Generic Name heparin
Trade Name Hepalean
Class anticoagulants
Action Inhibitory effect of antithrombin on factor and
thrombin. In low doses, prevents the conversion of
prothrombin to thrombin by its effects on factor.
Higher doses neutralize thrombin, preventing the
conversion of fibrinogen to fibrin.
Indication/s Treatment of various thromboembolic disorders
including venous thromboembolism, Pulmonary
emboli, Atrial fibrillation.
Contraindication/s Hypersensitivity, Uncontrolled bleeding, Severe
thrombocytopenia, Open wounds and severe liver
or kidney disease.
Side effect/s Anemia, pain at injection site, osteoporosis and
fever
Common interaction/s with other Risk of bleeding may be increase by concurrent
medication/s use of drugs that affect platelet function like
aspirin.
Drug food interaction: increase risk of bleeding
with arnica, anise, and chamomile, and clove,
fever few, garlic, ginger.
Route/s of administration with IV, SC
dosage
Therapeutic level R O P D
Heparin 20–60 min 2 hr 8–12 hr
subcut
Heparin immediate 5–10 min 2–6 hr
IV
Method/s of preparation and Subcut administer deep into subcut tissue.
administration Alternate injection sites between arm and the left
and right abdominal wall above the iliac crest.
Direct IV administer loading dose undiluted.
Nursing consideration/s / Assess for signs of bleeding and hemorrhage.
precaution/s Monitor patient for hypersensitivity reactions.
Monitor platelet count every 2–3 days throughout
therapy.
Patient / Family teaching Advise patient to report any symptoms of unusual
bleeding.
Instruct patient not to take medications containing
aspirin or NSAIDs while on heparin therapy.
Advise patient to inform health care professional
of medication regimen prior to treatment or
surgery.
Reference (Use APA Guidelines) Deglin, j., vallerand, A., sanoski, c. (2015) “Davis’s
drug guide for nurses”. (14th ed.) USA: F.A Davis
company. P(631)