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Platelets Review

The document reviews platelets and their 4 clotting functions: maintaining vascular integrity, contributing to fibrin formation, helping to arrest bleeding, and promoting vascular healing. It describes how to estimate and minimize platelet clumping, lists normal platelet count ranges for common species, defines thrombocytosis and thrombocytopenia, reviews the coagulation cascade pathways and common bleeding terms, and identifies inherited and acquired bleeding disorders including their causes.

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Lindsey Kochanski
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79 views3 pages

Platelets Review

The document reviews platelets and their 4 clotting functions: maintaining vascular integrity, contributing to fibrin formation, helping to arrest bleeding, and promoting vascular healing. It describes how to estimate and minimize platelet clumping, lists normal platelet count ranges for common species, defines thrombocytosis and thrombocytopenia, reviews the coagulation cascade pathways and common bleeding terms, and identifies inherited and acquired bleeding disorders including their causes.

Uploaded by

Lindsey Kochanski
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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PLATELETS REVIEW

1. What are the 4 clotting functions?

 Maintain vascular integrity  Contribute to fibrin formation


 Help arrest bleeding  Promote vascular healing

2. Describe platelets in the 5 species named in the packet:

 Canine: o Clump easily


o Small  Equine:
o Round to oval o Same as canine
o Stain light blue o Don’t stain intensely
o Pink to purple granules  Bovine:
 Feline: o Same as canine
o Same as canine  Llama:
o Vary in size o Extremely small

3. How do you estimate platelets?


 Count platelets in 10 fields and average
 Multiply by 15,000/µl

4. How can you minimize platelet clumping?

 Make sure to use a large vein  Invert tube immediately


 Use right size needle (largest possible)  Perform a platelet count ASAP

5. Normal Range for Platelet count:


 Canine= 200,000-500,000/µl
 Feline= 300,000-800,000/µl

6. Thrombocytosis- More than 1,000,000/µl


7. Thrombocytopenia- Less than 100,000/µl

8. Clotting Factors

I. Fibrinogen Foolish
II. Prothrombin People
III. Tissue Thromboplastin Try
IV. Calcium Climbing
V. Labile Factor Long
VI. Factor 6
VII. Stabile Factor Slopes
VIII. Antihemophiliac Factor(vWd) After
IX. Christmas Factor Christmas
X. Stuart-Prower Factor Some
XI. Plasma Thromboplastic Antecedent People
XII. Hageman Factor Have
XIII. Fibrin Stabilizing Factor Fallen

9. Describe hemostasis:
 Primary-
o Platelet Adhesion
o Platelet Activation- changing shape
o Platelet aggregation- plug
 Secondary- Coagulation Cascade
o Extrinsic Pathway- used when damage occurs outside a vessel
o Intrinsic Pathway- used when damage occurs inside a vessel
o Common Pathway- Ultimate production of fibrin from fibrinogen
 Tertiary-
o Plasmin breaks down clot
10. Epistaxis- Bleeding from the nose
11. Melena- Tarry stool
12. Hematuria- Blood in the urine
13. Petechial Hemorrhage- Pin point bleeding
14. Ecchymotic Hemorrhage- Severe bruising
15. What are the three pathways of the coagulation cascade?
 Extrinsic Pathway
 Intrinsic Pathway
 Common Pathway

16. A defect in the secondary hemostasis often results in what?


Bleeding in cavities & joints

17. What is the most common inherited disease of hemostasis?


Von Willebrand Disease

18. Hemophilia is a deficiency of:


a. Factor 8
b. Factor 9
c. Factor 11

19. DIC- Inappropriate clotting throughout vessels


o Always secondary to another disease
 Sepsis, Heat stroke, Burns, Shock, Pancreatitis, Neoplasia, Trauma
20. Why might an animal be deficient in Vitamin K?
 Diet
 Malabsorption
 Toxins
21. What are some toxicities that can cause an acquired hemostasis disorder?
 Warfarin
 Onions
 Garlic

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