According to the Punjab University College of Pharmacy (PUCP) Past papers (2015-2021)

PHARMACOLOGY AND THERAPEUTICS-I

(THEORY)
PAST PAPER QUESTIONS

UNIT:1 GENERAL PHARMACOLOGY

1. Define the following terms: (05 each) (A/2015)
a. Pharmacokinetics and pharmacodynamics.
b. Agonist , Antagonist, and partial antagonist
c. Volume of distribution and clearance of drug.
d. Drug receptor and mechanism of action of drug

(c) PHARMACOKINETICS
1. What is biotransformation? Discuss phase I and phase II metabolic reactions.
(20) (A/2015,16,17,19,21) (2nd A/2016,18)
2. What is bioavailability? What factors can modify the bioavailability of the
drugs. (20) (A/2016)
3. What is drug absorption? Discuss different ways by which drug can be
transported across the membranes. (20) (2nd A/2017)
4. Define pharmacokinetics. Describe the absorption of drugs. State the factors
which can affect the absorption of drugs. (20) (2nd A/2018)

(d) PHARMACODYNAMICS
1. What are the different classes of receptors. Discuss G-protein coupled
receptors GPCRS in detail. (20) (A/2016)
2. Describe main classes of receptor and discuss ligand-gated ion channels
thoroughly. (20) (2nd A/2016, A/2018 )
3. Classify receptors. Give detailed account of ligand gated ion channels. (20)
(A/2017)

Prepared by: Ahmad Raza (ASCP-02)

Mubeen Bilal (ASCP-47)

 According to the Punjab University College of Pharmacy (PUCP) Past papers (2015-2021)

4. Write down the pharmacology of proton pump inhibitors. (10) (A/2017, 2 nd

A/2018)
5. Discuss G-protein coupled receptors in details. (20) (2nd A/2017)
6. What are the different classes of receptors. Discuss G protein coupled
receptors. (20) (A/2018)
7. Discuss the structure and signaling of kinase linked receptors. Give
examples. (20) (2nd A/2018)
8. Classify receptors. Give a comprehensive account of inotropic receptors.
(10) (A/2019)
9. Discuss Briefly: (05+05+05+05+05) (A/2021)
a. Cholinergic receptors with their distribution.
b. Ligand-gated ion channels
c. Treatment of organophosphorus poisoning.
d. Therapeutic uses of atropine

UNIT:2 DRUGS ACTING ON AUTONOMIC NERVOUS

SYSTEM (ANS)
1. Classify Anti-muscarinic drugs. Discuss ATROPINE with respects to its
mechanism of action effect and different organic systems and toxicity. (20)
(A/2015)
2. Classify Beta Adrenergic Blockers therapeutic uses side effect and contra
indications of PROPONALOL. (20) (A/2015)
3. Classify Anti-muscarinic drugs. Discuss mechanism of action,
pharmacological properties, toxicity and therapeutic uses of ATROPINE.
(20) (A/2016)
4. Classify direct acting sympathomimetics. Discuss EPINEPHRINE with
respect to its mechanism of action, effects of different organ/systems toxicity
and contraindication. (20) (A/2016)
5. Classify β-adrenergic blockers discuss mechanism of action, therapeutic uses
side effect and contraindication of Propranolol. (20) (2nd A/2016)
6. Classify muscarinic receptors agonists. Describe mechanism of action
therapeutic uses and adverse effect of these agents. (20) (2nd A/2016)
7. Write short notes on: (10+10) (2nd A/2016)
a) Prazosin
b) Digoxin

Prepared by: Ahmad Raza (ASCP-02)

Mubeen Bilal (ASCP-47)

 According to the Punjab University College of Pharmacy (PUCP) Past papers (2015-2021)

8. Classify Para sympathomimetic. Give mechanism of action therapeutic uses

and toxicity of Physostigmine. (20) (A/2017)
9. Classify sympathomimetic. Give the pharmacology of Epinephrine. (20)
(A/2017)
10. Discuss the pharmacology of Captopril. (10) (A/2017)
11. Classify Anti-muscarinic drugs. Give mechanism of action, therapeutic uses
and toxicity of Atropine. (20) (2nd A/2017)
12. Classify sympatholytic drugs. Discuss propranolol in details. (20) (2nd
A/2017)
13. Give the mechanism of action therapeutic uses and adverse effects of the
following: (5+5+5+5) (A/2018)
a) Prazosine
b) Dobutamine
c) Succinylcholine
d) Ephedrine
14. Give the mechanism of action therapeutic uses and adverse effects of the
following (5+5+5+5) (2nd A/2018)
a) Physostigmine
b) Phenoxybenzamine
c) Pilocarpine
d) Reserpine
15. Give the therapeutic uses of drugs affecting parasympathetic nervous
nd
system. (10) (2 A/2018)
16. Discuss the pharmacological action therapeutic uses and toxicity of
Atropine. (10) (2nd A/2018)
17. Describe types of cholinergic receptors. Their distribution on signal
transduction pathways. Classify Anti-muscarinic drug and explain their
therapeutic uses and adverse effects. (20) (A/2019)
18. Classify Adrenergic Receptors steps of their signals transduction pathways.
Distribution of adrenergic receptors in body and therapeutic uses of
adrenergic agonists and antagonists. (10) (A/2019)
19. Illustrate and explain mechanism of control of pupil diameter.
Accommodation and intraocular pressure. Also describe ocular
pharmacology of cholinergic and adrenergic drugs. (10) (A/2019)
20. Describe synthesis, storage and release of nor-Adrenaline from adrenergic
neurons and various drugs affecting the pathways. (10) (A/2021)

Prepared by: Ahmad Raza (ASCP-02)

Mubeen Bilal (ASCP-47)

 According to the Punjab University College of Pharmacy (PUCP) Past papers (2015-2021)

21. Classify different types of adrenergic receptors. Explain their signal

transduction pathways. Describe MOA, pharmacokinetics, adverse effects,
contraindications and therapeutic uses of Epinephrine. (10) (A/2021)
22. Classify Anti-cholinergic drugs. Describe MOA, pharmacological
properties, therapeutics uses, adverse effects, drug interactions of atropine.
(20) (A/2021)
23. Discuss Briefly: (05+05+05+05+05) (A/2021)
a. Cholinergic receptors with their distribution.
b. Ligand-gated ion channels
c. Treatment of organophosphorus poisoning.
d. Therapeutic uses of atropine

UNIT:3 DRUGS ACTING ON GASTROINTESTINAL TRACT

(GIT)
1. Classify Anti-ulcer drugs. Discuss the mechanism of action, therapeutic uses
side effect of PROTO PUMP INHIBITIONS. (20) (A/2015)
2. Write notes on: (10+10) (A/2016)
a. Nitroglycerine
b. Irritant laxatives
3. Classify Anti-ulcer drugs and enumerate detailed pharmacology of these
drugs. (20) (2nd A/2016)
4. Define Emesis give the mechanism of action and therapeutic uses of Anti-
emetic drugs. (10) (A/2017)
5. Give the pharmacology of Anti-diarrheal drugs. (10) (2nd A/2017)
6. Classify the drugs used in constipation and discuss prokinetics agents in
detail. (10) (2nd A/2018)
7. Define Emesis? Discuss the pharmacology of 5HT3 receptors antagonists.
(10) (2nd A/2018)

UNIT:4 AUTOCOIDS AND THEIR ANATAGONISTS

1. Write Short note on: (07, 07, 06) (A/2015)
a. Digoxin
b. Prostaglandians
c. Irritant purgatives
Prepared by: Ahmad Raza (ASCP-02)

Mubeen Bilal (ASCP-47)

 According to the Punjab University College of Pharmacy (PUCP) Past papers (2015-2021)

2. Define Autacoids? Give in detail the effects of histamine and Anti-histamine

on different organs. (20) (2nd A/2016)
3. Discuss H2 receptors antagonists. (10) (2nd A/2017)
4. Classify Anti-histamines and discuss their pharmacology. (10) (2 nd A/2018)

UNIT:5 DRUGS ACTING ON RESPIRATORY SYSTEM

1. What is Asthma? Classify Anti-asthma drugs and discuss pharmacology of
leukotriene antagonist lgE anti bodies in details. (20) (A/2016)
2. Classify Anti-asthmatic drugs. Give the pharmacology of leukotriene
receptors antagonistic. (20) (A/2017)
3. Write note on the following. (20) (2nd A/2017)
a. Potassium sparing diuretics
b. Salbutamol
4. Classify Bronchodilators? Discuss in detail pharmacology of beta 2 agonists
and Methylxanthines. (20) (A/2018)
5. Classify Anti-asthma drug write in detail pharmacology of Theophylline.
(20) (A/2019)
6. Classify the drugs used in treatment of bronchial asthma. Explain
mechanism of action adverse effect contraindications and therapeutic uses of
BETA-2 Adrenergic agonists. (20) (A/2021)

UNIT:6 DRUGS ACTING ON CARDIO-VASCULAR SYSTEM

(CVS)
1. Classify Anti-hyperlipidemic drugs. Discuss the pharmacology of
SIMVASTATIN. (20) (A/2015)
2. Classify Diuretics. Describe mechanism of action, effects on renal
hemodynamics adverse effects and therapeutic uses of Spironolactone.
(20) (A/2016)
3. Describe the mechanism of action and therapeutic uses of Amiodarone. (10)
(A/2017) HINT: Amiodarone is an anti-arrhythmic drug.
4. What is congestive heart failure, give the pharmacology of Digoxin. (20) (2nd
A/2017)

Prepared by: Ahmad Raza (ASCP-02)

Mubeen Bilal (ASCP-47)

 According to the Punjab University College of Pharmacy (PUCP) Past papers (2015-2021)

5. Define Angina pectoris? Explain in details the mechanism of action of Anti-

anginal drugs, (20) (A/2018)
6. What do you understand by cardiac arrhythmias? Discuss various kinds of
arrhythmias? Explain anti-arrhythmic drugs in details. (20) (A/2018, 2nd
A/2018)
7. What do you understand by hypertension? Classify Anti-hypertensive
drugs? Explain calcium channels blockers and ACE inhibitors in detail.
(20) (2nd A/2018)
8. What do you understand by Cardiac Failure. Explain Digitalis glycosides in
details. (20) (2nd A/2018)
9. Discuss the mechanism of action of Class I and II anti-arrhythmic drugs.
(10) (2nd A/2018)
10. Define angina pectoris? Explain in detail the mechanism of action of anti-
anginal drugs. (20) (2nd A/2018)
11. Define angina pectoris. What are the major types of angina. Classify Anti-
angina drugs and discuss the Nitrates in detail. (20) (A/2019)
12. Give the classification of diuretics. Explain mechanism of action uses
adverse effects and toxicity of furosemide. (10) (A/2019)
13. Define hypertension and its stages. Classify Anti-hypertensive drugs and
discuss role of Diuretics & Angiotensin II receptors Blockers in detail.
(20) (A/2021)
14. Write note on the following. (20) (2nd A/2017)
a. Potassium sparing diuretics
b. Salbutamol

UNIT:7 DRUGS ACTING ON GENTIO-URINARY SYSTEM

N/A
UNIT:8 ANTI-ANAEMIC DRUGS

N/A
UNIT:9 HORMONES, ANTAGONIST AND OTHER AGNETS
AFFECTING ENDOCRINE FUNCTIONS

N/A

Prepared by: Ahmad Raza (ASCP-02)

Mubeen Bilal (ASCP-47)