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Dat 3728

This document provides guidance for substituting platelet requests based on blood type. It presents a platelet substitution matrix showing the preferred platelet type for recipients of different blood groups as first, second, or third choice. It also provides guidance on D selection and anti-D prophylaxis, recommending D negative platelets for D negative patients when possible due to risk of developing antibodies. ABO non-identical platelets may be used in emergencies or shortage situations. High titer negative platelets can reduce the risk of haemolysis for certain blood group mismatches.

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DR.RAJESWARI SUBRAMANIYAN
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79 views2 pages

Dat 3728

This document provides guidance for substituting platelet requests based on blood type. It presents a platelet substitution matrix showing the preferred platelet type for recipients of different blood groups as first, second, or third choice. It also provides guidance on D selection and anti-D prophylaxis, recommending D negative platelets for D negative patients when possible due to risk of developing antibodies. ABO non-identical platelets may be used in emergencies or shortage situations. High titer negative platelets can reduce the risk of haemolysis for certain blood group mismatches.

Uploaded by

DR.RAJESWARI SUBRAMANIYAN
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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DAT3728/1 – Platelet substitution matrix

Copy No:
Effective date: 01/07/2020

Guidance for substituting platelets requests

ABO non-identical platelets may be given at times of shortage or in an emergency, where no ABO identical
platelets are available.
They may also be used when specific requirements are necessary, the blood group is unknown or to prevent
wastage due to expiry.
High Titre (HT) negative platelets are available to reduce the risk of haemolysis.

Recipient Group Group O Group A Group B Group AB Unknown

1st Choice O A B AB AB

2nd Choice A or B AB AB A* or B* A* or B*

3rd Choice AB B* or O* A* or O* O* O*

Controlled if copy number stated on document and issued by QA


(Template Version 03/02/2020)
Page 1 of 2
Cross-Referenced in Primary Document: SOP4144

CONTROLLED
DAT3728/1 – Platelet substitution matrix

Copy No:
Effective date: 01/07/2020

For A or B units transfused into an O patient, or when AB is transfused, high-titre (HT) negative is not required. 

*HT negative anti-A and/or anti-B platelets should be selected where available which would lower the risk of haemolysis.
 Group O platelets for non-group O neonates and children should be avoided where possible due to the risk of haemolysis.

Due to the population distribution of group AB and its value as a universal plasma donor, stocks may be limited.
Guidance on D selection and anti-D prophylaxis
D negative platelets should be given to D negative patients where possible, particularly to D negative women of childbearing potential, boys
under 18 years and those who already have anti-D antibodies.

D positive may be transfused if D negative unavailable. In the case of women of child-bearing potential, anti-D prophylaxis should be given.

Controlled if copy number stated on document and issued by QA


(Template Version 03/02/2020)
Page 2 of 2
Cross-Referenced in Primary Document: SOP4144

CONTROLLED

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