Arthrocentesis
Arthrocentesis
 Abstract
The temporomandibular joint forms one of the most fascinating and complex synovial joints in the body. Movements of the temporomandibular
joint are regulated by an intricate neurological controlling mechanism, which is essential for the system to function normally and efficiently.
Lack of such harmony may cause disruptive muscle behavior or structural damage to any of the components. The management of refractory
pain and dysfunctions in the temporomandibular joint poses challenge both to the oral physician and maxillofacial surgeon. Arthrocentesis
is a simple, minimally invasive technique that can be used instead of more invasive procedures in patients with pain that fails to respond to
conventional conservative measures. This review provides a full comprehensive overview of the literature about the various technical and
prognostic aspects in relation to arthrocentesis of the temporomandibular joint, and every clinician must take into account this consideration
when performing this procedure in treating patients with temporomandibular disorders.
other relevant journals were also used. The bibliographies were                the TMJ region is often associated with morbidity and fraught
also reviewed to identify additional relevant studies.                         with many risks, and more often, it does not produce expected
                                                                               results. Surgery is often considered as an option of last resort.
Arthrocentesis: An Emerging Alternative to                                     TMJ arthrocentesis procedure bridged the gap between surgical
                                                                               and nonsurgical treatment.[13] The aim of TMJ arthrocentesis is
Surgical Intervention                                                          to make an intolerable situation tolerable. It is often considered
Treatment strategies for TMDs are as diverse as the patients                   to be the highly effective method to restore normal maximal
that present with it. Although in managing the TMDs, one                       mouth opening and functioning.
should utilize first the conservative treatment; however, in
some circumstances, surgery is usually considered to be the                    Rationale of Arthrocentesis
definitive treatment modality and sometimes the only treatment
                                                                               TMDs, either inflammatory or noninflammatory, are
option.[10,11] The right combination of symptomatic history,                   typically associated with structural alterations in joint
clinical features, and radiological signs will readily reveal                  tissues, such as cartilage degradation and subchondral bone
whether the TMD patient is an appropriate candidate for                        alterations secondary to the change in the articular loading.
surgery.[10] There are various conditions where surgery plays                  In inflammatory TMDs, various mediators of inflammation,
a pivotal role such as:[11,12]                                                 particularly cytokines, may be responsible for enzymatic
a.	 In case to restore and repair the damaged tissue or to                     degradation of the matrix. Macromolecular degradation of the
     remove tissue that cannot be salvaged                                     matrix determines the physical and biological deterioration of
b.	 To promote healing of tissues by replacing missing                         the tissues and promotes the disease because the degradation
     tissues with grafts, for example, in case of chronically                  fragments, proteoglycans, and collagen released into the
     displaced disc or in case of collapsed articular cartilage                synovial fluid generate inflammatory pain.[14] There are
     and osteophytes that interfere with the smooth, pain‑free                 different types of inflammatory and anti‑inflammatory
     function of the joint, and                                                cytokines, the balance of which affects the development
c.	 When there is significant disease affecting the joint.                     of degenerative and inflammatory changes. Inflammatory
Dolwick and Dimitroulis[11] divided the indications for surgery                cytokines include interleukin‑1 (IL‑1), IL‑6, IL‑8, and tumor
into relative and absolute [Table 1]. From a clinical standpoint,              necrosis factor‑α while anti‑inflammatory cytokines include
the most common general indication for TMJ surgery is where                    IL‑4, tissue inhibitors of metalloproteinases (TIMP‑1),
                                                                               TIMP‑2, and tumor growth factor transforming growth
the joint disorder remains refractory, or not responding to
                                                                               factor‑β.[15] In the course of the inflammation, monocytes
nonsurgical therapies,[4] or where the source of the pain and
                                                                               and macrophages quickly release IL‑1 and IL‑6. Fibroblasts
dysfunction is well localized to the TMJ region. Therefore,
                                                                               and chondrocytes also have this ability, but at the same time,
specific indications for TMJ surgery include the following:[11]
                                                                               through the action of IL‑6, they release TIMP as well. Further,
•	 Chronic severe limited mouth opening and gross
                                                                               synovial cells and mononuclear cells infiltrating the edge of
     mechanical interferences such as painful clicking and
                                                                               the blood vessels also produce IL‑6 in both synovial tissue
     crepitus that fail to respond to TMJ arthrocentesis and
                                                                               and synovial fluid. High levels of IL‑6 in the synovial fluid of
     arthroscopy
                                                                               the TMJ are associated with extensive acute synovitis.[16] In
•	 Radiologically confirmed degenerative joint disease,                        addition to this, the current clinical evidence also suggested
     with clinical features of intolerable pain and joint                      that the TMJ pain or dysfunction may be attributed to
     dysfunction, is essentially the key criterion for TMJ                     alterations in joint pressure (negative intra‑articular pressure)
     surgical intervention.                                                    and biochemical constituents of the synovial fluid (failure of
Controversy still surrounds the role of surgery in the                         lubrication) which may lead to clicking and derangement of
management of pain and dysfunction of the TMJ. Surgery in                      the TMJ.[15,17,18]
                                                                               Arthrocentesis reduces the pain by allowing the elimination
Table 1: Indications for surgery by Dolwick and                                of inflammatory cells from the joint space and increases the
Dimitroulis                                                                    mandibular mobility by removing intra‑articular adhesions,
Absolute indication
                                                                               eliminating the negative pressure within the joint, thus
 Ankylosis of TMJ (e.g., fibrous or osseous joint fusion)
                                                                               recovering disc and fossa space which reduces the mechanical
 Neoplasia (e.g., osteochondroma of the condyle)                               obstruction caused by anterior disc displacement.[15,19‑23]
 Dislocation of TMJ either recurrent or chronic
 Developmental disorders affecting the TMJ                                     Procedure of Temporomandibular Joint
Relative indication
 Internal derangement of TMJ
                                                                               Arthrocentesis – Technical Considerations
 Osteoarthrosis                                                                Various techniques for arthrocentesis have been mentioned
 Trauma to the TMJ                                                             in the literature which itself varies considerably over the
TMJ=Temporomandibular joints                                                   period of time. Murakami et al.[24] first described a technique
of TMJ arthrocentesis with pumping irrigation and hydraulic               •	    With the patient’s mouth open, the first needle is inserted
pressure to the upper joint cavity followed by manipulation                     into the superior joint space in the most posterior point
of the jaw. After that, Nitzan et al.[19] described a technique                 directing upward, forward, and inward to a depth of
utilizing the insertion of two needles into the upper joint                     about 20–25 mm, after the tip of the needle has come
compartment, permitting more effective lavage of the joint.                     into contact with the posterior wall of the articular
In this technique, the landmarks for the insertion of needles                   eminence[37]
are marked on the skin according to the method suggested by               •	    This is followed by administration of irrigating
McCain et al.[25,26] for arthroscopy (posterolateral approach to                solution (Hartmann solution [also known as Ringer’s
the upper joint space).                                                         lactate solution] or physiological saline) through the
                                                                                first needle with the aim of distending the superior joint
Preprocedural considerations
                                                                                space.[29] This compartment will take up to 5 mL of
TMJ arthrocentesis is a minimally invasive procedure[27,28]
                                                                                fluid[31]
and can be comfortably performed under local anesthesia
or intravenous conscious sedation or general anesthesia,                  •	    Now, the second needle is introduced in the distended
depending on patient comfort and surgeon preference. Before                     compartment, in front of the first needle at the marked
performing the procedure, the following points should be kept                   point, allowing the visualization of the solution and
in mind:[29]                                                                    orienting the flow of the joint lavage solution,[29] as shown
•	 The surgical field is properly draped and cleaned with                       in Figure 2.
    povidone iodine or similar substance, particularly in                 Laskin[38] mentioned that it is usually difficult to insert the
    preauricular region and ear                                           second needle anterior to the first one, and therefore, he had
•	 External auditory canal is protected from accumulation                 inserted the anterior needle in the posterior recess of the upper
    of blood and fluid using a cotton pledget                             joint compartment by placing it 3–4 mm anterior to the first
•	 The auriculotemporal nerve block is given, and the areas               one and suggested this technique to be much easier than the
    of joint penetration should be infiltrated.                           previous method. However, if the second needle is entered
The two‑needle technique                                                  anterior to the first one, it is inserted into a narrower region of
The classical technique to perform TMJ arthrocentesis utilizes            the upper joint compartment, and this may cause damage to
double access to the joint cavity. This technique uses two needles,       the articular disc leading to failure of the outflow of irrigating
one for injecting and the other for aspirating the solution.[30]          solution. Alkan and Etöz[39] proposed a new technique, in which
•	 For two‑needle technique, access is performed by taking                the posterior point of entry for the first needle was the same
    as indicator the Holmlund–Hellsing line (canthotragal                 while the second needle is inserted 7 mm anterior from the
    line),[31] as depicted in Figure 1. A straight line is drawn          middle of the tragus and 2 mm inferior along the canthotragal
    on the skin joining the medial portion of the tragus of the           line. This second needle was adjusted parallel and almost
    ear to the outer canthus of the ipsilateral eye                       3 mm posterior to the first until bony contact was made. It was
•	 Two points are marked on this line for needle insertion.               assumed that when the second needle is inserted posterior to
    The first, more posterior point will be marked at a                   the first one in the wider part of the upper joint compartment,
    distance of 10 mm from the tragus and 2 mm inferior to                the outflow of the solution from the joint cavity is easier to
    canthotragal line. This point corresponds to the posterior            achieve. They thoroughly irrigated numerous joints with
    extent of the glenoid fossa. The second point will be                 complete success by this technique and suggested that the use
    marked at 20 mm anterior to tragus and 10 mm inferior                 of this landmark as the default technique may be reasonable,
    to canthotragal line, which corresponds to the height of              as repeated insertions of a needle are uncomfortable both for
    articular eminence[19,32‑34]                                          physicians and patients and adversely affect the success of
•	 The glenoid fossa is thin, with a range of 0.5–1.5 mm.[25,35]          the treatment.
    The dura and temporal lobe are located beneath the glenoid            The positioning of two needles within the joint cavity may cause
    fossa. Joints may also be eroded by degenerative arthritis            some discomfort to patients, particularly at the time of the first
    or previous infections. Hence, it is possible that during the         lavage. A study evaluating the efficacy and tolerability of a cycle
    procedure, this structure may get perforated. Therefore,              of 5 weekly hyaluronic acid injections performed after a classical
    the surgeon must be cautious not to insert the needle much
                                                                          two‑needle arthrocentesis showed that the patient’s perception
    into the joint space. About 25 mm depth is enough to reach
                                                                          of tolerability increased with time. Possible explanation for
    to upper joint space[27]
                                                                          this is that with the sequential arthrocentesis interventions, the
•	 To increase the joint space during arthrocentesis, the
                                                                          catabolytes are removed and adhesions are broken down, which
    patient is usually asked to open the mouth and deviate
                                                                          made the insertion of the needles easier and consequently, the
    it to the opposite side so as to distract the condyle from
                                                                          quality of the posttreatment course was improved.[40]
    the glenoid fossa thereby increasing joint space. Nagori
    et  al.[36] suggested that custom‑made mouth prop is an               Recently, a technique using a single needle for both injection
    effective tool to hold the mandible in eccentric position             and ejection of irrigating solution has been described[31] and
    during arthrocentesis                                                 gave interesting results over a short period.[41]
clinical study on 30 consecutive patients with TMJ disorders                       either next to the fossa and/or the upper aspect of the
found a significant reduction in pain in all the patients after                    articular tubercle, with mouth opening restrictions[29]
arthrocentesis using saline and sodium hyaluronate injections.                     •	 In case of closed lock, the central portion of healthy disc
This pain reduction is attributed to high‑pressure irrigation,                           indeed separates from the fossa, leaving rims fastened to
which washes away inflammatory mediators, providing                                      surface of eminence causing increased negative pressure
immediate pain relief.                                                                   in closed space between fossa and disc. This pressure
However, it should be kept in mind that the pressure applied                             difference constitutes a force sufficient to keep the disc
on the syringe during the procedure should be under control                              compressed against the fossa (suction cup effect).[27,72]
to avoid any complication.                                                               Arthrocentesis abolishes this negative pressure, loosens
                                                                                         the adhered disc, and reinstitutes its free sliding
Postarthrocentesis Considerations                                                        movement. It also helps the joint to reassume its normal
                                                                                         movement bringing about recovery of intra‑articular
At the end of lavage, it was proposed that steroids or sodium
                                                                                         pressure fluctuations, which in turn allows perfusion of
hyaluronate injection should be administered into the
joint space to alleviate intracapsular inflammation.[60] The                             nutrients and medications. Thus, in patients with disc
anti‑inflammatory effects of intra‑articular corticosteroids                             adhesions, there was marked improvement in mouth
are useful for alleviating pain, swelling, and dysfunction                               opening and decreased deviation.[73]
in patients with inflammatory and noninflammatory joint                      •	    It can be used in cases of synovitis/capsulitis not
diseases.[61,62] There are many glucocorticoid preparations,                       responding to nonsurgical treatment[29]
but methylprednisolone and triamcinolone (40 mg/1 ml)                              •	 Substantial concentrations of inflammatory mediators
preparations are long acting and may be preferable.[61]                                  of pain have been found in synovial fluid in patients
                                                                                         with painful dysfunctional TMJs. Lavage of the upper
Postarthrocentesis, the patient should be kept on soft diet
                                                                                         joint space reduces pain by removing inflammation
for a few days. Exercises of range of movement are started
                                                                                         mediators from the joint.[37]
immediately and continued for several days. Analgesics should
                                                                             •	    Arthrocentesis procedure can be implemented as palliation
be prescribed as necessary for pain.[25,27,58]
                                                                                   treatment for degenerative osteoarthritis[29,73,74]
Brennan and Ilankovan[63] suggested intra‑articular injection of                   •	 Patients of TMJ osteoarthritis complain of early
morphine (10 mg in 1 ml) as a long‑acting analgesic in patients                          morning stiffness in TMJ, severe joint pain, and
with continuing pain in the TMJ. In a study by Kunjur et al.,[64]                        limitation in mouth opening and function along with
they performed 405 arthrocentesis (with 50 ml of 0.9% normal                             swelling in the respective area.[27] These symptoms
saline solution followed by morphine 10 mg [in 1 ml] infusion)                           arise due to joint overloading and increased
over a 10‑year period for 298 patients and found significant                             intra‑articular pressure, which leads to sclerosis of
reduction in pain score after arthrocentesis (P < 0.001) and                             subchondral bone,[18] compromised blood supply
269 patients (90%) found the procedure beneficial. In another
                                                                                         which is due to pain, and absence of elimination of
study, Furst et  al.[65] reported that bupivacaine alone was a
                                                                                         inflammatory substrates which are removed during
better analgesic than morphine alone or the combination of
                                                                                         normal joint mobilization.[27] Arthrocentesis forces
morphine and bupivacaine.
                                                                                         apart the joint constituents and washes away inflamed
                                                                                         synovial fluid, thereby reducing pain and loading
Indications                                                                              effect thus in turn increasing mouth opening.[75,76]
•	   Arthrocentesis is used in patients with internal TMDs not               •	    It can be used in patients with painful joint noises occurring
     responding to conservative clinical treatment                                 during mouth opening and/or closing.[29] Joint sounds such as
•	   It is indicated in patients with anterior disc displacement                   clicking could be intermittent or constant which is caused by
     with or without reduction.[29] Arthrocentesis has been                        displacement of the disc. Arthrocentesis distends the upper
     reported to be up to 91% effective in treating patients with                  joint compartment thereby relieving the lag, and disc‑condyle
     anterior disc displacement without reduction[21,66,67]                        complex moves synchronously reducing the clicking.[75]
     •	 Studies have shown that arthrocentesis can produce
           long‑term relief of pain and dysfunction in patients
                                                                             Contraindications
           with internal derangements of the TMJ.[68,69] Frost
           et al.[70] reported that arthrocentesis is the first line         There are certain conditions where arthrocentesis procedure
                                                                             are strictly contraindicated. Contraindication for the procedure
           procedure for the treatment of acute and chronic
                                                                             can be either absolute or relative.[37]
           closed lock of the TMJ in internal derangement.
           Similarly, Thomas et  al.[71] also suggested in their             Absolute contraindication
           study that arthrocentesis is a very useful technique              An inflammatory focus (abscess or cellulitis) at the site of the
           for treatment of acute closed lock of TMJ.                        needle insertion during arthrocentesis is generally considered
•	   Arthrocentesis can be used in cases of disc adhesions,                  an absolute contraindication for this procedure.
make arthrocentesis a valid treatment option for patients with                          factor‑alpha: Implications for treatment outcome. Int J Oral Maxillofac
TMJ disorders not responding to nonsurgical therapies.                                  Surg 2000;29:176‑82.
                                                                                   17.	 Dolwick MF. Intra‑articular disc displacement. Part I: Its questionable
Declaration of patient consent                                                          role in temporomandibular joint pathology. J Oral Maxillofac Surg
                                                                                        1995;53:1069‑72.
The authors certify that they have obtained all appropriate                        18.	Alpaslan C, Bilgihan A, Alpaslan GH, Güner B, Ozgür Yis M,
patient consent forms. In the form the patient(s) has/have                              Erbaş D, et al. Effect of arthrocentesis and sodium hyaluronate injection
given his/her/their consent for his/her/their images and other                          on nitrite, nitrate, and thiobarbituric acid‑reactive substance levels in
clinical information to be reported in the journal. The patients                        the synovial fluid. Oral Surg Oral Med Oral Pathol Oral Radiol Endod
                                                                                        2000;89:686‑90.
understand that their names and initials will not be published                     19.	Nitzan DW, Dolwick MF, Martinez GA. Temporomandibular joint
and due efforts will be made to conceal their identity, but                             arthrocentesis: A simplified treatment for severe, limited mouth opening.
anonymity cannot be guaranteed.                                                         J Oral Maxillofac Surg 1991;49:1163‑7.
                                                                                   20.	Dimitroulis G, Dolwick MF, Martinez A. Temporomandibular joint
Financial support and sponsorship                                                       arthrocentesis and lavage for the treatment of closed lock: A follow‑up
Nil.                                                                                    study. Br J Oral Maxillofac Surg 1995;33:23‑6.
                                                                                   21.	 Kaneyama K, Segami N, Nishimura M, Sato J, Fujimura K, Yoshimura H,
Conflicts of interest                                                                   et al. The ideal lavage volume for removing bradykinin, interleukin‑6,
                                                                                        and protein from the temporomandibular joint by arthrocentesis. J Oral
There are no conflicts of interest.                                                     Maxillofac Surg 2004;62:657‑61.
                                                                                   22.	Moses JJ, Sartoris D, Glass R, Tanaka T, Poker I. The effect of
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