DRUG STUDY
Name: Juan dela Cruz Ward/Bed Number: 101 Attending Physician: Dr. Santos
Age: 75 Impression/Diagnosis: Acute Respiratory Failure Type II Secondary to Aspiration Pneumonia
Dosage,
Mechanism of Adverse Nursing
Name of Drug Route Freq., Indication Special Precautions
Action Reactions Responsibilities
Timing
Generic: Dosage: Decreases This drug is given for CV: Bradycardia, - Use propofol - Resuscitative
Propofol Anesthesia cerebral blood induction/maintenance hypotension cautiously in equipment, suction,
ADULTS, flow, cerebral of anesthesia. hemodynamically and O2 must be
Brand: ELDERLY: metabolic Also, continuous RESP: Apnea unstable patients, available. Obtain
Diprivan Induction, oxygen sedation in intubated hypovolemia, vital signs before
2–2.5 mg/kg. consumption, and respiratory Other: severe administration.
Maintenance: and controlled adult pts in Anaphylaxis, cardiac/respiratory
Initially, 100– intracranial ICU. propofol infusion disease, elevated ICP, - Ensure that IV
200 mcg/kg/ pressure and syndrome impaired cerebral administration of
min or 6–12 increases circulation, propofol is not too
mg/kg/hr for cerebrovascular preexisting rapid as it may
Classification 10–15 min. resistance, which Contraindications Side Effects pancreatitis, produce marked
Usual may play a hyperlipidemia, severe hypotension,
Functional: maintenance role in propofol’s Hypersensitivity to GI: Nausea, history of epilepsy, respiratory
Sedative- infusion: 50– hypnotic effects. propofol or its vomiting seizure disorder, depression, and
hypnotic 100 components, to eggs elderly patients, irregular muscle
mcg/kg/min Causes CNS or egg products, or to MS: Involuntary debilitated patients, movements.
or 3–6 depression soybeans or soy muscle patients allergic to
Chemical: mg/kg/hr. through agonist products movement peanuts. - Observe the patient
Rapid-acting CHILDREN action of GABA (transient) for signs of
general 3–16 YRS: receptors. Pregnancy/Lactation: wakefulness and
anesthetic. Induction, Therapeutic Other: Injection- Unknown agitation.
2.5–3.5 Effect: Produces site burning, pain, if drug crosses
mg/kg over hypnosis rapidly. or stinging placenta. Distributed - Monitor RR, BP,
20–30 sec, in breast milk. Not heart rate, O2
then infusion recommended for Saturation, ABGs.
of 125–300 obstetrics,
mcg/kg/min breastfeeding - Monitor the patency
or 7.5–18 mothers. of ETT, suction as
mg/kg/hr. needed.
Sedation in Children: Safety and
ICU: efficacy not - Ensure that
ADULTS, established. propofol is
ELDERLY: FDA-approved for use administered slowly,
Initially, 5 in pts 2 mos and older. fast administration
mcg/kg/min; may cause seizure to
increase by - Elderly: No age- the patient
increments of related
5–10 precautions noted; -Taper drug dosage
mcg/kg/min lower dosages of propofol before
q5–10 min recommended. stopping therapy.
until desired Abrupt stop can
sedation - Dosage must be cause rapid
level tapered before awakening, anxiety,
achieved. stopping therapy. agitation and
Usual Stopping abruptly will resistance to
maintenance: cause rapid mechanical
5–50 awakening, ventilation
mcg/kg/min anxiety, agitation and
resistance to - Monitor patient for
Route: IV mechanical ventilation. propofol infusion
syndrome. It may
cause severe
Frequency: metabolic acidosis,
hyperkalemia,
Timing: lipemia,
rhabdomyolysis,
hepatomegaly and
cardiac and
renal failure. Alert
prescriber at once
and be prepared to
provide emergency
supportive care as
ordered.
- Inform patient and
family that caution is
required when
performing activities
requiring mental
alertness, such as
driving, because
mental alertness
may be impaired for
some time after
general
anesthesia or
sedation such as
propofol has been
given
Student’s Name: _______________________________________________________________________________________________________
References:___________________________________________________________________________________________________________
Clinical Instructor: ______________________________________________________________________________________________________
