Nama Obat Sediaan Rekonstitusi Perhatian Storage Vial Stability Product Product Keterangan

Stability
Asparaginase 1000 Unit 4 mL SWI Do not shake 2-8°C 48 h F, RT - syringe 14 d F Intermitten : ≥ 30 mnt
IM : 2 mL NS / SWI - 50 mL* NS or D5W 14 d F, 2 d RT
Bevacizumab 100 mg/4 mL, - Jangan 2-8°C discard unused 100-250 mL NS only 48 h F, RT  Intermitten:100 mL 10-
dikocok portion 1.4-16.5 mg/mL 60mnt (1st >90mnt),
 Intravitreal
Bleomycin Vial 15 Unit 6 mL NS or SWI no overfill 15-25°C 48 h F, 24 h RT 50-100 mL NS 24 h RT Intermitten/bolus: 10-
Im/sc : 1-5 mL (recommended) 15mnt
Intrapleura : 15-120 or 4wF, 2w RT
unit 100 mL

Bortezomib 3,5 mg 3,5 ml NS 2-8°C 2 d RT syringe 8 h RT WARNING:

SUBCUTANEOUS or
INTRAVENOUS use only
Carboplatin 150mg/ 15mL - Jangan 15-25°C discard unused NS, D5(less decomp) 24 h RT, 48 h F Intermitten : 15-60 mnt
450mg/45mL, gunakan spuit, portion 0,5-10mg/mL
Cisplatin 10 mg/10 mL - jarum atau 15-25 °C 48 h RT < 60mg: 100mL NS 48 h RT Intermitten: 15-30 mnt
50 mg/50 mL wadah yang Not > 60 mg: 250mL NS Rekomendasi premedikasi :
mengandung refrigera D5-NS,D5-NS dg hydration with NS, hypertonic
aluminium saline infusion, and mannitol, or
ted mannitol furosemide-induced diuresis to
effectively decrease cisplatin-
induced nephrotoxicity
Cetuximab 100 mg/50 mL solution may 2-8°C 12 h F, 8 h RT 100-250 mL NS only 12 h F, 8 h RT Intermitten : pertama 2 jam,
contain white selanjutnya 1 jam
particulates
which do not
affect product
quality
Clodronate 300 mg/10 mL - Inc. dg kalsium 15-25 °C discard unused 500 mL NS or D5, jgn 12 h RT Intermitten : ≥2 jam
spt infus RL portion dg RL
Cyclophospha 200 mg ,500 mg, NS 15-25 °C 48 h F,24 h RT < 1 g: 100 mL NS 72 h F, 24 h RT Intermitten: 20-60 mnt
mide 1000 mg, serbuk 200 mg: 10 mL Cytoxan : 24h > 1 g: 250 mL NS
500 mg: 25 mL RT, 6 d F high dose may need
1 g: 50 mL 500 NS; D5; D5NS

1
Cytarabine - 15-25°C 24 h RT SC, IM
100mg/mL, 1 g/10mL 100 mL*NS, WFI, D5,RL 72 h F, 24 h RT
IV : 15 mnt, HD (≥1g) 1-3jam
14 d F, 48 h RT
Syringe (SC,IM) Continuous Infus ≥ 24 jam
Cytarabine IT 100mg/mL, 1 g/10mL - 15-25°C 24 h RT 4h Anak: 5-15 mL pelarut
Injection (5mg/mL)
Dacarbazine 200 mg 200mg:19.7mL SWI Light&heat 2-8 °C 24 h RT, 8 d F 250-1000mL NS or 24 h F , 8 h RT Intermitten:1-2jam
sensitive D5 (0.19–3.0 mg/mL) Lindungi dr cahaya saat
pink pemberian
Daunorubicin 15-25°C Bolus:10-15mL 2-3mnt,
20 mg 4 mL SWI 48 h F, 24 h RT 100-250 mL NS or D5 24 h RT, 48 h F
Intrmit: 50-100 mL 10-45
mnt, anak:30-60mnt
Dactinomycin Dont filter, 15-25°C discard at end of Intermitten : 10-15 mnt
0,5 mg 1.1 mL SWI day
Syringe 4h
avoid benzyl
alkohol NS or D5 10 mcg/mL
or greater
Docetaxel 20 mg/0.5 mL  No reconst. non-PVC 2-8 °C  14 d F 250 mL NS or D5, 4hF Intermitten: >1jam
80 mg/2 mL  With diluent, if bag&tubing  48 h F, RT 0.3–0.74 mg/mL Rekomendasi Premedikasi :
refrigerated, warm only, 3 dosis dexamethason sblm
5mnt at RT,mix by dont shake terapi atau single dose
repeated inversions dexametason dan 50mg
for 45sec, Let sit for diphenhidramin 30 mnt
5minutes sblm terapi
Doxorubicin 10mg, 50mg,  No reconst. 2-8 °C 48 h F, 24 h RT - syringe 48 h F, 24 h RT Bolus, Intermitten : 15-
 NS, SWI, D5 - 100mL NS, D5 (0,2- 60mnt, bilas dg 20mL NS
10 mg: 5 mL 2mg/mL) atau D5, awasi ekstravasasi
50 mg: 25 mL
Epirubicin 10 mg  No reconst. 2-8 °C 48 h F, 24 h RT Syringe 48 h F, 24h RT Bolus, Intermitten : 15-
50mg  NS, SWI, D5 100 mL NS or D5 2 d F, RT 60mnt, bilas dg 20mL NS
10 mg: 5 mL atau D5, awasi ekstravasasi
50 mg: 25 mL
Etoposide 100 mg/5 mL - use non-PVC 15-25 °C discard unused NS 0.2-0.3 mg/mL: Intermitten iv: 30-60mnt
bag and tubing portion (no 7 d F,2 d RT Continuous infusion: ≥ 24
Stability is
only preservative) 0.4-0.5 mg/mL: jam
concentration
14 d RT 1 d F, 1 d RT
dependent
(Preservative) 0.6-9.0mg/mL:
generally unstable
9.5 mg/mL:

2
 2 d F, 1d RT
10-12 mg/mL:
7 d F,2 d RT
D5 4 h RT
Fludarabin 50 mg - 2-8 °C discard unused 50-100 mL* NS or 48 h F, 24 h RT Intermitten : 30 – 60 mnt
portion D5W Continuous Infusion : ≥ 24
dilute to maximum of jam
1 mg/mL
Fluorouracil 250 mg/5 mL , - 15-25 °C 48 h RT syringe 48 h RT Bolus :1-3mnt
500mg/10 mL 50-1000 mL D5, NS 24 h RT Intermitten :50mL15mnt
(2-10mg/mL) Continuous infus ≥ 24 jam
Gemcitabine 200 mg , 1 g 200 mg: 5 mL NS Kocok saat 15-25 °C 48 h RT - syringe 48 h RT Intrmitten :30-60 mnt
Serbuk 1000 mg: 25 mL NS pertama - 0.1 - 38 mg/mL NS
merekonst.
Ibandronic 6 mg/6 ml - 15-25 250-500 mL NS atau 24 h F i.v. inf. : 2 jam
Acid D5, jgn dg RL
Ifosfamide 1g 1 g: 20 mL SWI 15-25 °C 48 h F, 24 h RT 0.6–20 mg/mL 72 h F, 24 h RT Intrmit.: 60-120 mnt (>30
Atau 500–1000 mL when mix with mnt, tgtg konsentrasi)
NS, D5W, RL mesna 24hF,RT Continuous infus ≥ 24 jam
Pemberian bersama Mesna
Irinotecan 40mg/2mL, - Dont 15-25 °C 2 days RT 0.12-2.8 mg/mL 24 h RT: D5,NS Intermitten : 30 – 90 mnt
100mg/ 5mL refrigerate if in D5 (recommended), 48 h F: D5
NS NS
Leucovorin 50 mg/5 mL - 2-8 °C discard unused Syringe - 7 d F, 48 h RT IM
portion 50-250 mL NS, D5, RL 24 h RT (NS, RL), Bolus : ≥3mnt
12 h RT (D5) Intermitten : tgtg volume
Diberikan sebelum 5-FU
atau setelah Methotrexat
Mesna 1000 mg/10mL 2-8 °C 14 d F, RT ≥1mg/mL NS or D5W 48 h F, 24 h RT IM
Intrmitten:15-30mnt
Continuous Infus ≥ 24 jam
Methotrexat 50 mg/2mL - Dosis tinggi pd 15-25 °C Unpresrvatived: -syringe - 2d F, RT;14d F(P) SC, IM,
5 mg/2 mL single dose 2d F, RT 0.4–2 mg/mL 24 h RT B olus
free Preservatived: 100 mL NS, D5 Intrmitten :20mnt
pengawet, 14 d F High dose: 500- Continuous Infus : ≥ 24 jam
lindungi dr chy 1000ml
3
Methotrexat 50 mg/2mL - Label “IT” atau 15-25 °C discard unused 4h IT
IT Inj. “Intrathecal” portion Free preservative
Mitomycin 5 mg , 10 mg 5mg:10mL shake well 15-25 °C 48 h F, RT syringeintravesica -14 d F, 48 h RT Intravesica : 2-3jam
20 mg 10mg: 20mL 2mg/mL Inra ocular, intraperitoneal
2mg: 40mL SWI 0,02-0,04mg/mL NS, 12hRT:NS,3h: Intermitten :15-30 mnt
D5W, Na lactate D5,24h:Na lactat
Eye drop : 0,02-0,04 14d F, 2 d RT
% (b/v) SWI
Oxaliplatin 50 mg/10 mL - -dont use NS 2-25°C 48h F, RT 0.2-1.3 mg/mL: 14 Intermitten :250-500 mL
100mg /20 mL or other d F, 48 h RT 30 mnt – 3 jam
200mg/40mL chloride- 1.3-2 mg/mL: Diberikan sblm
250–500 mL D5 only 48 h F, 24 h RT
50 mg , 100 mg SWI, D5W: containing sol. 24 h F, RT fluoropyrimidin spt 5-FU
50 mg: 10 mL - Alimunium
100 mg: 20 mL free tubing
Paclitaxel 30 mg/5 mL - -use non-PVC 2-25°C 48 h RT 100–1000mL 27 h RT i.peritoneal
100 mg/16.7 mL bag and tubing D5,NS,RL (0.3–1.2 intrmitten :1-3jam
-avoid mg/mL) Rekomendasi premedikasi
excessive 30 mnt sblm paclitaxel:
shaking dexamethasone 20 mg IV +
diphenhydramine 50 mg IV +
ranitidine 50 mg IV
Rituximab 100 mg/10 mL - Jangan 2-8 °C discard unused 1-4mg/mL dlm 24h F+additional Iv: 1st50mg/jam dtgktkn
500 mg/50 mL dikocok portion NS/D5 (250-500 mL) 12h RT 50m/jam tiap 30mnt
2nd100mg/jm dtgktkn 100
(Jgn lbh dr 12 jam mg /jam tiap 30mnt
di suhu kamar) Max 400mg/jam
Trastuzumab 440 mg 20 mL supplied BWI, Putar 2-8 °C 28 d F 250mL NS only 24 h F, RT Intrmitten :pemberian
dont shake perlahan, (manufacturer), pertama90mnt,
diamkn 5mnt 14 d slnjtny60mnt
Vinblastine 10 mg/10 mL - Label with: discard unused syringe 4 h F, RT Bolus :>1mnt
WARNING: portion 100–250 mL D5,NS 24 h F, RT Intrmitten :5-15mnt
HANYA RUTE
INTRAVENA,
Vincristine 1 mg/1 mL , 2mg / - 2-8 °C 14 d F,RT(P), 50 - 100 mL NS, D5W 72 h F, 24 h RT Intrmitten :5-15mnt
FATAL JIKA
2mL 8h(UP) Continuous infus: 24 jam, 4-

4
 DIGUNAKAN 5 hari
Vinorelbine 10 mg/1 mL RUTE LAIN 2-8 °C discard unused syringe 24 h F, RT 50mL NS6-10 mnt bilas dg
50 mg/5 mL port 50mL NS, D5, RL(0,5- 75-125mL NS
2mg/mL) Continuous Infus
:1L96jam via central
venous catheter
Zoledronic 4mg/5mL - Inc. dg kalsium 2-25°C discard at end of 100 mL NS atau D5, 24 h F intermitten: 100mL
Acid spt infus RL day jgn dengan RL ≥15mnt

Keterangan : h = hour = jam P = Preservatived = mengandung pengawet

d = day = hari UP = Unpreservatived = tanpa pengawet
F = refrigerated = suhu kulkas = 2-8 °C BWI = Bacterostatic Water for Injection
RT = Room Temperature = 15-25 °C SWI = Sterile Water for Injection

Sumber :
Drug Information Handbook, 17th Edition. 2009
Handbook On Injectable Drugs, 15th Edition. 2009
BC Cancer Agency Cancer Drug Manual
Chemotherapy Preparation and Stability. BC Cancer Agency