PRODUCT SPECIFICATIONS

Thermo Scientific Nicolet iS20 FTIR Spectrometer

Advanced FTIR spectroscopy for busy analytical labs
Designed for laboratories with analytical services, quality
control, or forensic applications, the Thermo Scientific™
Nicolet™ iS20 FTIR Spectrometer delivers the highest
confidence in material verification and identification. With its
redesigned Thermo Scientific™ LightDrive™ Optical Engine
and integrated touch panel, the Nicolet iS20 spectrometer
provides next generation performance with a standard
10-year warranty on all critical optical components.

The Nicolet iS20 FTIR spectrometer includes features that

allow the user to validate the instrument performance,
quickly verify the quality of materials, create and run
workflows, identify unknowns or mixtures, and quantify Designed for maximum productivity
mixture ingredients. Users of any skill level can operate The Nicolet iS20 FTIR spectrometer delivers maximum
the system with many tasks completed in one step. ease of use and reliability.

• A 10-year warranty on the interferometer, laser, and IR

Specifications you can trust
source ensures peace of mind – for a decade to come.
The Nicolet iS20 FTIR spectrometer is built to inspire a high
level of customer confidence. Instrument specifications • Integrated touch panel, workflow software, and
are factory verified to ensure each unit meets our rigorous multi-colored LED scan bar provide consistency
quality standards. Our specifications are: and productivity

• Certified on each instrument before leaving the • Multi-component analysis software identifies principal
manufacturing floor ingredients in mixtures, allowing laboratories to
troubleshoot contamination problems or conduct
• Representative of actual instrument performance, not
failure analysis
typical or achievable results
• Simplified validation software equips users with an
Audit Manager and streamlined pharmacopeia compliant
methods (Ph. Eur., USP, JP, and CP)

• Cloud-based Thermo Scientific™ OMNIC™ Anywhere

Software gives students and scientists the ability to
analyze their data anywhere, anytime, on any device

• Thermo Scientific™ Nicolet™ Smart™ Accessory

technology provides simple accessory exchange,
automatic experimental conditions setup, and convenient
accessory purge
 Beamsplitter
• Standard – KBr/Ge mid-infrared beamsplitter optimized
for the highest spectral throughput

• Optional – XT-KBr/Ge beamsplitter with an extended

range for mid- to near-infrared measurements

Laser
• Solid-state, temperature-controlled diode laser with
long lifetime

• 10-year warranty included

Humidity and vapor protection

• Sealed and desiccated optical bench with protective
Optical system coating on KBr windows
The sealed and desiccated optical unit protects the
• Rechargeable desiccant cartridges and integrated
instrument from humidity and solvent vapors. A self-
humidity indicator
compensating, dynamically aligned interferometer
automatically tunes the instrument for best throughput • Multi-zone pressure system with optional
while providing fast analytical speed for real-time purge; Smart accessories purge around sample
screening. Diamond turned, alignment-free optics compartment windows
guarantee long-life performance with minimal maintenance.
Spectrometer self-performance verification
Detectors • Integrated validation wheel with NG-11 and NIST
• Standard – Thermoelectrically cooled (TEC) traceable, serialized polystyrene film standards
fast-recovery deuterated triglycine sulfate (DTGS)
• System Performance Verification (SPV) software with
detector provides response linearity and maximum
programmable interface
data reproducibility
External beam port – optional
• Optional – High-speed and ultra-sensitive mercury
• External beam for infrared microscopes or Nicolet iZ10
cadmium telluride (MCT) detector; includes fast scan
FTIR module
capabilities for kinetics studies
• Nicolet iZ10 module can be used with the Smart NIR
Source
integrating sphere (integrated InGaAs detector), TGA
• Standard – Non-migrating hotspot, single-point source
interface, or other third party accessories, and can be
with a 10-year warranty provides unmatched lifetime
equipped with a DTGS or MCT detector
and data reproducibility

• Optional – Tungsten/halogen near-infrared source easily Quality and low-cost of

replaceable by the user from the sample compartment ownership – guaranteed
• 10-year warranty on the interferometer, laser,
and IR source

• 5-year warranty on diamond crystal of the

Smart iTX ATR accessory

Electronics
• Integrated touch panel includes multi-colored LED
indicator lighting and capacitive touch technology

• USB 2.0 high-speed bidirectional communication;

compatible with USB 3.0
Optional tungsten halogen
source and desiccant The Nicolet iS20 source • Smart accessory automatic recognition, parameter
compartment are easily is mounted in the sample
setting, and spectral quality monitoring
accessible compartment, allowing quick
and easy optimization of
• Synchronization protocol continuously monitors power
data collection
supply, laser, source, and detector
Enhanced analytical power Nicolet iS20 FTIR spectrometer equipped
with the Nicolet iN5 FTIR microscope
• Capture the smallest details by integrating
the Nicolet iS20 FTIR spectrometer with the
Thermo Scientific™ Nicolet™ iN5 FTIR Microscope or
the Thermo Scientific™ Nicolet™ Continuμm™ FTIR
Microscope; easily measure small particles and defects
down to 10 microns

• Characterize materials quickly and easily by switching

to the TGA/IR interface installed in the Nicolet iZ10
spectrometer module
The Nicolet iS20 provides
• Identify unknowns with the power of Thermo Scientific™ efficient tools to identify
OMNIC™ Specta™ Analysis Software and compare your pure compounds and
mixtures. The OMNIC
spectrum in minutes to a database of over 9,000 chemical Specta software includes
spectra using innovative multi-component search routines innovative ways to
manage your results and
provide answers with the
Designed for instrument qualification confidence you need.
System Performance Verification (SPV) is a powerful tool
to ensure the spectrometer is performing as expected,
day after day. SPV includes hardware and software to
test the instrument against the ASTM E1421 method
using Schott NG-11 and NIST traceable standards, all
contained in a built-in motorized wheel. The Nicolet iS20
SPV is user programmable and can be used for:

• Daily performance verification

• Assessing system suitability for specific

customer applications

• Monitoring validation standards’ expiration dates

• Scheduling preventative maintenance visits

Nicolet iS20 FTIR spectrometer

OMNIC software suite
• System status and diagnostic information displayed on multi- • Automatic atmospheric suppression (no standards needed) to
colored LED touch panel remove H2O and CO2 interferences
• OMNIC Anywhere cloud-based spectroscopy software allows users • Customized workflows can be executed through integrated
to upload, share, and analyze their data anytime, anywhere, on touch panel
any device
• Thermo Scientific™ QCheck™ Algorithm performs spectrum-
• OMNIC Specta software includes multi-component search to-spectrum or spectrum-to-multiple spectra QC/QA verification;
capabilities and 9,000 library spectra includes correlation, high-sensitivity compare, and customizable
pass/fail threshold
• New Thermo Scientific™ ValPro™ System Qualification methods
updated with the latest pharmacopeia methodology, including • Quantitative and discriminant analysis package includes:
European Pharmacopeia (Ph. Eur.), United States Pharmacopeia
(USP), Japanese Pharmacopeia (JP), and China Pharmacopeia (CP) –– Beer-Lambert calibration and prediction (peak height or area
integration)
• New Audit Manager software includes easy QA audit trail review
and displays file change logging, even when OMNIC software is –– Classical Least Squares calibration and prediction
not running –– Discriminant analysis, Partial Least Squares (PLS) and Principal
• Data conversion and corrections: Kubelka Munk, Kramers Kronig, Component Analysis (PCR) prediction
Photoacoustic, ATR correction including settings for crystal
material, reflections, angle, and sample refractive index
Performance specifications
Factory verified – These specifications are certified on each instrument before it leaves the manufacturing facility.
Specifications represent actual performance data, not typical or achievable results.

Signal-to-noise 50,000:1 (peak to peak, 1 minute measurement)

Spectral resolution Better than 0.25 cm-1
Wavenumber precision 0.0008 cm-1 at 2000 cm-1
Wavenumber accuracy 0.02 cm-1 at 2000 cm-1

Validation options for FDA, Ph. Eur., JP, Other specifications

CP, or USP regulated industries • Spectral range: 7,800-350 cm-1 optimized,
• Includes test routines for IQ/OQ (installation and mid-infrared KBr beamsplitter; 11,000-375 cm-1 XT-KBr
operational qualification) extended mid-infrared optics

• Fully automated test routines for European • Collection speed: Selectable from 0.16 cm/sec to
Pharmacopeia (Ph. Eur.), United States Pharmacopeia 3.1 cm/sec; suitable to slow responsivity (PAS) and
(USP), Japanese Pharmacopeia (JP), and China high-sensitivity (MCT) detectors
Pharmacopeia (CP)
• Maximum speed: 40 spectra per second at 16 cm-1
• Digital and electronic signature 21 CFR Part 11 resolution, individually collected and stored
compliance package
• Dimensions (W x D x H): 550 x 570 x 250 mm;
21.6 x 22.4 x 9.8 inches

• Weight: 32 Kg (70 lbs)

• Regulatory Approvals: CE, ETL, ISO/IEC

• Warranty:
––1 year on complete system
––10 years on interferometer
––10 years on laser
––10 years on IR source
––5 years on Smart iTX diamond ATR

Learn more at thermofisher.com/iS20

For Research Use Only. Not for use in diagnostic procedures. ©2018 Thermo Fisher Scientific Inc.
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