Scribd
Upload
38 views2 pages

Ofloxacin

Ofloxacin is a second generation fluoroquinolone antibiotic that is active against both Gram-positive and Gram-negative bacteria by inhibiting bacterial DNA gyrase and topoisomerase IV. It is prescribed orally or intravenously to treat conditions such as pneumonia, gonorrhea, urinary tract infections, and skin, bone, respiratory tract, and reproductive organ infections. Ofloxacin is well absorbed but absorption is reduced by antacids containing divalent or trivalent cations; most of the drug is eliminated unchanged through urine. Adverse effects can include nausea, diarrhea, headaches, rash, and tendon damage.

Uploaded by

Waseem Haider
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
38 views2 pages

Ofloxacin

Ofloxacin is a second generation fluoroquinolone antibiotic that is active against both Gram-positive and Gram-negative bacteria by inhibiting bacterial DNA gyrase and topoisomerase IV. It is prescribed orally or intravenously to treat conditions such as pneumonia, gonorrhea, urinary tract infections, and skin, bone, respiratory tract, and reproductive organ infections. Ofloxacin is well absorbed but absorption is reduced by antacids containing divalent or trivalent cations; most of the drug is eliminated unchanged through urine. Adverse effects can include nausea, diarrhea, headaches, rash, and tendon damage.

Uploaded by

Waseem Haider
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 2

Ofloxacin

Introduction: Ofloxacin is a second generation fluoroquinolone.


Brand name:  Floxin, Ocuflox, Floxin Otic
Doses: 200-400mg
Mechanism: Ofloxacin is a second generation florouinolone.it is active against both Gram positive and
Gram negative bacteria. It functions by inhibiting two bacterial type II topoisomerases, DNA gyrase and
topoisomerase IV. Topoisomerase IV is an enzyme necessary to separate (mostly in prokaryotes, in
bacteria in particular) replicated DNA, thereby inhibiting bacterial cell division.
Antibacterial Action: Ofloxacin is active against Gram –ve and Gram+ve bacteria.
Gram+ ve bacteria
• Staphylococcus aureus
• Streptococcus pneumoniae
• Streptococcus pyogens
Gram –ve bacteria
• Enterobacter aerogenes
• Escherichia coli
• Neisseria gonorrhoeae
• Pseudomonas aeruginosa
Pharmacokinetics:

Route: Oral, IV, drops

Absorption: Well absorbed. Absorption impaired by: divalent and trivalent cations, including
those in antacid. Therefore, oral ofloxacin should be taken 2 hours before or 4 hours after any
products containing these cations.

Bioavailability: 80–95%

Distribution: Body fluids& tissue

Elimination: Mainly by renal excretion. 65 to 80% excrete unchanged via urine, also in feces.

Dosage adjustment: Required for patients with renal dysfunction 20 to 50 mL/min

Indication: Ofloxacin is primarily indicated in conditions like Pneumonia, Gonorrhea, Urinary


tract infection, Skin infections, Osteomyelitis, Respiratory tract infections, reproductive organs
and prostate.

Adverse effects: vomiting, diarrhea, headache, rash, tendon rupture, numbness, seizures,
psychosis, insomnia.
Drug interaction: It may affect the QT prolongation including amiodarone, quinidine and
satalol.

Contraindications: Ofloxacin is contraindicated in conditions like Epilepsy, pregnancy and in


patients with liver disease.

You might also like