SKIN HEALTH AND

BEAUTY INGREDIENT

COLLAGEN PEPTIDES

Juan Manuel La Camera

Beauty from within

 Nutricosmetic market and trends

 Beauty from within

 Skin aging and collagen

 Mechanism of action

 Clinical studies confirm - anti-

aging effects

 Market products & LATAM

page 2
 UK AND BRAZIL LEAD FOR COLLAGEN BEAUTY NPD

Source: Innova
Nutri-Cosmetics
= Ingestible Beauty supplements & food/drinks

A variety of factors is driving sales of nutricosmetics

Shift toward
Aging
less invasive
population
procedures

Environmental Growth in Increasing

consumer
factors
Nutricosmetics awareness

Societal
Spa culture
factors

page 4
Global market for nutricosmetics

The ‘beauty
from within’
concept is well
established in
Japan/Asia,
with fish
collagen
as a key
…and the ingredient…
market is
growing in
Europe and
Americas…

Source: Euromonitor

page 5
Following the Asian Health & Beauty approach

Japan:
Shiseido The Collagen Drink
Three bottles of low molecular fish
collagen drink with eucommia
ulmoides tea, ginseng, pearl-barley,
GABA, ornithine, hyaluronic acid,
ceramide, royal jelly, vitamin C.

Most popular sales channel

Convenience stores;
Lawson, FamilyMart, 7-Eleven
 Ingredient awareness amongst UK Consumers!

Source: Survey, SenseReach, UK, +1500 consumers, 70 pct female

7
 CONSUMERS BELIEVE THAT DIETARY CHANGES CAN HELP
TO IMPROVE SKIN HEALTH

Top beauty claims

on products:

Anti-aging
anti wrinkle

Elasticity of the
skin
Flexibility of the
skin

Stronger/firmer:
skin, hair & nails

Source: Innova
 HEALTHY LIVING POSITIONING INCREASING

Supplements is still the biggest market category for beauty from within, however healthy
living positioned F&B launches are increasing.

Source: Innova
BEAUTY SUPPLEMENT RETURNING TO GROWTH
 CONSUMER BEHAVIOR TOWARDS NUTRICOSMETICS

• Consumers that choose

nutricosmetics products prefer
those having the highest degree
of natural image.

• Nutricosmetics are perceived as

complementary to their current
skincare routine

• Consumers that purchase

nutricosmetics product, trust
brands that are strong in
nutraceutical fields

• People who are already used to

consuming food supplements are
more willing to try nutricosmetics

• The products should be adapt to

consumers’ everyday habits and
enable daily supplementation to
be easier and more pleasurable

Source: Target Research, Euromonitor

NUTRICOSMETICS MARKET IN THE EAST TAKES THE LEAD

The notion of ‘beauty from within’ is taken rather seriously in the Asian market. The
addition of collagen to dried fruits, yogurt drinks, and other foods is a trend that has
immense potential and has been driving food and beverage manufacturers to up their
game and venture into the ever-transforming beauty industry.

Source: Transparency market research, Euromonitor

BEVERAGES LEAD FOR COLLAGEN SKIN HEALTH CLAIMS

Although confectionery accounts for almost 1/3 of all product launches tracked with skin
health claims associated with collagen, the highest share of skin health claimed products
is seen for beverages with a big focus on soft drinks.

Source: Innova
 SUPPLEMENTS: ASIA VS NORTH AMERICA

In North America, capsules, tablets and gummies are dominating the market, while
the supplements in Asia include powder, liquid, and jelly.

Source: Innova Analysis

 DELIVERY FORMS- FUNCTIONAL FOOD

In Asia, especially Japan functional food delivery forms are popular among consumers. In
Europe, UK is leading the trend and in LATAM, Brazil also has many collagen food product
launches

Multiple
active
health
claims

Morinaga Collagen 100000 Beauty

Bella Drink
Berry Abacaxi
SummerComFruitHotela
Beauty&
Collagen Drink (Japan, Nov 2014) Beauty Drink Abacaxi Com Hotela & Maracuja
Drink (UK,
(Brazil,
Dec Jun
2015)
2015)
Maracuja (Brazil, Jun 2015)
Claim: Morinaga collagen drink in peach flavor Claim:
Claim: Rich inDietary
vitamins supplement for joints
A, B1, B6 and B12.0% fat, sugar
with high concentration collagen (10, 000mg) Claim: Rich in vitamins A, B1, B6 and andfor runners
sodium. and cyclists.
With collagen. Gluten Regenerates
free. Recyclable
blended with"ceramide" for moisturizing. B12.0% fat, sugar and sodium. With ligaments,
packaging. Braziltendons
anniversaryand articular
edition. Collagen is
collagen. Gluten free. Recyclable packaging. surfaces.
protein engaged Reduces
in firmnessfriction during
and elasticity of the skin.
Brazil anniversary edition. Collagen is protein movement.
Beauty'in Limits pain
formula specifically in the joints.
developed to meet
engaged in firmness and elasticity of the Supports recovering from injury.
vitamins.
skin. Beauty'in formula specifically developed
Source: Innova Analysis to meet vitamins.
 DELIVERY FORMS- FUNCTIONAL FOOD 2
(COLLAGEN BASED MOBILITY CLAIMS USED CROSS
CATEGORY)

The variety expands to everyday food- ambient dessert, bread, chocolate, or gummy…

Moderna Benefit Pan Universal Gelatina Diet Extra

Integral Con Colageno Colageno Sabor A Fresa (Peru,
(Ecuador, Oct 2015) Jun 2015)
Claim: …Benefits of collagen Claim: …Collagen protein that take Sinnipai Collagen Jelly On the go
care of the body and health. (Japan, Feb 2014)
and sunflower seeds:
Nourishes, protects and helps
format is
collagen is a protein molecule Claim: Improves the rough
that helps in the structure, maintain healthy and strong and dry skin. Widely used for particularly
elasticity and integrity of bones. Moisturizes and healthy and beautiful body. popular in
organs such as skin, hair, strengthens the skin. Prevents Collagen jelly is a beauty
nails and joints, and hair loss. It reduces pain caused ingredient for beautiful skin.
Asia and
sunflower seeds prevent the by arthritis, slowing the process of Contains 15, 400mg of arriving in
osteoporosis and maintains collagen. Can be eaten easily.
disintegration of collagen in
healthy joints.
UK too
the body.
Source: Innova Analysis
Health claims – Examples in the context of EFSA

Which claims can be used in the marketing of Collagen peptides today?

 Bone health
 Protein contributes to the maintenance of normal bones
• Protein is needed for normal growth and development of bone in children (art. 14)
Condition: source of protein (12% of the energy)

 Joint health – none

But with Vit C: Contributes to normal collagen formation for the normal function of cartilage

 Muscle mass
 Protein contributes to growth in muscle mass
 Protein contributes to the maintenance of muscle mass
Condition: source of protein (12% of energy)

 Skin Beauty claims, -more complex situation, interpretation of EFSA scope

 A claim referring to a function on the body or the skin would fall under the scope of the regulation.
 “beauty” claims with no reference on health or functional properties should be excluded
Example of beauty claims
-Enhance skin beauty, -Help to fight against the visible signs of skin ageing
Beauty from within

 Nutricosmetic market and trends

 Beauty from within

 Skin aging and collagen

 Mechanism of action

 Clinical studies confirm - anti-

aging effects

 Market products & LATAM

page 18
Skin aging : The important role of collagen

 Collagen and elastin create skin’s structure, collagen provides

infrastructure, while elastin allows skin to stretch.
 Collagen also traps moisture, hyaluronic acid

 During aging, decreased fibroblast (skin cells) activity

slows collagen+elastin synthesis, leading to loss of collagen and
fragmentation:

 Dehydration
 Wrinkle formation
 Loss of firmness
 Loss of elasticity

Maintaining a well structured collagen network is the key to youthful skin

page 19
Peptides stimulates Collagen production
Ex-vivo study -skin explants

Morphology of a skin explant sample treated with

Peptan. The density of the collagen fibers
(green color) is enhanced.
Human skin explants in culture media
Stratum corneum

Collagen
peptides
Epidermis
sample

Collagen structure
(with Collagen peptides)

Papillary dermis

Untreated control explant sample with less dense

coloration due to less collagen present.
Addition of collagen peptides to the
media stimulated collagen production
Stratum corneum

Control
Increase in collagen density:
sample
- Collagen peptides treated sample (top) Epidermis

- compared to control (bottom),

by staining collagen fibers with Collagen structure
green/blue colour (day 9) (with control)

Papillary dermis

(from Bio EC lab., France)

page 20
Collagen peptides stimulates Hyaluronic acid (HA)
production

Collagen
Ex vivo: Addition of Collagen peptides to the media peptides
stimulated and increased the level of sample
Glycoaminoglycans (main component= HA): (P2)
Acidic GAGs are more evident (alcian blue colour)
in the epidermis of the Peptan sample,
compared to control (day 9).
GAG increase by image analysis: +745 % !

Control
sample
(T)

(Bio EC lab, France. Rousselot)

page 21
Beauty from within

 Collagen peptides

 Nutricosmetic market and trends

 Beauty from within

 Skin aging and collagen

 Mechanism of action

 Clinical studies confirm anti-

aging effects

 Market products & LATAM

page 22
 Mechanism of action of collagen peptides

1- Production of collagen:
 Hydrolyzed collagens have an effect on the cells of connective
tissues
 The main hypothesis of action is that peptides coming from the oral intake
of collagen may be recognized as a fake signal of the destruction of
endogenous collagen
 Two Japanese studies show that ingestion of collagen peptides increases
the size of the collagen fibrils, (Minaguchi, 2005) and enhances formation of
the collagen fibrils (Matsuda, 2006).

BLOOD
Local
Specific Collagen derived production
peptides Activation
Collagen Gly-Glu, Pro-Hypro
of collagen
of Skin cells by the
Peptides
recognized by the cells as body
local collagen destruction

page 23
Mechanism of action of collagen peptides

Collagen
Peptides
Anti-aging

collagen
production
+++
fibroblasts
proliferation
+ activation
of the enz.
HAS2
+++

hyaluronic
acid
Hydration
synthesis
+++

page 24
Beauty from within

 Collagen peptides

 Nutricosmetic market and trends

 Beauty from within

 Skin aging and collagen

 Mechanism of action

 Clinical studies confirm

anti-aging effects

 Market Products & LATAM

page 25
Benefits are proven in clinical skin studies

Placebo controlled Clinical studies carried out in Japan and France confirm
the anti aging effect of taking Peptan®

Successfully tested by leading skin research centers

 SOUKEN institute in Tokyo
 DERMSCAN institute in Lyon Increase
 COSDERMA laboratories in Bordeaux moisture

 >150 women participated Reduce Denser

wrinkles Youthful collagen
 Placebo controlled studies
 Latest advanced skin analysis Skin

Smooth
Collagen
restructure supple
Scientifically proven skin
Anti-age benefits
- in just one month!

page 26
Japanese clinical study- SOUKEN

Double-blind placebo-controlled trial of Oral supplementation of

Collagen peptides in improving skin condition.
Souken, Tokyo, Japan, 2008, Study YNTKK – 2008 – 4144

Objectives
 Assess the efficacy of Collagen peptides after 4 and 8 weeks during winter,
and in particular:
 Cutaneous water content
 Self-assessment by volunteers

Study design
 33 volunteers (40-59 years old women)
 Normal to dry skin
 Double blind vs placebo (dextrins)
 10g of Peptan once a day in 100ml drink
 8 weeks (October – December)

page 27
French clinical study- DERMSCAN

Evaluation of the effects of an oral intake of Collagen Peptides

on cutaneous properties versus placebo.
Dermscan, France, 2008 - Study 2008 – A00654 – 51

Objectives
 Assess the efficacy of Collagen peptides after 6 and 12 weeks during winter
 Anti-wrinkle effect & Biomechanical properties
 Self-assessment

Study design
 47 volunteers (35-55 years old women)
 Normal to dry skin
 Double blind vs placebo (dextrins)
 10g of Peptan / day ( 2 x 5g powder)
 12 weeks (October – January)

page 28
Increases skin hydration

The skin hydration level of 91%

Increases skin hydration by 28% of Collagen peptides group
after 8 weeks volunteers increased after 8
weeks Study YNTKK – 2008 - 4144
page 29
Prevents deep wrinkle formation

The number of deep wrinkles significantly increases with the placebo

between baseline and 12 weeks: +30%
Study 2008 – A00654 - 51

page 30
Clinical study- Cosderma, France, 2012

Effect of oral ingestion of fish collagen peptides versus placebo on skin

properties assessed in vivo by visual and laser scanning technology

Objectives
 Investigation of skins collagen structure using the latest advanced
technology incl. laser, – to demonstrate the underlying skin
improvements leading to visible anti-age effects

Study design
 106 volunteers , 40-65 years old women, Caucasian
 Double blind vs placebo, treatments given as powder drink
 Daily dosage of 10g in the morning
 Duration of 84 days.

Materials
Fish collagen peptides
Maltodextrins (placebo).

page 31
 Collagen fragmentation is a key indicator of skin aging !

Illustration of increased fragmentation of collagen with age

(source ORION CONCEPT, Tours, France)

25 years old 68 years old

The information in this presentation cannot be reproduced without the permission of Rousselot

page 32
 Improves skin structure,
- reversing the effect of aging!

Collagen fragmentation decreases significantly in the deep layers of the

skin with collagen peptides: - 31 % . Significant effect after just 1 month

* p < 0.05
** p < 0.001
Collagen
peptides
* improves skin
structure,
** by decreasing
collagen
fragmentation
(Vivascope® confocal
laser results)

Study Cosderma 2012, in press

page 33
Increases collagen density
- boosting skin from the inside

Collagen density was significantly increased after just 1 month

with Collagen peptides: + 9 %

** **
** p < 0.001
Collagen
peptides
increases
collagen density

(Dermcup® high
resolution
echogenicity)

Study Cosderma 2012, in press

page 34
Beauty from within

 Collagen peptides

 Nutricosmetic market and trends

 Beauty from within

 Skin aging and collagen

 Mechanism of action

 Clinical studies confirm

anti-aging effects

 Market products & LATAM

page 35
 Beauty Dietary supplements from the WW market

FRENCH SECRET
Beauty secret from within
US

What is interesting?
15 natural ingredients: Collagen, Vitamin C,
Alpha Lipoic acid, Fish oil fatty acids, ….
natural substances designed to support skin, hair and nail health
90 capsules - 3 capsules a day
Beauty

WRINKLE Remedy
Dietary Supplement
US

What is interesting?
Collagen, Vitamins A, C, E and Minerals
“For younger-looking skin”
60 Count

page 36
page 37
page 38
Recent market launches

Id 1275948 1276372 (source-www)

Compañía SAPANAN SINNIPPAI YAKUHIN SkinGain _Med-eq

País Tailandia Japón Noruega

Lanzamiento 07/2012 07/2012 2012

Marca St. Anna Collagen Drink Sinnippai Collagen Jelly Peach Aji: SkinGain
Stick Shaped Collagen Jelly with
Peach Flavor

Descripción del Bebida de colágeno, en botella de Siete sticks de gomitas de colágeno, Skingain es un suplemento en
producto plástico sabor durazno. Presentación pouch. polvo saborizado.

Claims Certificado halal. Colágeno Contiene15400mg de péptidos de Contraataca el proceso de

2,000mg. Suplemento dietario. colágeno de pescado, 105mg N- envejecimiento de la piel.
acetilglucosamina, 52.5mg Skingain contiene Peptan
condroitina, 10.5mg ácido combinado con otro colágeno de
hialurónico y 25.2mg royal jelly pescado.
extract. Cada sachet contiene 5000 mg de
péptidos de colágeno.

Detalles

Fuente: Innova
database 2012

page 39
Recent market launches

Id 1248419 1275566 1260075

Compañía KIM HENG ULTRA PRIMA ARTABOGA NATURES BOUNTY

País Tailandia Indonesia Brasil

Lanzamiento 05/2012 07/2012 06/2012

Marca Jelly Beautie Collagen Juice Drink OT Vitacharm Collagen Multi Natures Bounty Collagen Dietary
with Mixed Fruit Flavor Probiotic Drink Supplement 90 Tablets

Descripción del Jugo bebible con mix de sabores Cinco botellas individuales de bebida Colágeno hidrolizado con
producto frutales, en envase doy pouch. de colágeno y probióticos. Vitamina C. El colágeno es una
proteína importante para el
crecimiento, reparación y
mantenimiento de la piel, cabello,
uñas y huesos.

Claims Contiene 60 calorías. Con 700mg de Contiene 1,000mg de colágeno. La belleza comienza desde el
colágeno y plus de vitamina C. Multi-probióticos ABC. Sin azúcar. interior. No contiene colorantes,
Con Lactobacillus Acidophilus, saborizantes ni endulcorantes
Bifidobacterium, Lactobacillus Casei. artificiales. No contiene
Shot individual. Ready-to-drink. conservantes.

Detalles

page 40
Recent market launches

Id 1272791 1237998 1247709

Compañía PURITANS PRIDE MEIJI KANRO

País United States Thailand Japan

Lanzamiento 06/2012 05/2012 05/2012

Marca Puritans Pride Ultra Woman Meiji Yoghurt Beauti Brightt: Yogurt Kanro Pure Gummy Himitsu No Koi
Collagen Support with Hyaluronic with Crystal Collagen Beads Aji: Gummy
Acid and Resveratro: 90 Capsules

Descripción del Puritan's Pride presenta Ultra Woman Cuatro vasos de yogurt bajo en Gomitas con sabor oliva.
producto Collagen Support con ácido grasas con 0.8% perlas de cristales Presentación en envase plástico
hialurónico y Resveratrol. Productos de colágeno. con cierre.
de alta calidad y nutritivos a precios
accesibles.

Claims No contiene colorantes, saborizantes Bajo en grasas y azúcar. Alto Sabor secreto del amor. Contiene
ni edulcorantes artificiales. Sin azúcar contenido de calcio y fibras. extracto de amor. Edición limitada.
ni preservantes. No contiene almidón, Contiene Colágeno 1120mg. Contiene vitamina C y colágeno.
leche, lactosa, soja. No contiene trigo, Certificado halal y HACCP.
levaduras ni pescado. Libre de sodio.

Detalles

page 41
Recent market launches

Id 1184479 1249834 1158841

Compañía TC UNION GLOBAL TC UNION GLOBAL SAMYANG

País Tailandia Tailandia Korea del sur

Lanzamiento 02/2012 05/2012 12/2011

Marca Blink Collagen Drink Blink Collagen & Co Q10 Drink Samyang BDlab Beauty Aid Soft
Drink

Descripción del Seis botellas de bebida de colágeno, Seis botellas de colágeno con Bebida con ácido hialurónico y
producto en caja de cartón. colágeno y Co Q10, en cajas de colágeno, para tratamiento de
cartón. belleza.

Claims Colágeno 2,000mg. Sin azúcar Certificado halal. Sin azúcar Contiene ácido hialurónico y
agregada. Colágeno proveniente de agregada. Alto contenido de colágeno. Extracto de acerola
Francia. Certificado GMP y Halal. vitaminas C y E. adicionado.

Detalles

page 42
Recent market launches

Id 1297414 1323096 1321057

Compañía MEIJI TROPICAL OASIS DK HEALTH

País Japón Estados Unidos Tailandia

Lanzamiento Aug 2012 Oct 2012 Oct 2012

Marca Meiji Shokkans Gummi Gunittu Cola Tropical Oasis Sleep-A-Weigh Plus NatureGift Instant Coffee Powder
Aji: Hard Gummies with Cola Flavor Dietary Supplement with Collagen, Vitamin & Minerals

Descripción del Gomitas duras sabor cola, en envase Tropical Oasis Sleep-A-Weigh ayuda Cinco sachets de café instantáneo
producto plástico (pouch) con cierre. la reconstitución muscular, aumenta en polvo con colágeno, vitaminas
el metabolismo y combate el y minerales.
envejecimiento, todo esto mientras
duermes! El colágeno es una
proteína estructural que
constituye el tejido conectivo,
incluyendo tendones, ligamentos,
músculos y cartílagos, que el cuerpo
repara y reconstruye mientras
duermes. Además, se trata de un
nutriente que aporta fuerza y
engrosamiento de la piel, cabello y
uñas.

Claims Contiene 2800mg de colágeno. Con vitamina C, vitamina B12 y

colágeno. Certificado halal.

Detalles

page 43
LATAM
Q4 2014 to date
LATAM
Q4 2014 to date
LATAM
Q4 2014 to date
Peptan® Collagen Peptides

Rousselot® technology
based on a specific enzymatic hydrolysis process Peptan® is a bioactive ingredient
characterized by a unique amino
acid composition and high
bioavailability

Collagen type 1 peptides

high in the AA’s Glycine,
Hydroxyproline, Proline and
Glutamic acid

Excellent organoleptic profile

 Product consistency  2000 – 5000 Da
 Highly digestible
 Soluble in cold water

Peptan® collagen peptides page 47

Peptan® product range

 Broad range to meet all customer needs

 Peptan® is available in different standard grades,
raw material, molecular weight, and powder specifications

Peptan P is Porcine collagen peptides

Peptan B is Bovine collagen peptides
Peptan F is Fish collagen peptides

HD (High density): 0.4 - 0.55 g/cm3 - LD (Low density): 0.25 - 0.35 g/cm3 /EU Pharma grade Peptan® is also available.

Peptan® collagen peptides page 48

Peptan® – scientifically proven bioactive peptides

Building blocks for

innovative products

Beauty from
within

Healthy Aging
& Mobility

Sports/Fitness &
Senior Nutrition

Peptan® collagen peptides

www.peptan.com

Péptidos de
colágeno para
un estilo de vida
saludable

Peptan® Péptidos de colágeno 50