counter [ib-engl.] = medicamente care pot fi eliberate din far- macie f8r8 prescriptie medical’ PEV = perfuzie endovenoasa (~ i PEVC = perfuzie endov PPC = plasma proaspata congelatd. Se perfuzeaz4 ix. dup decongelare si incdlzire la temperatura corpului. Odata decongelats, daca nu este admi- nistrata, NU se mai poate recongela, se arunca! PPD. = protein purified derivative {I6.engi,] = derivatul purificat proteic al inei,utilizat sub forma de IDR pentru depistarea alergi UAL DE FARMAC. PVC = pol tru ambalaje © = registered mark {lb.engl,] = marca inregistrata (ca denumire comerci RAA = reumatism articular acut, ~ boala produsa de streptococul B-hem grupa A ( Streptococcus pyogenes) si care ,linge articulatile si museca inima” RMN = rezonanfé magnetica nucleara, investigatic imagistic’ de mare finete ROR = rujeoli + oreion + rubeola = abreviere pentru vaecinul optional care se poate face la copii in scop profilactic fata de aceste trei boli infecto-con- tagioase. Rp= recipe [ib latina] = primeste! preia! (Golictare adresata farmacist Ingerie la inceputul unei pre medicale) de limba engleza) = medicament care se elibereaza numai pe baz chloride = clorura de poli polimer si se Rx, de preser RUV = raze se. = subeutanat Se = seleniu, ~ element chimic cu caracter semimetalic, valenta variabila TV sau VI), masa atomica 79, avand in organism rolul de oligoelement ie de glucoza 5 % (care este izoton’) SG 10 % = solugie glucozats 10 % (care este hipertona) SIDA = syndrome immunodeficitaire acquis {tbfranc] = sindromul imunode- dobandit (> AIDS) {rare a unor medicamente ; ex. : nitroglicerina) ‘SNC = sisterul nervos central SNV = sistemul nervos vegetativ sol. = solu STH = somatotrop hormone (= hormone = GH) {tb-engleza] = hormo- ‘ul somatotrop (hormonul de erestere) secretat de hipofiza anterioara sub acfiunea hormonului corespunzator din hipotalamus (care se numeste GH releasing hormone = hormonul eliberator de hormon de erestere) sup. = superior TBC (sau TB) = tubereutoza = trade mark floengl] = marek comerciald inregistraté ‘rat, = tratamentwn ~ ~~ [dydvsSoonmunyd| A1AVADOOVWUVA “T sjoutuodes “S91 ‘aqounsed ¥9T pulang) apPIOUONELL “ET 2200115 “79'1 ~ Howry “T9'T “ [ojo2rx01 pun ‘ohmacnypooousoyd a seouonsqns fo sdnos3 Woy) ‘sfBojoarxor #$ atdexsjoqpuus%y up aiuessqns op armenodust adn) “ST = [auroipow aatyousanp pun Kypodoowoy ‘éyrodoyty ‘ausye eujypouts erndoouoyeioqooeutmy ‘rede eioqooeueg 5 9’ ss [spunspou puD sqySt20% ‘up fo wos uousoypou nati i (Bojospuanyd (oupag pun pyo.f yrBojooennm ajsnurer juaWog “11 [amp &xojanposnut} AALLAGOULN INATLON “T [ADO TOOVWAVHd TVAANAD [240 HIN) YIVUINAD ADO TOOVIAVE sy eoungio0g juds po suuosrn ‘suoprscagqy] nyoqus 6 sua0ise ua}gy SNIUd ND ae oyun rawad 18 sopyuourestpaut [e OLY Tnpoo naquod ‘ourens 1qun ‘uy nes gza}@uo wquay UY aysIUuNUap najuad ausojoy aN oxdoxp ajezaquered [ ] copa usojsen, one 2yvod & suomoo8q0 ap olor wstuBI0 Ws pupae Sco woluiow wsvur ‘juopearg ‘oreIaUH JaIOBIE No STINTS yUAUIa}S = UFZ = UZ (SO) eveuEs v prepuoyy eriezimedig = [ez0/Su2"gy] wonecUe840 YIoeH POM = OHM UTUTYEA “COHEN = own, aopimg voodoseueg = [pz0/3u2"q]] vasdoopmurys sams pasa = eS. yoondun = Sun TOSTTNAIN VINVA-UINIGWTA NVEOUVWNTEDMANTA 2213. injectabil 2.2.2. Forme farmaceutice semisolide [Drugs in semisol 2.2.3, Forme farmaceutice lichide [Drugs in fluid state] 2.2.31, Pentru uz intern (calea orala) 2.2.32. Pentru uz injectabil... 2.2.33, Pentru uz. exteM. wn 2.24, Forme farmaceutice gazoase sau flosite prin inbalare [Drugs in gaseous state or used by in 23 2.28, Forme farmaceutice pentru administrare rectalé 24 24 24 26 2.4. Dozarea (posologia) medicamentelor [Drugs dosage (posolagy)]....26 3. FARMACOCINETICA [Pharmacokineties} 30 31. Absorbti,circuitul si dstribuyia medicamentelor [Drug absorption, ‘movement and distribution throughout the organism) nen 30 3.1.1. Absorbtia medicamentelor [Drug absorpric 3.111. Absorbtia medicamentelor de wz sstemic [Absorption of the drugs for systemic us]. ica gi distributia medicamentelor fn organism ibution of absorbed drugs [Peak (the highest plasma concentration le soon ST 3.34, Clearance plasma oefemu de epurat) Plasma clearance (coefficient of removal)| MANUAL DE FARMACOLOGIE 4, FARMACODINAMIE $I FARMACOLOGIE MOLECULARA [Pharmacodynamics and molecular pharmacology)... 39 *harmacoreceptors) . 40 eisai nA 45 428. Tromboxanal A2 [Thromboxane A2] 4.29, Leucotrienele [Leukotrienes]. 4.2.10, Factorul activator plachetar (PAF = platelet act 43, Transferul prin membrane [Membrane transfer] 4.4, Neurotransmitatorii [Newrotransmitters] 5, ADMINISTRAREA MEDICAMENTELOR [Drug administration] ..56 5.1, Reguli generale (General 52. Chi rechniques by gastrointes 2. Administrarea pe by respiratory tract) iocal in afeefiuni ORL (Nasal & 14 lea in oftimologie (Ophamic a8“~auodsai ap ¢z0q ad ayesedasd “CTL raps 18 yoy 1q ZIO8 n> ayesedazg “TTS iq s0ytR> wader, (sual maquospy] aMeQuospe sojazeiprue aust ues [sjonyaseypyruy| sorerrpnay “SL (saqnoxo7] annexe FL soi sino waren aonauIEMEY SEL [tiadoud aowornun uns p01" [son 2uoHUe 4.2419} BUN ruoBojuD 40}0486} 190! UOIO.2% sor gor (sorouryoug] (1 [powosjoun pun soypousedsiue “orSzouoyotue Suypnjous suo jeu 1 aansedsnue no anSiouyjoonue op wiusqwn SZ uoavded ‘TTL ssurfooHUY VZL [sxapuosip ouonunf muyysonqous08 wp pasn sBnap soyto 7 soxpousodsyuy) a aqpuoriouny taeangim vy aieotpur asnposd aye 8 ex rupos ap jaeuoquearg °¢ juruanye ap sHieuIqWNOD *¥ [AaVaFHLOOVWUVHd 2060 HUA] ‘AldVUALOOVWAVA re-q] 8 vauntioag “-gorfa(doniaueg '7'¢°9 xeu0y| Sue aiuensqns “£9 [s1uatin Buy00/9 ) 9018:0U)/0011Ue AUSWEDIPIW 779 06 [suuaBo asouoysounjoyouuy) sarzesoqsaurjoanue alueisqns 1S aquowes1payy °Z1'7'9 68°" (suo o1S.0ujoy.9) aopousrutuoreduisesed a1veLNeSIPaN 79 uo Benue = so1s243ip so1Ss2uaupe aruvoorg “¢1'9 [s1ia80 21Riauaspo ‘s1swwo80 21B.ousspy| (Gonauworedusts syuoue>ypaut =) rBsauaspe nsIUoRy ZT'9 61°" [suonnusunsioanou pup suordeoo4 oyBsouaspp] a18z9u29pe [MIUaHOP tp dueasqns #8 oneduuts so949u inno = rBsauarpe 1HOW=02y "T1'9 we * [pjof aB1ouaipo ous °p worst snosuou _2ueuodies 24) aBrouospe jnuauop 18 nedwHs Sosiau NWOSIS 9 uw aise snossou nuouomnn 242] (ANS) ALLVIS94A SONWAN ITTANLSIS VANLINLS § oe |uuaysits snowau anuouosnn 24) fo MBojor0u0y) AILVIADIA SOAUAN IN TAWALSIS VIDOTOOVINAYA “9 ADSTTIVHIN VINVIFMINIGV IA NVSD¥IN NBOCRIN MARCEAN. VLADIMIR-MANTA MI 8. MEDICATIA BOLILOR DE NUTRITIE $I METABOLISM [Drugs used in nutritional and metabolic disorders} 8.1. Medic 8, cu 78.2. Meicamenteheptoproeseare [Hepat 18.22. Pe baza de acid aspartic 78.23. Pe bazi de ani 7.8.2.4, Pe baza de sil 7.8.2.6, Pe baza de vitamine: fatty acids) . 3. Medicatia antidiabet 8.3.2.2. Biguanide 83.23, Jindione 8324 83.25, £33. Strategia terapeuticd in diabetul zaharat. MANUAL DE FARMACOLOGIE 84. Vitamine (Vitamins} 84.1. Vitamine liposolt 8.4.2. Vitamine hidrosolubile (1arer~ tami 8.4.3. Factori vitamin-like (asemanatori vitaminelor) [Vitamin-like FaCt0rS soon sentence 3D 145 sta LAT ia) parenterala endovenoasd eT) 152 13 9, MEDICATIA SANGELUI SI A ORGANELOR HEMATOPOIETICE [Drugs affecting the hematologic system] 154 9.1. Medicatia antianemicd {4ntianemic agent 136 Produse pe baza de fier («terapia mar sncnignenssonneleeee 156 e produse antianemice [Other antianemic products] 157 ies for systemic use] ‘Hemostatice capilare si vitamina K. 9.2.1.2 Factors ai coaguli antitromboticecoz [om joordor 4of sruaie porgoxorunruy) aidon 2n ap auaysaronqniue aaidesaio1umys i 22n01qny zor — [Bojorousap ut ido1 sof suai jy) a1Bojoreunop odor zn ap asworloazunn aTuDUUeDIPAN “TTT logis massits Auppuounsoruf] YDOWOLVINNAG VILVOIGAN TE 66 “(ground v1) etiuase Vi. H ul younodesa exdorens “701 661 ~~ gagsuansodt 661 . soppjeueo aye ayue2019 + I] foulsuanor@ue 1 66 oursuaiorue we sol” patuigi S61 ues soon] edness) 2920 mporere|EPOSeA, Lol ser youspeadiypuy] aisuaried 96 odo /] uisuoyorSup] || ouisuao!due re nstuoseIUY “6 SOL sot : {(:a98) siongnya sur2u9 uorssossto0 wisuator3up) (vg) jauisuaroidue e ajsiequoo ap youryzu3 sot nav aassuapiadysiun so suayoo}g [ouUDYD wn}2}) sol 0 o 2pRtovaspo aonozios-ig) snoaps-tg niauaipe aeDo|geP ES 1 v6 . (soo Bury2019-0109 psu) ans aoriaige a0E9}EE SOL {s1oxdaoa wyonopi9 uoseiwy e's'0t nog an8agpo vzsot fewoig ayRasuaupo aa hago onypano 1oeup yrs sa2yooqg [auuoy9 wnio}2) 2241p 9p sojayeuw> aye DOSY HOY StuLay2S1 91MOAY> MW pasn S10 JAXX. suu2u9 worsionwo9 uistajorSuy] go1uos wonueyost eHredorpse> UL Heoipus (Va) ulsuoto‘ue w ays10,u0> op rows!ZuD 18 oat 9st 9st Iv 9EO! Vv SEOL Vv PEO! est e81 cst zai Ist os out sul sui le 18) soyenaip aouororpse> capsosyp wra4ssts s0]n38D80) 1qe| DuINuBs asnposg “PG jugs op a1eaLiop 1S asmpory 6 yayast soyroton No = gD TwaNwny aCRIN MARCEAN, VLADIMIR-MANTA 203 lermatofitozelor) dupa localizare..203 locale [Antimyeotic agents for 16. Meicamenteaipsranice nigerian agent) 17. Produse antiacneice [4ntiacne age 11.72. Antiacneice de uz topic (aplica agents for topical use] 12, MEDICATIA APARATULUI URINAR [Drugs for the the urinary (Loop diuretic agents are de potasiu [Porassium-sparing di ugs used in nephro- and w ve nepal agen for urinary tract 12.32. Amispastice neurotrope - 12.3.3. Asociatii de antispastice + analgezice 12.4, Protectoare ale tractului urinar {Urinary tract protectors} 214 13, MEDICATIA APARATULUI GENITAL FEMININ [Drugs for the fectioasi de uz local ginecologic [4 for gynecological use) ALDE Ac and prostaglandins), 13,3. Simpatomimetice to ic sympathomimetic agents . 13.4. Contraceptive locale [Local contraceptives] 13.5. Contraceptive hormonatesistemice [Systemic hormonal contraceptives} en 13.51, Progestogeni si estrogen (combinati fixe). 219 13.52. Progestogeni si estrogeni (preparate secven} 13.53. Progestogeni (neasoc 14, MEDICATIA GLANDELOR ENDOCRINE (HORMONI PENTRU ADMINISTRARE SISTEMICA) [Drugs to treat endocrine disorders 14.1.1. Hormonii naturali secretati de hipotalamus si domeniul lor de 14.5.2. Derive 1452.2, Preparate pe baz de iod(iodorerapice). oid hormone (PTH) 235 tiparathyroid agen 235 co 235 235 147, Hormoni androgeni si antiandrogeni [4ndrogenic hormones & antiandrogen agents) 236 14.74, Hormoni androgeni Androgenic hormon 236UE {oystoSomy £499) 9999 InsuodeIBY “97ST ei {6ISND Seonquyuy puoaig anajonyy stony (4) son qu oso] ewan 9p UOHANLL'S¥ SL ong Buz’ amg Yor) Suouqnyy worsn.f] sunZny 2p UONANYL “py Z'S| siz [éstad) ssongiyty asvaroag) ezeayoud 2p uongnyul “eY' 7ST gut [sLnainn) ssonguyuy asouduaosuayg assaszy aptsoajany-u0N} jazexduosuesissana fe yprzoojonuau woH@yu"Z'PT'SL Lace Istayin siongupn asoiduosuna assaxa4 aptioajonu pub (SLLYN) suongiyiy, asoudtsosuo4y ass0892¥ 2p} preiduiosuensi9ged 1 jprioajant 8 (sIPizo9foNU HojeuUE) IoxprZ09jaNU LONE “TPTSE “a [bvuodp pouasnuo powwja'S CTF snp jpasouroasuy] pRenronatnue aheaIpoyy "PTST [sass sodioypsuo sopioaponu 7 sopisoa}ony} apna 1 1§ tinsnatasaduoy ad aang aphoojanu tS aprzozjanN '€'S suc {suo says auodoyuy aonnedounue aeaaay ZeSL az aredoauoy 2jedusdiue asnpodg "¢TTST a ssn PeppURUEEAMOU 3P HOUGIUL “Z'LZ'ST a - : Soup auiuy “TTZSL oe [swat ozuanyluy-up] ayeduiBnuy TC's siz 2 anuaysts sof swuaRo oxgstiuy] oluiarsts 20 ap 2ouOMANEY "ZS a vgn} (swoqnoseqnante) 299etoreeqoa UY “I TSI Bo [suousmnrquuos {y opnuojns] sppramuoses ae weuqueD BFS eee (dnou3 mowofry) ouioiuseyts e819 “LETS Ea - ‘uouy vst ue earsap uoanfosnyi} weanyonuu ap HeaLieq 'SI'1'S ig lsouyosopjocopuu] ozepis 2 90 PES suojouryD AY “ZELTSL auoyouypouonty “TELT'St [souojounG] auojourys ese) our’ sono (dno uaugjog) aucctunjod ese Oo {dn048 pudedooso) spudodooys ese} “1111 ace {rouoSob.ieg| ouyp!oeNAL) AUY!> BSED “OUTST i a]uajtay) NoDta} SUID “6ST 9c (aos apisonioutay przomourse ese) "8 co “= [sopruesooury]spunesoou ese) Spuorsy ese) ae (s2prj.20) 29028 wdns8 no apyo1seW ee SST be jsous8 ap aut1odsoieD FFT'ST peed isauad ap auisods0je}29 “EFS ‘e]] 8 exlesoUusd ap aurz0dsoye425 | vilesouss ap sursodsoye32.) “11'S “ [dro48 upsodsopoyde5) auys0dsoye}o9 ¥Se1) "PSL ‘asiauadeque ese) “E'S soNOIQuUY uBI20pDI2g PHONPOL eoroog ayosoouoyy = souvipoqouoy) weeoeGOUON BED CSI jojuadixoqiey “STTSt wuadOUUoY “PETS ‘e1o1s098 912 quo fuuadowus) Ry naoods no sumaIed ET TSL ssc oor @aqDODOIYEISHUE OU zeurerse|-¢ vf ousansizas e22tu “¢gzenier- 921 vem dnoaB wp onta} ~ fouongou nyrepeig} sunurioe-eig wsssong § 990" 09" 652" Ceuraqsadopsn) a came uaBy “'St wonoyissoy> uous wa1eoyise,> § ove [osm ayuo)sts sof sua30 Shonda} SUWGASIS 7230 ASVOLLIAINTIINY ASNGORd St sre “ {(sauonsoy on0asoued) ed jyuoui0) LED0pUD |MSPIIOur| “CI ere - [a] onsasuaw fo jt9 P gleuOULOY ea1e}22y ITP uorpynso anaysuts} friejnao ae oonaqUIs aHUEIMLUNS “Z-OL"FL [suidonopeuon] sudonopeuon 11 [sruppnaays wonrpns) toviejnno aye aque [seayouuap uous] uansa 2p Heasieql “f'6°p1 * fsoansoaquap ualpouterg] uatpeuBaad ap WeaLssa Tsp ~~ fraapeatiap aubuiBoic) uauBard ap GeALACL V6 PL [suadinysaBou, tuatorsodoud 1uows0}{ “61 {suoB0usq) 1wo8ox3so 1woWLOH “8p “ aisiunieu asmpoud "PEL'PL aredoawioy asnporg "EEF lazmonpo-ng-lo1s}soys2} 18 HONGYL TELL ‘S9\Rs0Uo4pE-[ aIUEDOIE “TELL [ydossaadty aymrsoud uB3uag m1 posn sBrig] xl ap guStuog pyonsodiy wy ateapu aWaWEDIPAH"ELP [suaRopuouy} juazospuenuy ZL TST VINVIGHINIGVIA NVIDAVI NI279. 279 281 282 sn 282 sn 282 282 § Instructiuni de pi antiinfectioase inject and administration of some injectable antinfectious agents} 16. PRODUSE BIOLOGICE FOLOSITE PENTRU IMUNIZARE_ [Biological products used to immunization} - Vaccinuri virale (Viral vaccines) Combinatii de vaccinuri bacteriene si viral and viral vaccines} te produse pentru vaccinari {Other vaccines 16.3. Seruri heteroloage hiperimune [Hyperimmae heterologous seram]...297 11 IMUNOMODULATOARE [Immunomodulators ulatori [Zmmunostimulator agents). OTT erro Interferons] 17.2. Factori de stimulare a coloniilor celulare [Cell colonies stimulating factors) smn 2298 e299 299 300 MAN! DE FARMACOLOGIE 1713. Diverse imunomodulatoare gi citokine [Some immmamomodulators ‘and eytokines.. 172, Agenti imunosupresori Uinmunosuppressor agent 172.1. Conceptul de boaléautoimund {Concept of autoimmune disease] .201 172.2. Imunosupresoare selective [Selective immunasuppressor agents}. 303 172.3. Inhibitor ai factorului de necroza tumoral a Unhibitors of a-tumoral necrosis fact 303 terleukinei[Jnterleukine inhibitor factors} oo.ou.304 ai caleineurinei [Caleinowrine inhibitors} ocnoneonnn 305 305 18, ANTINEOPLAZICE (MEDICAMENTE ANTICANCEROASE) [Antineoplastic agents) 4 314 34 315 315 315 31 315 315 316 lari (Enzymes'of cellular aminoacids) 18.1.6. Compusi pl [Platinum compounds 18.17. Metilhidrazine [Methyliydrazine age ri de proteinkinaza [Proteinkinase inhibitors}. sn 319 lostatice cu diferite mecanisme de actiune [Other cytostaticise [esdepide fo sods poownys ise ose [sate s1pousedsiuo 2 [squase oypousndstuy| PAN LOC [sxopdydoud ouroasio ‘syeuatojey tunquesoupiy ojesaua ao1za1s0 “[goysaBpoun wnrd@] mydo a jjoun prordo pup unde] aprordo aprza8Ieuy ‘€ 02 -p soisoSppuy] sonandgue-sorza8yeay ‘T0Z |suo8> Spownous pun of}ony) AQYTAASANY IS SONZATWNW 82 use ssou0doo1 pas sBngp s0410) lszosodoaso exodus auiouesipau ayy ‘TEL ove [ssrouoydsoudig) j ajasnpoud wip ajduroxa) neuOISOHIE'T 6] oee tog 4ays0 pun s}souodoayso wi posn snag) * gee" cee” we" ove" fap Buryo0)9 Burztaojodoy Buryooy9 Buyztumjodapuoy) auezseiod: [(Sojormunays ut pasn siuado jeaxpuy no (aayte}sox19) aa!XO10U9 aTUDLUEDIPAWN “S"T'61 ie sossosddnsounuuuy] a¥S0joveurnas wy axsseadnsoUnuy| "YT 2p myquowsoy we BOEUY ZT 1000's fut 9 109 EUIXOL “ETTSL (swaze nue aquezseIND ‘ZTE dap ameziseIn 3 “T1Z%L v- [(Bojonpuunoys fdosoys 1) goreydoouriue eunnopua mide. "TSL uzanp won) gues Sv ARVA ad TWANYIN DST WR vINVR TA NVA AWN NODCRIN MARCEAN. VL WIR-MANTA MIHAILESCU: 360 361 1.2.2. Barbiturice 364 112.3, Benzodiazepine. 364 1.2.4. Derivati de carboxamids. 364 1.2.5. Derivati de hidantoina 365 de succinimids., 365 : 365 365 de urgenta al unei sial stirii de rau e a generalized epileptic attack] 366 21.2. Medicatia antiparkinsoniand [Antiparkinsonian agents. 367 21.21. Anticolinergice [Anticholinergic agents). 367 367 368. 368. 368 21.2.2, Dopaminergice [Dopaminergic agents)... 21.2.2. DOPA $i derivati ‘monoaminooxidaze tip B.. 368 [Antivertigo ag 368, 22. MEDICATIA PSIHOTROPA [Antipsychotic agents} . 370 22.1. Medicamente psiholeptice [Psycholeptic agents) 37 Antipsihotice (neuroleptice) [Newroleptic agent 372 31 373 one 318 sa 36 tranchilizante) [Anxiolties (tranguillizers), 376 22.1.4. Hipnotice si sedative [Hypnoties and sedatives) 377 22.2, Medicamente psihoanaleptice [Psychoanalept ee) 22.2.1. Antidepresive (Antidepressants) 379 2222. fedicamente psihostimulante si nootrope (Poyotostimatants and MANUAL DE FARMACOLOGIE 23. SUBSTANTE ANTIPARAZITARE $1 INSECTICIDE, ‘agents and insecticides} oe 23,3, Eetoparaziticide [Eetoparasiticide agents}. 24, MEDICATIA APARATULUI RESPIRATOR [Drugs to treat 24.2. Expectorante [Expectorant 243. Mucolitice [Mucolytic agents) 24.4, Antitusive [Antitussive ager response)EGsosoupsorpr {&q suonoo24 ascenpy) aeresosoxp! wad aionpe foway TOE zap [snap fo (s1oaffo apts) suor2024 28129pV\ HO TAINAN VOICI ‘ATV (AUVANAIAS ALAA) ISUAAGY TLIVAL “OE ser er 5 . : (poviad Busan ay 090 sina) won [lournsoad 2 Bane sucrose isin w ADORN TL sev = [fouBoud Suanp sBnap awos fo suoro0f opeozop{] ways \nsuno wi syPwoUtRD:PaUt [e812 op WwOrPey “TT zy" [Suypaof ys0o1q pun SounuSoad Sunanp spoaffe sBnaq TRAVLAYTV 18 INDUS TASHA NEMOTALNANVOIGAN ATV ALOAAA 62 ier [sorpota8 ut pos ayersa8 Uy yuasno aveZ4|IN IHAWeOIPI "TTS zee {suon.20 3nap s2)p0 ue 104) swuated Auapye out fo soanioaf joorBojorsAye] sojawuatueoIpaut eauns}e _Fevauongl 69 © sip fe Foor HRHsEONNEd TCT ver eer” ler 6ly sac anion ate apa any u ason aU. TUE sir [pooupny 4 snag] doo vy faseorpow rpastunUpe ope ea EONAES 1ST sir »Bo ay wo Sipuodap “(nfiasn 10 roifouag) soelf Bua YASHYA AG ALON NI MOTALNAIVDIGAI FTV (BAIDON AVS ADLTINAA) NATL 87 [x90 TOOIXOLOOVINUVHd 2240 380] AIDOTOIXOLODV WAVE Se-TIT® voungivas Lr - - = : savant nuasoud fo sondospun-suosioiag) yore ndasee-eBIAC SLL Ly [sondostnue snoring) aondastiue 2s1901C1 “LLZ ol vr [svonou Buyanojo9) suesojoD LZ ra vs cmon [squad uossoppro) thueplxo taeBy °S'Cz sir : so (gos sposous Kaaqs) ay>uB 2qeI2U BP LNIES "YLT sv soem Supa 18 OpIUENBEE “ELE sir a i mal mpold ‘TTLE ipo Smposd “TELE “= gpunodueo nouadoqry) eusBoqeywndweD "CL vie “[qo4ery] woo "14e slp [sondosnuo puv spapvafusia| ALAASLINY aLAY: ANIZA ‘LT zw ~ ano tpe0| zn nun ytoans020on18 no aono1gnse ap nieuaten “e792 [asn 210 40f stuoB0 snoypsouo ‘lane apedo} aaizaysaue 18 orzo [eu “1797 juaBo 2110) 301804010 asnPOrd “T9T [s0p82jdopo% pun sonpiapay] 22480ydo]>19 18 2: ""affojoueyo zn 9p ojouipuniansoud ye oqeuy “TET IT uv {1020} pun 23698 youy a ww alr ay ur Vfoouyeyo [B30] zn rand anesBox soa nya vay Te T'9e lly = {sia mwoonppSisuy] wooneysnue asnporg *€T9Z iy “o(Hojousjeyo 2n ap suaipfosaysou aseoeMEyUMUY “CT TIT li YB0]Ou[eYO zn ap rZIOONIO20INID “TTT Ww some Fas meayoundo sof s1ua30 Ceopouaucyfu up) o1S0jousjnyo [B00j zn nAwad a1eoWwUIeYUINUY 7192 ip (fojousjeyo zn ap sonosanuy ‘ZTT9T ow nap onolgnuy “T1197 ol [osn onuyoysydo sof spua80 snousafunnuy aBojoussyo so] zm sited aseornapusnuy “L192 ow [sade onaporydo) soeBojoueyo asnpord “97 arr’ — “aguas pojaads fo suniio Supsoaffo sSnaq| AALLIZNAS HOTANVOUO VILVOIGAW “97 sor [sounwrsryssuo uoqsn.9wa8-puosag] 2-1] 8 eHes0us8 ap somurUEIsIYHUY “Z'e'SZ sor » : + souurrsiyeuo opros9W98- 194.) | eex2U98 2p 201 ay See 2quiassts sof stuad oiupupssrypiuy] s1uists Zn 2p 29 nuy esz sor’ ~ ~ [pswodsou arBuayp oquarsts a124ag] axesd aojurans|s 991819]8 116189 WRIA 'S TST. sor’ esuodsou n8uoqpo jounsengosss05) anuisaBip 201849[8 ULASARUEY TST por fesuodsau 99812qy0 o1uporydg) ax6yn90 2918s9ye LIEISAAIUCWN "€°7'SE qip0 Toa WWva 3a TANYA ADSTTVAIN VINVINUINIGVTA NVSOAVA NTO,CRIN MARCEAN. VLADIMIR-MANTA MIHAILESCU 30.2. Reactii adverse prin efecte toxice [Adverse reactions by toxic 30.2.4, Reacji adverse din partea aparatul reactions on musculo-skeletal system 436 30.2.5. Reactii adverse ale organelor respirat (on respiratory SySt0MA non 436 30.2.6. Reacti adverse cardiovasculare (efectecardiotoxi reactions on cardiovascular system] suru 437 30.227. Reactii adverse digestive (Adverse reactions on alimentary rraci) 30.28. Reacti adverse hepatice (efecte hepatotonice) (He reactions}. 30.2.9, React adverse panere adverse reactions). 30.2.10, Reacji adverse reno-urinare (efectenefrotoxiee) [Adverse ‘reactions on urinary tract}. 30.2.11. React adverse din partea aparatuli geni tions on genital system... © (efecte pancreatotoxice) [Pancreatic 438 [Adverse reactions on the central nervous system 38 30.2.13, Reactii adverse din partea organelor de sim (efecte oculotoxice $i ototoxice) [Adverse reactions on organs of special sense. 439 300M Rees ers eosin [Ah exe rection endocrine 39 [Hematologic adverse reactions] 0.2.16. Reactii adverse din partea sistemul ‘on the immune system. 30.3. React adverse prin mecanism alergic [Adverse reactions by allergic mechanism). 31. INTERACTIUNI $I INCOMPATIBILITATI MEDICAMENTOASE [Drugs interactions and incompatibilities| 447 31.1. Medicamente a c&ror asociere este contraindicata [Drugs which are forbidden to be associated), bo 448 xl MANUAL DE FARMACOLOGIE 31.2. Medicamente care prin asociere sufera modificari ale soni [Drugs whose association alter their action} 32. TOXICOLOGIE, EAINTOXICATIL ACUTE) [asicotagy (acute 452 453 433 i prin inhalare (Poisoning by inhalation)... on 55 i prin absorbtie cutanata [Poisoning by skin absorption} 455 32.1.4. Valabil pentru toate catez all kinds of poisoning 456 32.2. Deserieres §i tat ‘poisonings description 1 56 414 32.3, Antidoturi [4 33. TOXICOMANIILE (DROGURI, STUPEFIANTE, NARCOTICE) [Drug addiction (drugs, narcoties)| 482 ledge about drug dependence] 483 jologie [The etiology). in 483 33:12, Caractere comune ae txisomanilor [Common features son 83 of the drug dependence) 382 Droguri cu atiune deprimanta asupra sistem nervos central [Drugs with sedative action over the nervous system 33.211. Aleool j 3522. Substante opiacee (op! gi der — 33.2.3. Medicamente anxiolitice si hipnotice. 333. Droguri cu actiune stimulant& asupra sistem: lant act (Drugs w 3331. Cocaina 33.3.2. Amfetamine 33.33. Cofeina, 333.4, Solventi volat 333.5, Nicotina, ‘substanfe volatile din industrie,sgolinaowuusny plnsnpur nsiwed mueyodut oud ‘2oqumyp 1S 2012 ‘9p sojpquaute>1paut Pot saueztjoqerows) sta uatvotpou Bune. [Sojosnuunyd fo saysuv.g pun pjett] 1AIDOTOOVAAVA TTAANVA IS TAINAWOG “TT [np &uosonposuy] AALLOAGOUINI INALLON “1 KDOTOD¥WaV Hd TWUANAD :au0 nun] VYIVYANAD ALO TOOVUAVAL s] BounTjIag ‘usBoUlsnyey LNBoIp NW “PEE siqeuue>) ruerpur edaugo wip noua TYEE rap oquaouronpopy) auaBourmnyey LinBOsC “yeeCRIN MARCEAN, VLADIMIR-MANTA Farmacologia molecular /Molecular pharmacology), ramur& a farmaco- dinamiei fundamentale, descrie mecanismele intime, de mare finete, prin care actioneaza agentii terapeutici la nivel de receptori, organite celulare, canale ‘membranare, sinapse, enzime, sisteme mesagere secundare, faze ale diferitelor ‘metabolisme. Ex.: farmacoreceptorii, neurotransmititori Farmacogenetica [Pharmacogenetics] se ocupl de genetici si reactiile produse de unele medicamente. Farmacoepidemiologia [Pharmacoepidemiology] = studiul la scart populationala al utilizarii si al efectelor— benefice dar si nocive — determinate ile dintre factorii de medicamente asupra unor esantioane largi de mase umane. Farmacografia [Pharmacography} studiaz’ nomenclatura medicamente- lor, formele farmaceutice, posologia (stabilirea dozelor), reglementarile privind prescrierea (reteta medicala) si eliberarea medicamentelor; claboreaza sche- mele farmacografice gi realizeaza monitorizarea farmacografica. Farmacoterapia (Pharmacotherapy) aplica datele de farmacologi practica terapeutica, la diferite boli si categorii de bolnavi; stabileste regulile, dozele si etapele tratamentului medicamentos in raport cu afectiunea tratati, Farmacotoxicologia /Pharmacotoxicology] se ocupa de reactiile adverse (cfectele secundare) ale medicamentelor, de intoxicatiile medicamentoase acute sau cronice, de factorii care favorizeaza aceste fenomene si de combaterea lor. Poate fi consideratd o ramura a toxicologiei Farmacovigilenta (Drug monitoring] = domeniul si activitatea prin care reacfiile adverse si efectele toxice ale medicamentelor, survenite in con: normale de utilizare in scop terapeutic, sunt studiate prin centre de profil si publicatii periodice special destinate acestui scop, Biofarmaceutica [Biopharmaceutics} studiaz’ relatile dintre proprietitile zico-chimice ale medicamentelor si activitatea lor in organismul viu. De mentionat ca formele cristalizate sau amorfe, m&rimea particulelor, natura cexcipientului si metodele de fabricare influenteaza absorbfia, distributia, bio- isponibilitatea, metabolizarea si epurarea substanfelor din organism, Farmacologia informationala si farmacocibernetica introduc conceptia informationala in acest domeniu, privind medicamentul ca pe un semnal care interfereaza cu semnalele biologice si care actioneaz asupra unor mecanisme de reglare cibernetica, Psihofarmacologia /Psychopharmacology] are ca domeniu studiul expe~ imental 5 clinic al agentilor terapeutici folositi in bolile si tulburarile psihice, adica studiul medicatiei psihotrope sub toate aspectele ei Toxicologia /Toxicology/ este stiinta care studiaza substantele otravitoare, simptomatologia caracteristicd diferitelor intoxicatii (otraviri) accidentale sau 2 MANUAL DE EARMA\ voluntare, intoxicatiile medicamentoase in caz de supradozare a acestora, mij loacele de prevenire, antidoturile nespecifice gi specifice precum si toate mij loacele de prevenire gi tratament in asemenea cazuri Farmacotoxicologia informationali colecteaza toate cunostinfele exis- tente cu privire la proprietitile intrinseei ale substantei toxice, datele fizico-cl mice in vitro si in vivo (objinute in urma testarilor), cele obtinute cu ajutorul ‘metodelor de predictie, precum si informatile privitoare la expunerea la toxice, pentru a infelege care sunt populatiile si domeniile expuse, precum si natura expunerilor, adica ruta, frecventa si durata. Posologia (Posology] se ocupa de caleularea dozelor de medicamente in functie de afectiunea trataté, de stadiul in care aceasta se afl, de durata trata- mentului, de modul de administrare, de toleranta fafa de medicament in functie de sex, varsti, greutate, suprafuta corporald, de starea rinichiului si a ficatului Ia bolnavul tratat 1.2. CLASIFICAREA MEDICAMENTELOR DUPA SISTEMUL ATC [Anatomical, Therapeutic, Chemical Classification System] Este o elasificare multinivel a medicamentelor, care permite situarea intr-o categorie bine definita a oricirui produs utilizat in scop terapeutic sau diag- nostic. Ea foloseste cele trei criterii mentionate la denumire (anatomic, terapé utic, chimic) si aplica un sistem de exprimare codificat, stabilit conventional admis de forurile internationale de specialitate. NIVELUL I indica grupa anatomica (aparatul sau sistemul din organism la care se refera) si este exprimat printr-o initial, dupa cum urmeaz3: A (initiala provine de la Alimentary tract and metabolism) ~ cuprinde medicamentele pentru toate segmentele si organele aparatului digestiv (inclu- siv fica liare si pancreasul) precum si medicamentele care se adre, seazii bolilor si tulburarilor metabolice si de nutritie. Aici sunt incluse deci si toate tipurile de insulina, ant orale, medicamentele antiobezitate, produsele pe baza de saruri minerale si vitaminele. B (de la Blood and blood forming organs) — include medicamentel in bolile sAngelui si ale organelor hematopoietice, exceptar sucemii) care sunt prezentate te in hemopatiile maligne turi de celelalte medicamente antineoplazice. 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Preparat oficinal = medicamentul cu compozitie stabi g2atit anticipat in farmacie si corespunzand standardelor prev: peea in vigoare. Produs farmaceutie = forma dozati finala a unui medicament, continand substanfa activa cu excipienfi selectati $i ambalata pent 1.4. MASURI $I ECHIVALENTE FOLOSITE PENTRU MEDICAMENTE [System of drug weights and measures] ‘Tabelul 1.1 ~ Masuri si echivalente utilizate in farmacografie MANUAL DE FARMAC 45 picaturi 1 ingurd de desert, confine url de sop 1 eeaged mic de cafea Tecagca Tncie (ounce) (2) Peniru substante solide si pulberi Teeazea (eup) 1 (eg) = 24 1 Kilogram (kg) ~ 10 hectograme (hg) = 100 decagrame (ag) = 1.000 grame (=) a a oo, (os) = 480-500 ml 1 gram (g) = 10 decigrame (dg) = 100 centigrame (es) = 1.000 miligrame (mg) | 000 micrograme ( 960-1.000 m 728 uncit (02) = 3.840-4.000 ml, cu varf de pulbere ‘Masuri pentru substan solide foloste tn unele fri a 7 ncie (ounce) (02) contine lived (pound) (lb) contine 1,000 micro a confine 20 picaturi ‘este echivalenté ow 06m confine ‘52-60 picaturi inetwra ml soluje uleioasis = I 40-50 piesturh Tm exteact fluid . 40:50 piesturh (ion sirop i I 18-20 pieatur (Gontinware in pagina urmatoare) 1.5. FARMACOLOGIA ALOPATA, FARMACOLOGIA HOMEOPATA SI MEDICINA ALTERNATIVA [Allopathy, homeopathy and alternative medicine] Farmacologia alopati pleacd de Ia principiul de baz ci un medicament eficace trebuie sé produca asupra organismului santos un efect invers decat cel care i realizeaza boala impotriva cireia este recomandat (ex. antibioticele, ite mecanisme asupra unor componente din structura bac~ ‘este cea mai rAspanditd metoda terapeutica si ea face obiectul le medicale de uz curent actionand prin rale (de origine vegetala, animala sau minerald), produse semisintetice si pro- use sintetice, realizate integral in industria farmaceutica, Farmacologia homeopati pleaca de la principiul opus, anume c& un medica- ‘ment eficace trebuie si produc& asupra organismului sAnatos acelasi efect (aceleagi 76 © yaar -1uew0o1x0) ango ap Soup wo yS0(0) 16 sOVeIOgeT MH zy (eULyZOWN 2p rereoeip) Fouyjiow fe reaap “oneyuISTINAS Plo|saLe Un 2IS9 eULOAD ~ nsopyy ora (nsnposd 23895005 a5 aldesajoo0uuses uy (onounworedwsesed ‘2yzeso3so0yfoonue 008%) o18s0U “hoo atusoind 21s9“wnsououse puSisostc Wp PIOTeTe “eUNBNSOZL ~ “yulnawo8io ymvaizop yreoziin 25 wazasd uy 3!90190 bo 8 ouorSnu ymuouaoyen wy genstumpe 2489 (oaundend sdoorso[.) ~ 1039) jnusoo e2e30s tip anyforedaus #$ o}oENSUODOSea ploweore “wuyUTEOBL ~ sjbioua8 frzaisoue insano utp oye}s018 Wunusuoyodty eatsodt quozoud oy ‘aorSroqe es afaun #8 o1Suo3g IMjMUEISE rMoUTEeH wy DAN UE US ojo Soreretpouuoag 18 z0;o11sUODOseS “DNS Te Ie|MUUNS “onoWwINOVedAS) SuSzouospe wiouieorpoua un 2389 “eypauce uyp BSED RimEISgNS “eULAPaA ~ pruexejoxorud sunt no a1wez}iesn9 “onayS [9 WeALIOp Ezvazin 26 Besouos ‘rzojsut up “pjery suowatdsosorzuezed pugonpoxd “gre[sasnosnou ereUr=1 uoroat een tnjooj200 wountie gzeoq90(9 [IPB eAeAI0 “eA ~ (eruewourajoo) ayovan -oorvo1 9 sunfe aweod 28 “ieodoa pou wy wreunsuoD “eSUENSEL aeZT|NN G97 “ud uy thynpssoowut fe auejnuus “guateuese9 16218490199 J0]9588 J TEP taorowose # Hoyestdsas soqunu2> ye andayeue aIsa "Ieasogo 2p eHlezUes PUEL ‘suoroutoytslasejauuis pupoonoud “ONS exdase ERIOXD 19999 OV (s1suours cays) 929 9p af22un4y UL 1 (P2IqDA vaffoD) FapEO ep IIPIOGTE 2] nay ut pjeanne a1 wy ax$osy8 25 ‘YojauLand ede wp PLO}ETe “eEMIey0D~ ssmaque ts eagle nzjuad o1pU F291 susiuas utid snpoid‘nido wip ses peunaeu projoTe un 2189 eNO ~ ‘nrowsoureo0d wy sanp preiadox easwzyqin aissidap 2p ares 0 2p aqeutan eorsaoe 2100) ‘ure 2p fatlezuaselsedsIp‘soI0u mjmuDes “pues vaioisar9 “yjosoqo asersndapus “a[0jn@ ap axmis 0 sesoduios onpoxd uewootxo} ango ap wef Bosp Fo Saye EBUH ISOfO}DS9 ZeP [800] o1ZOISOUE ypaje 210 "2000 uoproayrCy wnymsnqre afozuns} UIP PLOPETE "BUILD ~ (euriom samejnosnis et}senoo 2anposd) 2101100 29 snd ‘prooIkoz -tyos roajo payae ‘Qoueyeu) nyruwsrpnIed UOUEe 18 ereETLR! uy YoIpUL aso “fui 2p injsioqae ehzv02s wip Yor uNjoury proTeoqe "eAURS ~ ‘ONS IP uRHOx9 9159 TEU 2zOp Uy oqusoind 18 pugae ‘seurnoy ad zeqq ‘AnsaSIp imjmsen e ppatou eanIe|no snuu ¥2eoxbja4 (ontjoreduuisezed) por@souyfoonue aungioe are ‘saneueqos owed aie 8 (euuopojjaq odosny) yunSesreus usp yejoz1 proyesre “wuydoasy ~ ‘unisapuejo a2v0 ex0q] wy yezI[ea4 pully “SFanK|SILS 19 pemMIeE plojeate un as9 -)N “ianSoup xxpupdses feu 2]99 annm1p yun (euLyz0uN 1298p) 8 ‘wurosay go vilusie WedeNy ‘sof your's € eupoaeded ‘eurapos ‘euyjzour nico ‘usp yeamyeu rzioypaye Hiezzqqn your 19> "von naowULTe) eLAISNpU UL oHOsUISIUEDS 1S predasd 95 tun azeo annuip “ypsmyeu rzfoqeoqe ap ~iueLiodwH psIns 9189 (wngio umaafiuos s2avdeg = gje seu ap 2{aynsde> wip yeosn jnans) jmdo ~ sStujgiuy sap fur J90 210 [ope uRBIOwINU “sH>TUIS ISnposd IZ10[e9]e 18 easing “201N0} “{Z0UI 2zOp Uf 404 “NW 9zOp Uy STUIEUIpOOEUEIEY aAn|2e 21280} ‘Soze 18 uoBoapty “uod xo ‘uoqzea ap wore pynd2jOU us pugurluod “gorzeq atiaeal 18 pxojdwoo pinjonns 0 no plma8oa oust10 ep ao1uedI0 aluesqns yung UZIOWOT *V9't [Soj02%<01 pu soynadossyoovuunyd ut saounjsqns fo sdnos3 uyoyy] ALO TOIIXOL IS HAVATLOOVIAVA NIG GLNVLSAAS 40 ALNVLAOAWI IANA “9° gun uid eydesoy — eonsesdonyo “eamoundosoid ‘eydessioxayjau ‘ououye wud exderay sezoudiy wud edesoy — seumoundnoe — ‘selueuozasorg ‘evdeiaroiauseu — ‘Spuetim Sox atieyuouatye no wides9}0321p swidesoio1foy “exdesooouyeq — ‘youd no widest sqero8on ounqupo ‘aidessjoylsue no eidesojoyesourus — 18 &| ap asnposd no eidesoude — ‘oquoyd ap und rng “tuniajn ng “2yeu1osn aqueyd no “tunge=9 nd wideso) pugznjout ‘eidesaoy — [pzpaapeoul 9s 11y “(001s -e[p) s]euoriuanuos fouroipau wrRje UL Ye as e7e9 IUSUIEVEN op 18 anSoUTEIP ‘9p sapaooid yzeazi[i9n (efeuoyiuaAuOD9U RUID{POUH) EALUHIDITE BULDIPTA “ue jnumn wip soj2nouae!paus jrsoyefpuouON us sede ase woyaoe asjuIp uM 18 aredoawioy ssnpoud aurind 1uypiut wos winjor ynysooe ynsutadna uy “(ejeINg TE) 1409 Us us] aAjO7IP 98 BS BSP] 28 31RD 2INGO}E 9p euLuO} qus wIHezaxd jediuBqUe sp -oxi gtunu}s9090180 °%9) sojaquaueaIpaU oud 8 psu Bze9 ‘anoeut 21 ‘oiuejd ip aseanxo alumsqns ‘squaupoypatu niiuod aud wsorew idaup ‘a1$2s0|0y TVS NY TOSTIEHIN VINVIPMINIAW TA NVSIIVIE NT