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ABIM Laboratory Test Reference Ranges January 2022

The document provides reference ranges for over 100 common laboratory tests. It lists the test name, the type of sample needed (such as serum, plasma, urine), and the normal reference range for each test. The tests cover areas like metabolic panels, hormones, blood counts, coagulation factors, tumor markers, vitamins and minerals. The reference ranges provided are meant to indicate normal versus abnormal test results.

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0% found this document useful (0 votes)
226 views22 pages

ABIM Laboratory Test Reference Ranges January 2022

The document provides reference ranges for over 100 common laboratory tests. It lists the test name, the type of sample needed (such as serum, plasma, urine), and the normal reference range for each test. The tests cover areas like metabolic panels, hormones, blood counts, coagulation factors, tumor markers, vitamins and minerals. The reference ranges provided are meant to indicate normal versus abnormal test results.

Uploaded by

msk ahmad
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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ABIM Laboratory Test Reference Ranges ̶ January 2022

Laboratory Tests Reference Ranges


1,25-Dihydroxyvitamin D See Vitamin D metabolites
(1,25-dihydroxycholecalciferol), serum
17-Hydroxyprogesterone, serum
Female, follicular ˂80 ng/dL
Female, luteal ˂285 ng/dL
Female, postmenopausal ˂51 ng/dL
Male (adult) ˂220 ng/dL
25-Hydroxyvitamin D See Vitamin D metabolites
(25-hydroxycholecalciferol), serum
5-Hydroxyindoleacetic acid, urine 2–9 mg/24 hr
6-Thioguanine, whole blood 230–400 pmol/8x108 RBCs
Absolute neutrophil count (ANC) 2000–8250/μL
Acid phosphatase, serum
Total 0.5–2.0 (Bodansky) units/mL
Prostatic fraction 0.1–0.4 unit/mL
ACTH, plasma 10–60 pg/mL
Activated partial thromboplastin time 25–35 seconds
ADAMTS13 activity >60%
Adrenocorticotropic hormone (ACTH), plasma 10–60 pg/mL
Albumin, serum 3.5–5.5 g/dL
Albumin, urine ˂25 mg/24 hr
Albumin-to-creatinine ratio, urine ˂30 mg/g
Aldolase, serum 0.8–3.0 IU/mL
Aldosterone, plasma
Supine or seated ≤10 ng/dL
Standing ˂21 ng/dL
Low-sodium diet (supine) ≤30 ng/dL
Aldosterone, urine 5–19 μg/24 hr
Alkaline phosphatase, serum 30–120 U/L
Alpha1-antitrypsin (AAT), serum 150–350 mg/dL
Alpha2-antiplasmin activity, plasma 75%–115%
Alpha-amino nitrogen, urine 100–290 mg/24 hr
Alpha-fetoprotein, serum ˂10 ng/mL
Amino acids, urine 200–400 mg/24 hr
Aminotransferase, serum alanine (ALT, SGPT) 10–40 U/L
Aminotransferase, serum aspartate (AST, SGOT) 10–40 U/L
Ammonia, blood 40–70 μg/dL
Amylase, serum 25–125 U/L (80–180 [Somogyi] units/dL)
Amylase, urine 1–17 U/hr
Androstenedione, serum Female: 30–200 ng/dL; male: 40–150 ng/dL
Angiotensin-converting enzyme, serum 8–53 U/L
Anion gap, serum 7–13 mEq/L
Antibodies to double-stranded DNA 0–7 IU/mL
Anticardiolipin antibodies
IgG ˂20 GPL
IgM ˂20 MPL
Anti-cyclic citrullinated peptide, antibodies to ˂20 units
Antideoxyribonuclease B ˂280 units
Anti-F-actin antibodies, serum ≤1:80
Antihistone antibodies ˂1:16
Anti-liver-kidney microsomal antibodies (anti-LKM) ˂1:20
Antimitochondrial antibodies ≤1:5
Anti–myelin associated glycoprotein antibody ˂1:1600
Antimyeloperoxidase antibodies ˂1.0 U
Antinuclear antibodies ≤1:40
Anti–smooth muscle antibodies ≤1:80
Antistreptolysin O titer ˂200 Todd units
Antithrombin activity 80%–120%
Antithyroglobulin antibodies ˂20 U/mL
Antithyroid peroxidase antibodies ˂2.0 U/mL
Anti-tissue transglutaminase antibodies See Tissue transglutaminase antibody
Arterial blood gas studies (patient
breathing room air):
pH 7.38–7.44
PaCO2 38–42 mm Hg
PaO2 75–100 mm Hg
Bicarbonate 23–26 mEq/L
Oxygen saturation ≥95%
Methemoglobin 0.5%–3.0%
Ascorbic acid (vitamin C), blood 0.4–1.5 mg/dL
Ascorbic acid, leukocyte 16.5 ± 5.1 mg/dL of leukocytes
(1,3)-Beta-D-glucan, serum ˂60 pg/mL
Beta-human chorionic gonadotropin (beta-hCG), serum Female, premenopausal nonpregnant: ˂1.0 U/L;
female, postmenopausal: ˂7.0 U/L; male: ˂1.4 U/L
Beta-human chorionic gonadotropin (beta-hCG), urine ˂2 mIU/24 hr

Beta2-glycoprotein I antibodies:
IgG ˂21 SGU
IgM ˂21 SMU
Beta-hydroxybutyrate, serum ˂0.4 mmol/L
Beta2-microglobulin, serum 0.54–2.75 mg/L
Bicarbonate, serum 23–28 mEq/L
Bilirubin, serum
Total 0.3–1.0 mg/dL
Direct 0.1–0.3 mg/dL
Indirect 0.2–0.7 mg/dL
Bleeding time (template) ˂8 minutes
Blood urea nitrogen (BUN), serum or plasma 8–20 mg/dL
Bone-specific alkaline phosphatase, serum Female, premenopausal: 4.5–16.9 µg/L
Female, postmenopausal: 7.0–22.4 µg/L
Male, 25 years of age or older: 6.5–20.1 µg/L
B-type natriuretic peptide, plasma ˂100 pg/mL
C peptide, serum 0.8–3.1 ng/mL

2
Calcitonin, serum Female: ≤5 pg/mL; male: ≤10 pg/mL
Calcium, ionized, serum 1.12–1.23 mmol/L
Calcium, serum 8.6–10.2 mg/dL
Calcium, urine Female: ˂250 mg/24 hr; male: ˂300 mg/24 hr
Carbohydrate antigens, serum
CA 19-9 0–37 U/mL
CA 27-29 ˂38.0 U/mL
CA 125 ˂35 U/mL
Carbon dioxide content, serum 23–30 mEq/L
Carboxyhemoglobin, blood ˂5%
Carcinoembryonic antigen, plasma ˂2.5 ng/mL
Carotene, serum 75–300 μg/dL
Catecholamines, plasma
Dopamine ˂30 pg/mL
Epinephrine
Supine ˂50 pg/mL
Standing ˂95 pg/mL
Norepinephrine
Supine 112–658 pg/mL
Standing 217–1109 pg/mL
Catecholamines, urine
Dopamine 65–400 μg/24 hr
Epinephrine 2–24 μg/24 hr
Norepinephrine 15–100 μg/24 hr
Total 26–121 μg/24 hr
CD4 T-lymphocyte count 530–1570/μL
Cell count, CSF:
Leukocytes (WBCs) 0–5 cells/μL
Erythrocytes (RBCs) 0/µL
Ceruloplasmin, serum (plasma) 25–43 mg/dL
Chloride, CSF 120–130 mEq/L
Chloride, serum 98–106 mEq/L
Chloride, urine
Random ("spot") mEq/L; varies
24-hour measurement mEq/24 hr; varies with intake
Cholesterol, serum
Total
Desirable ˂200 mg/dL
Borderline-high 200–239 mg/dL
High >239 mg/dL
High-density lipoprotein
Low Female: ˂50 mg/dL; male: ˂40 mg/dL
Low-density lipoprotein
Optimal ˂100 mg/dL
Near-optimal 100–129 mg/dL
Borderline-high 130–159 mg/dL
High 160–189 mg/dL
Very high >189 mg/dL

3
Cholinesterase, serum (pseudocholinesterase) ≥0.5 pH units/hr
Packed cells ≥0.7 pH units/hr
Chorionic gonadotropin, beta-human See Beta-human chorionic gonadotropin (beta-hCG),
(beta-hCG), serum serum
Chorionic gonadotropin, beta-human See Beta-human chorionic gonadotropin (beta-hCG),
(beta-hCG), urine urine
Chromogranin A, serum ˂93 ng/mL
Citrate, urine 250–1000 mg/24 hr
Coagulation factors, plasma
Factor I (fibrinogen) 200–400 mg/dL
Factor II (prothrombin) 60%–130%
Factor V (accelerator globulin) 60%–130%
Factor VII (proconvertin) 60%–130%
Factor VIII (antihemophilic globulin) 50%–150%
Factor IX (plasma thromboplastin component) 60%–130%
Factor X (Stuart factor) 60%–130%
Factor XI (plasma thromboplastin antecedent) 60%–130%
Factor XII (Hageman factor) 60%–130%
Factor XIII 57%–192%
Cold agglutinin titer >1:64 positive
Complement components, serum
C3 100–233 mg/dL
C4 14–48 mg/dL
CH50 110–190 units/mL
Copper, serum 100–200 μg/dL
Copper, urine 0–100 μg/24 hr
Coproporphyrin, urine 50–250 μg/24 hr
Cortisol, free, urine 4–50 μg/24 hr
Cortisol, plasma
8 AM 5–25 μg/dL
4 PM ˂10 μg/dL
1 hour after cosyntropin ≥18 μg/dL
Overnight suppression test (1-mg) ˂1.8 μg/dL
Overnight suppression test (8-mg) >50% reduction in cortisol
Cortisol, saliva, 11 PM – midnight ˂0.09 µg/dL
C-reactive protein, serum ≤0.8 mg/dL
C-reactive protein (high sensitivity), serum Low risk: ˂1.0 mg/L; Average risk: 1.0–3.0 mg/L;
High risk: >3.0 mg/L
Creatine kinase, serum
Total Female: 30–135 U/L; male: 55–170 U/L
MB isoenzymes ˂5% of total
Creatine, urine Female: 0–100 mg/24 hr; male: 0–40 mg/24 hr
Creatinine clearance, urine 90–140 mL/min/1.73 m2
Creatinine, serum Female: 0.50–1.10 mg/dL; male: 0.70–1.30 mg/dL
Creatinine, urine
Random ("spot") mg/dL; varies
24-hour measurement 15–25 mg/kg body weight/24 hr
Cyclosporine, whole blood (trough)
Therapeutic 100–200 ng/mL
0–3 months post transplantation 150–250 ng/mL
More than 3 months post transplantation 75–125 ng/mL
4
D-dimer, plasma ˂0.5 μg/mL
Dehydroepiandrosterone sulfate (DHEA-S), serum Female: 44–332 μg/dL; male: 89–457 μg/dL
Delta-aminolevulinic acid, serum ˂20 μg/dL
Digoxin, serum Therapeutic: 1.0–2.0 ng/mL
(˂1.2 ng/mL for patients with heart failure)
Dihydrotestosterone, serum Adult male: 25–80 ng/dL
Dopamine, plasma ˂30 pg/mL
Dopamine, urine 65–400 μg/24 hr
D-Xylose absorption
(after ingestion of 25 g of D-xylose)
Serum 25–40 mg/dL
Urinary excretion 4.5–7.5 g during a 5-hr period
Electrolytes, serum
Sodium 136–145 mEq/L
Potassium 3.5–5.0 mEq/L
Chloride 98–106 mEq/L
Bicarbonate 23–28 mEq/L
Epinephrine, plasma
Supine ˂110 pg/mL
Standing ˂140 pg/mL
Epinephrine, urine ˂20 μg/24 hr
Erythrocyte count 4.2–5.9 million/μL
Erythrocyte sedimentation rate (Westergren) Female: 0–20 mm/hr; male: 0–15 mm/hr
51 T½ = 28 days
Erythrocyte survival rate ( Cr)
Erythropoietin, serum 4–26 mU/mL
Estradiol, serum
Female, follicular 10–180 pg/mL
Mid-cycle peak 100–300 pg/mL
Luteal 40–200 pg/mL
Postmenopausal ˂10 pg/mL
Male 20–50 pg/mL
Estriol, urine >12 mg/24 hr
Estrogen receptor protein Negative: ˂10 fmol/mg protein
Estrone, serum 10–60 pg/mL
Ethanol, blood ˂0.005% (˂5 mg/dL)
Coma level >0.5% (>500 mg/dL)
Intoxication ≥0.08%–0.1% (≥80–100 mg/dL)
Euglobulin clot lysis time 2–4 hours at 37.0 C
Everolimus, whole blood (trough) Therapeutic: 3.0–8.0 ng/mL
Factor XIII, B subunit, plasma 60–130 U/dL
Fecal fat ˂7 g/24 hr
Fecal nitrogen ˂2 g/24 hr
Fecal pH 7.0–7.5
Fecal potassium ˂10 mEq/L
Fecal sodium ˂10 mEq/L
Fecal urobilinogen 40–280 mg/24 hr
Fecal weight ˂250 g/24 hr
Ferritin, serum Female: 24–307 ng/mL; male: 24–336 ng/mL
Fibrin(ogen) degradation products ˂10 μg/mL
Fibrinogen, plasma 200–400 mg/dL

5
Fibroblast growth factor-23, serum 30–80 RU/mL
Flecainide, serum Therapeutic: 0.2–1.0 μg/mL
Folate, red cell 150–450 ng/mL of packed cells
Folate, serum 1.8–9.0 ng/mL
Follicle-stimulating hormone, serum
Female, follicular/luteal 2–9 mIU/mL (2–9 U/L)
Female, mid-cycle peak 4–22 mIU/mL (4–22 U/L)
Female, postmenopausal >30 mIU/mL (>30 U/L)
Male (adult) 1–7 mIU/mL (1–7 U/L)
Children, Tanner stages 1, 2 0.5–8.0 mIU/mL (0.5–8.0 U/L)
Children, Tanner stages 3, 4, 5 1–12 mIU/mL (1–12 U/L)
Free kappa light chain, serum 3.3–19.4 mg/L
Free kappa-to-free lambda light chain ratio, serum 0.26–1.65
Free lambda light chain, serum 5.7–26.3 mg/L
Gamma globulin, CSF 6.1–8.3 mg/dL
Gamma-glutamyltransferase
(gamma-glutamyl transpeptidase), serum Female: 8–40 U/L; male: 9–50 U/L
Gastrin, serum ˂100 pg/mL
Gentamicin, serum Therapeutic: peak 5.0–10.0 µg/mL;
trough: ˂2.0 µg/mL
Glucose, CSF 50–75 mg/dL
Glucose, plasma (fasting) 70–99 mg/dL
Glucose-6-phosphate dehydrogenase, blood 5–15 units/g of hemoglobin
Glycoprotein α-subunit, serum ˂1 ng/mL
Growth hormone, serum
At rest ˂5 ng/mL
Response to provocative stimuli >7 ng/mL
Haptoglobin, serum 83–267 mg/dL
Hematocrit, blood Female: 37%–47%; male: 42%–50%
Hemoglobin A1C 4.0%–5.6%
Hemoglobin, blood Female: 12–16 g/dL; male: 14–18 g/dL
Hemoglobin fractionation
Hb A 96%–98%
Hb A2 1.5%–3.5%
Hb F ˂1%
Hemoglobin, plasma ˂5.0 mg/dL
Heparin–anti-factor Xa assay, plasma 0.3–0.7 IU/mL [therapeutic range for standard
(unfractionated) heparin therapy]
Heparin–platelet factor 4 antibody, serum Positive: >0.4 optical density units
Hepatic copper 25–40 μg/g dry weight
Hepatic iron index ˂1.0
Histamine excretion, urine 20–50 μg/24 hr
Homocysteine, plasma 5–15 μmol/L
β-Human chorionic gonadotropin (β-hCG), serum Female, premenopausal nonpregnant: ˂1.0 U/L; female,
postmenopausal: ˂7.0 U/L; male: ˂1.4 U/L
β-Human chorionic gonadotropin (β-hCG), urine ˂2 mIU/24 hr
Hydroxyproline, urine 10–30 mg/sq meter of body surface/24 hr
Immature platelet fraction 1%–5% of platelet count
Immune complexes, serum 0–50 μg/dL

6
Immunoglobulins, serum
IgA 90–325 mg/dL
IgE <380 IU/mL
˂380 IU/mL
IgG 800–1500 mg/dL
800–1500
IgM 45–150 mg/dL
Immunoglobulin free light chains, serum
Kappa 3.3–19.4 mg/L
Lambda 5.7–26.3 mg/L
Kappa-to-lambda ratio 0.26–1.65
Insulin, serum (fasting) ˂20 μU/mL
Insulin-like growth factor 1 (IGF-1)
(somatomedin-C), serum
Ages 16–24 182–780 ng/mL
Ages 25–39 114–492 ng/mL
Ages 40–54 90–360 ng/mL
Ages 55 and older 71–290 ng/mL
Iodine, urine
Random ("spot") µg/L; varies
Iron, serum 50–150 μg/dL
Iron-binding capacity, serum (total) 250–310 μg/dL
Lactate dehydrogenase, serum 80–225 U/L
Lactate, arterial blood ˂1.3 mmol/L (˂1.3 mEq/L)
Lactate, serum or plasma 0.7–2.1 mmol/L
Lactate, venous blood 0.7–1.8 mEq/L; 6–16 mg/dL
Lactic acid, serum 6–19 mg/dL (0.7–2.1 mmol/L)
Lactose tolerance test, GI Increase in plasma glucose: >15 mg/dL
Lead, blood <5.0 μg/dL
Leukocyte count 4000–11,000/μL
Segmented neutrophils 50%–70%
Band forms 0%–5%
Lymphocytes 30%–45%
Monocytes 0%–6%
Basophils 0%–1%
Eosinophils 0%–3%
Lipase, serum 10–140 U/L
Lipoprotein(a), serum Desirable: ˂30 mg/dL
Lithium, plasma
Therapeutic 0.6–1.2 mEq/L
Toxic level >2 mEq/L
Luteinizing hormone (LH), serum
Female, follicular/luteal 1–12 mIU/mL (1–12 U/L)
Female, mid-cycle peak 9–80 mIU/mL (9–80 U/L)
Female, postmenopausal >30 mIU/mL (>30 U/L)
Male (adult) 2–9 mIU/mL (2–9 U/L)
Children, Tanner stages 1, 2, 3 ˂9.0 mIU/mL (˂9.0 U/L)
Children, Tanner stages 4, 5 1–15 mIU/mL (1–15 U/L)

7
Lymphocyte subsets
CD3 900–3245/μL
CD4 530–1570/μL
CD8 430–1060/μL
CD19 208–590/μL
CD56 40–500/µL
Magnesium, serum 1.6–2.6 mEq/L
Magnesium, urine 14–290 mg/24 hr
Mean corpuscular hemoglobin 28–32 pg
Mean corpuscular hemoglobin concentration 33–36 g/dL
Mean corpuscular volume 80–98 fL
Mean platelet volume 7–9 fL
Metanephrines, fractionated, plasma
Metanephrine ˂0.5 nmol/L
Normetanephrine ˂0.9 nmol/L
Metanephrines, fractionated, 24-hour urine
Metanephrine ˂400 µg/24 hr
Normetanephrine ˂900 µg/24 hr
Myoglobin, serum ˂100 μg/L
Norepinephrine, plasma
Supine 70–750 pg/mL
Standing 200–1700 pg/mL
Norepinephrine, urine 0–100 μg/24 hr
Normetanephrine, fractionated, plasma ˂0.9 nmol/L
Normetanephrine, fractionated, 24-hour urine ˂900 µg/24 hr
N -telopeptide, urine Female: 11–48 nmol BCE/mmol creatinine;
male: 7–68 nmol BCE/mmol creatinine
N -terminal-pro-B-type natriuretic peptide (NT-pro-BNP), If eGFR >60 mL/min/1.73 m2
serum or plasma 18 –49 years of age
Heart failure unlikely: ≤300 pg/mL
High probability of heart failure: ≥450 pg/mL
50–75 years of age
Heart failure unlikely: ≤300 pg/mL
High probability of heart failure: ≥900 pg/mL
Older than 75 years of age
Heart failure unlikely: ≤300 pg/mL
High probability of heart failure: ≥1800 pg/mL
If eGFR <60 mL/min/1.73 m2
18 years of age or older
High probability of heart failure: ≥1200 pg/mL
Osmolality, serum 275–295 mOsm/kg H2O
Osmolality, urine 38–1400 mOsm/kg H2O
Osmotic fragility of erythrocytes Increased if hemolysis occurs in over 0.5% NaCl;
decreased if hemolysis is incomplete in 0.3% NaCl
Osteocalcin, serum Female: 7.2–27.9 ng/mL; male: 11.3–35.4 ng/mL
Oxalate, urine ˂40 mg/24 hr
Oxygen consumption 225–275 mL/min
Oxygen saturation, arterial blood ≥95%
Parathyroid hormone, serum
C -terminal 150–350 pg/mL
Intact 10–65 pg/mL
Intact (dialysis patients only) Target: 130–585 pg/mL
8
Parathyroid hormone-related protein, serum ˂1.5 pmol/L
Partial thromboplastin time (activated) 25–35 seconds
pH, urine 4.5–8.0
Phenolsulfonphthalein, urine At least 25% excreted by 15 minutes;
40% by 30 minutes;
60% by 120 minutes
Phenytoin, serum Therapeutic: 10–20 μg/mL
Phosphatase (acid), serum
Total 0.5–2.0 (Bodansky) units/mL
Prostatic fraction 0.1–0.4 unit/mL
Phosphatase (alkaline), serum 30–120 U/L
Phospholipids, serum (total) 200–300 mg/dL
Phosphorus, serum 3.0–4.5 mg/dL
Phosphorus, urine 500–1200 mg/24 hr
Platelet count 150,000–450,000/μL
Platelet function analysis (PFA-100):
Collagen–epinephrine closure time 60–143 seconds
Collagen–ADP closure time 58–123 seconds
Platelet survival rate (51Cr) 10 days
Potassium, serum 3.5–5.0 mEq/L
Potassium, urine
Random ("spot") mEq/L; varies
24-hour measurement mEq/24 hr; varies with intake
Prealbumin, serum 16–30 mg/dL
Pregnanetriol, urine 0.2–3.5 mg/24 hr
Pressure (opening) [initial], CSF 70–180 mm CSF (70–180 mm H2O)
Procalcitonin, serum ≤0.10 ng/mL
Progesterone, serum
Female, follicular 0.02–0.9 ng/mL
Female, luteal 2–30 ng/mL
Male (adult) 0.12–0.3 ng/mL
Proinsulin, serum 3–20 pmol/L
Prolactin, serum ˂20 ng/mL
Prostate-specific antigen, serum ng/mL; no specific normal or abnormal level
Protein C activity, plasma 65%–150%
Protein C antigen, plasma 70%–140%
Protein catabolic rate, urine goal: 1.0–1.2 g/kg/24 hr
Protein S activity, plasma 57%–131%
Protein S antigen, plasma
Total 60%–140%
Free 60%–130%
Protein, urine
Random ("spot") mg/dL; varies
24-hour measurement ˂100 mg/24 hr
Proteins, CSF total 15–45 mg/dL
Proteins, serum
Total 5.5–9.0 g/dL
Albumin 3.5–5.5 g/dL

9
Proteins, serum (continued)
Globulin 2.0–3.5 g/dL
Alpha1 0.2–0.4 g/dL
Alpha2 0.5–0.9 g/dL
Beta 0.6–1.1 g/dL
Gamma 0.7–1.7 g/dL
Protein-to-creatinine ratio, urine ˂0.2 mg/mg
Prothrombin time, plasma 11–13 seconds
Pyruvic acid, blood 0.08–0.16 mmol/L
Quinidine, serum Therapeutic: 2–5 μg/mL
Red cell distribution width (RDW) 9.0%–14.5%
Red cell mass Female: 22.7–27.9 mL/kg; male: 24.9–32.5 mL/kg
Renin activity (angiotensin-I radioimmunoassay)
Peripheral plasma
Normal diet
Supine 0.3–2.5 ng/mL/hr
Upright 0.2–3.6 ng/mL/hr
Low sodium diet
Supine 0.9–4.5 ng/mL/hr
Upright 4.1–9.1 ng/mL/hr
Diuretics + low sodium diet 6.3–13.7 ng/mL/hr
Renal vein concentration Normal ratio (high:low): ˂1.5
Reptilase time 10–12 seconds
Reticulocyte count 0.5%–1.5% of red cells
Reticulocyte count, absolute 25,000–100,000/µL
Rheumatoid factor (nephelometry) ˂24 IU/mL
Rheumatoid factor, latex test for ≤1:80
Ristocetin cofactor activity of plasma ^ĞĞ von Willebrand factor activity (ristocetin cofactor
activity), plasma
Russell viper venom time, dilute 33–44 seconds
Salicylate, plasma Therapeutic: 20–30 mg/dL
Sex hormone-binding globulin Female, nonpregnant: 18–144 nmol/L;
male: 10–57 nmol/L
Sodium, serum 136–145 mEq/L
Sodium, urine
Random ("spot") mEq/L; varies
24-hour measurement mEq/24 hr; varies with intake
Specific gravity, urine 1.002–1.030
Sperm density 10–150 million/mL
Sweat test for sodium and chloride ˂60 mEq/L
T3 resin uptake 25%–35%
T-lymphocyte count, CD4 530–1570/μL
Tacrolimus, whole blood (trough) Therapeutic: 5–15 ng/mL {For transplant patients:
10.0–15.0 ng/mL (0–3 months post transplantation);
5.0–10.0 ng/mL (more than 3 months post
transplantation)}
Testosterone, serum Female: 18–54 ng/dL; male: 291–1100 ng/dL
Testosterone, bioavailable, serum Female, age 18–69 yrs: 0.5–8.5 ng/dL
Testosterone, free, serum Male: 70–300 pg/mL
Theophylline, serum Therapeutic: 8–20 μg/mL
Thrombin time 17–23 seconds

10
Thyroid function studies
T3 resin uptake 25%–35%
Thyroglobulin, serum ˂20 ng/mL
Thyroidal iodine (123I) uptake 5%–30% of administered dose at 24 hours
Thyroid-stimulating hormone (TSH), serum 0.5–4.0 μU/mL (0.5–4.0 mU/L)
Thyroid-stimulating immunoglobulin (TSI) ˂130%
Thyroxine-binding globulin, serum 12–27 µg/mL
Thyroxine index, free (estimate) 5–12
Thyroxine (T4), serum
Total 5–12 μg/dL
Free 0.8–1.8 ng/dL
Triiodothyronine (T3), serum
Total 80–180 ng/dL
Reverse 20–40 ng/dL
Free 2.3–4.2 pg/mL
Tissue transglutaminase antibody, IgA ˂20 AU
[by chemiluminescence method]
Tissue transglutaminase antibody, IgG ˂20 AU
[by chemiluminescence method]
Tissue transglutaminase antibody, IgA ˂4.0 U/mL
[by ELISA]
Tissue transglutaminase antibody, IgG ˂6.0 U/mL
[by ELISA]
Total proteins, CSF 15–45 mg/dL
Transaminase, serum glutamic oxaloacetic (SGOT) See Aminotransferase, serum aspartate (AST)
Transaminase, serum glutamic pyruvic (SGPT) See Aminotransferase, serum alanine (ALT)
Transferrin saturation 20%–50%
Transferrin, serum 200–400 mg/dL
Triglycerides, serum (fasting)
Optimal ˂100 mg/dL
Normal ˂150 mg/dL
Borderline-high 150–199 mg/dL
High 200–499 mg/dL
Very high >499 mg/dL
Troponin I, cardiac, serum ≤0.04 ng/mL
Troponin T, cardiac, serum ≤0.01 ng/mL
Tryptase, serum ˂11.5 ng/mL
Urea clearance, urine
Standard 40–60 mL/min
Maximal 60–100 mL/min
Urea nitrogen, blood 8–20 mg/dL
Urea nitrogen, urine 12–20 g/24 hr
Uric acid, serum 3.0–7.0 mg/dL
Uric acid, urine 250–750 mg/24 hr
Uroporphyrin, urine 10–30 μg/24 hr
Vanillylmandelic acid, urine ˂9 mg/24 hr
Venous oxygen content, mixed 14–16 mL/dL

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Venous studies, mixed, blood
pH 7.32–7.41
PCO2 42–53 mm Hg
PO2 35–42 mm Hg
Bicarbonate 24–28 mEq/L
Oxygen saturation (SvO2) 65%–75%
Viscosity, serum 1.4–1.8 cp
Vitamin A, serum:
Adult 32.5–78.0 μg/dL
Pediatric, age 1–2 yr (retinol) 20–43 μg/dL
Vitamin B12, serum 200–800 pg/mL
Vitamin D metabolites, serum
1,25-Dihydroxyvitamin D 15–60 pg/mL
(1,25-dihydroxycholecalciferol)
25-Hydroxyvitamin D 30–60 ng/mL
(25-hydroxycholecalciferol)
Vitamin E, serum:
Adult 5.5–17.0 mg/L
Pediatric, age 1–2 yr (alpha-tocopherol) 2.9–16.6 mg/L
Volume, blood
Plasma Female: 43 mL/kg body weight;
male: 44 mL/kg body weight
Red cell Female: 20–30 mL/kg body weight;
male: 25–35 mL/kg body weight
von Willebrand factor activity (ristocetin cofactor
activity), plasma 50%–150%
von Willebrand factor antigen, plasma 50%–150%
Zinc, serum 75–140 μg/dL
Revised - January 2022

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